ID A0A286XP38_CAVPO Unreviewed; 1422 AA.
AC A0A286XP38;
DT 22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 1.
DT 27-MAR-2024, entry version 30.
DE SubName: Full=Capping protein regulator and myosin 1 linker 1 {ECO:0000313|Ensembl:ENSCPOP00000027254.1};
GN Name=CARMIL1 {ECO:0000313|Ensembl:ENSCPOP00000027254.1};
OS Cavia porcellus (Guinea pig).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Hystricomorpha; Caviidae;
OC Cavia.
OX NCBI_TaxID=10141 {ECO:0000313|Ensembl:ENSCPOP00000027254.1, ECO:0000313|Proteomes:UP000005447};
RN [1] {ECO:0000313|Proteomes:UP000005447}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=2N {ECO:0000313|Proteomes:UP000005447};
RX PubMed=21993624; DOI=10.1038/nature10530;
RA Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J., Washietl S.,
RA Kheradpour P., Ernst J., Jordan G., Mauceli E., Ward L.D., Lowe C.B.,
RA Holloway A.K., Clamp M., Gnerre S., Alfoldi J., Beal K., Chang J.,
RA Clawson H., Cuff J., Di Palma F., Fitzgerald S., Flicek P., Guttman M.,
RA Hubisz M.J., Jaffe D.B., Jungreis I., Kent W.J., Kostka D., Lara M.,
RA Martins A.L., Massingham T., Moltke I., Raney B.J., Rasmussen M.D.,
RA Robinson J., Stark A., Vilella A.J., Wen J., Xie X., Zody M.C., Baldwin J.,
RA Bloom T., Chin C.W., Heiman D., Nicol R., Nusbaum C., Young S.,
RA Wilkinson J., Worley K.C., Kovar C.L., Muzny D.M., Gibbs R.A., Cree A.,
RA Dihn H.H., Fowler G., Jhangiani S., Joshi V., Lee S., Lewis L.R.,
RA Nazareth L.V., Okwuonu G., Santibanez J., Warren W.C., Mardis E.R.,
RA Weinstock G.M., Wilson R.K., Delehaunty K., Dooling D., Fronik C.,
RA Fulton L., Fulton B., Graves T., Minx P., Sodergren E., Birney E.,
RA Margulies E.H., Herrero J., Green E.D., Haussler D., Siepel A., Goldman N.,
RA Pollard K.S., Pedersen J.S., Lander E.S., Kellis M.;
RT "A high-resolution map of human evolutionary constraint using 29 mammals.";
RL Nature 478:476-482(2011).
RN [2] {ECO:0000313|Ensembl:ENSCPOP00000027254.1}
RP IDENTIFICATION.
RC STRAIN=2N {ECO:0000313|Ensembl:ENSCPOP00000027254.1};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the CARMIL family.
CC {ECO:0000256|ARBA:ARBA00007298}.
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DR EMBL; AAKN02037284; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAKN02037285; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAKN02037286; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAKN02037287; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAKN02037288; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAKN02037289; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_013006867.1; XM_013151413.1.
DR STRING; 10141.ENSCPOP00000027254; -.
DR Ensembl; ENSCPOT00000038515.1; ENSCPOP00000027254.1; ENSCPOG00000012999.4.
DR GeneID; 100724925; -.
DR KEGG; cpoc:100724925; -.
DR CTD; 55604; -.
DR VEuPathDB; HostDB:ENSCPOG00000012999; -.
DR GeneTree; ENSGT00940000155112; -.
DR InParanoid; A0A286XP38; -.
DR OMA; DKQENRV; -.
DR OrthoDB; 5476233at2759; -.
DR Proteomes; UP000005447; Unassembled WGS sequence.
DR Bgee; ENSCPOG00000012999; Expressed in uterine cervix and 13 other cell types or tissues.
DR GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR GO; GO:0031941; C:filamentous actin; IEA:Ensembl.
DR GO; GO:0030027; C:lamellipodium; IEA:Ensembl.
DR GO; GO:0044354; C:macropinosome; IEA:Ensembl.
DR GO; GO:0016607; C:nuclear speck; IEA:Ensembl.
DR GO; GO:0005886; C:plasma membrane; IEA:Ensembl.
DR GO; GO:0044877; F:protein-containing complex binding; IEA:Ensembl.
DR GO; GO:0051639; P:actin filament network formation; IEA:Ensembl.
DR GO; GO:0051638; P:barbed-end actin filament uncapping; IEA:Ensembl.
DR GO; GO:0016477; P:cell migration; IEA:Ensembl.
DR GO; GO:0030032; P:lamellipodium assembly; IEA:Ensembl.
DR GO; GO:0044351; P:macropinocytosis; IEA:Ensembl.
DR GO; GO:2000813; P:negative regulation of barbed-end actin filament capping; IEA:Ensembl.
DR GO; GO:0030335; P:positive regulation of cell migration; IEA:Ensembl.
DR GO; GO:1902745; P:positive regulation of lamellipodium organization; IEA:Ensembl.
DR GO; GO:0051496; P:positive regulation of stress fiber assembly; IEA:Ensembl.
DR GO; GO:1900026; P:positive regulation of substrate adhesion-dependent cell spreading; IEA:Ensembl.
DR GO; GO:0031529; P:ruffle organization; IEA:Ensembl.
DR GO; GO:0046415; P:urate metabolic process; IEA:Ensembl.
DR Gene3D; 6.10.140.1850; -; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 1.
DR InterPro; IPR031943; CARMIL_C.
DR InterPro; IPR041245; CARMIL_PH.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR011993; PH-like_dom_sf.
DR PANTHER; PTHR24112:SF39; F-ACTIN-UNCAPPING PROTEIN LRRC16A; 1.
DR PANTHER; PTHR24112; LEUCINE-RICH REPEAT, ISOFORM F-RELATED; 1.
DR Pfam; PF17888; Carm_PH; 1.
DR Pfam; PF16000; CARMIL_C; 1.
DR Pfam; PF13516; LRR_6; 3.
DR SMART; SM00368; LRR_RI; 6.
DR SUPFAM; SSF52047; RNI-like; 2.
PE 3: Inferred from homology;
KW Leucine-rich repeat {ECO:0000256|ARBA:ARBA00022614};
KW Reference proteome {ECO:0000313|Proteomes:UP000005447}.
FT DOMAIN 26..119
FT /note="CARMIL pleckstrin homology"
FT /evidence="ECO:0000259|Pfam:PF17888"
FT DOMAIN 786..1078
FT /note="CARMIL C-terminal"
FT /evidence="ECO:0000259|Pfam:PF16000"
FT REGION 957..976
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1036..1422
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1036..1069
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1102..1150
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1241..1255
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1313..1328
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1330..1349
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1370..1409
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1422 AA; 157190 MW; DFCEDC9881E4758A CRC64;
MTEESADVPR ELLESIKDVI GRKIKIAMKK KVKLEVKGDK VENKVLVLTS CRAFLVTARI
PTKLELTFSY LEIHGVVCTR PAQMVVETEK CNISMKMAAP EDVSDVLGHI GTCLRKIFPG
LSPVRIMKKV SMEPSERLAS LQALWDGQTV AEQGPCGGFS QMYACVCDWL GFSYREEVQW
DVDTIYLTQD TRELNLQDFS HLDHRDLIPI IAALEYNQWF TKLSSKDLKL STDVCEQILR
VVSRSNRLEE LVLENAGLRI DFAQKLAFAL AHNPNSGLHT INLAGNPLED RGVSSLSIQF
AKLPKGLKHL NLSKTSLSPK GVNSLSQSLS ANPLTASTLT HLDLSGNVLR GDDLSHLYNF
LAQPNAIAYL DLSNTECSLD MVCGALLRGC LQYLAVLNLS RTVFSHRKGK EVPLSFKQFF
SSSLALMQIN LSGTKLSPEP LKALLLGLAC NHNLKGVSLD LSNCELRSGG AQVLEGCIAE
IHNITSLDIS DNGLESDLST LIVWLSKNRS IQHLALGKNF NNMKSKNLTP VLDNLVQMIQ
DEDSPLQSLS LADSKLKTEV TIIINALGSN TSLTKVDISG NGMGDMGAKM LAKALQINTK
LRTVIWDKNN ITAQGFQDIA VAMEKNYTLR FMPIPMYDAS QALKTNPEKT EEALQKIENY
LLRNHETRKY LQEQAYRLQQ GIVTSTTQQM IDRICVKVQD HLNSLRNCGG DAIQEDLKSA
ERLMRDAKNS KTLLPNLYHV GGACWAGASG LLSSPIQETL ESMAGEVTRV VDEQLKALLE
SMVDAAENLC PNVMKKAHIR QDLIHASTEK ISIPRTFVKN VLLEQSGVDI LNKISEVKLT
VASFLSDRIV DEILDALSHC HHKLADHFNR RGKTLPQQDS LDIELAEEKP AKRSLITVEE
LTEVERLEDL DTCMMTPKSK RKSIHSRMLR PVSRAFEMEF DLDKALEEVP IHVEDPPFPS
VRQEKRSSGF ISELPSEEGR KLEHFTKLRP KRNKKQQPTQ AAVCAAAIVS QDGEQNGLMG
RVDEGVDEFF TKKVTKMDSK RTSARGSESH ELSEGGDEKK KRDSRKSGFL NLIKSRSKCE
RPPTVLMTEE PSSPKGAVRG SAVDTPRKEP KATEHNGNSD RAEEIKTPDS IDESLGEEAG
HTERGDSRSS PQAGRRYGVQ VMGSSLLAEM KAKQEQRAAC AQKKLGNDAM SQDYPSPTLS
SVERLDGGGA VPKLHPGLPE NRFGLGTPEK NAKAESKVEA SSRSRSSSCT PTSPKPLLQS
PKPTLAARPT IPQKPRTASR PEDVPDSPSG PSSPKVALLP PVLKKVPSDK ERDGQNSPQP
SPRTYSQEVQ RGDYYKRHSD HDSGKPSSRG KRSSKLSSTI AEEEVNAIGH RRSQPTNVSR
RSWGQQAQEY QEQRQQSSSK DGFQGSKSSD SGEEAEKEFI FV
//
