ID A0A286ITM3_9BACT Unreviewed; 1418 AA.
AC A0A286ITM3;
DT 22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 1.
DT 24-JAN-2024, entry version 18.
DE RecName: Full=histidine kinase {ECO:0000256|ARBA:ARBA00012438};
DE EC=2.7.13.3 {ECO:0000256|ARBA:ARBA00012438};
GN ORFNames=SAMN06298216_3612 {ECO:0000313|EMBL:SOE23218.1};
OS Spirosomataceae bacterium TFI 002.
OC Bacteria; Bacteroidota; Cytophagia; Cytophagales; Spirosomataceae.
OX NCBI_TaxID=1945892 {ECO:0000313|EMBL:SOE23218.1, ECO:0000313|Proteomes:UP000217493};
RN [1] {ECO:0000313|EMBL:SOE23218.1, ECO:0000313|Proteomes:UP000217493}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=TFI 002 {ECO:0000313|EMBL:SOE23218.1,
RC ECO:0000313|Proteomes:UP000217493};
RA Ehlers B., Leendertz F.H.;
RL Submitted (SEP-2017) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + protein L-histidine = ADP + protein N-phospho-L-
CC histidine.; EC=2.7.13.3; Evidence={ECO:0000256|ARBA:ARBA00000085};
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DR EMBL; LT907983; SOE23218.1; -; Genomic_DNA.
DR OrthoDB; 9806995at2; -.
DR Proteomes; UP000217493; Chromosome i.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR GO; GO:0000155; F:phosphorelay sensor kinase activity; IEA:InterPro.
DR GO; GO:0043565; F:sequence-specific DNA binding; IEA:InterPro.
DR CDD; cd00082; HisKA; 1.
DR CDD; cd17574; REC_OmpR; 1.
DR Gene3D; 1.10.287.130; -; 1.
DR Gene3D; 3.40.50.2300; -; 1.
DR Gene3D; 3.30.565.10; Histidine kinase-like ATPase, C-terminal domain; 1.
DR Gene3D; 1.10.10.60; Homeodomain-like; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 1.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 3.
DR InterPro; IPR011006; CheY-like_superfamily.
DR InterPro; IPR003594; HATPase_C.
DR InterPro; IPR036890; HATPase_C_sf.
DR InterPro; IPR005467; His_kinase_dom.
DR InterPro; IPR003661; HisK_dim/P.
DR InterPro; IPR036097; HisK_dim/P_sf.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR018060; HTH_AraC.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR011110; Reg_prop.
DR InterPro; IPR004358; Sig_transdc_His_kin-like_C.
DR InterPro; IPR001789; Sig_transdc_resp-reg_receiver.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR011123; Y_Y_Y.
DR PANTHER; PTHR43547:SF2; HYBRID SIGNAL TRANSDUCTION HISTIDINE KINASE C; 1.
DR PANTHER; PTHR43547; TWO-COMPONENT HISTIDINE KINASE; 1.
DR Pfam; PF02518; HATPase_c; 1.
DR Pfam; PF00512; HisKA; 1.
DR Pfam; PF12833; HTH_18; 1.
DR Pfam; PF07494; Reg_prop; 5.
DR Pfam; PF00072; Response_reg; 1.
DR Pfam; PF07495; Y_Y_Y; 1.
DR PRINTS; PR00344; BCTRLSENSOR.
DR SMART; SM00387; HATPase_c; 1.
DR SMART; SM00388; HisKA; 1.
DR SMART; SM00342; HTH_ARAC; 1.
DR SMART; SM00448; REC; 1.
DR SUPFAM; SSF55874; ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase; 1.
DR SUPFAM; SSF63829; Calcium-dependent phosphotriesterase; 3.
DR SUPFAM; SSF52172; CheY-like; 1.
DR SUPFAM; SSF46689; Homeodomain-like; 1.
DR SUPFAM; SSF47384; Homodimeric domain of signal transducing histidine kinase; 1.
DR PROSITE; PS50109; HIS_KIN; 1.
DR PROSITE; PS01124; HTH_ARAC_FAMILY_2; 1.
DR PROSITE; PS50110; RESPONSE_REGULATORY; 1.
PE 4: Predicted;
KW Kinase {ECO:0000313|EMBL:SOE23218.1}; Membrane {ECO:0000256|SAM:Phobius};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553, ECO:0000256|PROSITE-
KW ProRule:PRU00169}; Reference proteome {ECO:0000313|Proteomes:UP000217493};
KW Signal {ECO:0000256|SAM:SignalP};
KW Transferase {ECO:0000313|EMBL:SOE23218.1};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..23
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 24..1418
FT /note="histidine kinase"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5012109073"
FT TRANSMEM 837..858
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 895..1116
FT /note="Histidine kinase"
FT /evidence="ECO:0000259|PROSITE:PS50109"
FT DOMAIN 1166..1281
FT /note="Response regulatory"
FT /evidence="ECO:0000259|PROSITE:PS50110"
FT DOMAIN 1313..1412
FT /note="HTH araC/xylS-type"
FT /evidence="ECO:0000259|PROSITE:PS01124"
FT MOD_RES 1214
FT /note="4-aspartylphosphate"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00169"
SQ SEQUENCE 1418 AA; 161564 MW; 1C0162CCC8219F1F CRC64;
MASIVRKCFL VGILLLQSTS IFSQWRLNAI AGEEGLSHNT VTSIIQDEDG YLWFGTFNGI
NKYDGYSMKQ YNYSLNAEGL SSNVIFKLFE DKKGYLWAGT TAGLNRINPN TGNIDVYFKG
DDEPRYTGQN NIQQSKSGIF FINTIKGIKF FEIDGSGNLE YEFFLNKYKG LNLDIQNLTP
SSNGKYWFLT PSAKVKLHQV EVLKNGKTPK LNIDATDYTE SLFSSGGAIL DILEYPKNTV
WVINDQFELL KLKLNSDLKV VESEKILLVQ NIGKEQLKEQ GTVNMVADKE GRIWIAGNGL
LLNYNTELRE SNNLSRNNQL KGLLTNLDIQ EIFVDNSNIL WMGTLNNGLY KMDLDNHTFY
NSTEYLNSQE SQDLFKSPIH SMCEDERGNL WFGTQDGNIV ALRKNALKNN FSKSPIAYTY
QVTGKKLDKV FQKPQIKRLM SDREGAIWAG SLNGLFKFKY DETSQSFEVK KIDSIKDNFG
NIIDKPVFAI EEDRKGNIWF GAWEKGLVKM TFNKQRNSHQ SVIYSASNRD STSLSNNNIR
DILEDTQGNI WVGTIKGLNK LKRSESGKVT FEKIFSKSEG SNTLSSAHVL DIHQAQNGAI
YVGTYGGGLN RLNYSSKGNL EFTNYTVKNG LPSDVVYQIR EDFEGNIWLM HTRKISKLNP
STGEVIYFEK NNGFNVDEFK ENAMEFTSSG TMLCGGVNGF TFFQPNKIIV NNLEPQMTIT
DFKLLNESVR VNEVFDGRVI LSDGINKTNR IELPYHLNSF EFVFSSMHFS NPESNRYKFI
LEGFEENART TIGNERRFAS YTNVPPGKYI FKVYGSNSSG IWNNDPKEVL IVITPPWYLT
PLAILFFIAI CIAILYIINK VRWNQIKLKN DLKLESALHE KAEEINQMKL LFFTNISHEL
RTPLTLIIGP LQQIMEGHTD PKYLKRLNGI MYKNSTRLLR LINQLLDFRK AESGNVNLIV
EHGDLVVFLE EIYNAFEEIA IERNVGFTFK TKEKDLGAWF DNDKMEKILY NLLSNSFKFT
PPNRNIELLL KKETVDGKES AVIQVVDEGI GIASEDLINV FERFYQVKKE SDMIQMGSGL
GLAFTKRLIE VHRGNISINS STERGTTCTV SIPISKSEYE SDATLEMQTK QHNFSFVKNE
IKDFKDLLAA PSKRVKEVKH SKETPTLLVV EDNTGLREYI SDYFEDHYKV LSAKDGEEGL
KVAFEKSPDL IITDLMMPKM GGIEMCKIIK SDINTSHIPV IILTAKSGLE NEKEGLETGA
DEFVLKPFNM EVLRLRVNNI LQTKQQWTEK FKTEPTSSTW KELSSNLDKE FLKKSLKIIR
ENIDNSDYSG EDFAIDIGMS RSGLFKKIKS ITGQSTTEFI RTIRIKRAAN LITTCKYSIT
EVVFMVGFTD PKYFRTCFKK QFGKTPSDYL KAFKESVL
//
