ID A0A286XL18_CAVPO Unreviewed; 1017 AA.
AC A0A286XL18;
DT 22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 1.
DT 27-MAR-2024, entry version 32.
DE SubName: Full=EGF like, fibronectin type III and laminin G domains {ECO:0000313|Ensembl:ENSCPOP00000026144.1};
GN Name=EGFLAM {ECO:0000313|Ensembl:ENSCPOP00000026144.1};
OS Cavia porcellus (Guinea pig).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Hystricomorpha; Caviidae;
OC Cavia.
OX NCBI_TaxID=10141 {ECO:0000313|Ensembl:ENSCPOP00000026144.1, ECO:0000313|Proteomes:UP000005447};
RN [1] {ECO:0000313|Proteomes:UP000005447}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=2N {ECO:0000313|Proteomes:UP000005447};
RX PubMed=21993624; DOI=10.1038/nature10530;
RA Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J., Washietl S.,
RA Kheradpour P., Ernst J., Jordan G., Mauceli E., Ward L.D., Lowe C.B.,
RA Holloway A.K., Clamp M., Gnerre S., Alfoldi J., Beal K., Chang J.,
RA Clawson H., Cuff J., Di Palma F., Fitzgerald S., Flicek P., Guttman M.,
RA Hubisz M.J., Jaffe D.B., Jungreis I., Kent W.J., Kostka D., Lara M.,
RA Martins A.L., Massingham T., Moltke I., Raney B.J., Rasmussen M.D.,
RA Robinson J., Stark A., Vilella A.J., Wen J., Xie X., Zody M.C., Baldwin J.,
RA Bloom T., Chin C.W., Heiman D., Nicol R., Nusbaum C., Young S.,
RA Wilkinson J., Worley K.C., Kovar C.L., Muzny D.M., Gibbs R.A., Cree A.,
RA Dihn H.H., Fowler G., Jhangiani S., Joshi V., Lee S., Lewis L.R.,
RA Nazareth L.V., Okwuonu G., Santibanez J., Warren W.C., Mardis E.R.,
RA Weinstock G.M., Wilson R.K., Delehaunty K., Dooling D., Fronik C.,
RA Fulton L., Fulton B., Graves T., Minx P., Sodergren E., Birney E.,
RA Margulies E.H., Herrero J., Green E.D., Haussler D., Siepel A., Goldman N.,
RA Pollard K.S., Pedersen J.S., Lander E.S., Kellis M.;
RT "A high-resolution map of human evolutionary constraint using 29 mammals.";
RL Nature 478:476-482(2011).
RN [2] {ECO:0000313|Ensembl:ENSCPOP00000026144.1}
RP IDENTIFICATION.
RC STRAIN=2N {ECO:0000313|Ensembl:ENSCPOP00000026144.1};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00076}.
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DR EMBL; AAKN02031789; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAKN02031790; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAKN02031791; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAKN02031792; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAKN02031793; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAKN02031794; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_005003842.2; XM_005003785.2.
DR AlphaFoldDB; A0A286XL18; -.
DR STRING; 10141.ENSCPOP00000026144; -.
DR Ensembl; ENSCPOT00000031917.1; ENSCPOP00000026144.1; ENSCPOG00000002020.4.
DR GeneID; 100716729; -.
DR KEGG; cpoc:100716729; -.
DR CTD; 133584; -.
DR VEuPathDB; HostDB:ENSCPOG00000002020; -.
DR GeneTree; ENSGT00940000158504; -.
DR InParanoid; A0A286XL18; -.
DR OMA; CGEGTIE; -.
DR OrthoDB; 2878505at2759; -.
DR Proteomes; UP000005447; Unassembled WGS sequence.
DR Bgee; ENSCPOG00000002020; Expressed in ovary and 9 other cell types or tissues.
DR GO; GO:0005604; C:basement membrane; IEA:Ensembl.
DR GO; GO:0042995; C:cell projection; IEA:UniProtKB-KW.
DR GO; GO:0005614; C:interstitial matrix; IEA:Ensembl.
DR GO; GO:0098684; C:photoreceptor ribbon synapse; IEA:Ensembl.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR GO; GO:0005539; F:glycosaminoglycan binding; IEA:Ensembl.
DR GO; GO:0030198; P:extracellular matrix organization; IEA:Ensembl.
DR GO; GO:0010811; P:positive regulation of cell-substrate adhesion; IEA:Ensembl.
DR CDD; cd00054; EGF_CA; 2.
DR CDD; cd00063; FN3; 2.
DR CDD; cd00110; LamG; 3.
DR Gene3D; 2.60.120.200; -; 3.
DR Gene3D; 2.60.40.10; Immunoglobulins; 2.
DR Gene3D; 2.10.25.10; Laminin; 2.
DR InterPro; IPR013320; ConA-like_dom_sf.
DR InterPro; IPR001881; EGF-like_Ca-bd_dom.
DR InterPro; IPR013032; EGF-like_CS.
DR InterPro; IPR000742; EGF-like_dom.
DR InterPro; IPR003961; FN3_dom.
DR InterPro; IPR036116; FN3_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR001791; Laminin_G.
DR PANTHER; PTHR15036:SF88; PIKACHURIN; 1.
DR PANTHER; PTHR15036; PIKACHURIN-LIKE PROTEIN; 1.
DR Pfam; PF00008; EGF; 1.
DR Pfam; PF00041; fn3; 2.
DR Pfam; PF12661; hEGF; 1.
DR Pfam; PF00054; Laminin_G_1; 1.
DR Pfam; PF02210; Laminin_G_2; 2.
DR SMART; SM00181; EGF; 3.
DR SMART; SM00179; EGF_CA; 2.
DR SMART; SM00060; FN3; 2.
DR SMART; SM00282; LamG; 3.
DR SUPFAM; SSF49899; Concanavalin A-like lectins/glucanases; 3.
DR SUPFAM; SSF49265; Fibronectin type III; 1.
DR PROSITE; PS00022; EGF_1; 3.
DR PROSITE; PS01186; EGF_2; 2.
DR PROSITE; PS50026; EGF_3; 3.
DR PROSITE; PS50853; FN3; 2.
DR PROSITE; PS50025; LAM_G_DOMAIN; 3.
PE 4: Predicted;
KW Cell projection {ECO:0000256|ARBA:ARBA00023273};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00076};
KW EGF-like domain {ECO:0000256|ARBA:ARBA00022536, ECO:0000256|PROSITE-
KW ProRule:PRU00076}; Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Reference proteome {ECO:0000313|Proteomes:UP000005447};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}; Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..23
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 24..1017
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5011791879"
FT DOMAIN 37..147
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 153..248
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 351..389
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 394..572
FT /note="Laminin G"
FT /evidence="ECO:0000259|PROSITE:PS50025"
FT DOMAIN 573..610
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 617..796
FT /note="Laminin G"
FT /evidence="ECO:0000259|PROSITE:PS50025"
FT DOMAIN 792..828
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 835..1014
FT /note="Laminin G"
FT /evidence="ECO:0000259|PROSITE:PS50025"
FT REGION 301..338
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT DISULFID 360..377
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 379..388
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 600..609
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 818..827
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 987..1014
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00122"
SQ SEQUENCE 1017 AA; 111336 MW; A12D233597CA4C6A CRC64;
MDLIRGILLR LLLLASSLRP GAAPFPAALR LPGKLGPPLD IKLDALNCTA FSIKWKMPRS
TGSPIIGYTV FYSEVGADKS LWEQSRIVPF SWDTPVTGPT GHQTIFEEVI GNLKPGTEYR
VSIAAYSQTA KGRLSSPRHI TILSQDPCLP PAAPQQPHVL VVSDSRVALS WKPGESEGSS
PIRYYSVEFI RPDFDKNWTL IQEHFQMDTV VIKGLIPDTS YQFAVRAVNA HGSSPRSLPS
DTVRTLRPRE AESGQYGHYI TNMGIIMDDD GFEDNLNLNI SFEEVKPLPD TKGGHKKFLV
ESKTTSLSNP KTVSRPASPT SAPLSRTTAA LQPTPAQRKG TSGLAIMSRL FDLSCNETLC
SADSFCVNDY TLGGSRCHCN LGKGGESCSE DIVIQYPQFF GHSYVTFEPL KNSYQSFQIT
LEFRAEAEDG LLLYCGENEH GRGDFMSLAV IRRSLQFRFN CGTGVAIIIS GTKIKLGAWH
TVTLYRDGVN GLLQLNNDTP VTGQSQGQYS KITFRTPLYL GGAPSTYWLI RATGTNRNFH
GCVQSLAVNG RRIDMRPWPL GKALSGADVG ECSSGICDEA SCVNGGTCTA IKADSYICLC
PLGFKGHHCE DAFTLTIPQF RESLRSYAAV PWPLEPRHYL SFTEFEITFR PDSGDGVLLY
SYDTGSKDFL SITMAEGHVE FRFDCGSGTS ILRSEDPLTL GQWHELHVSR TAKNGILQVD
KQKVVEGMAE GGFTQIKCNT DIFIGGVPSY DEVKKNSGIF KPFSGSIQKI ILNDRTIDVR
HDFTSGVNVE NAAHPCVGSP CAHGGSCRPR KEGYECDCPL GFEGLHCQKA ITEAIEIPQF
IGRSYLTYDN PDILKRVSGS RSNAFMRFKT TAKDGLLMWR GDSPMRSNSD FISLGLRDGA
LVFSYNLGSG VASIMVNGSF NDGRWHRVKA VRDGQSGKIT VDDYGARTGK SPGMMRQLNI
NGALYVGGMK EIALHTNRQY TGGLVGCISH FTLSTDYHIS LVEDAVDGKN INTCGAK
//
