ID A0A286XEQ8_CAVPO Unreviewed; 458 AA.
AC A0A286XEQ8;
DT 22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 1.
DT 27-MAR-2024, entry version 24.
DE SubName: Full=Nischarin {ECO:0000313|Ensembl:ENSCPOP00000023890.1};
GN Name=NISCH {ECO:0000313|Ensembl:ENSCPOP00000023890.1};
OS Cavia porcellus (Guinea pig).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Hystricomorpha; Caviidae;
OC Cavia.
OX NCBI_TaxID=10141 {ECO:0000313|Ensembl:ENSCPOP00000023890.1, ECO:0000313|Proteomes:UP000005447};
RN [1] {ECO:0000313|Proteomes:UP000005447}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=2N {ECO:0000313|Proteomes:UP000005447};
RX PubMed=21993624; DOI=10.1038/nature10530;
RA Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J., Washietl S.,
RA Kheradpour P., Ernst J., Jordan G., Mauceli E., Ward L.D., Lowe C.B.,
RA Holloway A.K., Clamp M., Gnerre S., Alfoldi J., Beal K., Chang J.,
RA Clawson H., Cuff J., Di Palma F., Fitzgerald S., Flicek P., Guttman M.,
RA Hubisz M.J., Jaffe D.B., Jungreis I., Kent W.J., Kostka D., Lara M.,
RA Martins A.L., Massingham T., Moltke I., Raney B.J., Rasmussen M.D.,
RA Robinson J., Stark A., Vilella A.J., Wen J., Xie X., Zody M.C., Baldwin J.,
RA Bloom T., Chin C.W., Heiman D., Nicol R., Nusbaum C., Young S.,
RA Wilkinson J., Worley K.C., Kovar C.L., Muzny D.M., Gibbs R.A., Cree A.,
RA Dihn H.H., Fowler G., Jhangiani S., Joshi V., Lee S., Lewis L.R.,
RA Nazareth L.V., Okwuonu G., Santibanez J., Warren W.C., Mardis E.R.,
RA Weinstock G.M., Wilson R.K., Delehaunty K., Dooling D., Fronik C.,
RA Fulton L., Fulton B., Graves T., Minx P., Sodergren E., Birney E.,
RA Margulies E.H., Herrero J., Green E.D., Haussler D., Siepel A., Goldman N.,
RA Pollard K.S., Pedersen J.S., Lander E.S., Kellis M.;
RT "A high-resolution map of human evolutionary constraint using 29 mammals.";
RL Nature 478:476-482(2011).
RN [2] {ECO:0000313|Ensembl:ENSCPOP00000023890.1}
RP IDENTIFICATION.
RC STRAIN=2N {ECO:0000313|Ensembl:ENSCPOP00000023890.1};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR EMBL; AAKN02001401; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; A0A286XEQ8; -.
DR Ensembl; ENSCPOT00000036750.1; ENSCPOP00000023890.1; ENSCPOG00000003266.4.
DR VEuPathDB; HostDB:ENSCPOG00000003266; -.
DR GeneTree; ENSGT00940000156494; -.
DR Proteomes; UP000005447; Unassembled WGS sequence.
DR Bgee; ENSCPOG00000003266; Expressed in hypothalamus and 13 other cell types or tissues.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0005178; F:integrin binding; IEA:InterPro.
DR GO; GO:0035091; F:phosphatidylinositol binding; IEA:InterPro.
DR CDD; cd06875; PX_IRAS; 1.
DR Gene3D; 3.30.1520.10; Phox-like domain; 1.
DR Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 2.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR025875; Leu-rich_rpt_4.
DR InterPro; IPR003591; Leu-rich_rpt_typical-subtyp.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR037904; Nischarin_PX.
DR InterPro; IPR001683; PX_dom.
DR InterPro; IPR036871; PX_dom_sf.
DR PANTHER; PTHR15454:SF35; NISCHARIN; 1.
DR PANTHER; PTHR15454; NISCHARIN RELATED; 1.
DR Pfam; PF00560; LRR_1; 2.
DR Pfam; PF12799; LRR_4; 1.
DR Pfam; PF00787; PX; 1.
DR PRINTS; PR00019; LEURICHRPT.
DR SMART; SM00365; LRR_SD22; 5.
DR SMART; SM00369; LRR_TYP; 4.
DR SMART; SM00312; PX; 1.
DR SUPFAM; SSF52075; Outer arm dynein light chain 1; 1.
DR SUPFAM; SSF64268; PX domain; 1.
DR PROSITE; PS51450; LRR; 4.
DR PROSITE; PS50195; PX; 1.
PE 4: Predicted;
KW Leucine-rich repeat {ECO:0000256|ARBA:ARBA00022614};
KW Reference proteome {ECO:0000313|Proteomes:UP000005447};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT DOMAIN 13..128
FT /note="PX"
FT /evidence="ECO:0000259|PROSITE:PS50195"
FT REGION 437..458
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 458 AA; 50451 MW; 58518A6E94B528D3 CRC64;
MAAATARGFG PEREAEPAKE ARVVGSELVD TYTVYIIRVT DGNHEWTVKH RYSDFHDLHE
KLVAEKKIDK NLLPPKKIIG KNSRSLVEKR EKDLEVYLQT LLTSFPGVAP RVLAHFLHFH
FYEVNGITAA LAEELYEKGE QLLGAGEVFA IGPLQLYAVT EQLQQGKPTC ASGDAKTDLG
HILDFTCRLK YLKVSGTEGA FGTSNIQEQL LPFDLSIFKS LHQVEISHCD AKNIRGLVAS
KPTLATLSIR FSATSMKEVL VPEASEFDGW EPEGTALEGS VTAIIPTWQA LTTLDLSHNS
ISEIDESVKL IPKIEFLDLS HNGVLLMDNL QHLYNLVHLD LSYNKLSSLE GVHTKLGNIK
TLNLAGNLLE NLSGLHKLYS LVNLDLSNNR IEQMEEVRSI GGLPCLEHVS LLNNPLSIIP
DYRTKVLAQF GERASEVGAS STQAAQHTDG GPPSLPLH
//
