ID A0A286U6H1_9AGAM Unreviewed; 1214 AA.
AC A0A286U6H1;
DT 31-JAN-2018, integrated into UniProtKB/TrEMBL.
DT 31-JAN-2018, sequence version 1.
DT 27-MAR-2024, entry version 23.
DE SubName: Full=MFS general substrate transporter {ECO:0000313|EMBL:PAV15129.1};
GN ORFNames=PNOK_0889000 {ECO:0000313|EMBL:PAV15129.1};
OS Pyrrhoderma noxium.
OC Eukaryota; Fungi; Dikarya; Basidiomycota; Agaricomycotina; Agaricomycetes;
OC Hymenochaetales; Hymenochaetaceae; Pyrrhoderma.
OX NCBI_TaxID=2282107 {ECO:0000313|EMBL:PAV15129.1, ECO:0000313|Proteomes:UP000217199};
RN [1] {ECO:0000313|Proteomes:UP000217199}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=FFPRI411160 {ECO:0000313|Proteomes:UP000217199};
RA Chung C.-L., Lee J.T., Akiba M., Lee H.-H., Kuo T.-H., Liu D., Ke H.-M.,
RA Yokoi T., Roa M.B., Lu M.J., Chang Y.-Y., Ann P.-J., Tsai J.-N.,
RA Chen C.-Y., Tzean S.-S., Ota Y., Hattori T., Sahashi N., Liou R.-F.,
RA Kikuchi T., Tsai I.J.;
RT "The Genomic Landscape Of Tree Rot In Phellinus noxius And Its
RT Hymenochaetales Members.";
RL bioRxiv 0:0-0(2017).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the REXO1/REXO3 family.
CC {ECO:0000256|ARBA:ARBA00006357}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:PAV15129.1}.
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DR EMBL; NBII01000010; PAV15129.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A286U6H1; -.
DR STRING; 2282107.A0A286U6H1; -.
DR InParanoid; A0A286U6H1; -.
DR OrthoDB; 5479236at2759; -.
DR Proteomes; UP000217199; Chromosome 10.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR GO; GO:0022857; F:transmembrane transporter activity; IEA:InterPro.
DR CDD; cd06145; REX1_like; 1.
DR Gene3D; 1.20.1250.20; MFS general substrate transporter like domains; 2.
DR Gene3D; 3.30.420.10; Ribonuclease H-like superfamily/Ribonuclease H; 1.
DR InterPro; IPR013520; Exonuclease_RNaseT/DNA_pol3.
DR InterPro; IPR011701; MFS.
DR InterPro; IPR020846; MFS_dom.
DR InterPro; IPR036259; MFS_trans_sf.
DR InterPro; IPR034922; REX1-like_exo.
DR InterPro; IPR012337; RNaseH-like_sf.
DR InterPro; IPR036397; RNaseH_sf.
DR PANTHER; PTHR43791; PERMEASE-RELATED; 1.
DR PANTHER; PTHR43791:SF101; TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G08340)-RELATED; 1.
DR Pfam; PF07690; MFS_1; 1.
DR Pfam; PF00929; RNase_T; 1.
DR SMART; SM00479; EXOIII; 1.
DR SUPFAM; SSF103473; MFS general substrate transporter; 1.
DR SUPFAM; SSF53098; Ribonuclease H-like; 1.
DR PROSITE; PS50850; MFS; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000217199};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 839..859
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 865..888
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 900..920
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 932..952
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1000..1021
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1033..1052
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1064..1084
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1090..1113
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1157..1178
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 770..1179
FT /note="Major facilitator superfamily (MFS) profile"
FT /evidence="ECO:0000259|PROSITE:PS50850"
FT REGION 1..97
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 13..44
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 45..64
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 69..97
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1214 AA; 134460 MW; 003B16C28A58A101 CRC64;
MKRVSPDSLT PPSSEHKSKR HKTQMQSDDS EWTKVEKRKT RDNALSSLPK QSPVPSSNAF
ASLLQPQAKH EKATDEEWSK VERRKAKKAR KTEERSENAT PRFFYVNSEI LKRREAVTIG
DIRDLVLHLL GEAAPQPWLK VENRQAIGKV VVLFAPGILP EHLNISLQPT SSTSNPNLPV
SIPLPRDTPP SQTVTVKTLF GGTKEIDVTQ DNKEELLLPF IARTFSHACP TRAPGEAFRM
HSVLSAFFQG PVSPEERKRR AASAIAAEKG LEQSNPLRYV LTLSRMIENE YPIPKSLRGS
EDIGVNSAEE MKEDDWVETP IPSSDESGIP EVFAIDCEMC ITEDGKELTR VCAIDFNSGK
VLLDQLVKPP KPILDYLTRW SGITEEVLRD INTPLSSARN SLLSIMNSSK DKTGCTPILL
GHSLESDLRA LKFTHMRCID TALLYHHPRG RPLKPGLAWL TKKWCGREIQ NRGEGGHDAE
EDARACIELL QRKMKNGPGF GEYKTTTEQE SIFERLKRSI RGSTDGEPGT GEGAKLRTVV
IDRGNPASLH GAGAGTCVPC TSDEEVAKGI LQNIENNDFI FARLNRLAEV QNWLQQRSST
NTDTPATPYD PSEVKTALKA TNSNLSVIHA ALPPHTALVL FTGHSDPRDM VTLQSRKNAF
DNAFRASQAT GKEPTSIPSD LKWTNGDSRD LEEAFTHHIC TQLSPTLNAK ERLEDSMNSE
KQDLSIQKEH YDISTTRDPE LTLDYGENSK SIQAVSEEER KLVWKLDKRI LPITCLMYLF
SFLDRSNIGN ARLQGLPEDV LHGDPTGILF DWITSAFYFS YILCQVPATV TSKLFSPRLW
LGTTALGWGI CSTLMSTSFN FGGLMVARIG LGMFEAGFGP GVPLYFSYFY TKHEMGLRMA
YWFGFAAVAG AFGGLIAFGV QHAHASIENW KLLFIVEGIP AMLIGLVALV FLPDRPEITN
FLTEDERKLA IARMNRATSG DFGHVINKAH VWAALTDWRV YLGGVVYFGV NCALASISAF
LPTIIKTFGF TNAIAQLLTV PPYAVSAVVL TLTSYFSDRL QHRGIFMACA SIVGGVGYLI
LLLVHSNNHA RFFAVFCITS GTYTTIGLII AWFAHNLGSE TKRAAGIPLF MAIGQCGSVL
GSHMYPSTEG PRYIKGFAVT CALEFLAAIC ALILSASYHY DNRKRDKLYG RPTPETKVDT
SVLADKCPNF RYLT
//
