ID A0A286XJR1_CAVPO Unreviewed; 1431 AA.
AC A0A286XJR1;
DT 22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 1.
DT 27-MAR-2024, entry version 33.
DE SubName: Full=Regulator of G protein signaling 12 {ECO:0000313|Ensembl:ENSCPOP00000025553.1};
GN Name=RGS12 {ECO:0000313|Ensembl:ENSCPOP00000025553.1};
OS Cavia porcellus (Guinea pig).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Hystricomorpha; Caviidae;
OC Cavia.
OX NCBI_TaxID=10141 {ECO:0000313|Ensembl:ENSCPOP00000025553.1, ECO:0000313|Proteomes:UP000005447};
RN [1] {ECO:0000313|Proteomes:UP000005447}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=2N {ECO:0000313|Proteomes:UP000005447};
RX PubMed=21993624; DOI=10.1038/nature10530;
RA Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J., Washietl S.,
RA Kheradpour P., Ernst J., Jordan G., Mauceli E., Ward L.D., Lowe C.B.,
RA Holloway A.K., Clamp M., Gnerre S., Alfoldi J., Beal K., Chang J.,
RA Clawson H., Cuff J., Di Palma F., Fitzgerald S., Flicek P., Guttman M.,
RA Hubisz M.J., Jaffe D.B., Jungreis I., Kent W.J., Kostka D., Lara M.,
RA Martins A.L., Massingham T., Moltke I., Raney B.J., Rasmussen M.D.,
RA Robinson J., Stark A., Vilella A.J., Wen J., Xie X., Zody M.C., Baldwin J.,
RA Bloom T., Chin C.W., Heiman D., Nicol R., Nusbaum C., Young S.,
RA Wilkinson J., Worley K.C., Kovar C.L., Muzny D.M., Gibbs R.A., Cree A.,
RA Dihn H.H., Fowler G., Jhangiani S., Joshi V., Lee S., Lewis L.R.,
RA Nazareth L.V., Okwuonu G., Santibanez J., Warren W.C., Mardis E.R.,
RA Weinstock G.M., Wilson R.K., Delehaunty K., Dooling D., Fronik C.,
RA Fulton L., Fulton B., Graves T., Minx P., Sodergren E., Birney E.,
RA Margulies E.H., Herrero J., Green E.D., Haussler D., Siepel A., Goldman N.,
RA Pollard K.S., Pedersen J.S., Lander E.S., Kellis M.;
RT "A high-resolution map of human evolutionary constraint using 29 mammals.";
RL Nature 478:476-482(2011).
RN [2] {ECO:0000313|Ensembl:ENSCPOP00000025553.1}
RP IDENTIFICATION.
RC STRAIN=2N {ECO:0000313|Ensembl:ENSCPOP00000025553.1};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell projection, dendrite
CC {ECO:0000256|ARBA:ARBA00004279}. Cytoplasm
CC {ECO:0000256|ARBA:ARBA00004496}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AAKN02055219; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_013013129.1; XM_013157675.1.
DR STRING; 10141.ENSCPOP00000025553; -.
DR Ensembl; ENSCPOT00000033635.1; ENSCPOP00000025553.1; ENSCPOG00000005334.4.
DR GeneID; 100713051; -.
DR KEGG; cpoc:100713051; -.
DR CTD; 6002; -.
DR VEuPathDB; HostDB:ENSCPOG00000005334; -.
DR eggNOG; KOG3589; Eukaryota.
DR GeneTree; ENSGT00940000159741; -.
DR InParanoid; A0A286XJR1; -.
DR OMA; HKSEWSK; -.
DR OrthoDB; 22856at2759; -.
DR Proteomes; UP000005447; Unassembled WGS sequence.
DR Bgee; ENSCPOG00000005334; Expressed in frontal cortex and 13 other cell types or tissues.
DR GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR GO; GO:0030425; C:dendrite; IEA:UniProtKB-SubCell.
DR GO; GO:0005730; C:nucleolus; IEA:Ensembl.
DR GO; GO:0005654; C:nucleoplasm; IEA:Ensembl.
DR GO; GO:0005096; F:GTPase activator activity; IEA:UniProtKB-KW.
DR GO; GO:0009968; P:negative regulation of signal transduction; IEA:UniProt.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR CDD; cd00992; PDZ_signaling; 1.
DR CDD; cd13162; PTB_RGS12; 1.
DR CDD; cd17136; RBD1_RGS12; 1.
DR CDD; cd08742; RGS_RGS12; 1.
DR Gene3D; 1.10.196.10; -; 1.
DR Gene3D; 2.30.42.10; -; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR Gene3D; 1.10.167.10; Regulator of G-protein Signalling 4, domain 2; 1.
DR InterPro; IPR003109; GoLoco_motif.
DR InterPro; IPR001478; PDZ.
DR InterPro; IPR036034; PDZ_sf.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR006020; PTB/PI_dom.
DR InterPro; IPR003116; RBD_dom.
DR InterPro; IPR016137; RGS.
DR InterPro; IPR046995; RGS10/12/14-like.
DR InterPro; IPR037880; RGS12_RGS.
DR InterPro; IPR036305; RGS_sf.
DR InterPro; IPR024066; RGS_subdom1/3.
DR InterPro; IPR044926; RGS_subdomain_2.
DR InterPro; IPR029071; Ubiquitin-like_domsf.
DR PANTHER; PTHR45945:SF1; REGULATOR OF G-PROTEIN SIGNALING 12; 1.
DR PANTHER; PTHR45945; REGULATOR OF G-PROTEIN SIGNALING LOCO; 1.
DR Pfam; PF02188; GoLoco; 1.
DR Pfam; PF00595; PDZ; 1.
DR Pfam; PF02196; RBD; 1.
DR Pfam; PF00615; RGS; 1.
DR Pfam; PF16613; RGS12_us1; 1.
DR Pfam; PF16611; RGS12_us2; 1.
DR Pfam; PF16612; RGS12_usC; 1.
DR PRINTS; PR01301; RGSPROTEIN.
DR SMART; SM00390; GoLoco; 1.
DR SMART; SM00228; PDZ; 1.
DR SMART; SM00462; PTB; 1.
DR SMART; SM00455; RBD; 2.
DR SMART; SM00315; RGS; 1.
DR SUPFAM; SSF50156; PDZ domain-like; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR SUPFAM; SSF48097; Regulator of G-protein signaling, RGS; 1.
DR SUPFAM; SSF54236; Ubiquitin-like; 2.
DR PROSITE; PS50877; GOLOCO; 1.
DR PROSITE; PS50106; PDZ; 1.
DR PROSITE; PS01179; PID; 1.
DR PROSITE; PS50898; RBD; 2.
DR PROSITE; PS50132; RGS; 1.
PE 4: Predicted;
KW GTPase activation {ECO:0000256|ARBA:ARBA00022468};
KW Reference proteome {ECO:0000313|Proteomes:UP000005447};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT DOMAIN 23..100
FT /note="PDZ"
FT /evidence="ECO:0000259|PROSITE:PS50106"
FT DOMAIN 226..338
FT /note="PID"
FT /evidence="ECO:0000259|PROSITE:PS01179"
FT DOMAIN 714..831
FT /note="RGS"
FT /evidence="ECO:0000259|PROSITE:PS50132"
FT DOMAIN 962..1032
FT /note="RBD"
FT /evidence="ECO:0000259|PROSITE:PS50898"
FT DOMAIN 1034..1104
FT /note="RBD"
FT /evidence="ECO:0000259|PROSITE:PS50898"
FT REGION 159..181
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 408..427
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 500..520
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 620..648
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 842..943
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1103..1168
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1238..1375
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1391..1431
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 409..427
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 845..873
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 874..896
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 928..942
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1154..1168
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1253..1289
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1313..1334
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1346..1360
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1397..1412
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1431 AA; 154875 MW; E4555EBB7CEF78BB CRC64;
MMYRAGEPVK RPPLGPVPPR LRSVEVARGR AGYGFTLAGQ APCVLSGVIR GSPADFVGLR
AGDQIFTINE INVKKASHED VVKLIGKCSG VLRLVIGEGA GHPEACSSDD EGGLCEGKGW
LRPKLDSKAL GINRAERVVE EMQSGGIFSM IFENPSLCMS TPEPSQGKQR SLSESASVRL
EGSPNAVQTG LLSKEELVRV IHDDSVFSAG PENLDSFALD ASILNVAMVV GYLGSIELPS
TSCNLESDSL QAIRGCMRRL RAEQKIHSLV TMKVMHDRVL LCSDKACVVA EYPAEKLAFS
AVCPDDRRFF GLVTMQTNDD GSLAQGEEGA LRTSCHVFMV DPDLFHHKIH QGIARRFGFM
CTADPDTSGC LEFPASSLPV LQFISILYRD MGEFIEGVRA RAFLDGDADA HQNNSTSSNS
DSGIGNFNQE EKSNRVLVVD LGGGLSRHGP GSSASWEGAG ARSSQSWAAS WSRSFCHSPE
GCASFEAGPQ ADRLRDLSKH LGPASHTEGT PASLWSSVPP SKRGSASTSC GLSQRWLPVH
VLQEWQCGHA SDQESYTDST DGWSSVNCGT LPPPMSKIPA DRYRVEGSFM QAPLSAQKRD
WARKAFGMQN LFGPSRNVRR TKEDKKGSKF GRGIGLAQTS QRSSARRSFR RSKRFSITRS
LDDLESATVS DGELTGADLK DCVSSNSLSS NASLPSVQSC RRLRERRVAS WAVSFERLLQ
DPVGIRYFSD FLRKEFSEEN ILFWQACEYF NHVPAHDKKE LSHRAREIFS KFLCSKATTP
VNIDSQAQLA DDILNAPHPD MFKEQQLQIF NLMKFDSYTR FLKSQLYQEC ILAEVEGRAL
PDAQQVPSSP ASKHSIGSDH SSTSTPKKLS GKSKSGRSLN EDAGDEDSEK KRKGAFFSWS
RSRSTGRSQK KKEPGDHGQD TLPTNGGLCR RRESQGSVSS AGSLDLPEAC RTLVPEKDKA
VKHCCIYLPD GATCVVAVKS GFSIKEILAG LCERHGINGA AVDLFLVGGD KPLVLHQDSS
ILASRDLRLE KRTLFRLDLV PINRSVGLKA KPTKPVTEVL RPVVAKYGLD LGSLLVRLSG
EKEPLDLGAP ISSLDGQRVV LEERDPARGR APTDKQKGAL AKPSAAASSR PRDRSATGEE
RTLGKSNSIK IKGENGKNAR DPRLSKREES IAKIGKKKYQ KINLDEAEEF FELISKAQSN
RADDQRGLLT KEDLVLPEFL RLPPGSTKLP LCTLAAGKGF SKRPETTGHS REKASLPSDS
PATSPGSTQS TSSAQSPGSA QSPGSAHSPS GPRGASPLGQ KVQEGPTQVW RRRQSQEVED
GGIQTEDESR ADLTLVGEGD ISSPNSTLLP PPPSPQDAPG PLRPGGRARG SQGLPVNRIF
DVDLAAGMAP RVWPGPRRAR PMRPPASDCP GQSPSPGEPK AKLSTHHATF V
//
