ID A0A286UMK2_9AGAM Unreviewed; 812 AA.
AC A0A286UMK2;
DT 31-JAN-2018, integrated into UniProtKB/TrEMBL.
DT 31-JAN-2018, sequence version 1.
DT 27-MAR-2024, entry version 22.
DE SubName: Full=Kex {ECO:0000313|EMBL:PAV20769.1};
GN ORFNames=PNOK_0339600 {ECO:0000313|EMBL:PAV20769.1};
OS Pyrrhoderma noxium.
OC Eukaryota; Fungi; Dikarya; Basidiomycota; Agaricomycotina; Agaricomycetes;
OC Hymenochaetales; Hymenochaetaceae; Pyrrhoderma.
OX NCBI_TaxID=2282107 {ECO:0000313|EMBL:PAV20769.1, ECO:0000313|Proteomes:UP000217199};
RN [1] {ECO:0000313|Proteomes:UP000217199}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=FFPRI411160 {ECO:0000313|Proteomes:UP000217199};
RA Chung C.-L., Lee J.T., Akiba M., Lee H.-H., Kuo T.-H., Liu D., Ke H.-M.,
RA Yokoi T., Roa M.B., Lu M.J., Chang Y.-Y., Ann P.-J., Tsai J.-N.,
RA Chen C.-Y., Tzean S.-S., Ota Y., Hattori T., Sahashi N., Liou R.-F.,
RA Kikuchi T., Tsai I.J.;
RT "The Genomic Landscape Of Tree Rot In Phellinus noxius And Its
RT Hymenochaetales Members.";
RL bioRxiv 0:0-0(2017).
CC -!- SIMILARITY: Belongs to the peptidase S8 family. Furin subfamily.
CC {ECO:0000256|ARBA:ARBA00005325}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:PAV20769.1}.
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DR EMBL; NBII01000003; PAV20769.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A286UMK2; -.
DR STRING; 2282107.A0A286UMK2; -.
DR InParanoid; A0A286UMK2; -.
DR OrthoDB; 5474719at2759; -.
DR Proteomes; UP000217199; Chromosome 3.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProt.
DR GO; GO:0012505; C:endomembrane system; IEA:UniProt.
DR GO; GO:0043231; C:intracellular membrane-bounded organelle; IEA:UniProt.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0004252; F:serine-type endopeptidase activity; IEA:UniProtKB-UniRule.
DR GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR CDD; cd04059; Peptidases_S8_Protein_convertases_Kexins_Furin-like; 1.
DR Gene3D; 2.60.120.260; Galactose-binding domain-like; 1.
DR Gene3D; 3.40.50.200; Peptidase S8/S53 domain; 1.
DR InterPro; IPR008979; Galactose-bd-like_sf.
DR InterPro; IPR034182; Kexin/furin.
DR InterPro; IPR002884; P_dom.
DR InterPro; IPR000209; Peptidase_S8/S53_dom.
DR InterPro; IPR036852; Peptidase_S8/S53_dom_sf.
DR InterPro; IPR022398; Peptidase_S8_His-AS.
DR InterPro; IPR023828; Peptidase_S8_Ser-AS.
DR InterPro; IPR015500; Peptidase_S8_subtilisin-rel.
DR PANTHER; PTHR42884:SF14; NEUROENDOCRINE CONVERTASE 1; 1.
DR PANTHER; PTHR42884; PROPROTEIN CONVERTASE SUBTILISIN/KEXIN-RELATED; 1.
DR Pfam; PF01483; P_proprotein; 1.
DR Pfam; PF00082; Peptidase_S8; 1.
DR PRINTS; PR00723; SUBTILISIN.
DR SUPFAM; SSF49785; Galactose-binding domain-like; 1.
DR SUPFAM; SSF52743; Subtilisin-like; 1.
DR PROSITE; PS51829; P_HOMO_B; 1.
DR PROSITE; PS51892; SUBTILASE; 1.
DR PROSITE; PS00137; SUBTILASE_HIS; 1.
DR PROSITE; PS00138; SUBTILASE_SER; 1.
PE 3: Inferred from homology;
KW Calcium {ECO:0000256|ARBA:ARBA00022837};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|PROSITE-
KW ProRule:PRU01240}; Membrane {ECO:0000256|SAM:Phobius};
KW Protease {ECO:0000256|ARBA:ARBA00022670, ECO:0000256|PROSITE-
KW ProRule:PRU01240}; Reference proteome {ECO:0000313|Proteomes:UP000217199};
KW Serine protease {ECO:0000256|ARBA:ARBA00022825, ECO:0000256|PROSITE-
KW ProRule:PRU01240}; Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 711..732
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 484..630
FT /note="P/Homo B"
FT /evidence="ECO:0000259|PROSITE:PS51829"
FT REGION 649..705
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 768..812
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 662..702
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT ACT_SITE 196
FT /note="Charge relay system"
FT /evidence="ECO:0000256|PIRSR:PIRSR615500-1,
FT ECO:0000256|PROSITE-ProRule:PRU01240"
FT ACT_SITE 234
FT /note="Charge relay system"
FT /evidence="ECO:0000256|PIRSR:PIRSR615500-1,
FT ECO:0000256|PROSITE-ProRule:PRU01240"
FT ACT_SITE 408
FT /note="Charge relay system"
FT /evidence="ECO:0000256|PIRSR:PIRSR615500-1,
FT ECO:0000256|PROSITE-ProRule:PRU01240"
SQ SEQUENCE 812 AA; 89465 MW; 1F32DA49AE2793AA CRC64;
MSNFRRVSIR SWHILLAVAF SICVVTTSVI ASKPTKLSHD LYDYYVLEHN PAIGVSIEEC
AESLGAEVVD SAGELHNHWL LRRQKNERST RDDGVLTQHK SLLQRRDPVS FAIKHLSRQT
LRQRVKRAAL PAPAPQSPDD TLSLTRDIAE RLGIEDPLFK DQWHLINEEY PEHMVNAAPV
WDMGITGKDV VSCIIDDGLE YESEDLADNF DAAGSYDFND HTELPKPRLR DDHHGTRCAG
QIAAVKNGVC GVGIAYDSKV AGVRILSGPI SDIDEATALN FGYQNTSIYS CSWGPPDDGR
SMDVPSILVQ KAMLNGVQRG RDGLGSVFVF ASGNGANSGD QCNFDGYTNS IYSVTVASID
YQGQHPYYSE ACAANMVTTY SSGFDRNKHI VTTDIGRNKC TRNHGGTSAA APNAVGIFAL
ALSARPDLTW RDIQYLCVKT AQIVNPEDPD WEPIASGQLF SYKYGFGKLD ALKFVKAAQE
WSVVKPQTWI EAPAVQLENG SMDSNGKYSG GLPIAKDGIQ STLEITQDMI DDNNFEDLEH
VTIRVWIDHT RRGAVEVSLV SPNGIRSVLA GKRNSDFDRD GFPGWRFMSV KHWGENPLGT
WTLHVSDQNA KSESGSLIGW SLSLWGSSKD TSKVQTYVLK ASEELPIPFP PVVEDPVPDP
DSTTLDPSTT KQYQKPTVTG TSVSNQDDTE STQTGSSGGT SEKMSDDTRH IIVVVASIFT
VLLIGFGAFL IIRQLRQNRR DALERNRSGD NDVRMRLLDS DSRHLTPSES VTVLYDEEDE
GKADAVGPSD EEQTYNDSDD DHDVDESLLR SH
//
