ID A0A286XPV6_CAVPO Unreviewed; 2112 AA.
AC A0A286XPV6;
DT 22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 1.
DT 27-MAR-2024, entry version 36.
DE SubName: Full=Tenascin C {ECO:0000313|Ensembl:ENSCPOP00000027305.1};
GN Name=TNC {ECO:0000313|Ensembl:ENSCPOP00000027305.1};
OS Cavia porcellus (Guinea pig).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Hystricomorpha; Caviidae;
OC Cavia.
OX NCBI_TaxID=10141 {ECO:0000313|Ensembl:ENSCPOP00000027305.1, ECO:0000313|Proteomes:UP000005447};
RN [1] {ECO:0000313|Proteomes:UP000005447}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=2N {ECO:0000313|Proteomes:UP000005447};
RX PubMed=21993624; DOI=10.1038/nature10530;
RA Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J., Washietl S.,
RA Kheradpour P., Ernst J., Jordan G., Mauceli E., Ward L.D., Lowe C.B.,
RA Holloway A.K., Clamp M., Gnerre S., Alfoldi J., Beal K., Chang J.,
RA Clawson H., Cuff J., Di Palma F., Fitzgerald S., Flicek P., Guttman M.,
RA Hubisz M.J., Jaffe D.B., Jungreis I., Kent W.J., Kostka D., Lara M.,
RA Martins A.L., Massingham T., Moltke I., Raney B.J., Rasmussen M.D.,
RA Robinson J., Stark A., Vilella A.J., Wen J., Xie X., Zody M.C., Baldwin J.,
RA Bloom T., Chin C.W., Heiman D., Nicol R., Nusbaum C., Young S.,
RA Wilkinson J., Worley K.C., Kovar C.L., Muzny D.M., Gibbs R.A., Cree A.,
RA Dihn H.H., Fowler G., Jhangiani S., Joshi V., Lee S., Lewis L.R.,
RA Nazareth L.V., Okwuonu G., Santibanez J., Warren W.C., Mardis E.R.,
RA Weinstock G.M., Wilson R.K., Delehaunty K., Dooling D., Fronik C.,
RA Fulton L., Fulton B., Graves T., Minx P., Sodergren E., Birney E.,
RA Margulies E.H., Herrero J., Green E.D., Haussler D., Siepel A., Goldman N.,
RA Pollard K.S., Pedersen J.S., Lander E.S., Kellis M.;
RT "A high-resolution map of human evolutionary constraint using 29 mammals.";
RL Nature 478:476-482(2011).
RN [2] {ECO:0000313|Ensembl:ENSCPOP00000027305.1}
RP IDENTIFICATION.
RC STRAIN=2N {ECO:0000313|Ensembl:ENSCPOP00000027305.1};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular
CC matrix {ECO:0000256|ARBA:ARBA00004498}.
CC -!- SIMILARITY: Belongs to the tenascin family.
CC {ECO:0000256|ARBA:ARBA00008673}.
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DR EMBL; AAKN02005294; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_012998381.1; XM_013142927.1.
DR Ensembl; ENSCPOT00000041519.1; ENSCPOP00000027305.1; ENSCPOG00000003429.4.
DR GeneID; 100725345; -.
DR CTD; 3371; -.
DR VEuPathDB; HostDB:ENSCPOG00000003429; -.
DR GeneTree; ENSGT00940000155188; -.
DR OrthoDB; 5489847at2759; -.
DR Proteomes; UP000005447; Unassembled WGS sequence.
DR Bgee; ENSCPOG00000003429; Expressed in uterine cervix and 11 other cell types or tissues.
DR GO; GO:0062023; C:collagen-containing extracellular matrix; IEA:UniProt.
DR CDD; cd00054; EGF_CA; 2.
DR CDD; cd00063; FN3; 14.
DR CDD; cd00087; FReD; 1.
DR Gene3D; 2.20.25.10; -; 1.
DR Gene3D; 3.90.215.10; Gamma Fibrinogen, chain A, domain 1; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 14.
DR Gene3D; 2.10.25.10; Laminin; 14.
DR InterPro; IPR000742; EGF-like_dom.
DR InterPro; IPR013111; EGF_extracell.
DR InterPro; IPR041161; EGF_Tenascin.
DR InterPro; IPR036056; Fibrinogen-like_C.
DR InterPro; IPR014716; Fibrinogen_a/b/g_C_1.
DR InterPro; IPR002181; Fibrinogen_a/b/g_C_dom.
DR InterPro; IPR003961; FN3_dom.
DR InterPro; IPR036116; FN3_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR NCBIfam; NF040941; GGGWT_bact; 1.
DR PANTHER; PTHR46708; TENASCIN; 1.
DR PANTHER; PTHR46708:SF1; TENASCIN; 1.
DR Pfam; PF07974; EGF_2; 5.
DR Pfam; PF18720; EGF_Tenascin; 7.
DR Pfam; PF00147; Fibrinogen_C; 1.
DR Pfam; PF00041; fn3; 14.
DR SMART; SM00181; EGF; 14.
DR SMART; SM00186; FBG; 1.
DR SMART; SM00060; FN3; 14.
DR SUPFAM; SSF56496; Fibrinogen C-terminal domain-like; 1.
DR SUPFAM; SSF49265; Fibronectin type III; 11.
DR PROSITE; PS00022; EGF_1; 5.
DR PROSITE; PS01186; EGF_2; 5.
DR PROSITE; PS51406; FIBRINOGEN_C_2; 1.
DR PROSITE; PS50853; FN3; 13.
PE 3: Inferred from homology;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW EGF-like domain {ECO:0000256|ARBA:ARBA00022536};
KW Extracellular matrix {ECO:0000256|ARBA:ARBA00022530};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Reference proteome {ECO:0000313|Proteomes:UP000005447};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Secreted {ECO:0000256|ARBA:ARBA00022530}; Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..22
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 23..2112
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5011706081"
FT DOMAIN 625..715
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 805..896
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 897..986
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 987..1077
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 1078..1165
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 1167..1259
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 1260..1348
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 1349..1439
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 1440..1529
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 1531..1620
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 1621..1710
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 1711..1799
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 1800..1888
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 1886..2101
FT /note="Fibrinogen C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51406"
FT REGION 936..958
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 940..955
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2112 AA; 232354 MW; 9835705B41C428E7 CRC64;
MGAMIQLLLG IFLAFLVLPS EGGVLKKTIR HKRQSGLNVT FPEENQPVVF NHVYNIKLPV
GSQCSVDLES ASGEKDLALP LEPSESIQEH TVNGENQIVF THRINIPRRA CGCAAAPDVR
ELLSRLEELE LVVSSLREQC SMGTGCCLQS AEGRLDTRPF CSGRGNFSTE GCGCVCEPGW
KGPNCSEPEC PGNCNLRGQC LEGQCICDEG FTGEDCSQLA CPSDCNDQGK CVDGVCICFE
GYAGADCSQE VCPVPCSEEH GRCIDGRCVC QEGFAGDDCK EPLCLNNCYN RGRCVENECV
CEEGFTGEDC SELVCPNDCF DRGRCLNGTC YCEEGFTGED CGTLTCPNDC HQQGRCEEGQ
CVCDEGFAGA DCSEKRCPAD CHNRGRCLNG QCECDDGFTG ADCGELKCPN DCSGHGHCVN
GQCVCDEGYT GDDCSQLRCP NDCHSRGRCI EGKCVCEPGF QGYDCSDMSC PNDCHQHGRC
VNGMCVCDDN YIGEDCRDRR CPRDCSNRGR CVDGQCLCED GFTGLDCAEL SCPSDCHGQG
RCVNGQCVCH EGFMGQDCKE RRCPGDCHGQ GRCEDGQCVC HEGFTGIDCG QRSCPNDCSN
LGQCISGRCI CNAGYTGDDC SQVSPPKDLI VTEVTEETVN LAWDNEMRVT EYLVVYTPTH
ANGLEMQFRV PGDQTSTIIR ELEPGVEYFI RVFAILENKK SIPVSARVAT YLPAPEGLKF
KSIKETSVEV EWDPLDIAFE TWEIIFRNMN KEDEGEITKS LRRPETSYQQ TGLAPGQEYE
ISLHIVKNNT RGPGLKRVTT TRLDAPSQME VKDVTDTTAL VTWFKPLAEI DGIELSYGLK
DVPGDRTTID LTHDENQYSI GNLKPDTQYE VSLISRRGDM SSNPAKESFT TGLDAPRNLR
RVSQTDSSIT LEWRNVKAAI DSYRIKYAPI SGGDHAEVDV PKSQQTTTKT TLTGLRPGTE
YGIGVSAVKE DRESDPATIN AATEIDAPKD LQASETTENS LTLQWKTPLA KFDRYRLNYS
LPTGQSMEEQ LPRDTTSHVL RGLEPGQEYT VLLTAEKGRH KSKPVRVKAT TEHVPELENL
TVTEVGWDGL KLNWTAADQA YEHFVIQVQE ANKVEATHNL TVPGSMRAVD LPGLKAGTPY
RVSIYGVIRG YRTPVLSAEA STGETPNLGE ITVTEVGWDA LKLNWTAPEG AYEHFLIQVQ
EADTVTVVQN LTVPGGLRSV DLPGLKAATH YRVTIRGVAQ DFSTTPLSVE IWTEEVPSLG
NLTVTDVSWD AFKLDWTTPD EIYDQFVIEV QEADQVERTH NLTVPGSLRS VKIPGLTAGT
AYRITLHGEA RGRRTRPLAA EIFTEKLPQL GDLAVTEVGW DGLKLNWTAA DQTYEHFVIQ
VQEANKVEAT HNLTVPGSMR AVDLPGLKAG TPYRVSIYGV IRGYRTPVLS AEASTAKEPE
IGNLSVSDIT SESFNLSWTA THGIFETFTI EIIDSNRLLQ MVEYNISGAE RTAQISGLPP
NTDFIIYLSG LAPSIRTKTI SATATTEAEP EVDNLLVSDA TPDGFRLSWT ADEGMFDSFV
LKIRDSKKQS EPQEIILPSP ERTRDITNLR EATEYEIELY GVRNGRRSQP VSAKATTAMG
SPKELIFSDI TENAATVSWK APTAQVESFR VTYVPISGGM PSMVTVDGTT TEARLVQLIP
GVEYLVSVIA MKGFEESEPV SGSLTTALDG PSSLVIANIT DSEALAMWQP AIALVDNYII
SYTGERGLVP EITRTVSGNT VEYALTDLEP ATEYTLRIFA EKGPQKSSTM TTRFTTDLDA
PRDLTASEVQ SETALLTWQP PRASVTGYLL VYESLDGTLK EVILGPDTTS YSLIDLSPST
HYTARIQALR GPLRSKLIPT VFTTIGLLYP FPKDCSQAML NGDTTSGLYT IYLNNNKTQA
LEVFCDMSSD GGGWIVFLRR KNGREDFYRN WKAYAAGFGD RNEEFWLGLD NLSKITAQGQ
YELRVDLQDH GETAYAVYDR FSVGDAKTRY KLKVEGYSGT AGDSMAYHNG RSFSTYDKDT
DSAITNCALS YKGAFWYKNC HRVNLMGRYG DNNHSQGVNW FHWKGHEYSI QFAEMKLRPS
NFRNLESRRK RA
//
