ID A0A286X7T3_CAVPO Unreviewed; 187 AA.
AC A0A286X7T3;
DT 22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 1.
DT 27-MAR-2024, entry version 26.
DE SubName: Full=Interferon 1AJ8 {ECO:0000313|EMBL:CAB0000223.1};
GN Name=IF1AJ8 {ECO:0000313|EMBL:CAB0000223.1};
OS Cavia porcellus (Guinea pig).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Hystricomorpha; Caviidae;
OC Cavia.
OX NCBI_TaxID=10141 {ECO:0000313|Ensembl:ENSCPOP00000021491.1, ECO:0000313|Proteomes:UP000005447};
RN [1] {ECO:0000313|Proteomes:UP000005447}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=2N {ECO:0000313|Proteomes:UP000005447};
RX PubMed=21993624; DOI=10.1038/nature10530;
RA Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J., Washietl S.,
RA Kheradpour P., Ernst J., Jordan G., Mauceli E., Ward L.D., Lowe C.B.,
RA Holloway A.K., Clamp M., Gnerre S., Alfoldi J., Beal K., Chang J.,
RA Clawson H., Cuff J., Di Palma F., Fitzgerald S., Flicek P., Guttman M.,
RA Hubisz M.J., Jaffe D.B., Jungreis I., Kent W.J., Kostka D., Lara M.,
RA Martins A.L., Massingham T., Moltke I., Raney B.J., Rasmussen M.D.,
RA Robinson J., Stark A., Vilella A.J., Wen J., Xie X., Zody M.C., Baldwin J.,
RA Bloom T., Chin C.W., Heiman D., Nicol R., Nusbaum C., Young S.,
RA Wilkinson J., Worley K.C., Kovar C.L., Muzny D.M., Gibbs R.A., Cree A.,
RA Dihn H.H., Fowler G., Jhangiani S., Joshi V., Lee S., Lewis L.R.,
RA Nazareth L.V., Okwuonu G., Santibanez J., Warren W.C., Mardis E.R.,
RA Weinstock G.M., Wilson R.K., Delehaunty K., Dooling D., Fronik C.,
RA Fulton L., Fulton B., Graves T., Minx P., Sodergren E., Birney E.,
RA Margulies E.H., Herrero J., Green E.D., Haussler D., Siepel A., Goldman N.,
RA Pollard K.S., Pedersen J.S., Lander E.S., Kellis M.;
RT "A high-resolution map of human evolutionary constraint using 29 mammals.";
RL Nature 478:476-482(2011).
RN [2] {ECO:0000313|EMBL:CAB0000223.1}
RP NUCLEOTIDE SEQUENCE.
RA Premzl M.;
RT "Comparative genomic analysis of eutherian interferon genes.";
RL Genomics 112:4749-4759(2020).
RN [3] {ECO:0000313|Ensembl:ENSCPOP00000021491.1}
RP IDENTIFICATION.
RC STRAIN=2N {ECO:0000313|Ensembl:ENSCPOP00000021491.1};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613}.
CC -!- SIMILARITY: Belongs to the alpha/beta interferon family.
CC {ECO:0000256|ARBA:ARBA00011033, ECO:0000256|RuleBase:RU000436}.
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DR EMBL; AAKN02003557; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; LR761049; CAB0000223.1; -; Genomic_DNA.
DR RefSeq; XP_003478912.1; XM_003478864.3.
DR STRING; 10141.ENSCPOP00000021491; -.
DR Ensembl; ENSCPOT00000034007.1; ENSCPOP00000021491.1; ENSCPOG00000037617.1.
DR GeneID; 100735600; -.
DR KEGG; cpoc:100735600; -.
DR VEuPathDB; HostDB:ENSCPOG00000037617; -.
DR GeneTree; ENSGT01000000214430; -.
DR OMA; CVIEERV; -.
DR OrthoDB; 5358931at2759; -.
DR Proteomes; UP000005447; Unassembled WGS sequence.
DR GO; GO:0005615; C:extracellular space; IEA:UniProtKB-KW.
DR GO; GO:0005125; F:cytokine activity; IEA:UniProtKB-KW.
DR GO; GO:0005126; F:cytokine receptor binding; IEA:InterPro.
DR GO; GO:0051607; P:defense response to virus; IEA:UniProtKB-KW.
DR Gene3D; 1.20.1250.10; -; 1.
DR InterPro; IPR009079; 4_helix_cytokine-like_core.
DR InterPro; IPR000471; Interferon_alpha/beta/delta.
DR PANTHER; PTHR11691:SF60; INTERFERON ALPHA-5; 1.
DR PANTHER; PTHR11691; TYPE I INTERFERON; 1.
DR Pfam; PF00143; Interferon; 1.
DR PRINTS; PR00266; INTERFERONAB.
DR SMART; SM00076; IFabd; 1.
DR SUPFAM; SSF47266; 4-helical cytokines; 1.
DR PROSITE; PS00252; INTERFERON_A_B_D; 1.
PE 3: Inferred from homology;
KW Antiviral defense {ECO:0000256|ARBA:ARBA00023118,
KW ECO:0000256|RuleBase:RU000436}; Cytokine {ECO:0000256|RuleBase:RU000436};
KW Reference proteome {ECO:0000313|Proteomes:UP000005447};
KW Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..23
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 24..187
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5041060204"
SQ SEQUENCE 187 AA; 21402 MW; 055F80EEE9F8F077 CRC64;
MAWPLTGLMA LPVLTIMASC SLACTLPLTY MQGNTTALSL LEQMRRTFAF SCLKHRQDFG
LALLDFDGKQ VQKIQALSVL HEMTTQTLIL FSSHNSHAAW NQSLRRTFCD ALRDQMNDLK
ACLTKETGLE YPSLLHEDSR NAVKKYFRGI TDYLKEKSYS PCAWEVVRAE FFRSFSSSKE
LLRKMQD
//
