ID A0A286XBT3_CAVPO Unreviewed; 1354 AA.
AC A0A286XBT3;
DT 22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 1.
DT 27-MAR-2024, entry version 22.
DE SubName: Full=Formin 1 {ECO:0000313|Ensembl:ENSCPOP00000022892.1};
GN Name=FMN1 {ECO:0000313|Ensembl:ENSCPOP00000022892.1};
OS Cavia porcellus (Guinea pig).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Hystricomorpha; Caviidae;
OC Cavia.
OX NCBI_TaxID=10141 {ECO:0000313|Ensembl:ENSCPOP00000022892.1, ECO:0000313|Proteomes:UP000005447};
RN [1] {ECO:0000313|Proteomes:UP000005447}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=2N {ECO:0000313|Proteomes:UP000005447};
RX PubMed=21993624; DOI=10.1038/nature10530;
RA Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J., Washietl S.,
RA Kheradpour P., Ernst J., Jordan G., Mauceli E., Ward L.D., Lowe C.B.,
RA Holloway A.K., Clamp M., Gnerre S., Alfoldi J., Beal K., Chang J.,
RA Clawson H., Cuff J., Di Palma F., Fitzgerald S., Flicek P., Guttman M.,
RA Hubisz M.J., Jaffe D.B., Jungreis I., Kent W.J., Kostka D., Lara M.,
RA Martins A.L., Massingham T., Moltke I., Raney B.J., Rasmussen M.D.,
RA Robinson J., Stark A., Vilella A.J., Wen J., Xie X., Zody M.C., Baldwin J.,
RA Bloom T., Chin C.W., Heiman D., Nicol R., Nusbaum C., Young S.,
RA Wilkinson J., Worley K.C., Kovar C.L., Muzny D.M., Gibbs R.A., Cree A.,
RA Dihn H.H., Fowler G., Jhangiani S., Joshi V., Lee S., Lewis L.R.,
RA Nazareth L.V., Okwuonu G., Santibanez J., Warren W.C., Mardis E.R.,
RA Weinstock G.M., Wilson R.K., Delehaunty K., Dooling D., Fronik C.,
RA Fulton L., Fulton B., Graves T., Minx P., Sodergren E., Birney E.,
RA Margulies E.H., Herrero J., Green E.D., Haussler D., Siepel A., Goldman N.,
RA Pollard K.S., Pedersen J.S., Lander E.S., Kellis M.;
RT "A high-resolution map of human evolutionary constraint using 29 mammals.";
RL Nature 478:476-482(2011).
RN [2] {ECO:0000313|Ensembl:ENSCPOP00000022892.1}
RP IDENTIFICATION.
RC STRAIN=2N {ECO:0000313|Ensembl:ENSCPOP00000022892.1};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the formin homology family. Cappuccino
CC subfamily. {ECO:0000256|ARBA:ARBA00005271}.
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DR EMBL; AAKN02015749; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAKN02015750; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAKN02015751; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAKN02015752; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAKN02015753; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAKN02015754; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAKN02015755; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR Ensembl; ENSCPOT00000043450.1; ENSCPOP00000022892.1; ENSCPOG00000002614.4.
DR VEuPathDB; HostDB:ENSCPOG00000002614; -.
DR eggNOG; KOG1654; Eukaryota.
DR eggNOG; KOG1922; Eukaryota.
DR GeneTree; ENSGT00940000154289; -.
DR Proteomes; UP000005447; Unassembled WGS sequence.
DR Bgee; ENSCPOG00000002614; Expressed in testis and 7 other cell types or tissues.
DR GO; GO:0005884; C:actin filament; IEA:InterPro.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0008017; F:microtubule binding; IEA:InterPro.
DR GO; GO:0045010; P:actin nucleation; IEA:InterPro.
DR Gene3D; 1.20.58.2220; Formin, FH2 domain; 1.
DR InterPro; IPR015425; FH2_Formin.
DR InterPro; IPR042201; FH2_Formin_sf.
DR InterPro; IPR001265; Formin_Cappuccino_subfam.
DR PANTHER; PTHR13037; FORMIN; 1.
DR PANTHER; PTHR13037:SF11; FORMIN-1; 1.
DR Pfam; PF02181; FH2; 1.
DR PRINTS; PR00828; FORMIN.
DR SMART; SM00498; FH2; 1.
DR SUPFAM; SSF101447; Formin homology 2 domain (FH2 domain); 1.
DR PROSITE; PS51444; FH2; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000005447}.
FT DOMAIN 923..1323
FT /note="FH2"
FT /evidence="ECO:0000259|PROSITE:PS51444"
FT REGION 147..199
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 245..319
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 376..413
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 437..530
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 553..642
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 675..708
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 838..932
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 1195..1262
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 160..181
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 274..319
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 385..413
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 512..528
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 556..589
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 609..624
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 862..908
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1354 AA; 149739 MW; C481052FC8413D63 CRC64;
MEGSHCTLQL RKPITELCYI SFYLPRGEVR GFSYKGTVIL DRSNKGFHNC YQVREGSNTF
SLSQQLNELP GDIFFKPSPT KDILTELYKL TAERERLLAN LRSSDHILGI SMGNQEGKLL
ELSVSVAPED GCSQSAVDWW REPAVSPLNK RSTQGNKKPR RFGGRRESFE VQKRIRRKGR
GGQESTPQMG KDQIPSSSCI PPFGAQLNLR LLEEKGNLVP NGVLTSSLQR RESCPADIPS
VPHADLGFAN SGTASEDAGL GRGALPTRSS STEAGDKGVR DLPKRPHRLE QQQTDLPESQ
EGAKKHPEAQ RGGLGKLTER TCRKKPISKV VAKVQDLSTQ VQRVVNVPPE GEEKIVVHPA
VKTEFISTVD LLTLPGPEAG ASGSRWQRKE QQGTRSLQLP ARESASVSSL PASAEGAVNK
VLLKVIESEK LDEATKGKRL DVPINARATH GPPETRSKRR AGVPQRGHKS LFLDLPYTTG
PGSSQCRGDE RRPSPPVPAA PCSGFNNSSQ QPPHQQPPPA PSPICPRCPS PQEHHRILLL
PPLPGEREAA LNAAPGRQSS ILSESSSPDT LEPPSSAKVT ETKGASPASL RAGQPQLVPG
GTVERSLGPK KTTAPSQPLS SPGVSSEGFP GDRFSEQTAK DFPRDTGAWV LGYRSGPPCP
FLLPEDREKS NRSKLYLDLN PDQSPTEPDD RTPGRLQAVW PPPKTKDAEE KVGLKYTEAE
HQAAILHLKR EHKEEIETLQ AQFELQAFHI RGEHAATTAR LEETIENLKL ELEQRLRGGR
EELRDACVCT DDCPPKAYRN VCIQTDRESF LKPCEGESKA TRSNQIVPKK LNICSLSQLS
PTNDSKDIPA PLPSGEGASP AHPKTAPPPA PPPPPPPLPI PPPPPLPPGP PAPAPSAGSP
PPLPLGSAGA PSSPLLTPRP ARGGGPPPAH LPMKPLYWTR KNNSSPEYLS HHLRVCLQFL
CFCDVLEKLF GSLSLYFSKF QIIKLLDGKR SQAVGILISS LHLEMKDIQQ AIFNVDDSVV
DLETLEALYE NRAQENELVK IRKYYETSKE EELKLLDKPE QFLHELAQIP NFAERAQCII
FRSVFAEGVT SLHRKVEIVT QASKGLLHMK SVKDILALIL AFGNYMNGGN RTRGQADGYS
LEILPKLKDV KSRDNGINLV DYVVKYYLRY YDQEAGTDKS IFPLPEPQDF FLASQVKFED
LIEDLRKLKK QLEASEKQMM VVCRESPKEY LQPFKNKLEE FFQKAKKEHK MEESHLENAQ
KSFQTTVGYF GMKPKAGEKE ITPSYVFMVW YEFCSDFKTI WKRESKNISK ERLKMAQASV
SKLTSEKKVE TKKINPTASL KERLRQKEAS VTTN
//
