ID A0A286XBJ5_CAVPO Unreviewed; 552 AA.
AC A0A286XBJ5;
DT 22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 1.
DT 27-MAR-2024, entry version 29.
DE SubName: Full=Copine family member 9 {ECO:0000313|Ensembl:ENSCPOP00000022813.1};
GN Name=CPNE9 {ECO:0000313|Ensembl:ENSCPOP00000022813.1};
OS Cavia porcellus (Guinea pig).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Hystricomorpha; Caviidae;
OC Cavia.
OX NCBI_TaxID=10141 {ECO:0000313|Ensembl:ENSCPOP00000022813.1, ECO:0000313|Proteomes:UP000005447};
RN [1] {ECO:0000313|Proteomes:UP000005447}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=2N {ECO:0000313|Proteomes:UP000005447};
RX PubMed=21993624; DOI=10.1038/nature10530;
RA Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J., Washietl S.,
RA Kheradpour P., Ernst J., Jordan G., Mauceli E., Ward L.D., Lowe C.B.,
RA Holloway A.K., Clamp M., Gnerre S., Alfoldi J., Beal K., Chang J.,
RA Clawson H., Cuff J., Di Palma F., Fitzgerald S., Flicek P., Guttman M.,
RA Hubisz M.J., Jaffe D.B., Jungreis I., Kent W.J., Kostka D., Lara M.,
RA Martins A.L., Massingham T., Moltke I., Raney B.J., Rasmussen M.D.,
RA Robinson J., Stark A., Vilella A.J., Wen J., Xie X., Zody M.C., Baldwin J.,
RA Bloom T., Chin C.W., Heiman D., Nicol R., Nusbaum C., Young S.,
RA Wilkinson J., Worley K.C., Kovar C.L., Muzny D.M., Gibbs R.A., Cree A.,
RA Dihn H.H., Fowler G., Jhangiani S., Joshi V., Lee S., Lewis L.R.,
RA Nazareth L.V., Okwuonu G., Santibanez J., Warren W.C., Mardis E.R.,
RA Weinstock G.M., Wilson R.K., Delehaunty K., Dooling D., Fronik C.,
RA Fulton L., Fulton B., Graves T., Minx P., Sodergren E., Birney E.,
RA Margulies E.H., Herrero J., Green E.D., Haussler D., Siepel A., Goldman N.,
RA Pollard K.S., Pedersen J.S., Lander E.S., Kellis M.;
RT "A high-resolution map of human evolutionary constraint using 29 mammals.";
RL Nature 478:476-482(2011).
RN [2] {ECO:0000313|Ensembl:ENSCPOP00000022813.1}
RP IDENTIFICATION.
RC STRAIN=2N {ECO:0000313|Ensembl:ENSCPOP00000022813.1};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the copine family.
CC {ECO:0000256|ARBA:ARBA00009048}.
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DR EMBL; AAKN02049214; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAKN02049215; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_005001158.1; XM_005001101.2.
DR AlphaFoldDB; A0A286XBJ5; -.
DR Ensembl; ENSCPOT00000033231.1; ENSCPOP00000022813.1; ENSCPOG00000008755.4.
DR GeneID; 100719941; -.
DR CTD; 151835; -.
DR VEuPathDB; HostDB:ENSCPOG00000008755; -.
DR eggNOG; KOG1327; Eukaryota.
DR GeneTree; ENSGT00940000159659; -.
DR OrthoDB; 672483at2759; -.
DR Proteomes; UP000005447; Unassembled WGS sequence.
DR Bgee; ENSCPOG00000008755; Expressed in cerebellum and 13 other cell types or tissues.
DR GO; GO:0005544; F:calcium-dependent phospholipid binding; IEA:InterPro.
DR CDD; cd04048; C2A_Copine; 1.
DR CDD; cd04047; C2B_Copine; 1.
DR CDD; cd01459; vWA_copine_like; 1.
DR Gene3D; 2.60.40.150; C2 domain; 2.
DR InterPro; IPR000008; C2_dom.
DR InterPro; IPR035892; C2_domain_sf.
DR InterPro; IPR037768; C2B_Copine.
DR InterPro; IPR045052; Copine.
DR InterPro; IPR010734; Copine_C.
DR InterPro; IPR002035; VWF_A.
DR InterPro; IPR036465; vWFA_dom_sf.
DR PANTHER; PTHR10857; COPINE; 1.
DR PANTHER; PTHR10857:SF112; COPINE-9; 1.
DR Pfam; PF00168; C2; 2.
DR Pfam; PF07002; Copine; 1.
DR SMART; SM00239; C2; 2.
DR SMART; SM00327; VWA; 1.
DR SUPFAM; SSF49562; C2 domain (Calcium/lipid-binding domain, CaLB); 2.
DR SUPFAM; SSF53300; vWA-like; 1.
DR PROSITE; PS50004; C2; 2.
DR PROSITE; PS50234; VWFA; 1.
PE 3: Inferred from homology;
KW Calcium {ECO:0000256|ARBA:ARBA00022837};
KW Reference proteome {ECO:0000313|Proteomes:UP000005447}.
FT DOMAIN 1..124
FT /note="C2"
FT /evidence="ECO:0000259|PROSITE:PS50004"
FT DOMAIN 131..254
FT /note="C2"
FT /evidence="ECO:0000259|PROSITE:PS50004"
FT DOMAIN 298..499
FT /note="VWFA"
FT /evidence="ECO:0000259|PROSITE:PS50234"
FT REGION 530..552
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 533..552
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 552 AA; 61713 MW; 7EDBCFD7F6EF064E CRC64;
MSLGGASERS VPATKIEITV SCRNLLDLDT FSKSDPMVVL YTQSRASQEW REFGRTEVID
NTLNPDFLRK FVLDYFFEEK QNLRFDVYNV DSRTNISKPD FLGQAFLALG EVIGGQGSRV
ERPLTGVPGK KCGSILLTAE ELSNCRDIAT MQLCANKLDK KDFFGKSDPF LVFYRSNEDG
TFTICHKTEV VKNTLNPVWQ PFSIPVRALC NGDYDRTVKI DVYDWDRDGS HDFIGEFTTS
YRELSRAQSQ FTVYEVLNPR KKCKKKKYVN SGTVTLLSFS VDSEFTFVDY IKGGTQLNFT
VAIDFTASNG NPLQPTSLHY MSPYQLSAYA LALKAVGEII QDYDSDKLFP AYGFGAKLPP
EGRISHQFPL NNNDEDPNCA GIEGVLESYF QSLRTVQLYG PTYFAPVINQ VARAAAKISD
GSQYYVLLII TDGVISDMIQ TKEAIVSASS LPMSIIIVGV GPAMFEAMEE LDGDDVRVSS
RGRFAERDIV QFVPFRDYVD RSGNQVLSMA RLAKDVLAEI PEQLLSYMRT RDIQPRPPPP
ANPSPSPAPE QP
//
