ID A0A286XDM8_CAVPO Unreviewed; 424 AA.
AC A0A286XDM8;
DT 22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 1.
DT 24-JAN-2024, entry version 25.
DE SubName: Full=Shisa family member 9 {ECO:0000313|Ensembl:ENSCPOP00000023531.1};
GN Name=SHISA9 {ECO:0000313|Ensembl:ENSCPOP00000023531.1};
OS Cavia porcellus (Guinea pig).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Hystricomorpha; Caviidae;
OC Cavia.
OX NCBI_TaxID=10141 {ECO:0000313|Ensembl:ENSCPOP00000023531.1, ECO:0000313|Proteomes:UP000005447};
RN [1] {ECO:0000313|Proteomes:UP000005447}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=2N {ECO:0000313|Proteomes:UP000005447};
RX PubMed=21993624; DOI=10.1038/nature10530;
RA Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J., Washietl S.,
RA Kheradpour P., Ernst J., Jordan G., Mauceli E., Ward L.D., Lowe C.B.,
RA Holloway A.K., Clamp M., Gnerre S., Alfoldi J., Beal K., Chang J.,
RA Clawson H., Cuff J., Di Palma F., Fitzgerald S., Flicek P., Guttman M.,
RA Hubisz M.J., Jaffe D.B., Jungreis I., Kent W.J., Kostka D., Lara M.,
RA Martins A.L., Massingham T., Moltke I., Raney B.J., Rasmussen M.D.,
RA Robinson J., Stark A., Vilella A.J., Wen J., Xie X., Zody M.C., Baldwin J.,
RA Bloom T., Chin C.W., Heiman D., Nicol R., Nusbaum C., Young S.,
RA Wilkinson J., Worley K.C., Kovar C.L., Muzny D.M., Gibbs R.A., Cree A.,
RA Dihn H.H., Fowler G., Jhangiani S., Joshi V., Lee S., Lewis L.R.,
RA Nazareth L.V., Okwuonu G., Santibanez J., Warren W.C., Mardis E.R.,
RA Weinstock G.M., Wilson R.K., Delehaunty K., Dooling D., Fronik C.,
RA Fulton L., Fulton B., Graves T., Minx P., Sodergren E., Birney E.,
RA Margulies E.H., Herrero J., Green E.D., Haussler D., Siepel A., Goldman N.,
RA Pollard K.S., Pedersen J.S., Lander E.S., Kellis M.;
RT "A high-resolution map of human evolutionary constraint using 29 mammals.";
RL Nature 478:476-482(2011).
RN [2] {ECO:0000313|Ensembl:ENSCPOP00000023531.1}
RP IDENTIFICATION.
RC STRAIN=2N {ECO:0000313|Ensembl:ENSCPOP00000023531.1};
RG Ensembl;
RL Submitted (JUL-2023) to UniProtKB.
CC -!- FUNCTION: Regulator of short-term neuronal synaptic plasticity in the
CC dentate gyrus. Associates with AMPA receptors (ionotropic glutamate
CC receptors) in synaptic spines and promotes AMPA receptor
CC desensitization at excitatory synapses.
CC {ECO:0000256|ARBA:ARBA00037492}.
CC -!- SUBCELLULAR LOCATION: Cell projection, dendritic spine membrane
CC {ECO:0000256|ARBA:ARBA00029429}; Single-pass type I membrane protein
CC {ECO:0000256|ARBA:ARBA00029429}. Membrane
CC {ECO:0000256|ARBA:ARBA00004479}; Single-pass type I membrane protein
CC {ECO:0000256|ARBA:ARBA00004479}. Synapse
CC {ECO:0000256|ARBA:ARBA00034103}.
CC -!- SIMILARITY: Belongs to the shisa family. SHISA9 subfamily.
CC {ECO:0000256|ARBA:ARBA00038448}.
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DR EMBL; AAKN02007542; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAKN02007543; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAKN02007544; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAKN02007545; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAKN02007546; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; A0A286XDM8; -.
DR STRING; 10141.ENSCPOP00000023531; -.
DR Ensembl; ENSCPOT00000040728.1; ENSCPOP00000023531.1; ENSCPOG00000000800.4.
DR VEuPathDB; HostDB:ENSCPOG00000000800; -.
DR eggNOG; ENOG502QT2A; Eukaryota.
DR GeneTree; ENSGT00940000161478; -.
DR InParanoid; A0A286XDM8; -.
DR OMA; EKTHRPH; -.
DR Proteomes; UP000005447; Unassembled WGS sequence.
DR Bgee; ENSCPOG00000000800; Expressed in frontal cortex and 4 other cell types or tissues.
DR GO; GO:0032281; C:AMPA glutamate receptor complex; IEA:Ensembl.
DR GO; GO:0032591; C:dendritic spine membrane; IEA:Ensembl.
DR GO; GO:0098978; C:glutamatergic synapse; IEA:Ensembl.
DR GO; GO:0098839; C:postsynaptic density membrane; IEA:Ensembl.
DR GO; GO:0030165; F:PDZ domain binding; IEA:Ensembl.
DR GO; GO:0048172; P:regulation of short-term neuronal synaptic plasticity; IEA:Ensembl.
DR InterPro; IPR026910; Shisa.
DR PANTHER; PTHR31774:SF1; PROTEIN SHISA-9; 1.
DR PANTHER; PTHR31774; PROTEIN SHISA-9-RELATED; 1.
DR Pfam; PF13908; Shisa; 1.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Cell projection {ECO:0000256|ARBA:ARBA00023273};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000005447};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW Synapse {ECO:0000256|ARBA:ARBA00023018};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..23
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 24..424
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5011706083"
FT TRANSMEM 152..175
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT REGION 333..369
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 382..424
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 343..369
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 397..424
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 424 AA; 46904 MW; F71DFD89EBB06F2B CRC64;
MRRVLRLLLG CFLTELCARV CRAQERTGHG QLAQLGGVLV LTGVNRSGAA SGEAGEGAGV
SDAPPTRAPT PDFCRGYFDV MGQWDPPFNC SSGDFIFCCG TCGFRFCCTF KKRRLNQSTC
TNYDTPLWLN TGKPPARKDD PLHDPTKDKT NLIVYIICGV VAVMVLVGIF TKLGLEKAHR
PQREHMSRAL ADVMRPQGHC NTDHMERDLN IVVHVQHYEN MDTRAPINNL HTTQMNNAVP
TSPLLQQMGH PHSYPNLGQI SNPYEQQPPG KELNKYASLK AVGNSDGDWT VATLKSPKAD
KVNDDFYSKR RHLAELAAKG NLPLHPVRVE DEPRAFSPEH GPAKQNGQKS RTNKMPQHPL
AYNSTTNFKG WDANEQSLRR QAYGNKGKLG AAESGSSDPL GTRSQHYPPT QPYFITNSKT
EVTV
//