ID A0A286EA67_9ACTN Unreviewed; 643 AA.
AC A0A286EA67;
DT 22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 1.
DT 27-MAR-2024, entry version 20.
DE SubName: Full=Erythronolide synthase docking {ECO:0000313|EMBL:SOD67802.1};
DE Flags: Fragment;
GN ORFNames=SAMN06297387_1351 {ECO:0000313|EMBL:SOD67802.1};
OS Streptomyces zhaozhouensis.
OC Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC Streptomycetaceae; Streptomyces.
OX NCBI_TaxID=1300267 {ECO:0000313|EMBL:SOD67802.1, ECO:0000313|Proteomes:UP000219072};
RN [1] {ECO:0000313|EMBL:SOD67802.1, ECO:0000313|Proteomes:UP000219072}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CGMCC 4.7095 {ECO:0000313|EMBL:SOD67802.1,
RC ECO:0000313|Proteomes:UP000219072};
RA Ehlers B., Leendertz F.H.;
RL Submitted (SEP-2017) to the EMBL/GenBank/DDBJ databases.
CC -!- COFACTOR:
CC Name=pantetheine 4'-phosphate; Xref=ChEBI:CHEBI:47942;
CC Evidence={ECO:0000256|ARBA:ARBA00001957};
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DR EMBL; OCNE01000035; SOD67802.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A286EA67; -.
DR OrthoDB; 9778690at2; -.
DR Proteomes; UP000219072; Unassembled WGS sequence.
DR GO; GO:0004315; F:3-oxoacyl-[acyl-carrier-protein] synthase activity; IEA:InterPro.
DR GO; GO:0017000; P:antibiotic biosynthetic process; IEA:UniProtKB-KW.
DR GO; GO:0006633; P:fatty acid biosynthetic process; IEA:InterPro.
DR CDD; cd00833; PKS; 1.
DR Gene3D; 3.30.70.3290; -; 1.
DR Gene3D; 3.40.47.10; -; 1.
DR Gene3D; 3.40.366.10; Malonyl-Coenzyme A Acyl Carrier Protein, domain 2; 1.
DR InterPro; IPR001227; Ac_transferase_dom_sf.
DR InterPro; IPR014043; Acyl_transferase.
DR InterPro; IPR016035; Acyl_Trfase/lysoPLipase.
DR InterPro; IPR018201; Ketoacyl_synth_AS.
DR InterPro; IPR014031; Ketoacyl_synth_C.
DR InterPro; IPR014030; Ketoacyl_synth_N.
DR InterPro; IPR032821; PKS_assoc.
DR InterPro; IPR020841; PKS_Beta-ketoAc_synthase_dom.
DR InterPro; IPR015083; Polyketide_synth_docking.
DR InterPro; IPR016039; Thiolase-like.
DR PANTHER; PTHR43775; FATTY ACID SYNTHASE; 1.
DR PANTHER; PTHR43775:SF51; PHENOLPHTHIOCEROL_PHTHIOCEROL POLYKETIDE SYNTHASE SUBUNIT E; 1.
DR Pfam; PF00698; Acyl_transf_1; 1.
DR Pfam; PF08990; Docking; 1.
DR Pfam; PF16197; KAsynt_C_assoc; 1.
DR Pfam; PF00109; ketoacyl-synt; 1.
DR Pfam; PF02801; Ketoacyl-synt_C; 1.
DR SMART; SM00825; PKS_KS; 1.
DR SUPFAM; SSF52151; FabD/lysophospholipase-like; 1.
DR SUPFAM; SSF53901; Thiolase-like; 1.
DR PROSITE; PS00606; KS3_1; 1.
DR PROSITE; PS52004; KS3_2; 1.
PE 4: Predicted;
KW Acyltransferase {ECO:0000256|ARBA:ARBA00023315};
KW Antibiotic biosynthesis {ECO:0000256|ARBA:ARBA00023194};
KW Reference proteome {ECO:0000313|Proteomes:UP000219072};
KW Transferase {ECO:0000256|ARBA:ARBA00023315}.
FT DOMAIN 33..460
FT /note="Ketosynthase family 3 (KS3)"
FT /evidence="ECO:0000259|PROSITE:PS52004"
FT NON_TER 643
FT /evidence="ECO:0000313|EMBL:SOD67802.1"
SQ SEQUENCE 643 AA; 67785 MW; E1D4A73DDABE0476 CRC64;
MSNEEKYLDY LRRATVDLQE MRGKLREVEE RESEPIAVVG MSCRFPGGVA SPEDLWRLLA
DGRDAVTEFP TDRGWDLDAL FDDDPDRQGT SYSRHGAFVH DVPDFDPAFF GISPREAAAM
DPQQRLLLET SWEVLERAGI DPGSLRGSRS GVFVGTNGQD YAVRLATGAP EGYEGYIGTG
NAASIISGRV AYTLGFEGPA LTVDTACSSS LVALHLAVHA LRHGECPLAI AGGVTVMSTP
GVFIDFSRQR GLALDGRCKA FADGADGTAW GEGAGLLLLE RLSDAQRNGH PVLAVIRGSA
INQDGASNGL TAPNGPSQQR VIRQALTSAG LTAADVDAVE AHGTGTRLGD PIEAQALLAT
YGQGRPADRP LWLGSVKSNI GHTQAAAGVV GVMKMILAMR HGELPRTLHV DAPSTHVDWS
AGAVELLTEH RPWPETGQRR RAGVSSFGVS GTNAHVIVEQ APEAAETAEA AETGDRLPPG
TLLPWVLSAR SAEALRAQAA RLAAGLGDHD PADIGHALVT SRATWEHRAV VVAGERSEFR
AALAALAEGR SSGAVVTGVA DEPGRLGFLF SGQGAQRLGM GRELASRFPV FAEALDEALG
EFEPAVRAVL FGADEGALNE TGVTQPALFA VEVALFRLLE SWG
//
