ID A0A286XEL9_CAVPO Unreviewed; 1267 AA.
AC A0A286XEL9;
DT 22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 1.
DT 27-MAR-2024, entry version 29.
DE SubName: Full=Myosin X {ECO:0000313|Ensembl:ENSCPOP00000023850.1};
GN Name=MYO10 {ECO:0000313|Ensembl:ENSCPOP00000023850.1};
OS Cavia porcellus (Guinea pig).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Hystricomorpha; Caviidae;
OC Cavia.
OX NCBI_TaxID=10141 {ECO:0000313|Ensembl:ENSCPOP00000023850.1, ECO:0000313|Proteomes:UP000005447};
RN [1] {ECO:0000313|Proteomes:UP000005447}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=2N {ECO:0000313|Proteomes:UP000005447};
RX PubMed=21993624; DOI=10.1038/nature10530;
RA Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J., Washietl S.,
RA Kheradpour P., Ernst J., Jordan G., Mauceli E., Ward L.D., Lowe C.B.,
RA Holloway A.K., Clamp M., Gnerre S., Alfoldi J., Beal K., Chang J.,
RA Clawson H., Cuff J., Di Palma F., Fitzgerald S., Flicek P., Guttman M.,
RA Hubisz M.J., Jaffe D.B., Jungreis I., Kent W.J., Kostka D., Lara M.,
RA Martins A.L., Massingham T., Moltke I., Raney B.J., Rasmussen M.D.,
RA Robinson J., Stark A., Vilella A.J., Wen J., Xie X., Zody M.C., Baldwin J.,
RA Bloom T., Chin C.W., Heiman D., Nicol R., Nusbaum C., Young S.,
RA Wilkinson J., Worley K.C., Kovar C.L., Muzny D.M., Gibbs R.A., Cree A.,
RA Dihn H.H., Fowler G., Jhangiani S., Joshi V., Lee S., Lewis L.R.,
RA Nazareth L.V., Okwuonu G., Santibanez J., Warren W.C., Mardis E.R.,
RA Weinstock G.M., Wilson R.K., Delehaunty K., Dooling D., Fronik C.,
RA Fulton L., Fulton B., Graves T., Minx P., Sodergren E., Birney E.,
RA Margulies E.H., Herrero J., Green E.D., Haussler D., Siepel A., Goldman N.,
RA Pollard K.S., Pedersen J.S., Lander E.S., Kellis M.;
RT "A high-resolution map of human evolutionary constraint using 29 mammals.";
RL Nature 478:476-482(2011).
RN [2] {ECO:0000313|Ensembl:ENSCPOP00000023850.1}
RP IDENTIFICATION.
RC STRAIN=2N {ECO:0000313|Ensembl:ENSCPOP00000023850.1};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cell cortex
CC {ECO:0000256|ARBA:ARBA00004544}.
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DR EMBL; AAKN02042807; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAKN02042808; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; A0A286XEL9; -.
DR Ensembl; ENSCPOT00000041096.1; ENSCPOP00000023850.1; ENSCPOG00000004645.4.
DR VEuPathDB; HostDB:ENSCPOG00000004645; -.
DR GeneTree; ENSGT00940000155469; -.
DR OMA; HYDVRGI; -.
DR Proteomes; UP000005447; Unassembled WGS sequence.
DR Bgee; ENSCPOG00000004645; Expressed in adrenal gland and 13 other cell types or tissues.
DR GO; GO:0005856; C:cytoskeleton; IEA:InterPro.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR CDD; cd14686; bZIP; 1.
DR CDD; cd14473; FERM_B-lobe; 1.
DR CDD; cd13202; FERM_C_MyoX; 1.
DR CDD; cd17206; FERM_F1_Myosin-X; 1.
DR CDD; cd13296; PH2_MyoX; 1.
DR CDD; cd13297; PH3_MyoX-like; 1.
DR Gene3D; 1.20.5.170; -; 1.
DR Gene3D; 1.20.5.190; -; 1.
DR Gene3D; 1.20.80.10; -; 1.
DR Gene3D; 1.25.40.530; MyTH4 domain; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 4.
DR InterPro; IPR027267; AH/BAR_dom_sf.
DR InterPro; IPR019749; Band_41_domain.
DR InterPro; IPR014352; FERM/acyl-CoA-bd_prot_sf.
DR InterPro; IPR035963; FERM_2.
DR InterPro; IPR019748; FERM_central.
DR InterPro; IPR000299; FERM_domain.
DR InterPro; IPR000048; IQ_motif_EF-hand-BS.
DR InterPro; IPR031971; MYO10_CC.
DR InterPro; IPR041797; MyoX_FERM_C.
DR InterPro; IPR000857; MyTH4_dom.
DR InterPro; IPR038185; MyTH4_dom_sf.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR000159; RA_dom.
DR PANTHER; PTHR46049; AGAP003327-PA; 1.
DR PANTHER; PTHR46049:SF2; UNCONVENTIONAL MYOSIN-X; 1.
DR Pfam; PF00373; FERM_M; 1.
DR Pfam; PF00612; IQ; 3.
DR Pfam; PF16735; MYO10_CC; 1.
DR Pfam; PF00784; MyTH4; 1.
DR Pfam; PF00169; PH; 2.
DR Pfam; PF00788; RA; 1.
DR SMART; SM00295; B41; 1.
DR SMART; SM00015; IQ; 3.
DR SMART; SM00139; MyTH4; 1.
DR SMART; SM00233; PH; 2.
DR SUPFAM; SSF103657; BAR/IMD domain-like; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF50729; PH domain-like; 4.
DR SUPFAM; SSF47031; Second domain of FERM; 1.
DR PROSITE; PS50057; FERM_3; 1.
DR PROSITE; PS50096; IQ; 2.
DR PROSITE; PS51016; MYTH4; 1.
DR PROSITE; PS50003; PH_DOMAIN; 2.
DR PROSITE; PS50200; RA; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Reference proteome {ECO:0000313|Proteomes:UP000005447};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT DOMAIN 423..521
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT DOMAIN 603..708
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT DOMAIN 758..906
FT /note="MyTH4"
FT /evidence="ECO:0000259|PROSITE:PS51016"
FT DOMAIN 911..1253
FT /note="FERM"
FT /evidence="ECO:0000259|PROSITE:PS50057"
FT DOMAIN 915..961
FT /note="Ras-associating"
FT /evidence="ECO:0000259|PROSITE:PS50200"
FT REGION 203..318
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 64..179
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 215..232
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 233..264
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1267 AA; 145031 MW; 5133ADC1AF7ED48D CRC64;
MVIRAHVLGY LARKHYRKVL HGVVTIQKNV RAFLLRRRFL HLKKAALVVQ KQLRGQRARR
VYGRMLAEKR EEEARKRLEE EERERQRVQK EAELRAQQEE EARRQRELEA AELSRELQKQ
RENKQVEEIL RLEREIEDLQ RMKEQQELSL TEASLQRLRR RRDEELRRLE DEASRAAHEF
LAALNFHEID ACVRGLERSL AAGGSSGPGF DFGQPYPEEE DEEEDEGFAA DEDADAFKDS
PNPSEHGHSD QRTSGIRTSD DSSEEDPYVN EAASGAPGDP DSHDATYCEP GAAPGGDSGH
QDQDDDEDDG AVTSGSSVTF SNSYGSQWSP DYRCSVGTCN SSGAYGFSSE GAQSSFEDSE
EDFDSRFDTD DELSYRRDSV YSCVTLPYFH SFLYMKGGLM NSWKRRWCVL KDETFLWFRS
KQEALKQGWL HKKGGGSSTL SRRNWKRRWF VLRQAKLMYF ENDSEEKLRG TIEVRMAREI
IDNTSKENGI DIIMGDRTFH LIAESPEDAS QWFSVLSQVH ASTEQEIREM HDEQANPQNA
VGTLDVGLID SVCASDNPDR PNSFVIITAN RVLHCNADAP EEMHHWITLL QRCKGDARVE
GQEFIVRGWL HKEVKNSPKM SSLKLKKRWF VLTHNSLDYY KSSEKNSLKL GTLVLNSLCS
VVPPDEKIFK ETGYWNITVY GRKHCYRLYT KLLNEATRWA SAIQNVTDTK APIDTPTQQL
IQDIKENCLN PDVVEQIYKR NPILRYTQHP LHSPLLPLPY GDINLNLLKD KGYTTLQDEA
IKLFHSLQQL ESVSDPVPII QGILQTGHDL RPLRDELYCQ LIKQTSNVPQ PGSVGNLYSW
QILACLGCTF LPSRSILKYL KFHLKRIREQ FPGTEMEKYA LFIYESLKKT KCREFVPSRD
EIEALIHRQE MTSTVYCHGG GSCKITITSH TTAGEVVEKL IRGLAMEDSR NMFALFEHNG
RVHKAIESRT IVADVLAKFE RLAAVPDAGE LPWKFYFKLY CFLDTDNVPK DSVEFAFMFE
QAHEAVIHGH HPAPEETLQV LAALRLQYLQ GDHSPQAVPP LEQVYSVDRL RARVRQAAQG
AATGERLQRR RTSFLDSTLR RSLRPGPVRQ RAEDEQALEL WLQEELGGVR AGVLDKWRRL
QGLSQEQAMA RYMALIKEWP GYGSTLFDVE CKEGGFPQEL WLGVSADAVS VYKRGEGRPL
EVFQYEHILS FGAPQANTYK IVVDERELLF ETSEVVDVAK LMKAYISMIV KKRYSTTRSL
SSQGSSR
//
