ID   A0A286UAP4_9AGAM        Unreviewed;       830 AA.
AC   A0A286UAP4;
DT   31-JAN-2018, integrated into UniProtKB/TrEMBL.
DT   31-JAN-2018, sequence version 1.
DT   24-JAN-2024, entry version 24.
DE   SubName: Full=PRMT5-domain-containing {ECO:0000313|EMBL:PAV16637.1};
GN   ORFNames=PNOK_0825700 {ECO:0000313|EMBL:PAV16637.1};
OS   Pyrrhoderma noxium.
OC   Eukaryota; Fungi; Dikarya; Basidiomycota; Agaricomycotina; Agaricomycetes;
OC   Hymenochaetales; Hymenochaetaceae; Pyrrhoderma.
OX   NCBI_TaxID=2282107 {ECO:0000313|EMBL:PAV16637.1, ECO:0000313|Proteomes:UP000217199};
RN   [1] {ECO:0000313|Proteomes:UP000217199}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=FFPRI411160 {ECO:0000313|Proteomes:UP000217199};
RA   Chung C.-L., Lee J.T., Akiba M., Lee H.-H., Kuo T.-H., Liu D., Ke H.-M.,
RA   Yokoi T., Roa M.B., Lu M.J., Chang Y.-Y., Ann P.-J., Tsai J.-N.,
RA   Chen C.-Y., Tzean S.-S., Ota Y., Hattori T., Sahashi N., Liou R.-F.,
RA   Kikuchi T., Tsai I.J.;
RT   "The Genomic Landscape Of Tree Rot In Phellinus noxius And Its
RT   Hymenochaetales Members.";
RL   bioRxiv 0:0-0(2017).
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:PAV16637.1}.
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DR   EMBL; NBII01000008; PAV16637.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A286UAP4; -.
DR   STRING; 2282107.A0A286UAP4; -.
DR   InParanoid; A0A286UAP4; -.
DR   OrthoDB; 5489665at2759; -.
DR   Proteomes; UP000217199; Chromosome 8.
DR   GO; GO:0016274; F:protein-arginine N-methyltransferase activity; IEA:InterPro.
DR   GO; GO:0032259; P:methylation; IEA:UniProtKB-KW.
DR   Gene3D; 3.20.20.150; Divalent-metal-dependent TIM barrel enzymes; 1.
DR   Gene3D; 2.70.160.11; Hnrnp arginine n-methyltransferase1; 1.
DR   Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 1.
DR   InterPro; IPR025799; Arg_MeTrfase.
DR   InterPro; IPR035075; PRMT5.
DR   InterPro; IPR035248; PRMT5_C.
DR   InterPro; IPR035247; PRMT5_TIM.
DR   InterPro; IPR029063; SAM-dependent_MTases_sf.
DR   PANTHER; PTHR10738; PROTEIN ARGININE N-METHYLTRANSFERASE 5; 1.
DR   PANTHER; PTHR10738:SF0; PROTEIN ARGININE N-METHYLTRANSFERASE 5; 1.
DR   Pfam; PF05185; PRMT5; 1.
DR   Pfam; PF17286; PRMT5_C; 1.
DR   Pfam; PF17285; PRMT5_TIM; 1.
DR   SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 1.
DR   PROSITE; PS51678; SAM_MT_PRMT; 1.
PE   4: Predicted;
KW   Methyltransferase {ECO:0000256|ARBA:ARBA00022603, ECO:0000256|PROSITE-
KW   ProRule:PRU01015}; Reference proteome {ECO:0000313|Proteomes:UP000217199};
KW   S-adenosyl-L-methionine {ECO:0000256|ARBA:ARBA00022691,
KW   ECO:0000256|PROSITE-ProRule:PRU01015};
KW   Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000256|PROSITE-
KW   ProRule:PRU01015}.
FT   DOMAIN          44..360
FT                   /note="PRMT5 TIM barrel"
FT                   /evidence="ECO:0000259|Pfam:PF17285"
FT   DOMAIN          375..536
FT                   /note="PRMT5 arginine-N-methyltransferase"
FT                   /evidence="ECO:0000259|Pfam:PF05185"
FT   DOMAIN          539..825
FT                   /note="PRMT5 oligomerisation"
FT                   /evidence="ECO:0000259|Pfam:PF17286"
FT   REGION          206..233
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        213..227
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   830 AA;  92412 MW;  F6A92A125439E099 CRC64;
     MAWSSSSSIA RLITNEDLSK VVEDDWQGYQ SPFLKLKDSG RRDFDSVVVP ITNEKWHCRW
     KSMCSVSTEN MLDGLEEDEE ERSKNEKELE ERAERWRAAP TFLREECNLI GLDETENVTG
     IAADWLELDS PDDWVRHDCE IALKQELAYA SYLGLSTVIL PPPVEREYAA SYGRSVKACL
     ESLPYMQLTI RLPLYDPDLL TNKRKPSLDT FPPVSSTYPP PPSPGISSGT SSPTIDLRKN
     VSIQASVGEL SSTWEAWDTI RTVCSYSSRL TLALDLTMPL PNTQGILSRW YAEPVSHIFL
     PASTFIPNAK GYPVLPKGTQ LFLQNMMRVH PRIILSGTGE KLHAKGTEDK YVDYLRYLEK
     SSLHTRRAQE ADTIENYAQG YYDYLQMPLQ PLQDHLASMV YENFERDPVK YQKYEEAVFK
     ALCDMPEDQR IVLTVAGAGR GPLVARSLNA IERSSRDVAV YAIEKNPSAY VTLQNRLQTE
     WNDKVKVMFG DMRYLEVPEK ADILVSELLG SFGDNELSPE CLDGAMRFLK EDGVSIPSSY
     AAYLAPIQSA KLYHEAGGGK DTKERDREKG LETPYVVMLQ SINFLGGDKS GPEHGGRCGG
     RIQQCWEFEH PRKEIVIDER GLPLTNSHNV RYTSLTFSIP YAGILHGFAG YFEAVLYDGI
     GLSIHPDRKD AISKDMLSWF PCFFPIKEPL YLPSNAELRI DLWRLTGGGK VWYEWFAESF
     LPVSVPSAPP PSPLPVQSQP GSAGMAVPST PRVNGAGALV APPGTLSSSP GPARSPLLDA
     VDLSFGRPGT PESSFGLGPR LTREEHPAGV VKIGQTSLHN PGGRSSFYGL
//