ID A0A286XH33_CAVPO Unreviewed; 1465 AA.
AC A0A286XH33;
DT 22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 1.
DT 27-MAR-2024, entry version 34.
DE SubName: Full=Adhesion G protein-coupled receptor B2 {ECO:0000313|Ensembl:ENSCPOP00000024747.1};
GN Name=ADGRB2 {ECO:0000313|Ensembl:ENSCPOP00000024747.1};
OS Cavia porcellus (Guinea pig).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Hystricomorpha; Caviidae;
OC Cavia.
OX NCBI_TaxID=10141 {ECO:0000313|Ensembl:ENSCPOP00000024747.1, ECO:0000313|Proteomes:UP000005447};
RN [1] {ECO:0000313|Proteomes:UP000005447}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=2N {ECO:0000313|Proteomes:UP000005447};
RX PubMed=21993624; DOI=10.1038/nature10530;
RA Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J., Washietl S.,
RA Kheradpour P., Ernst J., Jordan G., Mauceli E., Ward L.D., Lowe C.B.,
RA Holloway A.K., Clamp M., Gnerre S., Alfoldi J., Beal K., Chang J.,
RA Clawson H., Cuff J., Di Palma F., Fitzgerald S., Flicek P., Guttman M.,
RA Hubisz M.J., Jaffe D.B., Jungreis I., Kent W.J., Kostka D., Lara M.,
RA Martins A.L., Massingham T., Moltke I., Raney B.J., Rasmussen M.D.,
RA Robinson J., Stark A., Vilella A.J., Wen J., Xie X., Zody M.C., Baldwin J.,
RA Bloom T., Chin C.W., Heiman D., Nicol R., Nusbaum C., Young S.,
RA Wilkinson J., Worley K.C., Kovar C.L., Muzny D.M., Gibbs R.A., Cree A.,
RA Dihn H.H., Fowler G., Jhangiani S., Joshi V., Lee S., Lewis L.R.,
RA Nazareth L.V., Okwuonu G., Santibanez J., Warren W.C., Mardis E.R.,
RA Weinstock G.M., Wilson R.K., Delehaunty K., Dooling D., Fronik C.,
RA Fulton L., Fulton B., Graves T., Minx P., Sodergren E., Birney E.,
RA Margulies E.H., Herrero J., Green E.D., Haussler D., Siepel A., Goldman N.,
RA Pollard K.S., Pedersen J.S., Lander E.S., Kellis M.;
RT "A high-resolution map of human evolutionary constraint using 29 mammals.";
RL Nature 478:476-482(2011).
RN [2] {ECO:0000313|Ensembl:ENSCPOP00000024747.1}
RP IDENTIFICATION.
RC STRAIN=2N {ECO:0000313|Ensembl:ENSCPOP00000024747.1};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
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DR EMBL; AAKN02028604; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_013009330.1; XM_013153876.1.
DR Ensembl; ENSCPOT00000041652.1; ENSCPOP00000024747.1; ENSCPOG00000007198.4.
DR GeneID; 100728530; -.
DR CTD; 576; -.
DR VEuPathDB; HostDB:ENSCPOG00000007198; -.
DR GeneTree; ENSGT00940000160103; -.
DR OrthoDB; 4181250at2759; -.
DR Proteomes; UP000005447; Unassembled WGS sequence.
DR Bgee; ENSCPOG00000007198; Expressed in frontal cortex and 12 other cell types or tissues.
DR GO; GO:0005886; C:plasma membrane; IEA:InterPro.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR GO; GO:0007166; P:cell surface receptor signaling pathway; IEA:InterPro.
DR GO; GO:0016525; P:negative regulation of angiogenesis; IEA:InterPro.
DR Gene3D; 1.25.40.610; -; 1.
DR Gene3D; 2.60.220.50; -; 1.
DR Gene3D; 4.10.1240.10; GPCR, family 2, extracellular hormone receptor domain; 1.
DR Gene3D; 1.20.1070.10; Rhodopsin 7-helix transmembrane proteins; 1.
DR Gene3D; 2.20.100.10; Thrombospondin type-1 (TSP1) repeat; 3.
DR InterPro; IPR043838; AGRB_N.
DR InterPro; IPR032471; GAIN_dom_N.
DR InterPro; IPR046338; GAIN_dom_sf.
DR InterPro; IPR017981; GPCR_2-like_7TM.
DR InterPro; IPR008077; GPCR_2_brain_angio_inhib.
DR InterPro; IPR036445; GPCR_2_extracell_dom_sf.
DR InterPro; IPR001879; GPCR_2_extracellular_dom.
DR InterPro; IPR000832; GPCR_2_secretin-like.
DR InterPro; IPR000203; GPS.
DR InterPro; IPR000884; TSP1_rpt.
DR InterPro; IPR036383; TSP1_rpt_sf.
DR PANTHER; PTHR10239:SF32; ADHESION G PROTEIN-COUPLED RECEPTOR B2; 1.
DR PANTHER; PTHR10239; ISTHMIN-2; 1.
DR Pfam; PF00002; 7tm_2; 1.
DR Pfam; PF19188; AGRB_N; 1.
DR Pfam; PF16489; GAIN; 1.
DR Pfam; PF01825; GPS; 1.
DR Pfam; PF02793; HRM; 1.
DR Pfam; PF00090; TSP_1; 3.
DR PRINTS; PR01694; BAIPRECURSOR.
DR PRINTS; PR00249; GPCRSECRETIN.
DR SMART; SM00303; GPS; 1.
DR SMART; SM00008; HormR; 1.
DR SMART; SM00209; TSP1; 3.
DR SUPFAM; SSF81321; Family A G protein-coupled receptor-like; 1.
DR SUPFAM; SSF82895; TSP-1 type 1 repeat; 3.
DR PROSITE; PS50227; G_PROTEIN_RECEP_F2_3; 1.
DR PROSITE; PS50261; G_PROTEIN_RECEP_F2_4; 1.
DR PROSITE; PS50221; GPS; 1.
DR PROSITE; PS50092; TSP1; 3.
PE 4: Predicted;
KW G-protein coupled receptor {ECO:0000256|ARBA:ARBA00023040};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Receptor {ECO:0000256|ARBA:ARBA00023170};
KW Reference proteome {ECO:0000313|Proteomes:UP000005447};
KW Signal {ECO:0000256|SAM:SignalP};
KW Transducer {ECO:0000256|ARBA:ARBA00023224};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..20
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 21..1465
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5011688769"
FT TRANSMEM 868..889
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 901..922
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 934..958
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 970..988
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1008..1031
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1052..1074
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 453..523
FT /note="G-protein coupled receptors family 2 profile 1"
FT /evidence="ECO:0000259|PROSITE:PS50227"
FT DOMAIN 864..1105
FT /note="G-protein coupled receptors family 2 profile 2"
FT /evidence="ECO:0000259|PROSITE:PS50261"
FT REGION 216..255
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 702..736
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1257..1282
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1322..1352
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1397..1465
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1465 AA; 159615 MW; CA1F76DEBD03A612 CRC64;
MTPACPLLLS VILSLRLATA FDPAPSACSA LASGVLYGAF SLQDLFPTIA SGCSWTLENP
DPTKYSLYLR FNRQEQVCTH FAPRLLPLDH YLANFTCLRP SPEEAGAQAE PAVGQTGEEE
AAAAAGLELC GGSGPFTFLH FDKNFVQLCL SAEPSEAPRL LAPAALAFRF VEVLLINNNN
SSQFTCGVLC RWSEECGRAA GRACGFAQPG CSCPGEAGAS PATTPPGPPA AHTLSNALVP
GVPAPPAEAD LHSGSSNDLF TTEMRYGEEP EEEPKVKTQW PRSADEPGLY MAQTGDPAAE
EWSPWSVCSL TCGQGLQVRT RSCVSSPYGT LCSGPLRETR PCNNSATCPV EGQWLEWGPW
GPCSSSCANG TQQRSRKCSV AGPAWATCTG ALTDTRECSN LECPATDGKW GPWNAWSLCS
KTCDTGWQRR FRMCQASGTQ GYPCEGTGEE VKPCSEKRCP AFHEMCRDEY VMLMTWKKAA
AGEIIYNKCP PNATGSASRR CLLSAQGVAY WGLPSFARCI SHEYRYLYLS LREHLAKGQR
MLAGEGMSQV VRSLQELLAR RTYYSGDLLF SVDILRNVTD TFKRATYVPS ADDVQRFFQV
VSFMVDEENK DKWDDAQQVS PGSVHLLRVV EDFIHLVGDA LKAFQSSLIV TDNLVISIQR
EPISAVSSDI TFPMRGRRGM KDWVRHSEDR LFLPKEVLSL SSPANPSTAG AAGNPGKVRG
PGTVPPGPGH SHQRLLPADP DDSSYFVIGA VLYRTLGLIL PPPRPPLAVT SRVMTVTVRP
PTQPPSEPLI TVELSYIING TTDPHCASWD YSRADASSGD WDTESCQTLE TQAAHTRCQC
QHLSTFAVLA QPPKDLTLEL AGAPSVPLVI GCAVSCMALL TLLAIYAAFW RFIKSERSII
LLNFCLSILA SNILILVGQS RVLSKGVCTM TAAFLHFFFL SSFCWVLTEA WQSYLAVIGR
MRTRLVRKRF LCLGWGLPAL VVAVSVGFTR TKGYGTSSYC WLSLEGGLLY AFVGPAAVIV
LVNMLIGIIV FNKLMARDGI SDKSKKQRAG ASLWSSCVVL PLLALTWMSA VLAMTDRRSV
LFQALFAVFN SAQGFVITAV HCFLRREVQD VVKCQMGVCR ADESEDSPDS CKNGQLQILS
DFEKDVDLAC QTVLFKEVNT CNPSTITGTL SRLSLDEDEE PKSCLVGPEG GLSFSPLPGN
ILVPMAASPG LGEPPPPQET NPVYMCGEGG LRQLDLTWLR PTEPGSEGDY MVLPRRTMSL
QPGSGGGGGE DAPRARPEGT PRRAAKALTH TEGYPSFLSV EHSGLGLGPA YGSLQNPYGM
TFQPPPPTPS ARQVPEPGER SRTMPRTVPG STMKLGSLER KKLRYSDLDF EKVMHTRKRH
SELYHELNQK FHTFDRYHSQ SAAKEKPSPG ERPGLSQHRR HQSWSTFKSM TLGSLPPKPR
ERLTLHRAAA WEPTEPPDGD FQTEV
//
