ID A0A286X853_CAVPO Unreviewed; 1154 AA.
AC A0A286X853;
DT 22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 1.
DT 27-MAR-2024, entry version 33.
DE SubName: Full=PDZ domain containing 8 {ECO:0000313|Ensembl:ENSCPOP00000021616.1};
GN Name=PDZD8 {ECO:0000313|Ensembl:ENSCPOP00000021616.1};
OS Cavia porcellus (Guinea pig).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Hystricomorpha; Caviidae;
OC Cavia.
OX NCBI_TaxID=10141 {ECO:0000313|Ensembl:ENSCPOP00000021616.1, ECO:0000313|Proteomes:UP000005447};
RN [1] {ECO:0000313|Proteomes:UP000005447}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=2N {ECO:0000313|Proteomes:UP000005447};
RX PubMed=21993624; DOI=10.1038/nature10530;
RA Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J., Washietl S.,
RA Kheradpour P., Ernst J., Jordan G., Mauceli E., Ward L.D., Lowe C.B.,
RA Holloway A.K., Clamp M., Gnerre S., Alfoldi J., Beal K., Chang J.,
RA Clawson H., Cuff J., Di Palma F., Fitzgerald S., Flicek P., Guttman M.,
RA Hubisz M.J., Jaffe D.B., Jungreis I., Kent W.J., Kostka D., Lara M.,
RA Martins A.L., Massingham T., Moltke I., Raney B.J., Rasmussen M.D.,
RA Robinson J., Stark A., Vilella A.J., Wen J., Xie X., Zody M.C., Baldwin J.,
RA Bloom T., Chin C.W., Heiman D., Nicol R., Nusbaum C., Young S.,
RA Wilkinson J., Worley K.C., Kovar C.L., Muzny D.M., Gibbs R.A., Cree A.,
RA Dihn H.H., Fowler G., Jhangiani S., Joshi V., Lee S., Lewis L.R.,
RA Nazareth L.V., Okwuonu G., Santibanez J., Warren W.C., Mardis E.R.,
RA Weinstock G.M., Wilson R.K., Delehaunty K., Dooling D., Fronik C.,
RA Fulton L., Fulton B., Graves T., Minx P., Sodergren E., Birney E.,
RA Margulies E.H., Herrero J., Green E.D., Haussler D., Siepel A., Goldman N.,
RA Pollard K.S., Pedersen J.S., Lander E.S., Kellis M.;
RT "A high-resolution map of human evolutionary constraint using 29 mammals.";
RL Nature 478:476-482(2011).
RN [2] {ECO:0000313|Ensembl:ENSCPOP00000021616.1}
RP IDENTIFICATION.
RC STRAIN=2N {ECO:0000313|Ensembl:ENSCPOP00000021616.1};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR EMBL; AAKN02003078; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAKN02003079; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAKN02003080; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAKN02003081; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAKN02003082; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAKN02003083; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAKN02003084; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_003479365.1; XM_003479317.3.
DR AlphaFoldDB; A0A286X853; -.
DR STRING; 10141.ENSCPOP00000021616; -.
DR Ensembl; ENSCPOT00000036432.1; ENSCPOP00000021616.1; ENSCPOG00000029989.1.
DR GeneID; 100718824; -.
DR KEGG; cpoc:100718824; -.
DR CTD; 118987; -.
DR VEuPathDB; HostDB:ENSCPOG00000029989; -.
DR eggNOG; KOG3532; Eukaryota.
DR GeneTree; ENSGT00390000017746; -.
DR InParanoid; A0A286X853; -.
DR OMA; HIALECM; -.
DR OrthoDB; 3681901at2759; -.
DR Proteomes; UP000005447; Unassembled WGS sequence.
DR Bgee; ENSCPOG00000029989; Expressed in testis and 12 other cell types or tissues.
DR GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:Ensembl.
DR GO; GO:0044233; C:mitochondria-associated endoplasmic reticulum membrane; IEA:Ensembl.
DR GO; GO:0005739; C:mitochondrion; IEA:GOC.
DR GO; GO:0008289; F:lipid binding; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0007010; P:cytoskeleton organization; IEA:Ensembl.
DR GO; GO:0006869; P:lipid transport; IEA:UniProtKB-KW.
DR GO; GO:0051560; P:mitochondrial calcium ion homeostasis; IEA:Ensembl.
DR GO; GO:1990456; P:mitochondrion-endoplasmic reticulum membrane tethering; IEA:Ensembl.
DR GO; GO:0022604; P:regulation of cell morphogenesis; IEA:Ensembl.
DR CDD; cd20825; C1_PDZD8; 1.
DR CDD; cd00992; PDZ_signaling; 1.
DR CDD; cd21674; SMP_PDZD8; 1.
DR Gene3D; 2.30.42.10; -; 1.
DR Gene3D; 3.30.60.20; -; 1.
DR InterPro; IPR046349; C1-like_sf.
DR InterPro; IPR001478; PDZ.
DR InterPro; IPR041489; PDZ_6.
DR InterPro; IPR036034; PDZ_sf.
DR InterPro; IPR039275; PDZD8.
DR InterPro; IPR002219; PE/DAG-bd.
DR InterPro; IPR031468; SMP_LBD.
DR PANTHER; PTHR21519; PDZ DOMAIN-CONTAINING PROTEIN 8; 1.
DR PANTHER; PTHR21519:SF1; PDZ DOMAIN-CONTAINING PROTEIN 8; 1.
DR Pfam; PF00130; C1_1; 1.
DR Pfam; PF17820; PDZ_6; 1.
DR SMART; SM00109; C1; 1.
DR SMART; SM00228; PDZ; 1.
DR SUPFAM; SSF57889; Cysteine-rich domain; 1.
DR SUPFAM; SSF50156; PDZ domain-like; 1.
DR PROSITE; PS50106; PDZ; 1.
DR PROSITE; PS51847; SMP; 1.
DR PROSITE; PS50081; ZF_DAG_PE_2; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Endoplasmic reticulum {ECO:0000256|ARBA:ARBA00022824};
KW Lipid transport {ECO:0000256|ARBA:ARBA00023055};
KW Lipid-binding {ECO:0000256|ARBA:ARBA00023121};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000005447};
KW Transport {ECO:0000256|ARBA:ARBA00023055};
KW Zinc {ECO:0000256|ARBA:ARBA00022833}.
FT DOMAIN 91..294
FT /note="SMP-LTD"
FT /evidence="ECO:0000259|PROSITE:PS51847"
FT DOMAIN 366..449
FT /note="PDZ"
FT /evidence="ECO:0000259|PROSITE:PS50106"
FT DOMAIN 840..891
FT /note="Phorbol-ester/DAG-type"
FT /evidence="ECO:0000259|PROSITE:PS50081"
FT REGION 65..88
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 513..535
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 580..617
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 950..997
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 1033..1060
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 74..88
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 520..535
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 586..600
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 967..995
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1154 AA; 128813 MW; 71B704EFF8196EAE CRC64;
MGLLFMILAS AVLGSFLTLL TQFLLLYRRQ PEPPPDEAAR AGDGFRYIKP VPGLHLREYL
YGGGGAEEPA SGSAEGSGSP TSAPETPALP TRETCYFLNA TILFLFRELR DTALTRRWVT
KKIKVEFEEL LQTKTAGRLL EGLSLRDVFL GDTVPFIKTI RLVRPVVASA TGEPDGPEGE
TLPTTCPEEL AFEAEVEYNG GFHLAIDVDL VFGKSAYLFV KLSRVVGRLR FVFTRVPFTH
WFFSFVEDPL IDFEVRSQFE GRPMPQLTSI IVNQLKKVIK RRHTLPNYKI RFKPFFPYQT
PQGFEEDEEL IHIQHWALTE GRLKVTLLEC SRLFIFGSYD REANIHCTLE LSTGVWEEKQ
RSSIKTVELI KGSLQSVGLT LRLVQSTDGY GGHVIIETVA PNSPAAIADL QRGDRLIAIG
GVKITSTLQV LKLIKQAGER VLVYYERPVG QSNPGVVLQD NLSQLEENFL SSSSQPSYEE
EAVGLAVDTE NRDMDSEYED LASDVRVQNE FKDEAQPLSH SPKRTPTTLS IKPLGTVSPV
LNRKLVAGSH PPPPKISSKE AAKPLALKTS EVTDLIQVSK PTQGSTFKPP VPPRPQVKVP
LPSADAPSQA EPDTLVEKPE KVLLPTPVDK SAEKQVKSVD QVEDLSTSKQ FLAKQEVAKD
FTSESSCPTK DNTDDRHTWE SSEILYRNKL GKWTRTRASS LFDIEPCHRY LNIALWCRDP
FKLGGLICLG HVSLKLEDVA LGCLATSNME YVSKFRLEAP APKAMVTRTA LRNLSMQKGF
SDKFCYGDIT VHFKYLKEGE PDHQLVTNVE KEKESHLIEE VSALPKEENI TGQMSSPETK
HSFQDTQFQN PTWCDYCKKK VWTKAASQCM LCAYVCHKKC QEKCLAETPL CGASERRTDR
ILKNLRLEGQ EPLIGVPPRV DAETNKSVNK TTGLTRHIIN TSSRLLNLRP VSKSRFSEPG
TDLVEPSPKH TPNTSDNEGS DTEVCGPNSP SKRGNNAGIK LVRKEGGLDD SVFIAVKEIG
RDLYRGLPTE ERIQKLEFML DKLQNEIDQE LEHNNSLARE EKETTDTRKK ALLSAALIKS
GERLQALTLL MIHYRAGIED IETLESLSLD QHSKKISKYA DDAEEDLDSE ISQLIDSQPF
SSISDDLFGP SESV
//
