ID A0A286XEH4_CAVPO Unreviewed; 821 AA.
AC A0A286XEH4;
DT 22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 1.
DT 27-MAR-2024, entry version 28.
DE SubName: Full=Epidermal growth factor receptor pathway substrate 8 {ECO:0000313|Ensembl:ENSCPOP00000023873.1};
GN Name=EPS8 {ECO:0000313|Ensembl:ENSCPOP00000023873.1};
OS Cavia porcellus (Guinea pig).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Hystricomorpha; Caviidae;
OC Cavia.
OX NCBI_TaxID=10141 {ECO:0000313|Ensembl:ENSCPOP00000023873.1, ECO:0000313|Proteomes:UP000005447};
RN [1] {ECO:0000313|Proteomes:UP000005447}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=2N {ECO:0000313|Proteomes:UP000005447};
RX PubMed=21993624; DOI=10.1038/nature10530;
RA Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J., Washietl S.,
RA Kheradpour P., Ernst J., Jordan G., Mauceli E., Ward L.D., Lowe C.B.,
RA Holloway A.K., Clamp M., Gnerre S., Alfoldi J., Beal K., Chang J.,
RA Clawson H., Cuff J., Di Palma F., Fitzgerald S., Flicek P., Guttman M.,
RA Hubisz M.J., Jaffe D.B., Jungreis I., Kent W.J., Kostka D., Lara M.,
RA Martins A.L., Massingham T., Moltke I., Raney B.J., Rasmussen M.D.,
RA Robinson J., Stark A., Vilella A.J., Wen J., Xie X., Zody M.C., Baldwin J.,
RA Bloom T., Chin C.W., Heiman D., Nicol R., Nusbaum C., Young S.,
RA Wilkinson J., Worley K.C., Kovar C.L., Muzny D.M., Gibbs R.A., Cree A.,
RA Dihn H.H., Fowler G., Jhangiani S., Joshi V., Lee S., Lewis L.R.,
RA Nazareth L.V., Okwuonu G., Santibanez J., Warren W.C., Mardis E.R.,
RA Weinstock G.M., Wilson R.K., Delehaunty K., Dooling D., Fronik C.,
RA Fulton L., Fulton B., Graves T., Minx P., Sodergren E., Birney E.,
RA Margulies E.H., Herrero J., Green E.D., Haussler D., Siepel A., Goldman N.,
RA Pollard K.S., Pedersen J.S., Lander E.S., Kellis M.;
RT "A high-resolution map of human evolutionary constraint using 29 mammals.";
RL Nature 478:476-482(2011).
RN [2] {ECO:0000313|Ensembl:ENSCPOP00000023873.1}
RP IDENTIFICATION.
RC STRAIN=2N {ECO:0000313|Ensembl:ENSCPOP00000023873.1};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the EPS8 family.
CC {ECO:0000256|ARBA:ARBA00006197}.
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DR EMBL; AAKN02030958; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAKN02030959; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAKN02030960; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAKN02030961; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAKN02030962; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_003470484.2; XM_003470436.3.
DR RefSeq; XP_013008603.1; XM_013153149.1.
DR RefSeq; XP_013008604.1; XM_013153150.1.
DR AlphaFoldDB; A0A286XEH4; -.
DR STRING; 10141.ENSCPOP00000023873; -.
DR Ensembl; ENSCPOT00000035065.1; ENSCPOP00000023873.1; ENSCPOG00000012163.4.
DR GeneID; 100735652; -.
DR KEGG; cpoc:100735652; -.
DR CTD; 2059; -.
DR VEuPathDB; HostDB:ENSCPOG00000012163; -.
DR GeneTree; ENSGT00940000156403; -.
DR InParanoid; A0A286XEH4; -.
DR OMA; SEKYTIH; -.
DR OrthoDB; 2997036at2759; -.
DR Proteomes; UP000005447; Unassembled WGS sequence.
DR Bgee; ENSCPOG00000012163; Expressed in adult mammalian kidney and 13 other cell types or tissues.
DR GO; GO:0005903; C:brush border; IEA:Ensembl.
DR GO; GO:0005938; C:cell cortex; IEA:Ensembl.
DR GO; GO:0098978; C:glutamatergic synapse; IEA:Ensembl.
DR GO; GO:0017146; C:NMDA selective glutamate receptor complex; IEA:Ensembl.
DR GO; GO:0014069; C:postsynaptic density; IEA:Ensembl.
DR GO; GO:0032587; C:ruffle membrane; IEA:Ensembl.
DR GO; GO:0032426; C:stereocilium tip; IEA:Ensembl.
DR GO; GO:0003779; F:actin binding; IEA:Ensembl.
DR GO; GO:0031267; F:small GTPase binding; IEA:Ensembl.
DR GO; GO:0051764; P:actin crosslink formation; IEA:Ensembl.
DR GO; GO:0051017; P:actin filament bundle assembly; IEA:Ensembl.
DR GO; GO:0070358; P:actin polymerization-dependent cell motility; IEA:Ensembl.
DR GO; GO:0008344; P:adult locomotory behavior; IEA:Ensembl.
DR GO; GO:0051016; P:barbed-end actin filament capping; IEA:Ensembl.
DR GO; GO:0048149; P:behavioral response to ethanol; IEA:Ensembl.
DR GO; GO:1990830; P:cellular response to leukemia inhibitory factor; IEA:Ensembl.
DR GO; GO:0036336; P:dendritic cell migration; IEA:Ensembl.
DR GO; GO:0010458; P:exit from mitosis; IEA:Ensembl.
DR GO; GO:0016601; P:Rac protein signal transduction; IEA:Ensembl.
DR GO; GO:0008360; P:regulation of cell shape; IEA:Ensembl.
DR GO; GO:0099072; P:regulation of postsynaptic membrane neurotransmitter receptor levels; IEA:Ensembl.
DR CDD; cd01210; PTB_EPS8; 1.
DR CDD; cd09540; SAM_EPS8-like; 1.
DR CDD; cd11764; SH3_Eps8; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR Gene3D; 2.30.30.40; SH3 Domains; 1.
DR Gene3D; 1.10.150.50; Transcription Factor, Ets-1; 1.
DR InterPro; IPR039801; EPS8-like.
DR InterPro; IPR033928; EPS8_PTB.
DR InterPro; IPR035462; Eps8_SH3.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR013625; PTB.
DR InterPro; IPR006020; PTB/PI_dom.
DR InterPro; IPR013761; SAM/pointed_sf.
DR InterPro; IPR041418; SAM_3.
DR InterPro; IPR036028; SH3-like_dom_sf.
DR InterPro; IPR001452; SH3_domain.
DR PANTHER; PTHR12287:SF21; EPIDERMAL GROWTH FACTOR RECEPTOR KINASE SUBSTRATE 8; 1.
DR PANTHER; PTHR12287; EPIDERMAL GROWTH FACTOR RECEPTOR KINASE SUBSTRATE EPS8-RELATED PROTEIN; 1.
DR Pfam; PF08416; PTB; 1.
DR Pfam; PF18016; SAM_3; 1.
DR Pfam; PF00018; SH3_1; 1.
DR SMART; SM00462; PTB; 1.
DR SMART; SM00326; SH3; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR SUPFAM; SSF50044; SH3-domain; 1.
DR PROSITE; PS50002; SH3; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000005447};
KW SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW ProRule:PRU00192}.
FT DOMAIN 530..589
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT REGION 296..321
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 611..688
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 800..821
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 619..645
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 650..671
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 673..688
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 821 AA; 91805 MW; 16B1809D8ED7C118 CRC64;
MMNGHVSNHP SGFGTYPSQM NGYGSSSTYS QMDREHSSKT SAKALYEQRK NYARDSVSSV
SDISQYRVEH LTTFVLDRKD AMVTVDDGIR KLKLLDAKGK VWTQDMILQV DDRAVSLIDL
ESKNELENFP LSTIQHCQAV MHSCNYDSIL ALVCKEPTQN KPDLHLFQCD EVKANLIGED
IESAVSDSKG GKQKRRPEVL RMIAKAEPGI PPPPRAPAPV PPGMVTQVDV RSRVAAWSAW
AADQGDFEKP RQYHEQEETP EMTAARIDRD VQILNHILDD IEFFITKLQK AAEAFSELSK
RKKSKKSKRK GPGEGVLTLR AKPPPPDEFV DCFQKFKHGF NLLAKLKSHI QNPSASDLVH
FLFTPLNMVV QATGGPELAS SVLSPLLNKD TIDFLNYAVS TEERQLWVSL GEAWTKSRAE
WPKEQFIPPY VPRFRHGWEP PMLNFLGTPK EQDLYHLAES VANVAEHQRK QDMKRLSTEH
SSVSEYSPAD MYSSSNNMRG PHADQVDAAA AFKPTPNRHV DRHYDPLKTQ PKKYAKSKYD
FMARNNSELS VLKDDILEIL DDRKQWWKVR NASGDSGFVP NNILDIVRPP ESGLGRADPP
YTHTIQKQRM EYGPRAADTP SAPSPPPAPA PVPVPLPPSV PAPVPMSKVP ANITRQNSSS
SDSSSSIVRD GQRHKQLPVD RRKSQMEEVQ DELIHRLTIG RSAAQKKFQV PRQTVPVINI
TYDSTPEDVK TWLQSKGFNP VTVNSLGVLN GAQLFSLNKD ELRTVCPEGA RVFSQITVQK
AALEDSNGSS ELQEIMRRRQ EKISAAASDS GVESFDEGSS H
//
