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Database: UniProt
Entry: A0A286X8H2_CAVPO
LinkDB: A0A286X8H2_CAVPO
Original site: A0A286X8H2_CAVPO 
ID   A0A286X8H2_CAVPO        Unreviewed;       447 AA.
AC   A0A286X8H2;
DT   22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT   22-NOV-2017, sequence version 1.
DT   31-JUL-2019, entry version 13.
DE   SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSCPOP00000021714};
GN   Name=FLI1 {ECO:0000313|Ensembl:ENSCPOP00000021714};
OS   Cavia porcellus (Guinea pig).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia;
OC   Hystricomorpha; Caviidae; Cavia.
OX   NCBI_TaxID=10141 {ECO:0000313|Ensembl:ENSCPOP00000021714, ECO:0000313|Proteomes:UP000005447};
RN   [1] {ECO:0000313|Ensembl:ENSCPOP00000021714, ECO:0000313|Proteomes:UP000005447}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=2N {ECO:0000313|Ensembl:ENSCPOP00000021714,
RC   ECO:0000313|Proteomes:UP000005447};
RX   PubMed=21993624; DOI=10.1038/nature10530;
RA   Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J.,
RA   Washietl S., Kheradpour P., Ernst J., Jordan G., Mauceli E.,
RA   Ward L.D., Lowe C.B., Holloway A.K., Clamp M., Gnerre S., Alfoldi J.,
RA   Beal K., Chang J., Clawson H., Cuff J., Di Palma F., Fitzgerald S.,
RA   Flicek P., Guttman M., Hubisz M.J., Jaffe D.B., Jungreis I.,
RA   Kent W.J., Kostka D., Lara M., Martins A.L., Massingham T., Moltke I.,
RA   Raney B.J., Rasmussen M.D., Robinson J., Stark A., Vilella A.J.,
RA   Wen J., Xie X., Zody M.C., Baldwin J., Bloom T., Chin C.W., Heiman D.,
RA   Nicol R., Nusbaum C., Young S., Wilkinson J., Worley K.C., Kovar C.L.,
RA   Muzny D.M., Gibbs R.A., Cree A., Dihn H.H., Fowler G., Jhangiani S.,
RA   Joshi V., Lee S., Lewis L.R., Nazareth L.V., Okwuonu G.,
RA   Santibanez J., Warren W.C., Mardis E.R., Weinstock G.M., Wilson R.K.,
RA   Delehaunty K., Dooling D., Fronik C., Fulton L., Fulton B., Graves T.,
RA   Minx P., Sodergren E., Birney E., Margulies E.H., Herrero J.,
RA   Green E.D., Haussler D., Siepel A., Goldman N., Pollard K.S.,
RA   Pedersen J.S., Lander E.S., Kellis M.;
RT   "A high-resolution map of human evolutionary constraint using 29
RT   mammals.";
RL   Nature 478:476-482(2011).
RN   [2] {ECO:0000313|Ensembl:ENSCPOP00000021714}
RP   IDENTIFICATION.
RC   STRAIN=2N {ECO:0000313|Ensembl:ENSCPOP00000021714};
RG   Ensembl;
RL   Submitted (OCT-2017) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|RuleBase:RU004019,
CC       ECO:0000256|SAAS:SAAS00594387}.
CC   -!- SIMILARITY: Belongs to the ETS family.
CC       {ECO:0000256|RuleBase:RU004019, ECO:0000256|SAAS:SAAS00594391}.
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DR   EMBL; AAKN02024610; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   RefSeq; XP_013011074.1; XM_013155620.1.
DR   STRING; 10141.ENSCPOP00000012977; -.
DR   Ensembl; ENSCPOT00000033024; ENSCPOP00000021714; ENSCPOG00000030795.
DR   GeneID; 100716275; -.
DR   CTD; 2313; -.
DR   GeneTree; ENSGT00940000158261; -.
DR   OrthoDB; 1113327at2759; -.
DR   Proteomes; UP000005447; Unassembled WGS sequence.
DR   GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR   GO; GO:0016604; C:nuclear body; IEA:Ensembl.
DR   GO; GO:0003682; F:chromatin binding; IEA:Ensembl.
DR   GO; GO:0001228; F:DNA-binding transcription activator activity, RNA polymerase II-specific; IEA:Ensembl.
DR   GO; GO:0000980; F:RNA polymerase II distal enhancer sequence-specific DNA binding; IEA:Ensembl.
DR   GO; GO:0000978; F:RNA polymerase II proximal promoter sequence-specific DNA binding; IEA:Ensembl.
DR   GO; GO:0009887; P:animal organ morphogenesis; IEA:Ensembl.
DR   GO; GO:0008015; P:blood circulation; IEA:Ensembl.
DR   GO; GO:0035855; P:megakaryocyte development; IEA:Ensembl.
DR   CDD; cd08541; SAM_PNT-FLI-1; 1.
DR   Gene3D; 1.10.10.10; -; 1.
DR   Gene3D; 1.10.150.50; -; 1.
DR   InterPro; IPR000418; Ets_dom.
DR   InterPro; IPR035575; Fli-1.
DR   InterPro; IPR003118; Pointed_dom.
DR   InterPro; IPR013761; SAM/pointed_sf.
DR   InterPro; IPR035573; SAM_PNT-FLI-1.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   PANTHER; PTHR11849:SF161; PTHR11849:SF161; 1.
DR   Pfam; PF00178; Ets; 1.
DR   Pfam; PF02198; SAM_PNT; 1.
DR   PRINTS; PR00454; ETSDOMAIN.
DR   SMART; SM00413; ETS; 1.
DR   SMART; SM00251; SAM_PNT; 1.
DR   SUPFAM; SSF46785; SSF46785; 1.
DR   SUPFAM; SSF47769; SSF47769; 1.
DR   PROSITE; PS00345; ETS_DOMAIN_1; 1.
DR   PROSITE; PS00346; ETS_DOMAIN_2; 1.
DR   PROSITE; PS50061; ETS_DOMAIN_3; 1.
DR   PROSITE; PS51433; PNT; 1.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000005447};
KW   DNA-binding {ECO:0000256|RuleBase:RU004019,
KW   ECO:0000256|SAAS:SAAS00594397};
KW   Nucleus {ECO:0000256|RuleBase:RU004019,
KW   ECO:0000256|SAAS:SAAS00594400};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005447}.
FT   DOMAIN      107    193       PNT. {ECO:0000259|PROSITE:PS51433}.
FT   DOMAIN      276    356       ETS. {ECO:0000259|PROSITE:PS50061}.
FT   REGION       28     49       Disordered. {ECO:0000256|SAM:MobiDB-
FT                                lite}.
FT   REGION      203    267       Disordered. {ECO:0000256|SAM:MobiDB-
FT                                lite}.
FT   REGION      428    447       Disordered. {ECO:0000256|SAM:MobiDB-
FT                                lite}.
FT   COMPBIAS    223    267       Polar. {ECO:0000256|SAM:MobiDB-lite}.
SQ   SEQUENCE   447 AA;  50417 MW;  9D82239DB4CAA70B CRC64;
     MEALSVVSDD QSLFDSAYGA AAHLPKADMT ASGSPDYGQP HKINPLPPQQ EWINQPVRVN
     VKREYDHMNG SRESPVDCSV SKCSKLVGTG ESNPMNYNSY MDEKNGPPPP NMTTNERRVI
     VPADPTLWTQ EHVRQWLEWA IKEYGLMEID SSFFQNMDGK ELCKMSKEDF LRATSLYNTE
     VLLSHLSYLR ESSLLAYNTT SHTDQSSRLS VKEDPSYDSV RRGGWGNNMN SGLNKSPPLG
     GAQTMSKSTE QRPQPDPYQI LGPTSSRLAN PGSGQIQLWQ FLLELLSDSA NASCITWEGT
     NGEFKMTDPD EVARRWGERK SKPNMNYDKL SRALRYYYDK NIMTKVHGKR YAYKFDFHGI
     AQALQPHPTE SSMYKYPSDI SYMPSYHAHQ QKVNFVPPHP TSMPVTSSSF FGAASQYWTS
     PTGGIYPNPN VPRHPNTHVP SHLGSYY
//
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