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Database: UniProt
Entry: A0A286XKY8_CAVPO
LinkDB: A0A286XKY8_CAVPO
Original site: A0A286XKY8_CAVPO 
ID   A0A286XKY8_CAVPO        Unreviewed;      1427 AA.
AC   A0A286XKY8;
DT   22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT   22-NOV-2017, sequence version 1.
DT   11-DEC-2019, entry version 16.
DE   SubName: Full=CASK interacting protein 1 {ECO:0000313|Ensembl:ENSCPOP00000026109};
GN   Name=CASKIN1 {ECO:0000313|Ensembl:ENSCPOP00000026109};
OS   Cavia porcellus (Guinea pig).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Hystricomorpha; Caviidae;
OC   Cavia.
OX   NCBI_TaxID=10141 {ECO:0000313|Ensembl:ENSCPOP00000026109, ECO:0000313|Proteomes:UP000005447};
RN   [1] {ECO:0000313|Ensembl:ENSCPOP00000026109, ECO:0000313|Proteomes:UP000005447}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=2N {ECO:0000313|Ensembl:ENSCPOP00000026109,
RC   ECO:0000313|Proteomes:UP000005447};
RX   PubMed=21993624; DOI=10.1038/nature10530;
RA   Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J., Washietl S.,
RA   Kheradpour P., Ernst J., Jordan G., Mauceli E., Ward L.D., Lowe C.B.,
RA   Holloway A.K., Clamp M., Gnerre S., Alfoldi J., Beal K., Chang J.,
RA   Clawson H., Cuff J., Di Palma F., Fitzgerald S., Flicek P., Guttman M.,
RA   Hubisz M.J., Jaffe D.B., Jungreis I., Kent W.J., Kostka D., Lara M.,
RA   Martins A.L., Massingham T., Moltke I., Raney B.J., Rasmussen M.D.,
RA   Robinson J., Stark A., Vilella A.J., Wen J., Xie X., Zody M.C., Baldwin J.,
RA   Bloom T., Chin C.W., Heiman D., Nicol R., Nusbaum C., Young S.,
RA   Wilkinson J., Worley K.C., Kovar C.L., Muzny D.M., Gibbs R.A., Cree A.,
RA   Dihn H.H., Fowler G., Jhangiani S., Joshi V., Lee S., Lewis L.R.,
RA   Nazareth L.V., Okwuonu G., Santibanez J., Warren W.C., Mardis E.R.,
RA   Weinstock G.M., Wilson R.K., Delehaunty K., Dooling D., Fronik C.,
RA   Fulton L., Fulton B., Graves T., Minx P., Sodergren E., Birney E.,
RA   Margulies E.H., Herrero J., Green E.D., Haussler D., Siepel A., Goldman N.,
RA   Pollard K.S., Pedersen J.S., Lander E.S., Kellis M.;
RT   "A high-resolution map of human evolutionary constraint using 29 mammals.";
RL   Nature 478:476-482(2011).
RN   [2] {ECO:0000313|Ensembl:ENSCPOP00000026109}
RP   IDENTIFICATION.
RC   STRAIN=2N {ECO:0000313|Ensembl:ENSCPOP00000026109};
RG   Ensembl;
RL   Submitted (OCT-2017) to UniProtKB.
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DR   EMBL; AAKN02007402; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   RefSeq; XP_003478527.1; XM_003478479.3.
DR   STRING; 10141.ENSCPOP00000010658; -.
DR   Ensembl; ENSCPOT00000040943; ENSCPOP00000026109; ENSCPOG00000011848.
DR   GeneID; 100732339; -.
DR   CTD; 57524; -.
DR   GeneTree; ENSGT00940000158025; -.
DR   OMA; QEDGQGP; -.
DR   OrthoDB; 75723at2759; -.
DR   Proteomes; UP000005447; Unassembled WGS sequence.
DR   GO; GO:0042802; F:identical protein binding; IEA:Ensembl.
DR   CDD; cd09497; SAM_caskin1_2_repeat1; 1.
DR   CDD; cd09498; SAM_caskin1_2_repeat2; 1.
DR   CDD; cd12062; SH3_Caskin1; 1.
DR   Gene3D; 1.10.150.50; -; 2.
DR   Gene3D; 1.25.40.20; -; 1.
DR   InterPro; IPR002110; Ankyrin_rpt.
DR   InterPro; IPR020683; Ankyrin_rpt-contain_dom.
DR   InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR   InterPro; IPR027013; Caskin-1/2.
DR   InterPro; IPR032232; Caskin1-CID.
DR   InterPro; IPR035497; Caskin1/2_SAM_1.
DR   InterPro; IPR035498; Caskin1/2_SAM_2.
DR   InterPro; IPR035495; Caskin1_SH3.
DR   InterPro; IPR032117; Caskin_C.
DR   InterPro; IPR001660; SAM.
DR   InterPro; IPR013761; SAM/pointed_sf.
DR   InterPro; IPR036028; SH3-like_dom_sf.
DR   InterPro; IPR001452; SH3_domain.
DR   PANTHER; PTHR24174:SF11; PTHR24174:SF11; 1.
DR   Pfam; PF12796; Ank_2; 2.
DR   Pfam; PF16632; Caskin-tail; 1.
DR   Pfam; PF16600; Caskin1-CID; 1.
DR   Pfam; PF00536; SAM_1; 2.
DR   Pfam; PF07653; SH3_2; 1.
DR   PRINTS; PR01415; ANKYRIN.
DR   SMART; SM00248; ANK; 6.
DR   SMART; SM00454; SAM; 2.
DR   SMART; SM00326; SH3; 1.
DR   SUPFAM; SSF47769; SSF47769; 2.
DR   SUPFAM; SSF48403; SSF48403; 1.
DR   SUPFAM; SSF50044; SSF50044; 1.
DR   PROSITE; PS50297; ANK_REP_REGION; 1.
DR   PROSITE; PS50088; ANK_REPEAT; 6.
DR   PROSITE; PS50105; SAM_DOMAIN; 2.
DR   PROSITE; PS50002; SH3; 1.
PE   4: Predicted;
KW   ANK repeat {ECO:0000256|PROSITE-ProRule:PRU00023,
KW   ECO:0000256|SAAS:SAAS00752027};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005447};
KW   Repeat {ECO:0000256|SAAS:SAAS00752241};
KW   SH3 domain {ECO:0000256|PROSITE-ProRule:PRU00192}.
FT   DOMAIN          41..289
FT                   /note="ANK_REP_REGION"
FT                   /evidence="ECO:0000259|PROSITE:PS50297"
FT   REPEAT          48..80
FT                   /note="ANK"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT   REPEAT          81..113
FT                   /note="ANK"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT   REPEAT          114..146
FT                   /note="ANK"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT   REPEAT          147..171
FT                   /note="ANK"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT   REPEAT          188..220
FT                   /note="ANK"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT   REPEAT          220..252
FT                   /note="ANK"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT   DOMAIN          281..347
FT                   /note="SH3"
FT                   /evidence="ECO:0000259|PROSITE:PS50002"
FT   DOMAIN          472..535
FT                   /note="SAM"
FT                   /evidence="ECO:0000259|PROSITE:PS50105"
FT   DOMAIN          541..605
FT                   /note="SAM"
FT                   /evidence="ECO:0000259|PROSITE:PS50105"
FT   REGION          349..372
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          385..407
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          420..456
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          630..998
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1011..1039
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1072..1369
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1385..1413
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        354..372
FT                   /note="Polar"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        646..660
FT                   /note="Polar"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        869..895
FT                   /note="Polyampholyte"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1083..1098
FT                   /note="Polyampholyte"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1141..1158
FT                   /note="Polyampholyte"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1162..1177
FT                   /note="Polar"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1184..1230
FT                   /note="Pro-rich"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1263..1281
FT                   /note="Pro-rich"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1283..1297
FT                   /note="Polar"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1298..1312
FT                   /note="Pro-rich"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1319..1336
FT                   /note="Pro-rich"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1427 AA;  150523 MW;  68F83F0EBE47164F CRC64;
     MGKEQELVQA VKAEDVGTAQ RLLQRARPGK AKLLGSTKKI NVNFQDPDGF SALHHAALNG
     NTELISLLLE AQAAVDIKDN KGMRPLHYAA WQGRKEPMKL VLKAGSAVNV PSDEGHIPLH
     LAAQHGHYDV SEMLLQHQSN PCMVDNSGKT PLDLACEFGR VGVVQLLLSS NMCAALLEPR
     PSDTTDPNGT SPLHLAAKNG HIDIIRLLLQ AGIDINRQTK SGTALHEAAL CGKTEVVRLL
     LDSGINAQVR NTYSQTALDI VHQFTTSQAS KEIKQLLREA SAALQVRATK DYCNNYDLTS
     LNVKAGDIIT VLEQHPDGRW KGCIHDNRTG NDRVGYFPSS LGEAIVKRAG SRVGSEPSTA
     QVGSSSGSSA PSEEIWVLRK PFAGGDRSGS LSSVAGGRSG GGHTLHAGSE GVKLLATVLS
     QKSVSESSPG DSPVKPPEGT TGAARSQPPV AHTGQVYVEQ PPKKLEPASE GKSAEAVSQW
     LATFQLQLYA PNFTSAGYDL PTISRMTPED LTAIGVTKPG HRKKITAEIS GLNIPDWLPE
     HKPANLAVWL SMIGLAQYYK VLVDNGYENI DFITDITWED LQEIGITKLG HQKKLMLAVR
     KLAELQKAEY AKYEGGPLRR KAPQSLEMMA IESPPPPEPA PADCQSPKMT TFQDSELSGE
     LQAAMTGPAE GGTAEKPSNH LPTPKATMRH EPSLGGRVRH MSSSQELLGE GPPGSGSPMS
     RSQEYLLDEG QVPGTPPKEV RPSRHGHSVK RASVPPVPGK PRQVLPPSGS HFTPPQTPTK
     ARPGSPQALT GPHGPSPVTA KVKPTPQLLP PTERPMSPRS LPQSPTHRGF AYVLPQPVEG
     DTGPATPGPV PQTMPVAVPT LCLPPEAEAE PGRPKKRAHS LNRYAASDSE PERDELLVPA
     AAGPYATVQR RVGRSHSVRA PAGTDKNVNR SQSFAVRPRK KGPPPPPPKR SSSAMASANL
     VDEPAPDAET EDDRLGVRAQ RRRASDLAGS VDTGSAGSVK SIAAMLELSS IGGGGRAARR
     PPEGHPTPHP ASPEPGRVAT VLASVKHKEA IGPDGEVVNR RRTLSGPVTG LLATARQGPG
     EPTDHGHFVE DGKARQRPQG PAKGETSVDG PPLARVEASA TLKRRIRAKQ NQQENVKFIL
     TESDTVKRRP KAKEREAGSE TLPSLSVYQN GTATVRRRPA SEQAGPPELP PPPPPAEPPP
     TDLAHLPPLP LPEGDARKPA KPPVSPKPVL TQPVPKIQGS PTPSSKKVPL PGPGSPEVKR
     AHGTPPPVSP KPPPPPTAPK PAKATTGLQS GSTTPSPAPS PVRQPPAALA KPASTPPSLS
     ASPAKPPSPS APALHVPAKP PRAAAAAAAG APTVLDGASP GDSARQKLEE TSACLAAALQ
     AVEEKIRQED RQGSRPSAAE EKSTGSILDD IGSMFDDLAD QLDAMLE
//
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