ID A0A286XHJ5_CAVPO Unreviewed; 638 AA.
AC A0A286XHJ5;
DT 22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 1.
DT 27-MAR-2024, entry version 26.
DE SubName: Full=Exostosin like glycosyltransferase 1 {ECO:0000313|Ensembl:ENSCPOP00000024879.1};
GN Name=EXTL1 {ECO:0000313|Ensembl:ENSCPOP00000024879.1};
OS Cavia porcellus (Guinea pig).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Hystricomorpha; Caviidae;
OC Cavia.
OX NCBI_TaxID=10141 {ECO:0000313|Ensembl:ENSCPOP00000024879.1, ECO:0000313|Proteomes:UP000005447};
RN [1] {ECO:0000313|Proteomes:UP000005447}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=2N {ECO:0000313|Proteomes:UP000005447};
RX PubMed=21993624; DOI=10.1038/nature10530;
RA Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J., Washietl S.,
RA Kheradpour P., Ernst J., Jordan G., Mauceli E., Ward L.D., Lowe C.B.,
RA Holloway A.K., Clamp M., Gnerre S., Alfoldi J., Beal K., Chang J.,
RA Clawson H., Cuff J., Di Palma F., Fitzgerald S., Flicek P., Guttman M.,
RA Hubisz M.J., Jaffe D.B., Jungreis I., Kent W.J., Kostka D., Lara M.,
RA Martins A.L., Massingham T., Moltke I., Raney B.J., Rasmussen M.D.,
RA Robinson J., Stark A., Vilella A.J., Wen J., Xie X., Zody M.C., Baldwin J.,
RA Bloom T., Chin C.W., Heiman D., Nicol R., Nusbaum C., Young S.,
RA Wilkinson J., Worley K.C., Kovar C.L., Muzny D.M., Gibbs R.A., Cree A.,
RA Dihn H.H., Fowler G., Jhangiani S., Joshi V., Lee S., Lewis L.R.,
RA Nazareth L.V., Okwuonu G., Santibanez J., Warren W.C., Mardis E.R.,
RA Weinstock G.M., Wilson R.K., Delehaunty K., Dooling D., Fronik C.,
RA Fulton L., Fulton B., Graves T., Minx P., Sodergren E., Birney E.,
RA Margulies E.H., Herrero J., Green E.D., Haussler D., Siepel A., Goldman N.,
RA Pollard K.S., Pedersen J.S., Lander E.S., Kellis M.;
RT "A high-resolution map of human evolutionary constraint using 29 mammals.";
RL Nature 478:476-482(2011).
RN [2] {ECO:0000313|Ensembl:ENSCPOP00000024879.1}
RP IDENTIFICATION.
RC STRAIN=2N {ECO:0000313|Ensembl:ENSCPOP00000024879.1};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane
CC {ECO:0000256|ARBA:ARBA00004648}; Single-pass type II membrane protein
CC {ECO:0000256|ARBA:ARBA00004648}.
CC -!- SIMILARITY: Belongs to the glycosyltransferase 47 family.
CC {ECO:0000256|ARBA:ARBA00010271}.
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DR EMBL; AAKN02028660; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_005004338.1; XM_005004281.2.
DR AlphaFoldDB; A0A286XHJ5; -.
DR Ensembl; ENSCPOT00000045320.1; ENSCPOP00000024879.1; ENSCPOG00000000922.4.
DR GeneID; 100732210; -.
DR CTD; 2134; -.
DR VEuPathDB; HostDB:ENSCPOG00000000922; -.
DR GeneTree; ENSGT00940000161960; -.
DR OrthoDB; 1220028at2759; -.
DR Proteomes; UP000005447; Unassembled WGS sequence.
DR Bgee; ENSCPOG00000000922; Expressed in liver and 12 other cell types or tissues.
DR GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0016757; F:glycosyltransferase activity; IEA:InterPro.
DR GO; GO:0015012; P:heparan sulfate proteoglycan biosynthetic process; IEA:UniProt.
DR GO; GO:0006486; P:protein glycosylation; IEA:InterPro.
DR InterPro; IPR004263; Exostosin.
DR InterPro; IPR040911; Exostosin_GT47.
DR InterPro; IPR015338; GT64.
DR InterPro; IPR029044; Nucleotide-diphossugar_trans.
DR PANTHER; PTHR48261; ACETYLGLUCOSAMINYLTRANSFERASE; 1.
DR PANTHER; PTHR48261:SF2; EXOSTOSIN-1-LIKE; 1.
DR Pfam; PF03016; Exostosin; 1.
DR Pfam; PF09258; Glyco_transf_64; 1.
DR SUPFAM; SSF53448; Nucleotide-diphospho-sugar transferases; 1.
PE 3: Inferred from homology;
KW Endoplasmic reticulum {ECO:0000256|ARBA:ARBA00022824};
KW Reference proteome {ECO:0000313|Proteomes:UP000005447};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 106..290
FT /note="Exostosin GT47"
FT /evidence="ECO:0000259|Pfam:PF03016"
FT DOMAIN 381..621
FT /note="Glycosyl transferase 64"
FT /evidence="ECO:0000259|Pfam:PF09258"
SQ SEQUENCE 638 AA; 70934 MW; 501BC1CEC9E150A3 CRC64;
MQFWRRRSLW LALSASSLLL TLLGFFPFLR LAVSPRPQPA APQGWPRWLD TASLRSFSQP
EEPPEDVPQP PQAPHGTSCS WGICFDTSRC RGDGLKVFAH AAAQPTSEMH RRILASLEGS
RYHTRNLTEA CLLFVLSPED PDGQCGPAPQ HWNGGRNHLV IRLHPDPCPQ ASQLGQAMVA
QASPRVDTFR PGFDVALPLL PEAHPFRGGA PGQLQQHSPH PRAALLALAE EGGRWRTAGT
YSSTCPWDGH CEQDLGPKQT RPEEKLPNAT FCLIPGQRAE ASRFLQALQV LAALQEMAPA
RVLALRQQTQ FLWAAYFSSV EKVIHTTLEI IQDRILGASA HPSLLWNSPP GALLALSTFS
RSPQDFPFYH LQQGSRPEGR FSALIWVGTS SQHPLKLIQA VAGSQHCAQI LVLWSSEKPL
PPKWPETTVP LTVMDGHRKV SDRFFPYSAI STDAILSLDA HSSLSTSEVD FAFVVWQSFP
ERMVGFLTWN HFWDETRSGW GYTAEMANEF SMVLTAAAFY HRYYHSLFTH SLPKALRTLA
DEAPACVDVL MNFLVAAATK LPPIKVPFSK QHQGAAPLAP RIPASGSQPQ PPHQDCINRM
VAEFGHMPLV SSRLRLDPVL FKDPVSVQRK KYRRLEKP
//
