ID A0A286XH43_CAVPO Unreviewed; 4152 AA.
AC A0A286XH43;
DT 22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 1.
DT 27-MAR-2024, entry version 28.
DE SubName: Full=Dynein axonemal heavy chain 6 {ECO:0000313|Ensembl:ENSCPOP00000024757.1};
GN Name=DNAH6 {ECO:0000313|Ensembl:ENSCPOP00000024757.1};
OS Cavia porcellus (Guinea pig).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Hystricomorpha; Caviidae;
OC Cavia.
OX NCBI_TaxID=10141 {ECO:0000313|Ensembl:ENSCPOP00000024757.1, ECO:0000313|Proteomes:UP000005447};
RN [1] {ECO:0000313|Proteomes:UP000005447}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=2N {ECO:0000313|Proteomes:UP000005447};
RX PubMed=21993624; DOI=10.1038/nature10530;
RA Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J., Washietl S.,
RA Kheradpour P., Ernst J., Jordan G., Mauceli E., Ward L.D., Lowe C.B.,
RA Holloway A.K., Clamp M., Gnerre S., Alfoldi J., Beal K., Chang J.,
RA Clawson H., Cuff J., Di Palma F., Fitzgerald S., Flicek P., Guttman M.,
RA Hubisz M.J., Jaffe D.B., Jungreis I., Kent W.J., Kostka D., Lara M.,
RA Martins A.L., Massingham T., Moltke I., Raney B.J., Rasmussen M.D.,
RA Robinson J., Stark A., Vilella A.J., Wen J., Xie X., Zody M.C., Baldwin J.,
RA Bloom T., Chin C.W., Heiman D., Nicol R., Nusbaum C., Young S.,
RA Wilkinson J., Worley K.C., Kovar C.L., Muzny D.M., Gibbs R.A., Cree A.,
RA Dihn H.H., Fowler G., Jhangiani S., Joshi V., Lee S., Lewis L.R.,
RA Nazareth L.V., Okwuonu G., Santibanez J., Warren W.C., Mardis E.R.,
RA Weinstock G.M., Wilson R.K., Delehaunty K., Dooling D., Fronik C.,
RA Fulton L., Fulton B., Graves T., Minx P., Sodergren E., Birney E.,
RA Margulies E.H., Herrero J., Green E.D., Haussler D., Siepel A., Goldman N.,
RA Pollard K.S., Pedersen J.S., Lander E.S., Kellis M.;
RT "A high-resolution map of human evolutionary constraint using 29 mammals.";
RL Nature 478:476-482(2011).
RN [2] {ECO:0000313|Ensembl:ENSCPOP00000024757.1}
RP IDENTIFICATION.
RC STRAIN=2N {ECO:0000313|Ensembl:ENSCPOP00000024757.1};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the dynein heavy chain family.
CC {ECO:0000256|ARBA:ARBA00008887}.
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DR EMBL; AAKN02036556; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAKN02036557; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAKN02036558; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAKN02036559; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAKN02036560; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAKN02036561; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR STRING; 10141.ENSCPOP00000024757; -.
DR Ensembl; ENSCPOT00000033722.1; ENSCPOP00000024757.1; ENSCPOG00000015041.4.
DR VEuPathDB; HostDB:ENSCPOG00000015041; -.
DR GeneTree; ENSGT00940000154761; -.
DR InParanoid; A0A286XH43; -.
DR OMA; VESFDWQ; -.
DR Proteomes; UP000005447; Unassembled WGS sequence.
DR Bgee; ENSCPOG00000015041; Expressed in testis and 3 other cell types or tissues.
DR GO; GO:0005930; C:axoneme; IEA:UniProt.
DR GO; GO:0030286; C:dynein complex; IEA:UniProtKB-KW.
DR GO; GO:0005874; C:microtubule; IEA:UniProtKB-KW.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0045505; F:dynein intermediate chain binding; IEA:InterPro.
DR GO; GO:0051959; F:dynein light intermediate chain binding; IEA:InterPro.
DR GO; GO:0008569; F:minus-end-directed microtubule motor activity; IEA:InterPro.
DR GO; GO:0007018; P:microtubule-based movement; IEA:InterPro.
DR CDD; cd00009; AAA; 1.
DR Gene3D; 1.10.287.2620; -; 1.
DR Gene3D; 1.10.8.1220; -; 1.
DR Gene3D; 1.10.8.710; -; 1.
DR Gene3D; 1.20.1270.280; -; 1.
DR Gene3D; 1.20.58.1120; -; 1.
DR Gene3D; 1.20.920.20; -; 1.
DR Gene3D; 1.20.920.30; -; 1.
DR Gene3D; 3.10.490.20; -; 1.
DR Gene3D; 6.10.140.1060; -; 1.
DR Gene3D; 1.20.140.100; Dynein heavy chain, N-terminal domain 2; 1.
DR Gene3D; 3.20.180.20; Dynein heavy chain, N-terminal domain 2; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 5.
DR Gene3D; 1.10.8.720; Region D6 of dynein motor; 1.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR035699; AAA_6.
DR InterPro; IPR035706; AAA_9.
DR InterPro; IPR041658; AAA_lid_11.
DR InterPro; IPR042219; AAA_lid_11_sf.
DR InterPro; IPR026983; DHC_fam.
DR InterPro; IPR041589; DNAH3_AAA_lid_1.
DR InterPro; IPR042222; Dynein_2_N.
DR InterPro; IPR043157; Dynein_AAA1S.
DR InterPro; IPR041466; Dynein_AAA5_ext.
DR InterPro; IPR041228; Dynein_C.
DR InterPro; IPR043160; Dynein_C_barrel.
DR InterPro; IPR024743; Dynein_HC_stalk.
DR InterPro; IPR024317; Dynein_heavy_chain_D4_dom.
DR InterPro; IPR004273; Dynein_heavy_D6_P-loop.
DR InterPro; IPR013602; Dynein_heavy_linker.
DR InterPro; IPR042228; Dynein_linker_3.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR45703; DYNEIN HEAVY CHAIN; 1.
DR PANTHER; PTHR45703:SF34; DYNEIN HEAVY CHAIN, CYTOPLASMIC; 1.
DR Pfam; PF12774; AAA_6; 1.
DR Pfam; PF12775; AAA_7; 1.
DR Pfam; PF12780; AAA_8; 1.
DR Pfam; PF12781; AAA_9; 1.
DR Pfam; PF17857; AAA_lid_1; 1.
DR Pfam; PF18198; AAA_lid_11; 1.
DR Pfam; PF08393; DHC_N2; 1.
DR Pfam; PF17852; Dynein_AAA_lid; 1.
DR Pfam; PF18199; Dynein_C; 1.
DR Pfam; PF03028; Dynein_heavy; 1.
DR Pfam; PF12777; MT; 1.
DR SMART; SM00382; AAA; 3.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 4.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Cell projection {ECO:0000256|ARBA:ARBA00023273};
KW Cilium {ECO:0000256|ARBA:ARBA00023069};
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Cytoskeleton {ECO:0000256|ARBA:ARBA00023212};
KW Dynein {ECO:0000256|ARBA:ARBA00023017};
KW Microtubule {ECO:0000256|ARBA:ARBA00022701};
KW Motor protein {ECO:0000256|ARBA:ARBA00023175};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000005447}.
FT DOMAIN 1458..1561
FT /note="AAA+ ATPase"
FT /evidence="ECO:0000259|SMART:SM00382"
FT DOMAIN 1739..1880
FT /note="AAA+ ATPase"
FT /evidence="ECO:0000259|SMART:SM00382"
FT DOMAIN 2082..2231
FT /note="AAA+ ATPase"
FT /evidence="ECO:0000259|SMART:SM00382"
FT COILED 2913..2947
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 4152 AA; 474477 MW; FE00185D3B71BBDA CRC64;
MAYHTIESEM DLRSLADTSR NPSVSKLSTA TSKGRISYIT PTEHDSDKQI LTFRHTTKAQ
ERTRKRQQPV KLEPLPVLKA YQDHKQPEYI QEQNRIQLIT CGILKPSASV AERGSVKSLT
PLEPQDVMEK KKVQQASLEV FSPSPPKLPR TGIGRRGLFG TGSSTYPKYT FQDREEVVKA
NIRDPLQIIK IVRENETLGF LYMISAVPKS SIEYDTYNLK VVSYENINKN DYYTISQKAV
THIHNNDIEY IEIDRWEQEY LYHRELTKIP IFSLFRKWKA FTVWKKNVRS KKITACRNSL
QKNLFIVNAY LRPALLKINE LCYQISFMGL CCIEKCHTYT LQEFKAAQVI RLEEVTALLE
EFRSMAKDVV RKACRLALRA VGFVPDDCAL EPVENMKGRN ISGLNDCGLL LNSEKMTYTE
QASKRHHCIR LTCFIRLNDY LIENTLHVVT VNSANSLLNY LTDKIKRTPS ADVIQKWITE
EKPEATDKKG SPVVEKQEED ESLIPMFLTE LILTVQSLLF EPSLEDFLDG ISGAINHFQS
TVLSVPNLVP DGYFDAFTSP YINNKREEKT CGSGPSLSSV FDDDRNFHTI IFQIKETIHA
AFDSARLYAT TFEKFQIFFK ENESLDLQAL KLQEPDVKYF SEQLEKYHKQ HKDAVALRPT
RNVGLLLIDT KQLKEKLIPS PLRCLEVLNI MLPQLSKKKV DAIISEAQDA EYKLEFIPTT
TIEYVNSLVF LDEIQERIES LEEEGNIVVQ MYKLIDQYQV PTPPEDFAVF ATMKPSITAV
RNAIDKSVGD RETSIKQFCQ HLGRDLEELN NEVNEIKLQV QDPQILDINA DQDKIKVTLN
ELQYVIDDLQ KRAFQYKSYQ KNFKVEVSKF EALEEVSAEL KLKQLLWDSL SDWGKLQQEW
SQSKFDCLDT EVLNSQVSKY AKFVTQLEKG LPPNNVVPQL KSNVEKMKEK LPVIIDLRNP
TLKPRHWAAI EQTIDASLVD SEIPLTLERL SELHVFEYGQ EIQDISGQAS GEAALEIILK
KVEDSWKTTE FVVLPLRDSK DIFILGGTDD IQVQLDDSTI NIATIASSRY VGPLKTRVDE
WQKQLALFNQ TLEEWLTCQR NWLYLESIFN APDIQRQLPA EAKMFLQVDK SWKEIMRKVN
RLPNALRAAT QPGLLETFQN NNALLDQIQK CLEAYLESKR VIFPRFYFLS NDELLEILAQ
TRNPQAVQPH LRKCFDSISK LEFALMPPTE GKIPGIDTEP EKVYTNDILA MLSPEGERVS
LGKGLKARGN VEDWLGKVEE AMFTSLRRLC KAAIADYQGK PRTDWVIAGH PSQVILTISQ
IMWCRDLTEC LETEDNNHVE ALEAFEKVNF ERLNALAALV RGNLPKLHRN IITALITIDV
HARDIVTELV QAKVDTVDSF EWQRQLRYYW LVDVDNCVAR MALSQYTYGY EYLGACPRLV
ITPLTDRCYL CLMGALQLDL GGAPAGPAGT GKTETTKDLA KALAIQCVVF NCSDGLDYKM
MGRFFSGLAQ SGAWCCFDEF NRIDIEVLSV IAQQLITIRN AKAAKLSRFM FEGREIKLVM
TCAAFITMNP GYAGRTELPD NLKALFRPFA MMVPNYALIA EVILYSEGFE SSKVLARKMT
QMYKLCSEQL SQQDHYDFGM RAVKSVLVMA GSLKRENPDL NEDVVLIRAL RDSNLPKFLN
DDAILFSGII SDLFPGVQIP EHDYGILQST IVDVMNGQNL QPEICMVKKV IQFYETMLVR
HGVMLVGPTG GGKTTVYRIL AETLGNLQKL NLGNPFYQAV KTYVLNPKSI TMGELYGEVN
NITLEWKDGL MALSVRAAVN DTSEDHKWII SDGPVDALWI ENMNTVLDDN KMLCLANSER
IKLTPQIHML FEVQDLRVAS PATVSRCGMV FVDPEELKWM PCVKTWMKDI SKRLNEETQG
YILNLFQRYV DEGLNFINKK CNQAISQVDI SKVTTLCYLL ESLLFGKDGV NLSMEKTKLN
TVICQTFVFC YLWSVGGNLT ESYWDSFDTF IRTQFDDNPD ARLPTSGDLW SIHMDFDTKR
LDPWERIIPA FKYSRDVPFF EMLVPTTDTV RFGYLMEKLL AVKHSVLFTG ITGVGKSVIA
KGLLNKIQES AGYVPVYLNF SAQTSSARTQ EIIESKLERK RKNILGAPGN KQVVIFVDDL
NMPRLDRYGS QPPIELLRQY QDFGGFYDRN KLFWKDIQDV TIVSACAPPG GGRNPVTPRF
IRHFSMFCLP TPSEHSLKQI FQAILNGFLS DFTPAVKQTA SNIVEAAVEI YNRMSVDLLP
TPAKSHYVFN LRDLSKCVQG ILQCDSGTIR EEMQIFRLFC HECQRVFHDR LINNEDKQYF
HVILTEMANK HFGIAIDLEY FLNKPIIFGD FIKFGIEKSE RIYDDMPDMD KIANVLQDYL
DDYNLINPKE VRLVFFQDAI EHVSRIARMI RQERGNALLV GVGGTGKQCL TRLAAHICGY
KCLQIELTRG YNYDSFHEDL RKLYKMAGVE DKNMVFLFTD TQIVVEEFLE DINNILNSGE
VPNLFEKDEL EQVLAATRPK AKEAGISEGN RDEVFQYFIS RVRQKLHVVL CMSPVGEAFR
SRCRMFPSLV NCCTIDWFVQ WPREALLSVS KTFFSTVDPG NEELKDKLSL MCVNVHLSVS
QMAERYYAEL RRRYYTTPTS YLELINLYLS MLTEKRKQLV SARDRVKNGL TKLLETNVLV
DKMKLDLSAL EPVLLKKSQD VEALMEKLAV DQESADQVRN VVQEEEAIAK VKAEETQAIA
DDAQRDLEEA LPALEAANRA LDSLDKADIS EIRVFTKPPD LVMTVMEAIS ILLNAKPDWP
TAKQLLGDSN FLRRLLEYDK ENIKPQILAK LQKYINNPDF LPEKVEKVSK ACKSMCMWVR
AMDLYSRVLK EVEPKRQKLR AAQAELDITV ATLKQKQALL KQVEDQIQAL QDEYDKGVNE
KESLAKKMAQ TKARLLRAGK LTAALGDEQV RWEESIQKFQ EEIANITGNV FIAAACVAYY
GAFTAHLYMQ TLLLLQLIDC WIEYCQQLEV PIDPSFSLIN ILGDPYEIRQ WNADGLPRDL
ISTENGILVT QGRRWPLMID PQDQANRWIR NKESKNGLKV IKLTDRNFLR TLENSVRLGL
PVLLEELRET LDPALEPILL KQIFISGGRV LIHLGDSDID YDKNFRFYMT TKMSNPHYLP
EVCIKVTIIN FTVTKSGLED QLLSDVVRLE RPELEEQRVQ LIVRINSDKN QLKAIEEKIL
KMLFTSEGNI LDNEELIDTL QESKITSGAI KVRLKEAEST EQMINVAREK YRPVATQGSV
MYFVIASLSE MDPMYQYSLK YFKQLFNTTI ETSVKTDDLQ HRLQILLEQT LLNAYVNISR
GLFEQHKLIY SFMLCVEIMR QQGSLTEAEW NFFLRGSAGM EKERPPKPEA PWLSTAMWFA
CCDLEESFPV FQKLTEYILL HPISIRLGSF ETSINPPVWE GYPHSKREEH GTHGKDSRIS
ELSSFQKLIL IKCCKEEKVV FAVTDFVIEN LGKQFIETPP VDLATLYQDM SCSTPLVFIL
STGSDPMGTF QRFARESGYS ERVQSISLGQ GQGPIAEKMI KDAMKTGNWV FLQNCHLAVS
WMLAMEELIK TFTDPTQAIK DTFRLFLSSM PSSTFPVTVL QNSVKVTNEP PKGLRANIRR
AFTEMTPSFF EENILGKKWR QIIFGICFFH AIVQERKKFG PLGWNICYEF NDSDRECALL
NLNLYCQEGK IPWDALIYIT GEITYGGRVT DTWDQRCLRT VLKRFFSPET LEDNYKYSES
GIYFAPLADS LQEFKDYIEN LPLIDDPEIF GMHENANLVF QYKETNTLIN TILEVQPRSS
SGGEGKSNDE IVQELVASIQ TRVPEKLMME GASESLFVKD PQGRLNSLTT VLSQEVDRFN
NLLKLIHTSL ETLNKAIAGF VVMSEEMEKV YNSFLNNQVP SLWSNTAYPS LKPLGSWVKD
LVLRTAFVDL WLKRGQPKSF WISGFFFPQG FLTGTLQNHA RKYNLPIDEL SFKYNMVPTY
RDQAAVIEAA KTVKFGQELP MDLELPSPED GVLVHGMFMD ASRWDDKEMV IEDALPGQMN
PMLPVVHFEP QQNYEPAPTL YHSPLYKTGA RAGTLSTTGH STNFVVTVLL PSKRSKDYWI
AKGSALLCQL NE
//
