ID   A0A286GMS9_9PROT        Unreviewed;       378 AA.
AC   A0A286GMS9;
DT   22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT   22-NOV-2017, sequence version 1.
DT   27-MAR-2024, entry version 19.
DE   SubName: Full=3-ketoacyl-CoA thiolase {ECO:0000313|EMBL:SOD96294.1};
GN   ORFNames=SAMN05421508_105253 {ECO:0000313|EMBL:SOD96294.1};
OS   Caenispirillum bisanense.
OC   Bacteria; Pseudomonadota; Alphaproteobacteria; Rhodospirillales;
OC   Novispirillaceae; Caenispirillum.
OX   NCBI_TaxID=414052 {ECO:0000313|EMBL:SOD96294.1, ECO:0000313|Proteomes:UP000219621};
RN   [1] {ECO:0000313|EMBL:SOD96294.1, ECO:0000313|Proteomes:UP000219621}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=USBA 140 {ECO:0000313|EMBL:SOD96294.1,
RC   ECO:0000313|Proteomes:UP000219621};
RA   Ehlers B., Leendertz F.H.;
RL   Submitted (SEP-2017) to the EMBL/GenBank/DDBJ databases.
CC   -!- PATHWAY: Lipid metabolism. {ECO:0000256|ARBA:ARBA00005189}.
CC   -!- SIMILARITY: Belongs to the thiolase-like superfamily. Thiolase family.
CC       {ECO:0000256|ARBA:ARBA00010982, ECO:0000256|RuleBase:RU003557}.
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DR   EMBL; OCNJ01000005; SOD96294.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A286GMS9; -.
DR   OrthoDB; 9764638at2; -.
DR   Proteomes; UP000219621; Unassembled WGS sequence.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProt.
DR   GO; GO:0016747; F:acyltransferase activity, transferring groups other than amino-acyl groups; IEA:InterPro.
DR   CDD; cd00751; thiolase; 1.
DR   Gene3D; 3.40.47.10; -; 1.
DR   InterPro; IPR002155; Thiolase.
DR   InterPro; IPR016039; Thiolase-like.
DR   InterPro; IPR020615; Thiolase_acyl_enz_int_AS.
DR   InterPro; IPR020617; Thiolase_C.
DR   InterPro; IPR020613; Thiolase_CS.
DR   InterPro; IPR020616; Thiolase_N.
DR   NCBIfam; TIGR01930; AcCoA-C-Actrans; 1.
DR   PANTHER; PTHR43853; 3-KETOACYL-COA THIOLASE, PEROXISOMAL; 1.
DR   PANTHER; PTHR43853:SF8; 3-KETOACYL-COA THIOLASE, PEROXISOMAL; 1.
DR   Pfam; PF02803; Thiolase_C; 1.
DR   Pfam; PF00108; Thiolase_N; 1.
DR   PIRSF; PIRSF000429; Ac-CoA_Ac_transf; 1.
DR   SUPFAM; SSF53901; Thiolase-like; 2.
DR   PROSITE; PS00098; THIOLASE_1; 1.
DR   PROSITE; PS00737; THIOLASE_2; 1.
PE   3: Inferred from homology;
KW   Acyltransferase {ECO:0000256|RuleBase:RU003557};
KW   Reference proteome {ECO:0000313|Proteomes:UP000219621};
KW   Transferase {ECO:0000256|RuleBase:RU003557}.
FT   DOMAIN          6..248
FT                   /note="Thiolase N-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF00108"
FT   DOMAIN          256..376
FT                   /note="Thiolase C-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF02803"
FT   ACT_SITE        91
FT                   /note="Acyl-thioester intermediate"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR000429-1"
FT   ACT_SITE        334
FT                   /note="Proton acceptor"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR000429-1"
FT   ACT_SITE        364
FT                   /note="Proton acceptor"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR000429-1"
SQ   SEQUENCE   378 AA;  38988 MW;  76091CD8FC5A7D92 CRC64;
     MTRKAVIAGY CRTPFTFAHK GALAGMRPDD LGAHVVRALI ARTGVPPAEI EDVIWGCAFP
     EGEQGLNIGR VVGMLAGLPE TVAGATINRW CGSSIQAVQM AAGMIATNAG EAFVCGGTEC
     MSRVPMMGFN QLPNPAWDAQ MVADYINVGL TAERVAGMYG LTREDQDRFG HWSQSKAVAA
     RDGGRLAPEI VPVPMGDTLV DTDGCIRATT LEKLATLKPA FKADGTVTAA SSSPMTDGAT
     AVLVCTEDFA ARHGLTVLAA VKSFAVSGCA PGVMGLGPIE ATRKALARAG LTIADIDLVE
     MNEAFAAQAE ACRRDLGIPE ERLNIDGGAI ALGHPLGATG TRLVGKAASL LAREGKTHAL
     ATQCIGGGMG IAMILEAA
//