GenomeNet

Database: UniProt
Entry: A0A286XR17_CAVPO
LinkDB: A0A286XR17_CAVPO
Original site: A0A286XR17_CAVPO 
ID   A0A286XR17_CAVPO        Unreviewed;      4910 AA.
AC   A0A286XR17;
DT   22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT   22-NOV-2017, sequence version 1.
DT   05-DEC-2018, entry version 7.
DE   SubName: Full=Ryanodine receptor 2 {ECO:0000313|Ensembl:ENSCPOP00000027721};
GN   Name=RYR2 {ECO:0000313|Ensembl:ENSCPOP00000027721};
OS   Cavia porcellus (Guinea pig).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia;
OC   Hystricomorpha; Caviidae; Cavia.
OX   NCBI_TaxID=10141 {ECO:0000313|Ensembl:ENSCPOP00000027721, ECO:0000313|Proteomes:UP000005447};
RN   [1] {ECO:0000313|Ensembl:ENSCPOP00000027721, ECO:0000313|Proteomes:UP000005447}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=2N {ECO:0000313|Ensembl:ENSCPOP00000027721,
RC   ECO:0000313|Proteomes:UP000005447};
RX   PubMed=21993624; DOI=10.1038/nature10530;
RA   Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J.,
RA   Washietl S., Kheradpour P., Ernst J., Jordan G., Mauceli E.,
RA   Ward L.D., Lowe C.B., Holloway A.K., Clamp M., Gnerre S., Alfoldi J.,
RA   Beal K., Chang J., Clawson H., Cuff J., Di Palma F., Fitzgerald S.,
RA   Flicek P., Guttman M., Hubisz M.J., Jaffe D.B., Jungreis I.,
RA   Kent W.J., Kostka D., Lara M., Martins A.L., Massingham T., Moltke I.,
RA   Raney B.J., Rasmussen M.D., Robinson J., Stark A., Vilella A.J.,
RA   Wen J., Xie X., Zody M.C., Baldwin J., Bloom T., Chin C.W., Heiman D.,
RA   Nicol R., Nusbaum C., Young S., Wilkinson J., Worley K.C., Kovar C.L.,
RA   Muzny D.M., Gibbs R.A., Cree A., Dihn H.H., Fowler G., Jhangiani S.,
RA   Joshi V., Lee S., Lewis L.R., Nazareth L.V., Okwuonu G.,
RA   Santibanez J., Warren W.C., Mardis E.R., Weinstock G.M., Wilson R.K.,
RA   Delehaunty K., Dooling D., Fronik C., Fulton L., Fulton B., Graves T.,
RA   Minx P., Sodergren E., Birney E., Margulies E.H., Herrero J.,
RA   Green E.D., Haussler D., Siepel A., Goldman N., Pollard K.S.,
RA   Pedersen J.S., Lander E.S., Kellis M.;
RT   "A high-resolution map of human evolutionary constraint using 29
RT   mammals.";
RL   Nature 478:476-482(2011).
RN   [2] {ECO:0000313|Ensembl:ENSCPOP00000027721}
RP   IDENTIFICATION.
RC   STRAIN=2N {ECO:0000313|Ensembl:ENSCPOP00000027721};
RG   Ensembl;
RL   Submitted (OCT-2017) to UniProtKB.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation
CC       of feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00448}.
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DR   EMBL; AAKN02021705; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AAKN02021706; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AAKN02021707; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AAKN02021708; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AAKN02021709; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AAKN02021710; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AAKN02021711; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AAKN02021712; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AAKN02021713; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   Ensembl; ENSCPOT00000032170; ENSCPOP00000027721; ENSCPOG00000007936.
DR   GeneTree; ENSGT00940000154906; -.
DR   Proteomes; UP000005447; Unassembled WGS sequence.
DR   GO; GO:0034704; C:calcium channel complex; IEA:Ensembl.
DR   GO; GO:0033017; C:sarcoplasmic reticulum membrane; IEA:Ensembl.
DR   GO; GO:0005790; C:smooth endoplasmic reticulum; IEA:Ensembl.
DR   GO; GO:0030018; C:Z disc; IEA:Ensembl.
DR   GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR   GO; GO:0048763; F:calcium-induced calcium release activity; IEA:Ensembl.
DR   GO; GO:0005516; F:calmodulin binding; IEA:Ensembl.
DR   GO; GO:0042802; F:identical protein binding; IEA:Ensembl.
DR   GO; GO:0034236; F:protein kinase A catalytic subunit binding; IEA:Ensembl.
DR   GO; GO:0034237; F:protein kinase A regulatory subunit binding; IEA:Ensembl.
DR   GO; GO:0043621; F:protein self-association; IEA:Ensembl.
DR   GO; GO:0005219; F:ryanodine-sensitive calcium-release channel activity; IEA:Ensembl.
DR   GO; GO:0043924; F:suramin binding; IEA:Ensembl.
DR   GO; GO:0030509; P:BMP signaling pathway; IEA:Ensembl.
DR   GO; GO:0035584; P:calcium-mediated signaling using intracellular calcium source; IEA:Ensembl.
DR   GO; GO:0060070; P:canonical Wnt signaling pathway; IEA:Ensembl.
DR   GO; GO:0003300; P:cardiac muscle hypertrophy; IEA:Ensembl.
DR   GO; GO:0071313; P:cellular response to caffeine; IEA:Ensembl.
DR   GO; GO:0071872; P:cellular response to epinephrine stimulus; IEA:Ensembl.
DR   GO; GO:0005513; P:detection of calcium ion; IEA:Ensembl.
DR   GO; GO:0003143; P:embryonic heart tube morphogenesis; IEA:Ensembl.
DR   GO; GO:0072599; P:establishment of protein localization to endoplasmic reticulum; IEA:Ensembl.
DR   GO; GO:0003220; P:left ventricular cardiac muscle tissue morphogenesis; IEA:Ensembl.
DR   GO; GO:1901896; P:positive regulation of calcium-transporting ATPase activity; IEA:Ensembl.
DR   GO; GO:0010460; P:positive regulation of heart rate; IEA:Ensembl.
DR   GO; GO:0051284; P:positive regulation of sequestering of calcium ion; IEA:Ensembl.
DR   GO; GO:0098735; P:positive regulation of the force of heart contraction; IEA:Ensembl.
DR   GO; GO:0086029; P:Purkinje myocyte to ventricular cardiac muscle cell signaling; IEA:Ensembl.
DR   GO; GO:0098910; P:regulation of atrial cardiac muscle cell action potential; IEA:Ensembl.
DR   GO; GO:0098904; P:regulation of AV node cell action potential; IEA:Ensembl.
DR   GO; GO:0010881; P:regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion; IEA:Ensembl.
DR   GO; GO:0098907; P:regulation of SA node cell action potential; IEA:Ensembl.
DR   GO; GO:0098911; P:regulation of ventricular cardiac muscle cell action potential; IEA:Ensembl.
DR   GO; GO:0014808; P:release of sequestered calcium ion into cytosol by sarcoplasmic reticulum; IEA:Ensembl.
DR   GO; GO:0001666; P:response to hypoxia; IEA:Ensembl.
DR   GO; GO:0014850; P:response to muscle activity; IEA:Ensembl.
DR   GO; GO:0035994; P:response to muscle stretch; IEA:Ensembl.
DR   GO; GO:0051775; P:response to redox state; IEA:Ensembl.
DR   GO; GO:0097050; P:type B pancreatic cell apoptotic process; IEA:Ensembl.
DR   GO; GO:0086005; P:ventricular cardiac muscle cell action potential; IEA:Ensembl.
DR   CDD; cd12877; SPRY1_RyR; 1.
DR   CDD; cd12878; SPRY2_RyR; 1.
DR   CDD; cd12879; SPRY3_RyR; 1.
DR   InterPro; IPR001870; B30.2/SPRY.
DR   InterPro; IPR013320; ConA-like_dom_sf.
DR   InterPro; IPR011992; EF-hand-dom_pair.
DR   InterPro; IPR002048; EF_hand_dom.
DR   InterPro; IPR014821; Ins145_P3_rcpt.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR036300; MIR_dom_sf.
DR   InterPro; IPR016093; MIR_motif.
DR   InterPro; IPR013662; RIH_assoc-dom.
DR   InterPro; IPR000699; RIH_dom.
DR   InterPro; IPR013333; Ryan_recept.
DR   InterPro; IPR003032; Ryanodine_rcpt.
DR   InterPro; IPR015925; Ryanodine_recept-rel.
DR   InterPro; IPR009460; Ryanrecept_TM4-6.
DR   InterPro; IPR035910; RyR/IP3R_RIH_dom_sf.
DR   InterPro; IPR035761; SPRY1_RyR.
DR   InterPro; IPR035764; SPRY2_RyR.
DR   InterPro; IPR035762; SPRY3_RyR.
DR   InterPro; IPR003877; SPRY_dom.
DR   PANTHER; PTHR13715; PTHR13715; 2.
DR   Pfam; PF13833; EF-hand_8; 1.
DR   Pfam; PF08709; Ins145_P3_rec; 1.
DR   Pfam; PF00520; Ion_trans; 1.
DR   Pfam; PF02815; MIR; 1.
DR   Pfam; PF08454; RIH_assoc; 1.
DR   Pfam; PF06459; RR_TM4-6; 1.
DR   Pfam; PF01365; RYDR_ITPR; 3.
DR   Pfam; PF02026; RyR; 4.
DR   Pfam; PF00622; SPRY; 3.
DR   PRINTS; PR00795; RYANODINER.
DR   SMART; SM00472; MIR; 4.
DR   SMART; SM00449; SPRY; 3.
DR   SUPFAM; SSF100909; SSF100909; 1.
DR   SUPFAM; SSF47473; SSF47473; 1.
DR   SUPFAM; SSF49899; SSF49899; 2.
DR   SUPFAM; SSF82109; SSF82109; 2.
DR   PROSITE; PS50188; B302_SPRY; 3.
DR   PROSITE; PS50222; EF_HAND_2; 1.
DR   PROSITE; PS50919; MIR; 5.
PE   4: Predicted;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000005447};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005447};
KW   Repeat {ECO:0000256|SAAS:SAAS00903904};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4222   4241       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4442   4462       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4517   4536       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4653   4674       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4711   4732       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4787   4810       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN       82    137       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      144    189       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      197    252       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      258    315       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      323    380       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      571    781       B30.2/SPRY. {ECO:0000259|PROSITE:
FT                                PS50188}.
FT   DOMAIN      997   1194       B30.2/SPRY. {ECO:0000259|PROSITE:
FT                                PS50188}.
FT   DOMAIN     1309   1534       B30.2/SPRY. {ECO:0000259|PROSITE:
FT                                PS50188}.
FT   DOMAIN     3965   4000       EF-hand. {ECO:0000259|PROSITE:PS50222}.
FT   COILED      444    464       {ECO:0000256|SAM:Coils}.
FT   COILED     3000   3020       {ECO:0000256|SAM:Coils}.
FT   COILED     3265   3285       {ECO:0000256|SAM:Coils}.
FT   COILED     4354   4387       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   4910 AA;  557786 MW;  FFFE12FA09A1586F CRC64;
     QASFLRGSGV HEDKLPLMLD EYGILMTLSL PAQNVPPDLS ICTFVLEQSL SVRALQEMLA
     NTVEKSEGQV DVEKWTAQGG GHRTLLYGHA ILLRHSYSGM YLCCLSTSRS STDKLAFDVG
     LQEDTTGEAC WWTIHPASKQ RSEGEKVRVG DDLILVSVSS ERYLHLSYGT GSLHVDAAFQ
     QTLWSVAPIS SGSEAAQGYL IGGDVLRLLH GHMDECLTVP SGEHGEEQRR TVHYEGGAVS
     VHARSLWRLE TLRVAWSGSH IRWGQPFRLR HVTTGKYLSL LEDKNLLLMD KEKADVKSTA
     FTFRSSKEKL DVSVRKEVDG MGTSEIKYGD SVCYIQHVDT GLWLTYQSVD VKSVRMGSIQ
     RKAIMHHEGH MDDGLNLSRS QHEESRTARV IRSTVFLFNR FIRGLDALSK KVKVPAVDLP
     IESVSLSLQD LIGYFHPPDE HLEHEDKQNR LRALKNRQNL FQEEGMINLV LECIDRLHVY
     SSAAHFADVA GREAGEAWKS ILNSLYELLA ALIRGNRKNC AQFSGSLDWL ISRLERLEAS
     SGILEVLHCV LVESPEALNI IKEGHIKSII SLLDKHGRNH KVLDVLCSLC VCHGVAVRSN
     QHLICDNLLP GRDLLLQTRL VNHVSSMRPN IFLGISEGSA QYKKWYYELM VDHTEPFVTA
     EATHLRVGWA STEGYSPYPG GGEEWGGNGV GDDLFSYGFD GLHLWSGCIA RTVSSPNQHL
     LKTDDVISCC LDLSAPSISF RINGQPVQGM FENFNIDGLF FPVVSFSAGI KVRFLLGGRH
     GEFKFLPPPG YAPCYEAVLP KEKLKVEHSR EYKQERTYTR DLLGPTVSLT QAAFTPIPVD
     TTQIVLPPHL ERIREKLAEN IHELWVMNKI ELGWQYGPVR DDNKRQHPCL VEFSKLPEQE
     RNYNLQMSLE TLKTLLALGC HVGLSDEHAE EKVKKMKLPK NYQLTSGYKP APMDLSFIKL
     TPAQEAMVDR LAENAHNVWA RDRIRQGWTY GIQQDVKNRR NPRLVPYTLL DDRTKKSNKD
     SLREAVRTLL GYGYNLEAPD QDHAARAEVC SGTGERFRIF RAEKTYAVKA GRWYFEFEAV
     TAGDMRVGWS RPGCQPDQEL GSDERAFAFD GFKAQRWHQG NEHYGRSWQA GDVVGCMVDM
     NEHTMMFTLN GEILLDDSGS ELAFKDFDVG DGFIPACSLG VAQVGRMNFG KDVSTLKYFT
     ICGLQEGYEP FAVNTNRDIT MWLSKRLPQF LQVPSNHEHI EVTRIDGTID SSPCLKVTQK
     SFGSQNSSTD LMFYRLSMPI ECAEVFSKTM AGGLPGAGLF GPKNDLEDYD ADSDFEVLMK
     TAHGHLVPDR VDKDKEASKP EFNNHKDYAQ EKPSRLKQRF LLRRTKPDYS TSHSARLTED
     VLADDRDDYD YLMQTSTYYY SVRIFPGQEP ANVWVGWITS DFHQYDTGFD LDRVRTVTVT
     LGDEKGKVHE SIKRSNCYMV CAGESMSPGQ GRNNNGLEIG CVVDAASGLL TFIANGKELS
     TYYQVEPSTK LFPAVFAQAT SPNVFQFELG RIKNVMPLSA GLFKSEHKNP VPQCPPRLHV
     QFLSHVLWSR MPNQFLKVDV SRISERQGWL VQCLDPLQFM SLHIPEENRS VDILELTEQE
     ELLKFHYHTL RLYSAVCALG NHRVAHALCS HVDEPQLLYA IENKYMPGLL RSGYYDLLID
     IHLSSYATAR LMMNNEFIVP MTEETKSITL FPDENKKHGL PGIGLSTSLR PRMQFSSPSF
     VSISNECYQY SPEFPLDILK AKTMQMLTEA VKEGSLHARD PVGGTTEFLF VPLIKLFYTL
     LIMGIFHNED LKHILQLIEP RVFKEAACVE EEGDVLEKEL STEDSKLEGA GEEDVKVGKA
     PKEGLLQMKL PEPVKLQMCL LLQYLCDCQV RHRIEAIVAF SDDFVAKLQD NQRFRYNEVM
     QALNMSAALT ARKTKEFRSP PQEQINMLLN FKDDKSECPC PEEIRDQLLD FHEDLMTHCG
     IELDEDGSLD GNSDLTIRGR LLSLVEKVTY LKKKQSEKPV ASDAKKSSSL QQLISETMVR
     WAQESIIEDP ELVRAMFVLL HRQYDGIGGL VRALPKTYTI NGVSVEDTIN LLASLGQIRS
     LLSVRMGKEE EKLMIRGLGD IMNNKVFYQH PNLMRALGMH ETVMEVMVNV LGGGESKVKE
     ILTHPKTMTQ ASSPAMRGST PLDVAAASVM DNNELALALR EPDLEKVVRY LAGCGLQSCQ
     MLVSKGYPDI GWNPVEGERY LDFLRFAVFC NGESVEENAN VVVRLLIRRP ECFGPALRGE
     GGNGLLAAME EAIKIAEDPS RDGPSPTSGS SKTLDTEEEE DDTIHMGNAI MTFYAALIDL
     LGRCAPEMHL IHAGKGEAIR IRSILRSLIP LGDLVGVISI AFQMPTIAKD GNVVEPDMSA
     GFCPDHKAAM VLFLDRVYGI EVQDFLLHLL EVGFLPDLRA AASLDTAALS ATDMALALNR
     YLCTAVLPLL TRCAPLFAGT EHHASLIDSL LHTVYRLSKG CSLTKAQRDS IEVCLLSICG
     QLRPSMMQHL LRRLVFDVPL LNEHAKMPLK LLTNHYERCW KYYCLPGGWG NFGAASEEEL
     HLSRKLFWGI FDALSQKKYE QELFKLALPC LSAVAGALPP DYMESNYVSM MEKQSSMDSE
     GNFNPQPVDT SNITIPEKLE YFINKYAEHS HDKWSMDKLA NGWIYGEIYS DSSKIQPLMK
     PYKLLSEKEK EIYRWPIKES LKTMLAWGWR IERTREGDSM ALYNRTRRIS QTSQVSVDAA
     HGYSPRAIDM SNVTLSRDLH AMAEMMAENY HNIWAKKKKL ELESKGGGNH PLLVPYDTLT
     AKEKAKDREK AQDILKFLQI NGYAVSRGFK DLELDTPSIE KRFAYSFLQQ LIRYVDEAHQ
     YILEFDGGSR SKGEHFPYEQ EIKFFAKVVL PLIDQYFKNH RLYFLSAASR PLCSGGHASN
     KEKEMVTSLF CKLGVLVRHR ISLFGNDATS IVNCLHILGQ TLDARTVMKT GLESVKSALR
     AFLDNAAEDL ENTMENLKQG QFTHTRNQPK GVTQIINYTT VALLPMLSSL FEHIGQHQFG
     EDLILEDVQV SCYRILTSLY ALGTSKSIYV ERQRSALGEC LAAFAGAFPV AFLETHLDKH
     NVHSIYNTKS SRERAALNLP PNVEDVCPNI PSLEKLMEEI VELAESGIRY TQMPHVMEVV
     LPMLCSYMSR WWEHGPENNP ERSEMCCTAL NSEHMNTLLG NILKIIYNNL GIDEGAWMKR
     LAVFSQPIIN KVKPQLLKTH FLPLMEKLKK KAAMVVAEED HLKAEARGDM SEAELLILDE
     FTTLARDLYA FYPLLIRFVD YNRAKWLKEP NPEAEELFRM VAEVFIYWSK SHNFKREEQN
     FVVQNEINNM SFLITDTKSK MSKAAVSDQE RKKMKRKGDR YSMQTSLIVA ALKRLLPIGL
     NICAPGDQEL IALAKNRFSL KDTEDEVRDI IRSNIHLQGK LEDPAIRWQM ALYKDLPNRT
     EDTSDPERTV ERVLDIANVL FHLEQKSKCI GRRYYNLGKH PQRSKKAVWH KLLSKQRKRA
     VVACFRMAPL YNLPRHRAVN LFLQGYEKSW IETEEHYFED KLIEDLAKPG AKPPEEDEAA
     KRVDPLHQLI LLFSRTALTE KCKLEEDFLY MAYADIMAKS CHDEEDDDGE EEVKSFEEKE
     MEKQKLLYQQ ARLHDRGAAE MVLQTISASK GETGPMVAAT LKLGIAILNG GNSTVQQKML
     DYLKEKKDVG FFQSLAGLMQ SCSVLDLNAF ERQNKAEGLG MVTEEGSGEK VLQDDEFTCD
     LFRFLQLLCE GHNSDFQNYL RTQTGNNTTV NIIISTVDYL LRVQESISDF YWYYSGKDVI
     DEQGQRNFSK AIQVAKQVFN TLTEYIQGPC TGNQQSLAHS RLWDAVVGFL HVFAHMQMKL
     SQDSSQIELL KELMDLQKDM VVMLLSMLEG NVVNGTIGKQ MVDMLVESSN NVEMILKFFD
     MFLKLKDLTS SDTFKEYDPD GKGVISKRDF HKAMESHKHY TQSETEFLLS CAETDENETL
     DYEEFVKRFH EPAKDIGFNV AVLLTNLSEH MPNDTRLQTF LELAESVLNY FQPFLGRIEI
     MGSAKRIERV YFEISESSRT QWEKPQVKES KRQFIFDVVN EGGEKEKMEL FVNFCEDTIF
     EMQLAAQISE SDLNERSTNK EESEKERLEE QGPRMGFFSI LTVRSALLAL RYNILTLMRM
     LSLKSLKKQM KKMKKMTMKD MVTAFFSSYW SVFVTLLHFV ASVCRGFFRI VCSLLLGGSL
     VEGAKKIKVA ELLANMPDPT QDEVRGDGEE GERKPMETPL PSEDLTDLKE LAEESDLLSD
     IFGLDLKREG GQYKLIPHNP NAGLGDLMSN PVPIPEVQEK FQEQKTKEEE KEEKEETKSE
     PEKAEGEDGE KEEKAKEDKG KQKLRQLHTH RYGEPEVPES AFWKKIIAYQ QKLLNYFARN
     FYNMRMLALF VAFAINFILL FYKVSTASVA EGKELPTRSP SESAKVTTSL DSSSHRIIAV
     HYVLEESSGY MEPTLRILAI LHTVISFFCI IGYYCLKVPL VIFKREKEVA RKLEFDGLYI
     TEQPSEDDIK GQWDRLVINT QSFPNNYWDK FVKRKVMDKY GEFYGRDRIS ELLGMDKAAL
     DFSDAREKKK PKKDSSLSAV LNSIDVKYQM WKLGVVFTDN SFLYLAWYMT MSVLGHYNNF
     FFAAHLLDIA MGFKTLRTIL SSVTHNGKQL VLTVGLLAVV VYLYTVVAFN FFRKFYNKSE
     DGDTPDMKCD DMLTCYMFHM YVGVRAGGGI GDEIEDPAGD EYEIYRIIFD ITFFFFVIVI
     LLAIIQGLII DAFGELRDQQ EQVKEDMETK CFICGIGNDY FDTVPHGFET HTLQEHNLAN
     YLFFLMYLIN KDETEHTGQE SYVWKMYQER CWEFFPAGDC FRKQYEDQLN
//
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