ID A0A286XPH6_CAVPO Unreviewed; 258 AA.
AC A0A286XPH6;
DT 22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 1.
DT 27-MAR-2024, entry version 29.
DE RecName: Full=catechol O-methyltransferase {ECO:0000256|ARBA:ARBA00012880};
DE EC=2.1.1.6 {ECO:0000256|ARBA:ARBA00012880};
DE AltName: Full=Catechol O-methyltransferase 2 {ECO:0000256|ARBA:ARBA00033047};
GN Name=TOMT {ECO:0000313|Ensembl:ENSCPOP00000027396.1};
OS Cavia porcellus (Guinea pig).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Hystricomorpha; Caviidae;
OC Cavia.
OX NCBI_TaxID=10141 {ECO:0000313|Ensembl:ENSCPOP00000027396.1, ECO:0000313|Proteomes:UP000005447};
RN [1] {ECO:0000313|Proteomes:UP000005447}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=2N {ECO:0000313|Proteomes:UP000005447};
RX PubMed=21993624; DOI=10.1038/nature10530;
RA Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J., Washietl S.,
RA Kheradpour P., Ernst J., Jordan G., Mauceli E., Ward L.D., Lowe C.B.,
RA Holloway A.K., Clamp M., Gnerre S., Alfoldi J., Beal K., Chang J.,
RA Clawson H., Cuff J., Di Palma F., Fitzgerald S., Flicek P., Guttman M.,
RA Hubisz M.J., Jaffe D.B., Jungreis I., Kent W.J., Kostka D., Lara M.,
RA Martins A.L., Massingham T., Moltke I., Raney B.J., Rasmussen M.D.,
RA Robinson J., Stark A., Vilella A.J., Wen J., Xie X., Zody M.C., Baldwin J.,
RA Bloom T., Chin C.W., Heiman D., Nicol R., Nusbaum C., Young S.,
RA Wilkinson J., Worley K.C., Kovar C.L., Muzny D.M., Gibbs R.A., Cree A.,
RA Dihn H.H., Fowler G., Jhangiani S., Joshi V., Lee S., Lewis L.R.,
RA Nazareth L.V., Okwuonu G., Santibanez J., Warren W.C., Mardis E.R.,
RA Weinstock G.M., Wilson R.K., Delehaunty K., Dooling D., Fronik C.,
RA Fulton L., Fulton B., Graves T., Minx P., Sodergren E., Birney E.,
RA Margulies E.H., Herrero J., Green E.D., Haussler D., Siepel A., Goldman N.,
RA Pollard K.S., Pedersen J.S., Lander E.S., Kellis M.;
RT "A high-resolution map of human evolutionary constraint using 29 mammals.";
RL Nature 478:476-482(2011).
RN [2] {ECO:0000313|Ensembl:ENSCPOP00000027396.1}
RP IDENTIFICATION.
RC STRAIN=2N {ECO:0000313|Ensembl:ENSCPOP00000027396.1};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a catechol + S-adenosyl-L-methionine = a guaiacol + H(+) + S-
CC adenosyl-L-homocysteine; Xref=Rhea:RHEA:17877, ChEBI:CHEBI:15378,
CC ChEBI:CHEBI:33566, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789,
CC ChEBI:CHEBI:134251; EC=2.1.1.6;
CC Evidence={ECO:0000256|ARBA:ARBA00001722};
CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:17878;
CC Evidence={ECO:0000256|ARBA:ARBA00001722};
CC -!- SUBCELLULAR LOCATION: Endoplasmic reticulum
CC {ECO:0000256|ARBA:ARBA00004240}.
CC -!- SIMILARITY: Belongs to the class I-like SAM-binding methyltransferase
CC superfamily. Cation-dependent O-methyltransferase family.
CC {ECO:0000256|ARBA:ARBA00023453}.
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DR EMBL; AAKN02051226; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_013000810.1; XM_013145356.1.
DR AlphaFoldDB; A0A286XPH6; -.
DR STRING; 10141.ENSCPOP00000027396; -.
DR Ensembl; ENSCPOT00000047827.1; ENSCPOP00000027396.1; ENSCPOG00000040520.1.
DR VEuPathDB; HostDB:ENSCPOG00000040520; -.
DR eggNOG; KOG1663; Eukaryota.
DR GeneTree; ENSGT00940000161220; -.
DR InParanoid; A0A286XPH6; -.
DR OMA; DLMLCEQ; -.
DR Proteomes; UP000005447; Unassembled WGS sequence.
DR Bgee; ENSCPOG00000040520; Expressed in cerebellum and 7 other cell types or tissues.
DR GO; GO:0045177; C:apical part of cell; IEA:Ensembl.
DR GO; GO:0005783; C:endoplasmic reticulum; IEA:UniProtKB-SubCell.
DR GO; GO:0016206; F:catechol O-methyltransferase activity; IEA:UniProtKB-EC.
DR GO; GO:0102084; F:L-dopa O-methyltransferase activity; IEA:UniProtKB-EC.
DR GO; GO:0102938; F:orcinol O-methyltransferase activity; IEA:UniProtKB-EC.
DR GO; GO:0060117; P:auditory receptor cell development; IEA:Ensembl.
DR GO; GO:0042424; P:catecholamine catabolic process; IEA:Ensembl.
DR GO; GO:0032259; P:methylation; IEA:UniProtKB-KW.
DR GO; GO:1904591; P:positive regulation of protein import; IEA:Ensembl.
DR GO; GO:0007605; P:sensory perception of sound; IEA:UniProtKB-KW.
DR CDD; cd02440; AdoMet_MTases; 1.
DR Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 1.
DR InterPro; IPR029063; SAM-dependent_MTases_sf.
DR InterPro; IPR002935; SAM_O-MeTrfase.
DR PANTHER; PTHR43836; CATECHOL O-METHYLTRANSFERASE 1-RELATED; 1.
DR PANTHER; PTHR43836:SF1; TRANSMEMBRANE O-METHYLTRANSFERASE; 1.
DR Pfam; PF01596; Methyltransf_3; 1.
DR SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 1.
DR PROSITE; PS51682; SAM_OMT_I; 1.
PE 3: Inferred from homology;
KW Catecholamine metabolism {ECO:0000256|ARBA:ARBA00022939};
KW Endoplasmic reticulum {ECO:0000256|ARBA:ARBA00022824};
KW Hearing {ECO:0000256|ARBA:ARBA00022740};
KW Methyltransferase {ECO:0000256|ARBA:ARBA00022603};
KW Neurotransmitter degradation {ECO:0000256|ARBA:ARBA00022867};
KW Reference proteome {ECO:0000313|Proteomes:UP000005447};
KW S-adenosyl-L-methionine {ECO:0000256|ARBA:ARBA00022691};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
SQ SEQUENCE 258 AA; 28869 MW; 854EDF03F181ECF8 CRC64;
MSPAIALAFL PLVVTLLVRY RHYFRLLVRT VLLRSLRDCL SGLRIEERAF SYVLTHALPG
DPGHILTTLD HWSSHCEYLS HMGPVKGQIL MRLVEEKAPV CVLELGTYCG YSTLLIARVL
SPGSHLLTVE RDPRTAAVAE KLIRLAGFDE RTVELIVGSS EEVIPRLRAQ HQQSRLDLVL
LAHRPRYYLR DLQLLEAHAL LPAGATVLAD HVLFPGAPRF LQYAKSCGRY RCRLHHTGLL
DFPAIKDGIA QLTYAGPG
//
