GenomeNet

Database: UniProt
Entry: A0A286XCL1_CAVPO
LinkDB: A0A286XCL1_CAVPO
Original site: A0A286XCL1_CAVPO 
ID   A0A286XCL1_CAVPO        Unreviewed;      4806 AA.
AC   A0A286XCL1;
DT   22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT   22-NOV-2017, sequence version 1.
DT   05-DEC-2018, entry version 6.
DE   SubName: Full=Ryanodine receptor 3 {ECO:0000313|Ensembl:ENSCPOP00000023184};
GN   Name=RYR3 {ECO:0000313|Ensembl:ENSCPOP00000023184};
OS   Cavia porcellus (Guinea pig).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia;
OC   Hystricomorpha; Caviidae; Cavia.
OX   NCBI_TaxID=10141 {ECO:0000313|Ensembl:ENSCPOP00000023184, ECO:0000313|Proteomes:UP000005447};
RN   [1] {ECO:0000313|Ensembl:ENSCPOP00000023184, ECO:0000313|Proteomes:UP000005447}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=2N {ECO:0000313|Ensembl:ENSCPOP00000023184,
RC   ECO:0000313|Proteomes:UP000005447};
RX   PubMed=21993624; DOI=10.1038/nature10530;
RA   Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J.,
RA   Washietl S., Kheradpour P., Ernst J., Jordan G., Mauceli E.,
RA   Ward L.D., Lowe C.B., Holloway A.K., Clamp M., Gnerre S., Alfoldi J.,
RA   Beal K., Chang J., Clawson H., Cuff J., Di Palma F., Fitzgerald S.,
RA   Flicek P., Guttman M., Hubisz M.J., Jaffe D.B., Jungreis I.,
RA   Kent W.J., Kostka D., Lara M., Martins A.L., Massingham T., Moltke I.,
RA   Raney B.J., Rasmussen M.D., Robinson J., Stark A., Vilella A.J.,
RA   Wen J., Xie X., Zody M.C., Baldwin J., Bloom T., Chin C.W., Heiman D.,
RA   Nicol R., Nusbaum C., Young S., Wilkinson J., Worley K.C., Kovar C.L.,
RA   Muzny D.M., Gibbs R.A., Cree A., Dihn H.H., Fowler G., Jhangiani S.,
RA   Joshi V., Lee S., Lewis L.R., Nazareth L.V., Okwuonu G.,
RA   Santibanez J., Warren W.C., Mardis E.R., Weinstock G.M., Wilson R.K.,
RA   Delehaunty K., Dooling D., Fronik C., Fulton L., Fulton B., Graves T.,
RA   Minx P., Sodergren E., Birney E., Margulies E.H., Herrero J.,
RA   Green E.D., Haussler D., Siepel A., Goldman N., Pollard K.S.,
RA   Pedersen J.S., Lander E.S., Kellis M.;
RT   "A high-resolution map of human evolutionary constraint using 29
RT   mammals.";
RL   Nature 478:476-482(2011).
RN   [2] {ECO:0000313|Ensembl:ENSCPOP00000023184}
RP   IDENTIFICATION.
RC   STRAIN=2N {ECO:0000313|Ensembl:ENSCPOP00000023184};
RG   Ensembl;
RL   Submitted (OCT-2017) to UniProtKB.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation
CC       of feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00448}.
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DR   EMBL; AAKN02015737; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AAKN02015738; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AAKN02015739; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AAKN02015740; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AAKN02015741; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AAKN02015742; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AAKN02015743; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AAKN02015744; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   Ensembl; ENSCPOT00000035763; ENSCPOP00000023184; ENSCPOG00000003120.
DR   GeneTree; ENSGT00940000155507; -.
DR   Proteomes; UP000005447; Unassembled WGS sequence.
DR   GO; GO:0005623; C:cell; IEA:GOC.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR   GO; GO:0005219; F:ryanodine-sensitive calcium-release channel activity; IEA:InterPro.
DR   CDD; cd12877; SPRY1_RyR; 1.
DR   CDD; cd12878; SPRY2_RyR; 1.
DR   CDD; cd12879; SPRY3_RyR; 1.
DR   InterPro; IPR001870; B30.2/SPRY.
DR   InterPro; IPR013320; ConA-like_dom_sf.
DR   InterPro; IPR011992; EF-hand-dom_pair.
DR   InterPro; IPR002048; EF_hand_dom.
DR   InterPro; IPR014821; Ins145_P3_rcpt.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR036300; MIR_dom_sf.
DR   InterPro; IPR016093; MIR_motif.
DR   InterPro; IPR013662; RIH_assoc-dom.
DR   InterPro; IPR000699; RIH_dom.
DR   InterPro; IPR013333; Ryan_recept.
DR   InterPro; IPR003032; Ryanodine_rcpt.
DR   InterPro; IPR015925; Ryanodine_recept-rel.
DR   InterPro; IPR009460; Ryanrecept_TM4-6.
DR   InterPro; IPR035910; RyR/IP3R_RIH_dom_sf.
DR   InterPro; IPR035761; SPRY1_RyR.
DR   InterPro; IPR035764; SPRY2_RyR.
DR   InterPro; IPR035762; SPRY3_RyR.
DR   InterPro; IPR003877; SPRY_dom.
DR   PANTHER; PTHR13715; PTHR13715; 1.
DR   Pfam; PF08709; Ins145_P3_rec; 1.
DR   Pfam; PF00520; Ion_trans; 1.
DR   Pfam; PF02815; MIR; 1.
DR   Pfam; PF08454; RIH_assoc; 1.
DR   Pfam; PF06459; RR_TM4-6; 1.
DR   Pfam; PF01365; RYDR_ITPR; 2.
DR   Pfam; PF02026; RyR; 4.
DR   Pfam; PF00622; SPRY; 3.
DR   PRINTS; PR00795; RYANODINER.
DR   SMART; SM00472; MIR; 3.
DR   SMART; SM00449; SPRY; 3.
DR   SUPFAM; SSF100909; SSF100909; 2.
DR   SUPFAM; SSF47473; SSF47473; 1.
DR   SUPFAM; SSF49899; SSF49899; 3.
DR   SUPFAM; SSF82109; SSF82109; 2.
DR   PROSITE; PS50188; B302_SPRY; 3.
DR   PROSITE; PS50222; EF_HAND_2; 1.
DR   PROSITE; PS50919; MIR; 4.
PE   4: Predicted;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000005447};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005447};
KW   Repeat {ECO:0000256|SAAS:SAAS00903904};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4123   4156       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4347   4367       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4415   4434       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4546   4564       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4607   4628       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4687   4710       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN       99    154       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      161    206       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      260    318       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      328    385       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      570    781       B30.2/SPRY. {ECO:0000259|PROSITE:
FT                                PS50188}.
FT   DOMAIN      997   1193       B30.2/SPRY. {ECO:0000259|PROSITE:
FT                                PS50188}.
FT   DOMAIN     1239   1451       B30.2/SPRY. {ECO:0000259|PROSITE:
FT                                PS50188}.
FT   DOMAIN     3855   3890       EF-hand. {ECO:0000259|PROSITE:PS50222}.
FT   COILED      444    464       {ECO:0000256|SAM:Coils}.
FT   COILED     3186   3206       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   4806 AA;  544736 MW;  23D0C9C83751BBA3 CRC64;
     WGLAGQGGSP SPLTLCEDEV VLQCIANVHK EQRKFCLAAE GLGNRLCFLE PTSEAKYIPP
     DLCICNFVLE QSLSVRALQE MLANTGENGG EGAAQGGGHR TLLYGHAILL RHSFSGMYLT
     CLTTSRSQTD KLAFDVGLRE HATGEACWWT IHPASKQRSE GEKVRIGDDL ILVSVSSERY
     LHLSISNGNI QVDASFMQTL WNVHPTCSGS SIEEGYLLVG MVVLLISNST HRRVFYEAGG
     AGRRARSLWR VEPLRISWSG SNIRWGQAFR LRHLTTGHYL ALTEDQGLLL QDRGKSDTKS
     TAFSFRASKE IKEKLDSSHK RDMEGMGVPE IKYGDSVCFV QHVASGLWVT YKAQDAKTSR
     LGPLKRKVIL HQEGHMDDGL TLQRCQREES QAARIIRNTT ALFSRFVSGN NRTAAPIALP
     TEEVLQTLQD LIAYFQPPEE EMKHEDKQNK LRSLKNRQNL FKEEGMLALV LNCIDRLNIY
     NSVAHLTGIA REESGMAWKE ILNLLYKLLA ALIRGNRNNC AQFSNNLDWL ISKLDRLESS
     SGILEVLHCI LIESPEALNL IAEGHIKSII SLLDKHGRNH KVLDVLCSLC LCNGVAVRAN
     QNLICDNLLP RRNLLLQTRL INDVTSIRPN IFLGVAEGSA QYKKWYYELI IDQVDPFLTA
     EPTHLRVGWA SSSGYAPYPG GGEGWGGNGV GDDLYSYGFD GLHLWSGRIP RAVASINQHL
     LRSDDVVSCC LDLGVPSISF RINGQPVQGM FENFNTDGLF FPVMSFSAGV KVRFLMGGRH
     GEFKFLPPSG YAPCYEALLP KEKMRLEPVK EYKRDSDGVR DLLGTTQFLS QASFIPCPID
     TSQVVLPPHL EKIRDRLAEN IHELWGMNKI ELGWTFGKIR DDNKRQHPCL VEFSKLPETE
     KNYNLQMSTE TLKTLLALGC HIAHVNPAAE EDLKKVKLPK NYMMTNGYKP APLDLSDVKL
     LPPQEILVDK LAENAHNVWA KDRIKQGWTY GIQQDLKNKR NPRLVPYALL DERTKKSNRD
     SLREAIRTFV GYGYNIEPSD QELADPTVEK VSVDKIRFFR VERSYAVRSG KWYFEFEAVT
     GGDMRVGWAR PGCRPDIELG ADDQAFVFEG SRGQRWHQGS GYFGRTWQPG DVVGCMINLD
     DASMIFTLNG ELLITNKGSE LAFADYEIEN GFVPICCLGL SQIGRMNLGT DASTFKFYTM
     CGLQEGFEPF AVNMNRDVAM WFSKRLPTFV NVPEDHPHIE VARIDGTMDS PPCLKVTHKT
     FGTQNSNANM IYCRLSMPVE CYSSFSHSPC LDSDAFQKRK QMQEILSPTT TQCYYAIRIF
     AGQDPSCVWV GWVTPDYHLY SKKFDLNKNC TVTVTLGDER GRVHESVKRS NCYMVWGGDI
     VASSQRSSRS NVDLEIGCLV DLAMGMLSFS ANGKELGTCY QVEPNTKVFP AVFLQPTSTS
     LFQFELGKLK NAMPLSAAIF KSEEKNPVPQ CPPRLDVQTI QPVLWSRMPN SFLKVEIERV
     SERHGWAVQC LEPLQMMALH IPEENRCVDI LELCEQEDLM RFHYHTLRLY SAVCALGNSR
     VAYALCSHVD LSQLFYAIDN KYLPGLLRSG FFDLLISIHL ANAKERKLMM KNEYIIPINS
     TTRNIRLYPD ESKRHGLPGV GLRTCLKPGF RFSTPCFVVT SEEHQKQSPE IPLEILKTKA
     LSMLTEAVHC SGAHIRDPVG GSIEFQFVPV LKLIGTLLVI GVFDDDDVRQ ILLLIDPSVF
     GEHGGETEEG AEKEEVTQVE EKAVEAGEKA SKEAPVKGLL QTRLPESVKL QMCELLSYLC
     DCELQHRVEA IVAFGDIYVS KLQANQKFRY NELMQALNMS AALTARKTRE FRSPPQEQIN
     MLLNFQLGEN CPCPEEIREE LYDFHEDLLL HCGVPLEEEK EEEEDTSWTG KLCALVHKIK
     APSKPEKEQP AEEEERCPAT LKELVSQTMI HWAQEDQIQD AELVRMMFNL LRRQYDSIGE
     LLQALRKTYT ISQASVSDTI NLLAALGQIR SLLSVRMGKE EELLMINGLG DIMNNKVFYQ
     HPNLMRVLGM HETVMEVMVN VLGTEKSQIA FPKMVASCCR FLCYFCRISR QNQKAMFEHL
     SYLLENSSVG LASPSMRGST PLDVAASSVM DNNELALGLE EPDLEKVVTY LAGCGLQSCP
     MLLAKGYPDV GWNPIEGERY LSFLRFAVFV NSESVEENAS VVVKLLIRRP ECFGPALRGE
     GGNGLLAAMQ GAIKISENPA LDLPSQGYKR AVTEDREEEE EIVYMGNAIM SFYSALIDLL
     GRCAPEMHLI QTGKGEAIRI RSILRSLVPT EDLVGIISIP LKLPCLNKDG SVSEPNMAAN
     FCPDHKAPMV LFLDRVYGIK DQTFLLHLLE VGFLPDLRAS ASLDTVSLST TEAALALNRY
     ICSAVLPLLT RCAPLFAGTE HCTSLIDSTL QTIYRLSKGR SLTKAQRDTI EECLLAICNH
     LRPSMLQQLL RRLVFDVPLL NEYCKMPLKL LTNHYEQCWK YYCLPSGWGS YGLAVEEELH
     LTEKLFWGIF DSLSHKRYDP DLFRMALPCL SAIAGALPPD YLDTRITGTL EKQVSVDADG
     NFDPKPINTM NFSLPEKLEY IVTKYAEHSH DKWACDKSQN GWKYGISLDE NVKTHPLIRP
     FKTLTEKEKE IYRWPARESL KTMLAVGWTV ERTKEGEALV QQRENEKLRS VSQTSQGNSY
     SPAPLDLSNV VLSRELQGMV EVVAENYHNI WAKKKKLELE SKGGGSHPLL VPYDTLTAKE
     KFRDREKAQD LFKFLQVNGI IVSRGMKGME LDASSMEKRF AYKFLKKILK YVDSAQEFIA
     HLEAIVSSGK TEKSPHDQEI KFFAKVLLPL VDQYFTNHRL YFLSSPLKPL SSSGYASHKE
     KEMVASLFCK LAALVRHRIS LFGSDSATMV SCLHILAQTL DTRTVMKSGS ELVKAGLRGF
     FENAAEDLEK TSENLKLGKF THSRTQIRGV SQNINYTTVA LLPILTSIFE HVAQHQFGVD
     LLLGDVQISC YHILCSLYSL GTGKNIYVER QRPALGECLA SLAAAIPVAF LEPTLNRYNP
     LSVFNTKTSR ERSILGMPDT VEEMSGESGA RTQRCPRHRG DLPMPLNYLS YWWERGPENL
     PPSTGPCCTQ VTSEHLSLIL GNILKIINNN LGIDEASWMK RIAVFAQPII SKARPDLLRS
     HFIPTLEKLK KKAVKTVQEE EQLKADGKGD TQEAELLILD EFAVLCRDLY AFYPMLIRYV
     DNNRSNWLKS PDDDSDQLFR MVAEVFILWC KSHNFKREEQ NFVIQNEINN LAFLTGDSKS
     KMSKSGGQDQ ERKKTKRRGD LYSIQTSLIV AALKKMLPIG LNMCTPGDQE LISLAKSRYS
     CRDTDEEVKE HLRNNLHLQE KSDDPAVKWQ LNLYKDVLRN EEPATPERTV ERVQRISAAV
     FHLEQVEQPL RSKKAVWHKL LSKQRKRAVV ACFRMAPLYN LPRHKINNFF LSTFQRVWLE
     KVNEKTQYDR LIPILMKSPK VEEEEEEEME KQPDPLHQII LHFSRNALTE RSKLEDDPLY
     TSYSSMMAKS CQSAEDEEEE DKEKTFEEKE MEKQKTLYQQ ARLHERGAAE MVLQMISASK
     GEMSPMVVET LKLGIAILNG GNTGVQQKML DYLKEKKDAG FFQSLSGLMQ SLCYVFQGEK
     VLQNDEFTRD LFRFLQLLCE GHNSDFQNFL RTQMGNTTTV NIIISTVDYL LRLQESISDF
     YWYYSGKDII DESGQHNFSK ALAVTKQIFN SLTEYIQGPC IGNQQSLAHS RLWDAVVGFL
     HVFANMQMKL SQDSSQIELL KELLDLLQDM VVMLLSLLEG NVVNGTIGKQ MVDTLVESST
     NVEMILKFFD MFLKLKDLTS SDTFKEYDPD GKGIISKKEF QKAMEGQKQY TQSEIDFLLS
     CAEADENDMF NYIDFVNRFH EPAKDIGFNV AVLLTNLSEH MPNDSRLKCL LDPAESVLNY
     FEPYLGRIEI MGGAKKIERV YFEISESSRT QWEKPQVKES KRQFIFDVVN EGGEQEKMEL
     FVNFCEDTIF EMQLASQISE SDSADRPEEE EEENDSPCVL EVEGEKEEDK PLEPASAFAL
     ACVSAKRNVS SLLRKATLRN LRRQCRNVKK MSARELVKVF FSFYWMVFVG LFQMCFTILG
     GIFQVLWSTV FGGGLVEGAK NIRVTKILGD MPDPTQFGIH DDAMEAERVD VGEPDLTAEL
     VHCVRDEKGD PDIMSDLFGL HPKKEGGSKH GPEVGLGDLS EIISKDEPPT LESTVQKKRK
     AQAAEMKVAH EVGGKAESEK ADMEDGEKGD RAKEEEQAEY LWAEVTKRKK RRRGQKVEKP
     EAFMANFFKG LEIYQTKLLH YLARNFYNLR FLALFVAFAI NFILLFYKVT EEPLEEETED
     AANLWNSFND EEEEEAMVFF VLQESTGYMA PTLRALAVVH TIISFVCVIG YYCLKVPLVV
     FKREKEIARK LEFDGLYITE QPSEDDIKGQ WDRLVINTPS FPNNYWDKFV KRKVINKYGD
     LYGAERIAEL LGLDKNALDF SPVEEIKAEA ASLVSWLSSI DMKYHIWKLG VVFTDNSFLY
     LAWYTTMSIL GHYNNFFFAA HLLDIAMGFK TLRTILSSVT HNGKQLVLTV GLLAVVVYLY
     TVVAFNFFRK FYNKSEDDDE PDMKCDDMMT CYLFHMYVGV RAGGGIGDEI EDPAGDPYEM
     YRIVFDITFF FFVIVILLAI IQGLIIDAFG ELRDQQEQVR EDMETKCFIC GIGNDYFDTT
     PHGFETHTLQ EHNLANYLFF LMYLINKDET EHTGQESYVW KMYQERCWDF FPAGDCFRKQ
     YEDQLG
//
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