ID A0A286XBA4_CAVPO Unreviewed; 418 AA.
AC A0A286XBA4;
DT 22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 1.
DT 27-MAR-2024, entry version 26.
DE RecName: Full=Keratin, type I cytoskeletal 27 {ECO:0000256|ARBA:ARBA00040314};
DE AltName: Full=Cytokeratin-27 {ECO:0000256|ARBA:ARBA00041720};
DE AltName: Full=Keratin-27 {ECO:0000256|ARBA:ARBA00042484};
DE AltName: Full=Type I inner root sheath-specific keratin-K25irs3 {ECO:0000256|ARBA:ARBA00043216};
GN Name=KRT27 {ECO:0000313|Ensembl:ENSCPOP00000022679.1};
OS Cavia porcellus (Guinea pig).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Hystricomorpha; Caviidae;
OC Cavia.
OX NCBI_TaxID=10141 {ECO:0000313|Ensembl:ENSCPOP00000022679.1, ECO:0000313|Proteomes:UP000005447};
RN [1] {ECO:0000313|Proteomes:UP000005447}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=2N {ECO:0000313|Proteomes:UP000005447};
RX PubMed=21993624; DOI=10.1038/nature10530;
RA Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J., Washietl S.,
RA Kheradpour P., Ernst J., Jordan G., Mauceli E., Ward L.D., Lowe C.B.,
RA Holloway A.K., Clamp M., Gnerre S., Alfoldi J., Beal K., Chang J.,
RA Clawson H., Cuff J., Di Palma F., Fitzgerald S., Flicek P., Guttman M.,
RA Hubisz M.J., Jaffe D.B., Jungreis I., Kent W.J., Kostka D., Lara M.,
RA Martins A.L., Massingham T., Moltke I., Raney B.J., Rasmussen M.D.,
RA Robinson J., Stark A., Vilella A.J., Wen J., Xie X., Zody M.C., Baldwin J.,
RA Bloom T., Chin C.W., Heiman D., Nicol R., Nusbaum C., Young S.,
RA Wilkinson J., Worley K.C., Kovar C.L., Muzny D.M., Gibbs R.A., Cree A.,
RA Dihn H.H., Fowler G., Jhangiani S., Joshi V., Lee S., Lewis L.R.,
RA Nazareth L.V., Okwuonu G., Santibanez J., Warren W.C., Mardis E.R.,
RA Weinstock G.M., Wilson R.K., Delehaunty K., Dooling D., Fronik C.,
RA Fulton L., Fulton B., Graves T., Minx P., Sodergren E., Birney E.,
RA Margulies E.H., Herrero J., Green E.D., Haussler D., Siepel A., Goldman N.,
RA Pollard K.S., Pedersen J.S., Lander E.S., Kellis M.;
RT "A high-resolution map of human evolutionary constraint using 29 mammals.";
RL Nature 478:476-482(2011).
RN [2] {ECO:0000313|Ensembl:ENSCPOP00000022679.1}
RP IDENTIFICATION.
RC STRAIN=2N {ECO:0000313|Ensembl:ENSCPOP00000022679.1};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: Essential for the proper assembly of type I and type II
CC keratin protein complexes and formation of keratin intermediate
CC filaments in the inner root sheath (irs).
CC {ECO:0000256|ARBA:ARBA00037136}.
CC -!- SUBUNIT: Heterotetramer of two type I and two type II keratins.
CC Interacts with KRT6A to form filaments.
CC {ECO:0000256|ARBA:ARBA00038833}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AAKN02042399; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; A0A286XBA4; -.
DR Ensembl; ENSCPOT00000041432.1; ENSCPOP00000022679.1; ENSCPOG00000030964.1.
DR VEuPathDB; HostDB:ENSCPOG00000030964; -.
DR GeneTree; ENSGT00940000161982; -.
DR Proteomes; UP000005447; Unassembled WGS sequence.
DR Bgee; ENSCPOG00000030964; Expressed in zone of skin.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005882; C:intermediate filament; IEA:UniProtKB-KW.
DR GO; GO:0005198; F:structural molecule activity; IEA:InterPro.
DR Gene3D; 1.20.5.170; -; 1.
DR Gene3D; 1.20.5.500; Single helix bin; 1.
DR Gene3D; 1.20.5.1160; Vasodilator-stimulated phosphoprotein; 1.
DR InterPro; IPR039008; IF_rod_dom.
DR InterPro; IPR002957; Keratin_I.
DR PANTHER; PTHR23239; INTERMEDIATE FILAMENT; 1.
DR PANTHER; PTHR23239:SF120; KERATIN, TYPE I CYTOSKELETAL 27; 1.
DR Pfam; PF00038; Filament; 1.
DR PRINTS; PR01248; TYPE1KERATIN.
DR SMART; SM01391; Filament; 1.
DR SUPFAM; SSF64593; Intermediate filament protein, coiled coil region; 2.
DR PROSITE; PS51842; IF_ROD_2; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Intermediate filament {ECO:0000256|ARBA:ARBA00022754};
KW Reference proteome {ECO:0000313|Proteomes:UP000005447}.
FT DOMAIN 77..392
FT /note="IF rod"
FT /evidence="ECO:0000259|PROSITE:PS51842"
FT COILED 81..115
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 191..310
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 336..384
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 418 AA; 45902 MW; F391CB623D038658 CRC64;
MSVRFSSASK QLDSPGRLSG AGTSFAAGNP CGVPGIGSGF SCVFGGSLSA GGYAPGIGSV
PYAAFAGTEH ILLAGNEKVT MQNLNDRLAS YLDKVRALEE ANAELEQKIK GWYETFGPGS
CRGLDHDYSR YLPIIDDLRI QIISATASNA NLVLQNDNAR LTADDFRLKY ENELALHQSV
DADINGLRRV LDELTLCRTD LEVQLEMLTE ELTTLKKNHE EEMKALQCAA GGNVNVEMNA
APGVDLTVLL NNMRAEYEAL AEQNRRDAET WFSEKSASLQ QQISEDTGAA ASAKNELTEI
RRSALALQIE LQSNIALKHS LECSLSETEG NYCTQLAQIQ AQIGALEEQL HQVRTEMEGQ
KLEYQQLLDV KVHLEKEIET YRRLIDGDEG HVIVKTVVEE IDLQKPSKIN KSEQRVPS
//
