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Database: UniProt
Entry: A0A286XDM8_CAVPO
LinkDB: A0A286XDM8_CAVPO
Original site: A0A286XDM8_CAVPO 
ID   A0A286XDM8_CAVPO        Unreviewed;       424 AA.
AC   A0A286XDM8;
DT   22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT   22-NOV-2017, sequence version 1.
DT   24-JAN-2024, entry version 25.
DE   SubName: Full=Shisa family member 9 {ECO:0000313|Ensembl:ENSCPOP00000023531.1};
GN   Name=SHISA9 {ECO:0000313|Ensembl:ENSCPOP00000023531.1};
OS   Cavia porcellus (Guinea pig).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Hystricomorpha; Caviidae;
OC   Cavia.
OX   NCBI_TaxID=10141 {ECO:0000313|Ensembl:ENSCPOP00000023531.1, ECO:0000313|Proteomes:UP000005447};
RN   [1] {ECO:0000313|Proteomes:UP000005447}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=2N {ECO:0000313|Proteomes:UP000005447};
RX   PubMed=21993624; DOI=10.1038/nature10530;
RA   Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J., Washietl S.,
RA   Kheradpour P., Ernst J., Jordan G., Mauceli E., Ward L.D., Lowe C.B.,
RA   Holloway A.K., Clamp M., Gnerre S., Alfoldi J., Beal K., Chang J.,
RA   Clawson H., Cuff J., Di Palma F., Fitzgerald S., Flicek P., Guttman M.,
RA   Hubisz M.J., Jaffe D.B., Jungreis I., Kent W.J., Kostka D., Lara M.,
RA   Martins A.L., Massingham T., Moltke I., Raney B.J., Rasmussen M.D.,
RA   Robinson J., Stark A., Vilella A.J., Wen J., Xie X., Zody M.C., Baldwin J.,
RA   Bloom T., Chin C.W., Heiman D., Nicol R., Nusbaum C., Young S.,
RA   Wilkinson J., Worley K.C., Kovar C.L., Muzny D.M., Gibbs R.A., Cree A.,
RA   Dihn H.H., Fowler G., Jhangiani S., Joshi V., Lee S., Lewis L.R.,
RA   Nazareth L.V., Okwuonu G., Santibanez J., Warren W.C., Mardis E.R.,
RA   Weinstock G.M., Wilson R.K., Delehaunty K., Dooling D., Fronik C.,
RA   Fulton L., Fulton B., Graves T., Minx P., Sodergren E., Birney E.,
RA   Margulies E.H., Herrero J., Green E.D., Haussler D., Siepel A., Goldman N.,
RA   Pollard K.S., Pedersen J.S., Lander E.S., Kellis M.;
RT   "A high-resolution map of human evolutionary constraint using 29 mammals.";
RL   Nature 478:476-482(2011).
RN   [2] {ECO:0000313|Ensembl:ENSCPOP00000023531.1}
RP   IDENTIFICATION.
RC   STRAIN=2N {ECO:0000313|Ensembl:ENSCPOP00000023531.1};
RG   Ensembl;
RL   Submitted (JUL-2023) to UniProtKB.
CC   -!- FUNCTION: Regulator of short-term neuronal synaptic plasticity in the
CC       dentate gyrus. Associates with AMPA receptors (ionotropic glutamate
CC       receptors) in synaptic spines and promotes AMPA receptor
CC       desensitization at excitatory synapses.
CC       {ECO:0000256|ARBA:ARBA00037492}.
CC   -!- SUBCELLULAR LOCATION: Cell projection, dendritic spine membrane
CC       {ECO:0000256|ARBA:ARBA00029429}; Single-pass type I membrane protein
CC       {ECO:0000256|ARBA:ARBA00029429}. Membrane
CC       {ECO:0000256|ARBA:ARBA00004479}; Single-pass type I membrane protein
CC       {ECO:0000256|ARBA:ARBA00004479}. Synapse
CC       {ECO:0000256|ARBA:ARBA00034103}.
CC   -!- SIMILARITY: Belongs to the shisa family. SHISA9 subfamily.
CC       {ECO:0000256|ARBA:ARBA00038448}.
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DR   EMBL; AAKN02007542; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AAKN02007543; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AAKN02007544; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AAKN02007545; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AAKN02007546; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   AlphaFoldDB; A0A286XDM8; -.
DR   STRING; 10141.ENSCPOP00000023531; -.
DR   Ensembl; ENSCPOT00000040728.1; ENSCPOP00000023531.1; ENSCPOG00000000800.4.
DR   VEuPathDB; HostDB:ENSCPOG00000000800; -.
DR   eggNOG; ENOG502QT2A; Eukaryota.
DR   GeneTree; ENSGT00940000161478; -.
DR   InParanoid; A0A286XDM8; -.
DR   OMA; EKTHRPH; -.
DR   Proteomes; UP000005447; Unassembled WGS sequence.
DR   Bgee; ENSCPOG00000000800; Expressed in frontal cortex and 4 other cell types or tissues.
DR   GO; GO:0032281; C:AMPA glutamate receptor complex; IEA:Ensembl.
DR   GO; GO:0032591; C:dendritic spine membrane; IEA:Ensembl.
DR   GO; GO:0098978; C:glutamatergic synapse; IEA:Ensembl.
DR   GO; GO:0098839; C:postsynaptic density membrane; IEA:Ensembl.
DR   GO; GO:0030165; F:PDZ domain binding; IEA:Ensembl.
DR   GO; GO:0048172; P:regulation of short-term neuronal synaptic plasticity; IEA:Ensembl.
DR   InterPro; IPR026910; Shisa.
DR   PANTHER; PTHR31774:SF1; PROTEIN SHISA-9; 1.
DR   PANTHER; PTHR31774; PROTEIN SHISA-9-RELATED; 1.
DR   Pfam; PF13908; Shisa; 1.
PE   3: Inferred from homology;
KW   Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW   Cell projection {ECO:0000256|ARBA:ARBA00023273};
KW   Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005447};
KW   Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW   Synapse {ECO:0000256|ARBA:ARBA00023018};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius}.
FT   SIGNAL          1..23
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT   CHAIN           24..424
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT                   /id="PRO_5011706083"
FT   TRANSMEM        152..175
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   REGION          333..369
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          382..424
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        343..369
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        397..424
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   424 AA;  46904 MW;  F71DFD89EBB06F2B CRC64;
     MRRVLRLLLG CFLTELCARV CRAQERTGHG QLAQLGGVLV LTGVNRSGAA SGEAGEGAGV
     SDAPPTRAPT PDFCRGYFDV MGQWDPPFNC SSGDFIFCCG TCGFRFCCTF KKRRLNQSTC
     TNYDTPLWLN TGKPPARKDD PLHDPTKDKT NLIVYIICGV VAVMVLVGIF TKLGLEKAHR
     PQREHMSRAL ADVMRPQGHC NTDHMERDLN IVVHVQHYEN MDTRAPINNL HTTQMNNAVP
     TSPLLQQMGH PHSYPNLGQI SNPYEQQPPG KELNKYASLK AVGNSDGDWT VATLKSPKAD
     KVNDDFYSKR RHLAELAAKG NLPLHPVRVE DEPRAFSPEH GPAKQNGQKS RTNKMPQHPL
     AYNSTTNFKG WDANEQSLRR QAYGNKGKLG AAESGSSDPL GTRSQHYPPT QPYFITNSKT
     EVTV
//
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