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Database: UniProt
Entry: A0A286EA06_9NEIS
LinkDB: A0A286EA06_9NEIS
Original site: A0A286EA06_9NEIS 
ID   A0A286EA06_9NEIS        Unreviewed;       537 AA.
AC   A0A286EA06;
DT   22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT   22-NOV-2017, sequence version 1.
DT   16-JAN-2019, entry version 10.
DE   RecName: Full=Chromosomal replication initiator protein DnaA {ECO:0000256|HAMAP-Rule:MF_00377, ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS01081161};
GN   Name=dnaA {ECO:0000256|HAMAP-Rule:MF_00377};
GN   ORFNames=SAMN02746062_01022 {ECO:0000313|EMBL:SOD67757.1};
OS   Alysiella filiformis DSM 16848.
OC   Bacteria; Proteobacteria; Betaproteobacteria; Neisseriales;
OC   Neisseriaceae; Alysiella.
OX   NCBI_TaxID=1120981 {ECO:0000313|EMBL:SOD67757.1, ECO:0000313|Proteomes:UP000219669};
RN   [1] {ECO:0000313|EMBL:SOD67757.1, ECO:0000313|Proteomes:UP000219669}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 16848 {ECO:0000313|EMBL:SOD67757.1,
RC   ECO:0000313|Proteomes:UP000219669};
RA   Ehlers B., Leendertz F.H.;
RL   Submitted (SEP-2017) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Plays an important role in the initiation and regulation
CC       of chromosomal replication. Binds to the origin of replication; it
CC       binds specifically double-stranded DNA at a 9 bp consensus (dnaA
CC       box): 5'-TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic
CC       phospholipids. {ECO:0000256|HAMAP-Rule:MF_00377,
CC       ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00756121}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00377,
CC       ECO:0000256|SAAS:SAAS01082709}.
CC   -!- SIMILARITY: Belongs to the DnaA family. {ECO:0000256|HAMAP-
CC       Rule:MF_00377, ECO:0000256|RuleBase:RU004227,
CC       ECO:0000256|SAAS:SAAS00555179}.
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DR   EMBL; OCNF01000006; SOD67757.1; -; Genomic_DNA.
DR   Proteomes; UP000219669; Unassembled WGS sequence.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0003688; F:DNA replication origin binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0006270; P:DNA replication initiation; IEA:UniProtKB-UniRule.
DR   GO; GO:0006275; P:regulation of DNA replication; IEA:UniProtKB-UniRule.
DR   CDD; cd06571; Bac_DnaA_C; 1.
DR   Gene3D; 1.10.1750.10; -; 1.
DR   Gene3D; 3.30.300.180; -; 1.
DR   HAMAP; MF_00377; DnaA_bact; 1.
DR   InterPro; IPR003593; AAA+_ATPase.
DR   InterPro; IPR001957; Chromosome_initiator_DnaA.
DR   InterPro; IPR020591; Chromosome_initiator_DnaA-like.
DR   InterPro; IPR018312; Chromosome_initiator_DnaA_CS.
DR   InterPro; IPR013317; DnaA.
DR   InterPro; IPR013159; DnaA_C.
DR   InterPro; IPR024633; DnaA_N_dom.
DR   InterPro; IPR038454; DnaA_N_sf.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR010921; Trp_repressor/repl_initiator.
DR   PANTHER; PTHR30050:SF2; PTHR30050:SF2; 1.
DR   Pfam; PF00308; Bac_DnaA; 1.
DR   Pfam; PF08299; Bac_DnaA_C; 1.
DR   Pfam; PF11638; DnaA_N; 1.
DR   PRINTS; PR00051; DNAA.
DR   SMART; SM00382; AAA; 1.
DR   SMART; SM00760; Bac_DnaA_C; 1.
DR   SUPFAM; SSF48295; SSF48295; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   TIGRFAMs; TIGR00362; DnaA; 1.
DR   PROSITE; PS01008; DNAA; 1.
PE   3: Inferred from homology;
KW   ATP-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00756129};
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000219669};
KW   Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|SAAS:SAAS01082702};
KW   DNA replication {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU004227, ECO:0000256|SAAS:SAAS00756116};
KW   DNA-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS01082706};
KW   Nucleotide-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00756117};
KW   Reference proteome {ECO:0000313|Proteomes:UP000219669}.
FT   DOMAIN      233    363       AAA. {ECO:0000259|SMART:SM00382}.
FT   DOMAIN      445    514       Bac_DnaA_C. {ECO:0000259|SMART:SM00760}.
FT   NP_BIND     241    248       ATP. {ECO:0000256|HAMAP-Rule:MF_00377}.
FT   COILED      395    415       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   537 AA;  60691 MW;  F0186BFED50EB65D CRC64;
     MKLADFWAQT LRRLHTELSE QQFKNTIVPL TVGEEDGAWV IYAKNQFAIN LLRSQYAPKL
     AQIRAEIAPN APELLFKVGT GTHYEMAAES PKNTLSGSLK TPQNANKTLE IETPNIVEDQ
     QPSPQTHEVA KDVSGSLKTP ATSPKRSAQE MLAERMKNLR PSKKTPPSHE ENPTTKTKVS
     AIEAAKAKDD AAQRLAQTNL SPEYTFDTLV EGKGNHLAAA VAKSIAEKPG DSMYNPFFVY
     GSTGLGKTHL VQAIGNELLK FNPKAKVRYM HSDEYLKTFM ATVRNKTWDA FKQQYLHYNL
     LIIDDIQFIQ GKDRTMEEFF FLFEHFHSRN QQIILTCDQL PSSLENMEKR LISRFSWGMT
     IKLEPPELEM RIDILERKAQ AAGIELFEDA ALFIAQNVKQ NVRELEGALN RVLARCRFEK
     RSTIDIDLAT DALQDIVASN YKPITIELIM KAVADYHHIR MSDLLGKKRT RNIARPRQMA
     MALAKELTNM SLPAIGDAFG GRDHTTVMHA VKTIAQLRVE EPELGQDYEK LLILIQN
//
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