ID A0A286XMW5_CAVPO Unreviewed; 583 AA.
AC A0A286XMW5;
DT 22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 1.
DT 27-MAR-2024, entry version 29.
DE SubName: Full=Metadherin {ECO:0000313|Ensembl:ENSCPOP00000026836.1};
GN Name=MTDH {ECO:0000313|Ensembl:ENSCPOP00000026836.1};
OS Cavia porcellus (Guinea pig).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Hystricomorpha; Caviidae;
OC Cavia.
OX NCBI_TaxID=10141 {ECO:0000313|Ensembl:ENSCPOP00000026836.1, ECO:0000313|Proteomes:UP000005447};
RN [1] {ECO:0000313|Proteomes:UP000005447}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=2N {ECO:0000313|Proteomes:UP000005447};
RX PubMed=21993624; DOI=10.1038/nature10530;
RA Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J., Washietl S.,
RA Kheradpour P., Ernst J., Jordan G., Mauceli E., Ward L.D., Lowe C.B.,
RA Holloway A.K., Clamp M., Gnerre S., Alfoldi J., Beal K., Chang J.,
RA Clawson H., Cuff J., Di Palma F., Fitzgerald S., Flicek P., Guttman M.,
RA Hubisz M.J., Jaffe D.B., Jungreis I., Kent W.J., Kostka D., Lara M.,
RA Martins A.L., Massingham T., Moltke I., Raney B.J., Rasmussen M.D.,
RA Robinson J., Stark A., Vilella A.J., Wen J., Xie X., Zody M.C., Baldwin J.,
RA Bloom T., Chin C.W., Heiman D., Nicol R., Nusbaum C., Young S.,
RA Wilkinson J., Worley K.C., Kovar C.L., Muzny D.M., Gibbs R.A., Cree A.,
RA Dihn H.H., Fowler G., Jhangiani S., Joshi V., Lee S., Lewis L.R.,
RA Nazareth L.V., Okwuonu G., Santibanez J., Warren W.C., Mardis E.R.,
RA Weinstock G.M., Wilson R.K., Delehaunty K., Dooling D., Fronik C.,
RA Fulton L., Fulton B., Graves T., Minx P., Sodergren E., Birney E.,
RA Margulies E.H., Herrero J., Green E.D., Haussler D., Siepel A., Goldman N.,
RA Pollard K.S., Pedersen J.S., Lander E.S., Kellis M.;
RT "A high-resolution map of human evolutionary constraint using 29 mammals.";
RL Nature 478:476-482(2011).
RN [2] {ECO:0000313|Ensembl:ENSCPOP00000026836.1}
RP IDENTIFICATION.
RC STRAIN=2N {ECO:0000313|Ensembl:ENSCPOP00000026836.1};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR EMBL; AAKN02000375; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAKN02000376; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_003479943.1; XM_003479895.3.
DR AlphaFoldDB; A0A286XMW5; -.
DR STRING; 10141.ENSCPOP00000026836; -.
DR Ensembl; ENSCPOT00000034448.1; ENSCPOP00000026836.1; ENSCPOG00000037219.1.
DR GeneID; 100718640; -.
DR KEGG; cpoc:100718640; -.
DR CTD; 92140; -.
DR VEuPathDB; HostDB:ENSCPOG00000037219; -.
DR eggNOG; ENOG502QU7P; Eukaryota.
DR GeneTree; ENSGT00940000154181; -.
DR InParanoid; A0A286XMW5; -.
DR OMA; TTDFQWD; -.
DR OrthoDB; 5363141at2759; -.
DR Proteomes; UP000005447; Unassembled WGS sequence.
DR Bgee; ENSCPOG00000037219; Expressed in zone of skin and 12 other cell types or tissues.
DR GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:Ensembl.
DR GO; GO:0001650; C:fibrillar center; IEA:Ensembl.
DR GO; GO:0016604; C:nuclear body; IEA:Ensembl.
DR GO; GO:0048471; C:perinuclear region of cytoplasm; IEA:Ensembl.
DR GO; GO:0003725; F:double-stranded RNA binding; IEA:Ensembl.
DR GO; GO:0051059; F:NF-kappaB binding; IEA:Ensembl.
DR GO; GO:0003713; F:transcription coactivator activity; IEA:Ensembl.
DR GO; GO:0031663; P:lipopolysaccharide-mediated signaling pathway; IEA:Ensembl.
DR GO; GO:0043066; P:negative regulation of apoptotic process; IEA:Ensembl.
DR GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; IEA:Ensembl.
DR GO; GO:0045766; P:positive regulation of angiogenesis; IEA:Ensembl.
DR GO; GO:0010508; P:positive regulation of autophagy; IEA:Ensembl.
DR GO; GO:0043123; P:positive regulation of canonical NF-kappaB signal transduction; IEA:Ensembl.
DR GO; GO:0051897; P:positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction; IEA:Ensembl.
DR InterPro; IPR031402; LYRIC.
DR PANTHER; PTHR23251; LYSINE-RICH CEACAM1 CO-ISOLATED PROTEIN LYRIC PROTEIN; 1.
DR PANTHER; PTHR23251:SF0; PROTEIN LYRIC; 1.
DR Pfam; PF15686; LYRIC; 1.
PE 4: Predicted;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000005447};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 50..78
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT REGION 78..220
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 280..583
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 106..144
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 171..199
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 280..302
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 321..338
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 345..370
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 403..441
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 453..480
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 481..503
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 526..567
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 583 AA; 63914 MW; 20B3AD119AB6ECAB CRC64;
MAAQTWQEEL AQQAEEGSAR LREMLSVALG FLRTELGLDL GLEPRRYPGW VILVGAGALG
LLLLVLLGYG WAAACAGARK KRRSPPRRRE EAVAAPGPAP DDSALLRSVR GEEPKKKNRK
KQPEKPKPNG RTVEVAEDEI VRTPRSVTAK QPAEADKKNE KSKKNKKKSK SDAKAVQNSS
RHDGKEVDEG AWETKISHRE KRQQRKRDKV LTDSGSLDST ISGIENTITV TTEQLTTASF
PVGSKKNKGD SHLNVQVSNF KSGKGESTLQ VSSGLNENLT VNGGGWNEKP VKLSSQMSAG
EEKWNSVPPA TTAGKRKAEP SAWTQDTSDT NLNGRDWGRN WSDRSIFSGI GSTAEPVSQS
STSDCQWDVS RNQPYIDDEW SGLNGLSSAD PSSDWNAPAE EWGNWVDEER ASLLKSQEPA
PDDEKVSDDD KEKGEGANTT GKSKKKKKKK KKQGEDTSVA QDTEELEKEI REELSVNTSK
TRPKQEKTFS SKTMSTSDPA EVLVKNSQPV KTLPPAVPTE PSVPPAKSDS DKSSSQVPPL
LQETDKSKSS TKQNSVPPSQ TKSETNWESP KQIKKKKKAR RET
//
