ID A0A286X776_CAVPO Unreviewed; 568 AA.
AC A0A286X776;
DT 22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 1.
DT 27-MAR-2024, entry version 21.
DE SubName: Full=MTSS I-BAR domain containing 2 {ECO:0000313|Ensembl:ENSCPOP00000021270.1};
GN Name=MTSS2 {ECO:0000313|Ensembl:ENSCPOP00000021270.1};
OS Cavia porcellus (Guinea pig).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Hystricomorpha; Caviidae;
OC Cavia.
OX NCBI_TaxID=10141 {ECO:0000313|Ensembl:ENSCPOP00000021270.1, ECO:0000313|Proteomes:UP000005447};
RN [1] {ECO:0000313|Proteomes:UP000005447}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=2N {ECO:0000313|Proteomes:UP000005447};
RX PubMed=21993624; DOI=10.1038/nature10530;
RA Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J., Washietl S.,
RA Kheradpour P., Ernst J., Jordan G., Mauceli E., Ward L.D., Lowe C.B.,
RA Holloway A.K., Clamp M., Gnerre S., Alfoldi J., Beal K., Chang J.,
RA Clawson H., Cuff J., Di Palma F., Fitzgerald S., Flicek P., Guttman M.,
RA Hubisz M.J., Jaffe D.B., Jungreis I., Kent W.J., Kostka D., Lara M.,
RA Martins A.L., Massingham T., Moltke I., Raney B.J., Rasmussen M.D.,
RA Robinson J., Stark A., Vilella A.J., Wen J., Xie X., Zody M.C., Baldwin J.,
RA Bloom T., Chin C.W., Heiman D., Nicol R., Nusbaum C., Young S.,
RA Wilkinson J., Worley K.C., Kovar C.L., Muzny D.M., Gibbs R.A., Cree A.,
RA Dihn H.H., Fowler G., Jhangiani S., Joshi V., Lee S., Lewis L.R.,
RA Nazareth L.V., Okwuonu G., Santibanez J., Warren W.C., Mardis E.R.,
RA Weinstock G.M., Wilson R.K., Delehaunty K., Dooling D., Fronik C.,
RA Fulton L., Fulton B., Graves T., Minx P., Sodergren E., Birney E.,
RA Margulies E.H., Herrero J., Green E.D., Haussler D., Siepel A., Goldman N.,
RA Pollard K.S., Pedersen J.S., Lander E.S., Kellis M.;
RT "A high-resolution map of human evolutionary constraint using 29 mammals.";
RL Nature 478:476-482(2011).
RN [2] {ECO:0000313|Ensembl:ENSCPOP00000021270.1}
RP IDENTIFICATION.
RC STRAIN=2N {ECO:0000313|Ensembl:ENSCPOP00000021270.1};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR EMBL; AAKN02026387; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAKN02026388; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; A0A286X776; -.
DR Ensembl; ENSCPOT00000037938.1; ENSCPOP00000021270.1; ENSCPOG00000021684.2.
DR VEuPathDB; HostDB:ENSCPOG00000021684; -.
DR GeneTree; ENSGT00950000183156; -.
DR Proteomes; UP000005447; Unassembled WGS sequence.
DR Bgee; ENSCPOG00000021684; Expressed in cerebellum and 13 other cell types or tissues.
DR GO; GO:0003779; F:actin binding; IEA:InterPro.
DR GO; GO:0007009; P:plasma membrane organization; IEA:InterPro.
DR CDD; cd22060; WH2_MTSS1; 1.
DR Gene3D; 1.20.1270.60; Arfaptin homology (AH) domain/BAR domain; 1.
DR InterPro; IPR027267; AH/BAR_dom_sf.
DR InterPro; IPR013606; I-BAR_dom.
DR InterPro; IPR030127; MTSS1/MTSS2.
DR PANTHER; PTHR15708; ACTIN BUNDLING/MISSING IN METASTASIS-RELATED; 1.
DR PANTHER; PTHR15708:SF8; PROTEIN MTSS 2; 1.
DR Pfam; PF08397; IMD; 1.
DR SUPFAM; SSF103657; BAR/IMD domain-like; 1.
DR PROSITE; PS51338; IMD; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000005447}.
FT DOMAIN 1..188
FT /note="IMD"
FT /evidence="ECO:0000259|PROSITE:PS51338"
FT REGION 192..345
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 361..421
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 447..542
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 192..293
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 294..308
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 365..400
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 568 AA; 61555 MW; 3A48A2414AFADB7B CRC64;
MTGHRFPWAT RDIGSALTRM CMRHRSIETK LRQFTNALLE SLINPLQERI EDWKKSANQL
DKDHAKEYKR ARHEIKKKSS DTLKLQKKAR KGKGDLQPQL DSALQDVNDM YLLLEETEKQ
AVRRALIEER GRFCTFITFL QPVVNGELTM LGEITHLQGI IDDLVVLTAE PHKLPPASEQ
VIKDLKGSDY SWSYQTPPSS PSSSSSRKSS MCSLAQPATA TTRLSSVSSH DSGFVSQDAT
YSKPPSPMPS DITSQKSSSS ASSEASETCQ SVSECSSPTS DWTKTGPHEQ PSGTTLQRRK
DRVELLRDAE PGPASVGPLG PSGEEAPRPR MSPATIAAKH GEEVSPAASD LAMVLTRGLS
LEHQKSSRDS LQYSSGYSTQ TTTPSCSEDT IPSQGSDYDC YSVNGDADSE GPQEFDKSST
IPRNSNIAQN YRRLIQTKRP ASTAGLPTAG LPTATGLPSG APPGVATIRR TPSTKPTVRR
ALSSAGPIPI RPPITPTKLG ELVARGPCAG RGPVPLPHRP VSHPHRGDTT PPPAATSDPP
AEDMLVAIRR GVRLRRTVTN DRSAPRIL
//
