ID A0A286XI96_CAVPO Unreviewed; 887 AA.
AC A0A286XI96;
DT 22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 1.
DT 27-MAR-2024, entry version 31.
DE SubName: Full=Tubulin tyrosine ligase like 7 {ECO:0000313|Ensembl:ENSCPOP00000025167.1};
GN Name=TTLL7 {ECO:0000313|Ensembl:ENSCPOP00000025167.1};
OS Cavia porcellus (Guinea pig).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Hystricomorpha; Caviidae;
OC Cavia.
OX NCBI_TaxID=10141 {ECO:0000313|Ensembl:ENSCPOP00000025167.1, ECO:0000313|Proteomes:UP000005447};
RN [1] {ECO:0000313|Proteomes:UP000005447}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=2N {ECO:0000313|Proteomes:UP000005447};
RX PubMed=21993624; DOI=10.1038/nature10530;
RA Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J., Washietl S.,
RA Kheradpour P., Ernst J., Jordan G., Mauceli E., Ward L.D., Lowe C.B.,
RA Holloway A.K., Clamp M., Gnerre S., Alfoldi J., Beal K., Chang J.,
RA Clawson H., Cuff J., Di Palma F., Fitzgerald S., Flicek P., Guttman M.,
RA Hubisz M.J., Jaffe D.B., Jungreis I., Kent W.J., Kostka D., Lara M.,
RA Martins A.L., Massingham T., Moltke I., Raney B.J., Rasmussen M.D.,
RA Robinson J., Stark A., Vilella A.J., Wen J., Xie X., Zody M.C., Baldwin J.,
RA Bloom T., Chin C.W., Heiman D., Nicol R., Nusbaum C., Young S.,
RA Wilkinson J., Worley K.C., Kovar C.L., Muzny D.M., Gibbs R.A., Cree A.,
RA Dihn H.H., Fowler G., Jhangiani S., Joshi V., Lee S., Lewis L.R.,
RA Nazareth L.V., Okwuonu G., Santibanez J., Warren W.C., Mardis E.R.,
RA Weinstock G.M., Wilson R.K., Delehaunty K., Dooling D., Fronik C.,
RA Fulton L., Fulton B., Graves T., Minx P., Sodergren E., Birney E.,
RA Margulies E.H., Herrero J., Green E.D., Haussler D., Siepel A., Goldman N.,
RA Pollard K.S., Pedersen J.S., Lander E.S., Kellis M.;
RT "A high-resolution map of human evolutionary constraint using 29 mammals.";
RL Nature 478:476-482(2011).
RN [2] {ECO:0000313|Ensembl:ENSCPOP00000025167.1}
RP IDENTIFICATION.
RC STRAIN=2N {ECO:0000313|Ensembl:ENSCPOP00000025167.1};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- COFACTOR:
CC Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
CC Evidence={ECO:0000256|ARBA:ARBA00001946};
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DR EMBL; AAKN02004891; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAKN02004892; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAKN02004893; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_003478851.1; XM_003478803.3.
DR AlphaFoldDB; A0A286XI96; -.
DR Ensembl; ENSCPOT00000048215.1; ENSCPOP00000025167.1; ENSCPOG00000009630.4.
DR GeneID; 100712966; -.
DR KEGG; cpoc:100712966; -.
DR CTD; 79739; -.
DR VEuPathDB; HostDB:ENSCPOG00000009630; -.
DR eggNOG; KOG2158; Eukaryota.
DR GeneTree; ENSGT00940000159078; -.
DR OrthoDB; 7265at2759; -.
DR Proteomes; UP000005447; Unassembled WGS sequence.
DR Bgee; ENSCPOG00000009630; Expressed in testis and 10 other cell types or tissues.
DR GO; GO:0070740; F:tubulin-glutamic acid ligase activity; IEA:UniProt.
DR GO; GO:0036211; P:protein modification process; IEA:InterPro.
DR Gene3D; 3.30.470.20; ATP-grasp fold, B domain; 1.
DR InterPro; IPR004344; TTL/TTLL_fam.
DR PANTHER; PTHR12241; TUBULIN POLYGLUTAMYLASE; 1.
DR PANTHER; PTHR12241:SF147; TUBULIN POLYGLUTAMYLASE TTLL7; 1.
DR Pfam; PF03133; TTL; 1.
DR SUPFAM; SSF56059; Glutathione synthetase ATP-binding domain-like; 1.
DR PROSITE; PS51221; TTL; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Reference proteome {ECO:0000313|Proteomes:UP000005447}.
FT REGION 545..621
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 627..646
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 651..677
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 413..447
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 545..559
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 560..583
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 587..621
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 651..667
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 887 AA; 102982 MW; D3379D8874143CDA CRC64;
MPSLPQEGVI QAPSPLNLNT ELPYQSTMKR KVRKKKKKGI ITANVAGTKF EIVRLVIDEL
GFMKTPDEDE TSNLIWCDSA VQQEKIAELQ NYQRINHFPG MGEICRKDFL ARNMTKMIKS
RPLDYTFVPR TWIFPSEYTQ FQNYVKELKK KRKQKTFIVK PANGAMGHGI SLIRNGDKLP
SQDHLIVQEY IEKPFLMEGY KFDLRIYILV TSCDPLKIFL YHDGLVRMGT EKYIPPNESN
LTQLYMHLTN YSVNKHNERF ERDETEDKGS KRSIKWFTEF LQENHHDVAK FWSDISELVV
KTLIVAEPHV LHAYRMCRPG QPPGSESVCF EVLGFDILLD RKLKPWLLEI NRAPSFGTDQ
KIDYDVKRGV LLNALKLLNI RTSDKRRNLA KQKAEAQRRL YGQNSIKRLL PGSSDWEQQR
HQLERRKEEL KERLAQVRKQ ISREEHENRH MGNYRRIYPP EDKTLLEKYE NLLAVAFQTF
LSGRAASFQR ELNNPLKRMK EEDILDLLEQ CEIDDEKLMG KTAKHRGPKP LCSMPESAEI
MKRQKYYSSD SSYDSSSSSS ESEENEKEEY QNKQREKQVP YNPKHSSHCK LIQQSNSMRR
SVSCPRSISS HSPFSGDTRP LSAQQVIPVS RPASASRSHS LNRASSYTRQ LLQNSDASSS
SSQVSESFRK PKTKEQEDAL TSQTLFVLKD MKIRFPGKSD AESELLIEDI IDNWKYHKTK
VASYWLIKLD SLKQRKVLDI VKISIRSVLP RIWKVPDVEE INLYRIFNRV FNRLLWSHGQ
GLWNCFCDSG SSWESMFSKS PEVVTPLQLQ CCQRLVELCK QCLLVVYKYA ADSKGSLSGP
GPDWGNSRYL LPGSTQFFMR TPTYNMKYNT SGMTRSSVLF TSRYSHL
//
