ID A0A286XGE4_CAVPO Unreviewed; 1815 AA.
AC A0A286XGE4;
DT 22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 1.
DT 27-MAR-2024, entry version 30.
DE SubName: Full=Dedicator of cytokinesis 10 {ECO:0000313|Ensembl:ENSCPOP00000024492.1};
GN Name=DOCK10 {ECO:0000313|Ensembl:ENSCPOP00000024492.1};
OS Cavia porcellus (Guinea pig).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Hystricomorpha; Caviidae;
OC Cavia.
OX NCBI_TaxID=10141 {ECO:0000313|Ensembl:ENSCPOP00000024492.1, ECO:0000313|Proteomes:UP000005447};
RN [1] {ECO:0000313|Proteomes:UP000005447}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=2N {ECO:0000313|Proteomes:UP000005447};
RX PubMed=21993624; DOI=10.1038/nature10530;
RA Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J., Washietl S.,
RA Kheradpour P., Ernst J., Jordan G., Mauceli E., Ward L.D., Lowe C.B.,
RA Holloway A.K., Clamp M., Gnerre S., Alfoldi J., Beal K., Chang J.,
RA Clawson H., Cuff J., Di Palma F., Fitzgerald S., Flicek P., Guttman M.,
RA Hubisz M.J., Jaffe D.B., Jungreis I., Kent W.J., Kostka D., Lara M.,
RA Martins A.L., Massingham T., Moltke I., Raney B.J., Rasmussen M.D.,
RA Robinson J., Stark A., Vilella A.J., Wen J., Xie X., Zody M.C., Baldwin J.,
RA Bloom T., Chin C.W., Heiman D., Nicol R., Nusbaum C., Young S.,
RA Wilkinson J., Worley K.C., Kovar C.L., Muzny D.M., Gibbs R.A., Cree A.,
RA Dihn H.H., Fowler G., Jhangiani S., Joshi V., Lee S., Lewis L.R.,
RA Nazareth L.V., Okwuonu G., Santibanez J., Warren W.C., Mardis E.R.,
RA Weinstock G.M., Wilson R.K., Delehaunty K., Dooling D., Fronik C.,
RA Fulton L., Fulton B., Graves T., Minx P., Sodergren E., Birney E.,
RA Margulies E.H., Herrero J., Green E.D., Haussler D., Siepel A., Goldman N.,
RA Pollard K.S., Pedersen J.S., Lander E.S., Kellis M.;
RT "A high-resolution map of human evolutionary constraint using 29 mammals.";
RL Nature 478:476-482(2011).
RN [2] {ECO:0000313|Ensembl:ENSCPOP00000024492.1}
RP IDENTIFICATION.
RC STRAIN=2N {ECO:0000313|Ensembl:ENSCPOP00000024492.1};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the DOCK family. {ECO:0000256|PROSITE-
CC ProRule:PRU00983}.
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DR EMBL; AAKN02019408; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAKN02019409; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAKN02019410; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAKN02019411; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAKN02019412; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAKN02019413; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR Ensembl; ENSCPOT00000042037.1; ENSCPOP00000024492.1; ENSCPOG00000005801.4.
DR VEuPathDB; HostDB:ENSCPOG00000005801; -.
DR GeneTree; ENSGT00940000157469; -.
DR Proteomes; UP000005447; Unassembled WGS sequence.
DR Bgee; ENSCPOG00000005801; Expressed in hypothalamus and 10 other cell types or tissues.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
DR GO; GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
DR CDD; cd08697; C2_Dock-D; 1.
DR Gene3D; 1.20.58.740; -; 1.
DR Gene3D; 1.25.40.410; -; 1.
DR Gene3D; 2.60.40.150; C2 domain; 1.
DR InterPro; IPR037809; C2_Dock-D.
DR InterPro; IPR027007; C2_DOCK-type_domain.
DR InterPro; IPR035892; C2_domain_sf.
DR InterPro; IPR026791; DOCK.
DR InterPro; IPR043161; DOCK_C_lobe_A.
DR InterPro; IPR043162; DOCK_C_lobe_C.
DR InterPro; IPR027357; DOCKER_dom.
DR InterPro; IPR046769; DOCKER_Lobe_A.
DR InterPro; IPR046770; DOCKER_Lobe_B.
DR InterPro; IPR046773; DOCKER_Lobe_C.
DR PANTHER; PTHR23317; DEDICATOR OF CYTOKINESIS DOCK; 1.
DR PANTHER; PTHR23317:SF71; DEDICATOR OF CYTOKINESIS PROTEIN 10; 1.
DR Pfam; PF06920; DHR-2_Lobe_A; 1.
DR Pfam; PF20422; DHR-2_Lobe_B; 1.
DR Pfam; PF20421; DHR-2_Lobe_C; 1.
DR Pfam; PF14429; DOCK-C2; 1.
DR PROSITE; PS51650; C2_DOCK; 1.
DR PROSITE; PS51651; DOCKER; 1.
PE 3: Inferred from homology;
KW Guanine-nucleotide releasing factor {ECO:0000256|ARBA:ARBA00022658};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000005447}.
FT DOMAIN 325..503
FT /note="C2 DOCK-type"
FT /evidence="ECO:0000259|PROSITE:PS51650"
FT DOMAIN 1343..1772
FT /note="DOCKER"
FT /evidence="ECO:0000259|PROSITE:PS51651"
FT REGION 944..964
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1793..1815
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1815 AA; 207261 MW; 968ADF94AB11D75C CRC64;
VKASRNMERL NLFSLDPDID TLKLQKKDLL EPDAVIKPFE EKAAKRIMII CKALNLNLQG
CITENDNDPI TNIEPFFVSV ALYDLRVSRK ISADFHVDLN HAVVRQMLPG VPATLENGNI
DIITPRQSEE PHIKELPEEW LKFPKQAIFS VSDPHSEIVL VAKIEKVLMG NIASGAEPYI
KNPDSNKFAQ KILKSNRQFC SRLGKYRMPF AWAVRSVFKD NQGNVDRDSR FSPLYRQESN
KISTEDLLKL VSEYRRADRI SKMQTIPGIL DIAVDNVPLE HPNCVTSSFI PVKPFNVMAH
SEPTVEVEEF IYDSTKHCRP YRVYKNQIYV YPKHLKYDSQ KCFNKARNIT VCIEFRNSDE
ESAKPVKCIY GKPGGSLFTS AAYTAVLHHS QNPDFSDEVK IELPTQLHEK HHILFSFYHV
TCDINAKANA KKKEALETSV GYAWLPLMKH NQIASQEYNI PIATSLPPNY LSTQDPASGK
HGGSDIKWVD GGKPLFKVAT FVVSTVNTQD PHVNAFFHQC QKREKDMSQS PTSNFVRSCK
NLLNVDKIHT IMSFLPIILN QLFKVLVQNE EDEISTTVTR VLTDIVAKCH EEQLDHSVQA
YIKFVFKTSA YKERTIHEEL AKNVAGLLKS NDSTTVKHVL KHSWFFFAII LKSMAQHLVD
TNKIQLSRTQ RFPESYQNEL DNLVMVLCDH VIWKYKDSLE ETKRANHSVA RFLKRCFTFM
DRGFVFRIVN NYISMFSSGE LKTLCQYKFD FIQEVCQYEH FIPLCLPIRS SKIPDPLTPS
ESIQELHASD MPEYSVTNEF CRKHFLIGIL LREVGFALQE DQDIRHLALA VLKNLMAKHS
FDDRYREARK QAQIASLYMP LYGMLLDNMP RIYLKDLYPF TVNTSNQGSR DDLSTNGGFQ
IQTSMKHATS VDTSFSKDVL NSIAAFSSIA ISTVNHADSR ASLASIDSNP STNEKSSEKT
DNCEKIPRPL SLIGSTLRFD KLDQAETRSL LMCFLHIMKT ISDETLIAYW QRAPSPEVSD
FFSILDVCLQ NFRYLGKRNI IRKIAAAFKF VQSTQNNGTL KGSNPSCQTS GLLSQWMHTT
SGHEGHKQHR SQTLPIIRGK NALSNPKLLQ MLDNTMTSNS NEIDIVHHVD TEANIATEVC
LTILDLLSLF SQVHQRQLQQ SDCQNSLMKR VFDTYMLFFQ VNQSATALKH VFASLRLFVC
KFPSAFFQGP ADLCGSFCYE VLKCCNHRSR STQMEASALL YFFMRKNFEF NKQKSIVRSH
LQLIKAVSQL IADAGIGGSR FQHSLAITNN FANGDKQMKN SNFPAEVKDL TKRIRTVLMA
TAQMKEHEKD PEMLVDLQYS LANSYASTPE LRRTWLESMA KIHARNGDLS EAAMCYIHIA
ALIAEYLKRK GLFSMGWPAF LSITPNIKEE GAMKEDSGMQ DTPYNENILV EQLYMCVEFL
WKSERYELIA DVNKPIIAVF EKQRDFKKLS DLYYDIHRSY LKVAEVVNSE KRLFGRYYRV
AFYGQAVGFF EEEEGKEYIY KEPKLTGLSE ISQRLLKLYA DKFGADNVKI IQDSNKVNPK
DLDPKYAYIQ VTYVTPFFEE KEIEDRKTDF EMHHNINRFV FETPFTLSGK KHGGVAEQCK
RRTVLTTSHL FPYVKKRIQV ISQSSTELNP IEVAIDEMSR KVSELNQLCT MDEVDMIRLQ
LKLQGSVSVK VNAGPMAYAR AFLEETNAKK YPDNQVKLLK EIFRQFADAC GQALDVNERL
IKEDQLEYQE ELRSHYKDML SELSAVINEQ LCRGPCLYSF CSSVSSISLS TVSKSDYGQG
GPSKARGGAN LHSCN
//
