ID A0A286EHT4_9ACTN Unreviewed; 744 AA.
AC A0A286EHT4;
DT 22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 1.
DT 27-MAR-2024, entry version 16.
DE SubName: Full=RND superfamily putative drug exporter {ECO:0000313|EMBL:SOD70485.1};
GN ORFNames=SAMN05892883_0180 {ECO:0000313|EMBL:SOD70485.1};
OS Jatrophihabitans sp. GAS493.
OC Bacteria; Actinomycetota; Actinomycetes; Jatrophihabitantales;
OC Jatrophihabitantaceae; Jatrophihabitans.
OX NCBI_TaxID=1907575 {ECO:0000313|EMBL:SOD70485.1, ECO:0000313|Proteomes:UP000218903};
RN [1] {ECO:0000313|EMBL:SOD70485.1, ECO:0000313|Proteomes:UP000218903}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=GAS493 {ECO:0000313|EMBL:SOD70485.1,
RC ECO:0000313|Proteomes:UP000218903};
RA Ehlers B., Leendertz F.H.;
RL Submitted (SEP-2017) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; LT907982; SOD70485.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A286EHT4; -.
DR InParanoid; A0A286EHT4; -.
DR OrthoDB; 7051771at2; -.
DR Proteomes; UP000218903; Chromosome i.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR Gene3D; 1.20.1640.10; Multidrug efflux transporter AcrB transmembrane domain; 2.
DR InterPro; IPR004869; MMPL_dom.
DR InterPro; IPR000731; SSD.
DR PANTHER; PTHR33406; MEMBRANE PROTEIN MJ1562-RELATED; 1.
DR PANTHER; PTHR33406:SF2; MEMBRANE PROTEIN SCO6666-RELATED; 1.
DR Pfam; PF03176; MMPL; 2.
DR SUPFAM; SSF82866; Multidrug efflux transporter AcrB transmembrane domain; 2.
DR PROSITE; PS50156; SSD; 1.
PE 4: Predicted;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 231..252
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 280..301
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 307..332
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 368..390
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 534..555
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 560..578
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 598..618
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 639..660
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 666..686
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 209..330
FT /note="SSD"
FT /evidence="ECO:0000259|PROSITE:PS50156"
SQ SEQUENCE 744 AA; 78076 MW; 823A5220D69730E5 CRC64;
MIDRLAHLVF HRRRLVLALS AAVLVAFAAL AAGAFSVLKV GGFDDPRSDS SQAQHLLDTK
FGGQTNLIML VTPVAGGHLD DPAVVSAVGT LTENLRSTGD VGTITSYWST HSDSLRTRAG
DSALVTMHVE GDDDASFKAA QRIIDDYART DATIQVRAGG QLGVNHDVTA QVGKDLGIAE
GIAVPITLLL LILAFGSLVA ALLPLGIGLV AIAGTFAELS LLGHVTDVST YAINLTTALG
LGLAIDYSLL IVNRFREEVA AGSETEAAIA RTLHTAGRTV IFSSATVAVA LAAMVIFPLY
FLRSFAYAGI GVVLIAMLSA LITLPALLSW LGERVNSGRV IRRRPIRPAS QESAFWRRTA
TTVMRHPVLI ALPVIALLLV MGSPFLKIVF STPDDRALPT TLASRQVGDA LRSDFPGNAA
ANLYVVIDGP AEQNSLDAYA ARVSAITGVT SVQAPDGLWR AGQLTPASAP QLARSDARYL
VVTGPTDGAS AAAQQLVTTI RSVAAPAGTQ VRVGGAPAQL VDSKDAIGSR LPWALLWIAV
TTFVLLFLFT GSVVLPIKAL LLNALSLSAV FGAMVWIFQE GHFSSLLGFT PTPINTSMPV
LLFCIAFGLS MDYEVFLLSR IKEEHDHGAS NTEAVAAGLA RTGRIVSTAA LLLSVTFFAF
GTSHVSFLQL FGIGTAIAIV LDATVIRGIL VPAFMKVAGE ANWWAPAPLR RLHSRVGLSE
TVIPSDAQLA ELTGPVEPAG AGRS
//
