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Database: UniProt
Entry: A0A286EQZ3_9ACTN
LinkDB: A0A286EQZ3_9ACTN
Original site: A0A286EQZ3_9ACTN 
ID   A0A286EQZ3_9ACTN        Unreviewed;       428 AA.
AC   A0A286EQZ3;
DT   22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT   22-NOV-2017, sequence version 1.
DT   16-JAN-2019, entry version 6.
DE   RecName: Full=Homoserine dehydrogenase {ECO:0000256|RuleBase:RU000579};
DE            EC=1.1.1.3 {ECO:0000256|RuleBase:RU000579};
GN   ORFNames=SAMN05892883_2588 {ECO:0000313|EMBL:SOD73296.1};
OS   Jatrophihabitans sp. GAS493.
OC   Bacteria; Actinobacteria; Frankiales; Frankiaceae; Jatrophihabitans.
OX   NCBI_TaxID=1907575 {ECO:0000313|EMBL:SOD73296.1, ECO:0000313|Proteomes:UP000218903};
RN   [1] {ECO:0000313|EMBL:SOD73296.1, ECO:0000313|Proteomes:UP000218903}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=GAS493 {ECO:0000313|EMBL:SOD73296.1,
RC   ECO:0000313|Proteomes:UP000218903};
RA   Ehlers B., Leendertz F.H.;
RL   Submitted (SEP-2017) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=L-homoserine + NADP(+) = H(+) + L-aspartate 4-
CC         semialdehyde + NADPH; Xref=Rhea:RHEA:15761, ChEBI:CHEBI:15378,
CC         ChEBI:CHEBI:57476, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349,
CC         ChEBI:CHEBI:537519; EC=1.1.1.3;
CC         Evidence={ECO:0000256|RuleBase:RU000579};
CC   -!- PATHWAY: Amino-acid biosynthesis; L-methionine biosynthesis via de
CC       novo pathway; L-homoserine from L-aspartate: step 3/3.
CC       {ECO:0000256|RuleBase:RU000579}.
CC   -!- PATHWAY: Amino-acid biosynthesis; L-threonine biosynthesis; L-
CC       threonine from L-aspartate: step 3/5.
CC       {ECO:0000256|RuleBase:RU000579}.
CC   -!- SIMILARITY: Belongs to the homoserine dehydrogenase family.
CC       {ECO:0000256|RuleBase:RU004171}.
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DR   EMBL; LT907982; SOD73296.1; -; Genomic_DNA.
DR   UniPathway; UPA00050; UER00063.
DR   UniPathway; UPA00051; UER00465.
DR   Proteomes; UP000218903; Chromosome i.
DR   GO; GO:0004412; F:homoserine dehydrogenase activity; IEA:UniProtKB-EC.
DR   GO; GO:0050661; F:NADP binding; IEA:InterPro.
DR   GO; GO:0009097; P:isoleucine biosynthetic process; IEA:UniProtKB-KW.
DR   GO; GO:0009086; P:methionine biosynthetic process; IEA:UniProtKB-KW.
DR   GO; GO:0009088; P:threonine biosynthetic process; IEA:UniProtKB-UniPathway.
DR   InterPro; IPR002912; ACT_dom.
DR   InterPro; IPR005106; Asp/hSer_DH_NAD-bd.
DR   InterPro; IPR016204; HDH.
DR   InterPro; IPR001342; HDH_cat.
DR   InterPro; IPR019811; HDH_CS.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   Pfam; PF01842; ACT; 1.
DR   Pfam; PF00742; Homoserine_dh; 1.
DR   Pfam; PF03447; NAD_binding_3; 1.
DR   PIRSF; PIRSF000098; Homoser_dehydrog; 1.
DR   SUPFAM; SSF51735; SSF51735; 1.
DR   PROSITE; PS51671; ACT; 1.
DR   PROSITE; PS01042; HOMOSER_DHGENASE; 1.
PE   3: Inferred from homology;
KW   Amino-acid biosynthesis {ECO:0000256|RuleBase:RU000579};
KW   Branched-chain amino acid biosynthesis
KW   {ECO:0000256|RuleBase:RU000579};
KW   Complete proteome {ECO:0000313|Proteomes:UP000218903};
KW   Isoleucine biosynthesis {ECO:0000256|RuleBase:RU000579};
KW   Methionine biosynthesis {ECO:0000256|RuleBase:RU000579};
KW   NADP {ECO:0000256|PIRSR:PIRSR000098-2, ECO:0000256|RuleBase:RU000579};
KW   Oxidoreductase {ECO:0000256|RuleBase:RU000579};
KW   Reference proteome {ECO:0000313|Proteomes:UP000218903};
KW   Threonine biosynthesis {ECO:0000256|RuleBase:RU000579}.
FT   DOMAIN      348    427       ACT. {ECO:0000259|PROSITE:PS51671}.
FT   NP_BIND      10     17       NADP. {ECO:0000256|PIRSR:PIRSR000098-2}.
FT   ACT_SITE    204    204       Proton donor. {ECO:0000256|PIRSR:
FT                                PIRSR000098-1}.
FT   BINDING     104    104       NADP. {ECO:0000256|PIRSR:PIRSR000098-2}.
FT   BINDING     189    189       Substrate. {ECO:0000256|PIRSR:
FT                                PIRSR000098-2}.
SQ   SEQUENCE   428 AA;  44144 MW;  F0317CDDFAAAECDB CRC64;
     MSDSLKVALL GCGVVGSEVA RLLQEQAEDL TARIGAPLEL AGVAVRRPNR HPDIDPSLIT
     TDARELVARP DIDLVIEVIG GIEPVRSLLL EALKSGKSVV SANKALLAED GATLYEAAAG
     AGVDLYYEAA VAGAIPLLRP LRESLAGDRI TRVMGIVNGT TNFILSRMDA TGAGFDEALA
     EATELGYAEA DPSADIDGFD AAAKAAILAG LAFHTRVTTS DVYREGISDV TSADIASAKA
     MGCTVKLLAI CERTEESVSV RVHPAMIPRT HPLAGVSDAY NAVFVEAEAA GSLMFYGRGA
     GGAPTASAIL GDLVAVARNK LNGGRGSGAS TYADLRVVPM ADVHTRYHVA LDVADRPGVL
     ATVAGAFAEH GVSIQTVRQE GRGDAATLVL VTHSATDAAL AKTVDGLGGM GFLRRPANVL
     RVEGMPSD
//
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