ID A0A286XNG1_CAVPO Unreviewed; 1060 AA.
AC A0A286XNG1;
DT 22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 1.
DT 27-MAR-2024, entry version 32.
DE SubName: Full=Pleckstrin homology and RUN domain containing M1 {ECO:0000313|Ensembl:ENSCPOP00000026942.1};
GN Name=PLEKHM1 {ECO:0000313|Ensembl:ENSCPOP00000026942.1};
OS Cavia porcellus (Guinea pig).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Hystricomorpha; Caviidae;
OC Cavia.
OX NCBI_TaxID=10141 {ECO:0000313|Ensembl:ENSCPOP00000026942.1, ECO:0000313|Proteomes:UP000005447};
RN [1] {ECO:0000313|Proteomes:UP000005447}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=2N {ECO:0000313|Proteomes:UP000005447};
RX PubMed=21993624; DOI=10.1038/nature10530;
RA Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J., Washietl S.,
RA Kheradpour P., Ernst J., Jordan G., Mauceli E., Ward L.D., Lowe C.B.,
RA Holloway A.K., Clamp M., Gnerre S., Alfoldi J., Beal K., Chang J.,
RA Clawson H., Cuff J., Di Palma F., Fitzgerald S., Flicek P., Guttman M.,
RA Hubisz M.J., Jaffe D.B., Jungreis I., Kent W.J., Kostka D., Lara M.,
RA Martins A.L., Massingham T., Moltke I., Raney B.J., Rasmussen M.D.,
RA Robinson J., Stark A., Vilella A.J., Wen J., Xie X., Zody M.C., Baldwin J.,
RA Bloom T., Chin C.W., Heiman D., Nicol R., Nusbaum C., Young S.,
RA Wilkinson J., Worley K.C., Kovar C.L., Muzny D.M., Gibbs R.A., Cree A.,
RA Dihn H.H., Fowler G., Jhangiani S., Joshi V., Lee S., Lewis L.R.,
RA Nazareth L.V., Okwuonu G., Santibanez J., Warren W.C., Mardis E.R.,
RA Weinstock G.M., Wilson R.K., Delehaunty K., Dooling D., Fronik C.,
RA Fulton L., Fulton B., Graves T., Minx P., Sodergren E., Birney E.,
RA Margulies E.H., Herrero J., Green E.D., Haussler D., Siepel A., Goldman N.,
RA Pollard K.S., Pedersen J.S., Lander E.S., Kellis M.;
RT "A high-resolution map of human evolutionary constraint using 29 mammals.";
RL Nature 478:476-482(2011).
RN [2] {ECO:0000313|Ensembl:ENSCPOP00000026942.1}
RP IDENTIFICATION.
RC STRAIN=2N {ECO:0000313|Ensembl:ENSCPOP00000026942.1};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR EMBL; AAKN02045612; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_003465777.1; XM_003465729.3.
DR AlphaFoldDB; A0A286XNG1; -.
DR STRING; 10141.ENSCPOP00000026942; -.
DR Ensembl; ENSCPOT00000044335.1; ENSCPOP00000026942.1; ENSCPOG00000011348.4.
DR GeneID; 100719025; -.
DR KEGG; cpoc:100719025; -.
DR CTD; 9842; -.
DR VEuPathDB; HostDB:ENSCPOG00000011348; -.
DR eggNOG; KOG1829; Eukaryota.
DR GeneTree; ENSGT00940000155111; -.
DR InParanoid; A0A286XNG1; -.
DR OMA; HVLNCDL; -.
DR OrthoDB; 126314at2759; -.
DR Proteomes; UP000005447; Unassembled WGS sequence.
DR Bgee; ENSCPOG00000011348; Expressed in adrenal gland and 13 other cell types or tissues.
DR GO; GO:0044754; C:autolysosome; IEA:Ensembl.
DR GO; GO:0005768; C:endosome; IEA:UniProtKB-KW.
DR GO; GO:0005730; C:nucleolus; IEA:Ensembl.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0061909; P:autophagosome-lysosome fusion; IEA:Ensembl.
DR GO; GO:1902774; P:late endosome to lysosome transport; IEA:Ensembl.
DR GO; GO:0032418; P:lysosome localization; IEA:Ensembl.
DR GO; GO:0045780; P:positive regulation of bone resorption; IEA:Ensembl.
DR GO; GO:1900029; P:positive regulation of ruffle assembly; IEA:Ensembl.
DR CDD; cd13321; PH_PLEKHM1; 1.
DR CDD; cd17679; RUN_PLEKHM1; 1.
DR Gene3D; 1.20.58.900; -; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR InterPro; IPR002219; PE/DAG-bd.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR042827; PLEKHM1_PH.
DR InterPro; IPR025258; RH_dom.
DR InterPro; IPR004012; Run_dom.
DR InterPro; IPR037213; Run_dom_sf.
DR InterPro; IPR047326; RUN_PLEKHM1.
DR PANTHER; PTHR12326; PLECKSTRIN HOMOLOGY DOMAIN CONTAINING PROTEIN; 1.
DR PANTHER; PTHR12326:SF5; PLECKSTRIN HOMOLOGY DOMAIN-CONTAINING FAMILY M MEMBER 1; 1.
DR Pfam; PF00169; PH; 1.
DR Pfam; PF13901; RH_dom; 1.
DR Pfam; PF02759; RUN; 1.
DR SMART; SM00109; C1; 1.
DR SMART; SM01175; DUF4206; 1.
DR SMART; SM00233; PH; 2.
DR SMART; SM00593; RUN; 1.
DR SUPFAM; SSF50729; PH domain-like; 2.
DR SUPFAM; SSF140741; RUN domain-like; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
DR PROSITE; PS50826; RUN; 1.
DR PROSITE; PS50081; ZF_DAG_PE_2; 1.
PE 4: Predicted;
KW Autophagy {ECO:0000256|ARBA:ARBA00023006};
KW Endosome {ECO:0000256|ARBA:ARBA00022753};
KW Lysosome {ECO:0000256|ARBA:ARBA00023228};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000005447};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771}.
FT DOMAIN 41..183
FT /note="RUN"
FT /evidence="ECO:0000259|PROSITE:PS50826"
FT DOMAIN 537..628
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT DOMAIN 990..1044
FT /note="Phorbol-ester/DAG-type"
FT /evidence="ECO:0000259|PROSITE:PS50081"
FT REGION 223..246
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 258..305
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 355..381
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 396..423
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 450..470
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 645..670
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 258..285
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 396..422
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1060 AA; 117769 MW; 4A0D0DB73C8CA288 CRC64;
MLSVVENGLD PRATIPVIKK KLVESVKALQ KQYVSLDTAV TSEDGDANIM CSALEAVFIH
GLHAKHIRTE SGGKWKKSTH QKPLPQPVFW SLLKAVTHKH IISDLEHLAF VNTDVGRCRA
WLRLALNDGL MECYLKLLLQ EQMRLCEYYQ PTALLRDAEE GEFLLSFLQG LTSLSFELSY
KSAILNEWTL TPLALSGLCP LSELEPLPTS SIEFQRKESL DSISHSSGSE DIEVQHSGHK
IRQNRKLTAS SLSLDTATSS QMSCSPNSDS CLLQENGSKS PGRSEEPMSY DSDLGTANAD
DSDQSLQEVL SELSKAQVNS VPTCGPSQES EIAILQAPLS FHDLAISTHL LSDMPAESLP
DCTSSRTPGG DYEQEPLPQA LGTPHVKQPV IAQACPAGST SGQQPSDPGR EVSGTVGQGS
SLQKALEDRR LGLKLVVPSP TSPEIKSWIS EDDFYRPPQD PTPNNAGAAS KGFLEPKAAL
HQCCSQGPKK SCSNGTLDKM CMHSPGHRST RAAPVQEHKN FWVVHRRQMG LSNPFRGLLK
LGTVSRRGAM GIWKELFCEL SPMELRLYLS DKERTCVESC SLLRCESVGP AHSDGRFELV
FSSKKLALRA SSQDEAEDWL DRVREALQKV RPQQEDEWVT IEYPDQPEEP AEVPPGSHPS
YSALLPAPAS PQSSQCDWTS AQVPEPDAIK ESLLYLYADR TWMPYIFSLS LESLKCFRVR
NNEKMLSDSH GVETIRDILP DTSLGGPAFF KIITAKAILK LQAGNAKEAA LWRDLVRKVL
ASYLEMAEEA VTLGGSLDES CQEVLKFATR ENGFLLQYLV AIPTEKGLDS QGCFCAGCSR
QIGFSFVRPK LCAFSGLYYC DICHQDDTSV IPARIIHNWD LTKRPVCRQA LKFLAQIQAQ
PLINLQLVNP SLYDHVEQMH LISQKREQLK LLGDYLGLCR SGALKELNKR LGYRHYLLES
PHKFSVADLQ QIAEGLYEGF LKVLIEFASQ HVYHCDLCTQ RGFICQICHH SDIIFPFEFD
TTVRCAECKT VFHQSCQTVV KKGCPRCARR RKYLEQNSLS
//
