GenomeNet

Database: UniProt
Entry: A0A286XR39_CAVPO
LinkDB: A0A286XR39_CAVPO
Original site: A0A286XR39_CAVPO 
ID   A0A286XR39_CAVPO        Unreviewed;      4843 AA.
AC   A0A286XR39;
DT   22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT   22-NOV-2017, sequence version 1.
DT   05-DEC-2018, entry version 6.
DE   SubName: Full=Ryanodine receptor 3 {ECO:0000313|Ensembl:ENSCPOP00000027963};
GN   Name=RYR3 {ECO:0000313|Ensembl:ENSCPOP00000027963};
OS   Cavia porcellus (Guinea pig).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia;
OC   Hystricomorpha; Caviidae; Cavia.
OX   NCBI_TaxID=10141 {ECO:0000313|Ensembl:ENSCPOP00000027963, ECO:0000313|Proteomes:UP000005447};
RN   [1] {ECO:0000313|Ensembl:ENSCPOP00000027963, ECO:0000313|Proteomes:UP000005447}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=2N {ECO:0000313|Ensembl:ENSCPOP00000027963,
RC   ECO:0000313|Proteomes:UP000005447};
RX   PubMed=21993624; DOI=10.1038/nature10530;
RA   Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J.,
RA   Washietl S., Kheradpour P., Ernst J., Jordan G., Mauceli E.,
RA   Ward L.D., Lowe C.B., Holloway A.K., Clamp M., Gnerre S., Alfoldi J.,
RA   Beal K., Chang J., Clawson H., Cuff J., Di Palma F., Fitzgerald S.,
RA   Flicek P., Guttman M., Hubisz M.J., Jaffe D.B., Jungreis I.,
RA   Kent W.J., Kostka D., Lara M., Martins A.L., Massingham T., Moltke I.,
RA   Raney B.J., Rasmussen M.D., Robinson J., Stark A., Vilella A.J.,
RA   Wen J., Xie X., Zody M.C., Baldwin J., Bloom T., Chin C.W., Heiman D.,
RA   Nicol R., Nusbaum C., Young S., Wilkinson J., Worley K.C., Kovar C.L.,
RA   Muzny D.M., Gibbs R.A., Cree A., Dihn H.H., Fowler G., Jhangiani S.,
RA   Joshi V., Lee S., Lewis L.R., Nazareth L.V., Okwuonu G.,
RA   Santibanez J., Warren W.C., Mardis E.R., Weinstock G.M., Wilson R.K.,
RA   Delehaunty K., Dooling D., Fronik C., Fulton L., Fulton B., Graves T.,
RA   Minx P., Sodergren E., Birney E., Margulies E.H., Herrero J.,
RA   Green E.D., Haussler D., Siepel A., Goldman N., Pollard K.S.,
RA   Pedersen J.S., Lander E.S., Kellis M.;
RT   "A high-resolution map of human evolutionary constraint using 29
RT   mammals.";
RL   Nature 478:476-482(2011).
RN   [2] {ECO:0000313|Ensembl:ENSCPOP00000027963}
RP   IDENTIFICATION.
RC   STRAIN=2N {ECO:0000313|Ensembl:ENSCPOP00000027963};
RG   Ensembl;
RL   Submitted (OCT-2017) to UniProtKB.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation
CC       of feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00448}.
CC   -----------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   -----------------------------------------------------------------------
DR   EMBL; AAKN02015737; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AAKN02015738; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AAKN02015739; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AAKN02015740; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AAKN02015741; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AAKN02015742; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AAKN02015743; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AAKN02015744; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   Ensembl; ENSCPOT00000047042; ENSCPOP00000027963; ENSCPOG00000003120.
DR   GeneTree; ENSGT00940000155507; -.
DR   Proteomes; UP000005447; Unassembled WGS sequence.
DR   GO; GO:0005623; C:cell; IEA:GOC.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR   GO; GO:0005219; F:ryanodine-sensitive calcium-release channel activity; IEA:InterPro.
DR   CDD; cd12877; SPRY1_RyR; 1.
DR   CDD; cd12878; SPRY2_RyR; 1.
DR   CDD; cd12879; SPRY3_RyR; 1.
DR   InterPro; IPR001870; B30.2/SPRY.
DR   InterPro; IPR013320; ConA-like_dom_sf.
DR   InterPro; IPR011992; EF-hand-dom_pair.
DR   InterPro; IPR002048; EF_hand_dom.
DR   InterPro; IPR014821; Ins145_P3_rcpt.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR036300; MIR_dom_sf.
DR   InterPro; IPR016093; MIR_motif.
DR   InterPro; IPR013662; RIH_assoc-dom.
DR   InterPro; IPR000699; RIH_dom.
DR   InterPro; IPR013333; Ryan_recept.
DR   InterPro; IPR003032; Ryanodine_rcpt.
DR   InterPro; IPR015925; Ryanodine_recept-rel.
DR   InterPro; IPR009460; Ryanrecept_TM4-6.
DR   InterPro; IPR035910; RyR/IP3R_RIH_dom_sf.
DR   InterPro; IPR035761; SPRY1_RyR.
DR   InterPro; IPR035764; SPRY2_RyR.
DR   InterPro; IPR035762; SPRY3_RyR.
DR   InterPro; IPR003877; SPRY_dom.
DR   PANTHER; PTHR13715; PTHR13715; 1.
DR   Pfam; PF08709; Ins145_P3_rec; 1.
DR   Pfam; PF00520; Ion_trans; 1.
DR   Pfam; PF02815; MIR; 1.
DR   Pfam; PF08454; RIH_assoc; 1.
DR   Pfam; PF06459; RR_TM4-6; 1.
DR   Pfam; PF01365; RYDR_ITPR; 2.
DR   Pfam; PF02026; RyR; 4.
DR   Pfam; PF00622; SPRY; 3.
DR   PRINTS; PR00795; RYANODINER.
DR   SMART; SM00472; MIR; 3.
DR   SMART; SM00449; SPRY; 3.
DR   SUPFAM; SSF100909; SSF100909; 2.
DR   SUPFAM; SSF47473; SSF47473; 1.
DR   SUPFAM; SSF49899; SSF49899; 3.
DR   SUPFAM; SSF82109; SSF82109; 2.
DR   PROSITE; PS50188; B302_SPRY; 3.
DR   PROSITE; PS50222; EF_HAND_2; 1.
DR   PROSITE; PS50919; MIR; 4.
PE   4: Predicted;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000005447};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005447};
KW   Repeat {ECO:0000256|SAAS:SAAS00903904};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4160   4193       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4384   4404       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4452   4471       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4583   4601       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4644   4665       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4724   4747       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN      105    160       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      167    212       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      266    324       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      334    391       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      576    787       B30.2/SPRY. {ECO:0000259|PROSITE:
FT                                PS50188}.
FT   DOMAIN     1003   1199       B30.2/SPRY. {ECO:0000259|PROSITE:
FT                                PS50188}.
FT   DOMAIN     1245   1457       B30.2/SPRY. {ECO:0000259|PROSITE:
FT                                PS50188}.
FT   DOMAIN     3892   3927       EF-hand. {ECO:0000259|PROSITE:PS50222}.
FT   COILED      450    470       {ECO:0000256|SAM:Coils}.
FT   COILED     3192   3212       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   4843 AA;  549166 MW;  E3D2FDE69B96C746 CRC64;
     HFENCLLWRQ PLTTHSVCLS WQEDEVVLQC IANVHKEQRK FCLAAEGLGN RLCFLEPTSE
     AKYIPPDLCI CNFVLEQSLS VRALQEMLAN TGENGGEGAA QGGGHRTLLY GHAILLRHSF
     SGMYLTCLTT SRSQTDKLAF DVGLREHATG EACWWTIHPA SKQRSEGEKV RIGDDLILVS
     VSSERYLHLS ISNGNIQVDA SFMQTLWNVH PTCSGSSIEE GYLLVGMVVL LISNSTHRRV
     FYEAGGAGRR ARSLWRVEPL RISWSGSNIR WGQAFRLRHL TTGHYLALTE DQGLLLQDRG
     KSDTKSTAFS FRASKEIKEK LDSSHKRDME GMGVPEIKYG DSVCFVQHVA SGLWVTYKAQ
     DAKTSRLGPL KRKVILHQEG HMDDGLTLQR CQREESQAAR IIRNTTALFS RFVSGNNRTA
     APIALPTEEV LQTLQDLIAY FQPPEEEMKH EDKQNKLRSL KNRQNLFKEE GMLALVLNCI
     DRLNIYNSVA HLTGIAREES GMAWKEILNL LYKLLAALIR GNRNNCAQFS NNLDWLISKL
     DRLESSSGIL EVLHCILIES PEALNLIAEG HIKSIISLLD KHGRNHKVLD VLCSLCLCNG
     VAVRANQNLI CDNLLPRRNL LLQTRLINDV TSIRPNIFLG VAEGSAQYKK WYYELIIDQV
     DPFLTAEPTH LRVGWASSSG YAPYPGGGEG WGGNGVGDDL YSYGFDGLHL WSGRIPRAVA
     SINQHLLRSD DVVSCCLDLG VPSISFRING QPVQGMFENF NTDGLFFPVM SFSAGVKVRF
     LMGGRHGEFK FLPPSGYAPC YEALLPKEKM RLEPVKEYKR DSDGVRDLLG TTQFLSQASF
     IPCPIDTSQV VLPPHLEKIR DRLAENIHEL WGMNKIELGW TFGKIRDDNK RQHPCLVEFS
     KLPETEKNYN LQMSTETLKT LLALGCHIAH VNPAAEEDLK KVKLPKNYMM TNGYKPAPLD
     LSDVKLLPPQ EILVDKLAEN AHNVWAKDRI KQGWTYGIQQ DLKNKRNPRL VPYALLDERT
     KKSNRDSLRE AIRTFVGYGY NIEPSDQELA DPTVEKVSVD KIRFFRVERS YAVRSGKWYF
     EFEAVTGGDM RVGWARPGCR PDIELGADDQ AFVFEGSRGQ RWHQGSGYFG RTWQPGDVVG
     CMINLDDASM IFTLNGELLI TNKGSELAFA DYEIENGFVP ICCLGLSQIG RMNLGTDAST
     FKFYTMCGLQ EGFEPFAVNM NRDVAMWFSK RLPTFVNVPE DHPHIEVARI DGTMDSPPCL
     KVTHKTFGTQ NSNANMIYCR LSMPVECYSS FSHSPCLDSD AFQKRKQMQE ILSPTTTQCY
     YAIRIFAGQD PSCVWVGWVT PDYHLYSKKF DLNKNCTVTV TLGDERGRVH ESVKRSNCYM
     VWGGDIVASS QRSSRSNVDL EIGCLVDLAM GMLSFSANGK ELGTCYQVEP NTKVFPAVFL
     QPTSTSLFQF ELGKLKNAMP LSAAIFKSEE KNPVPQCPPR LDVQTIQPVL WSRMPNSFLK
     VEIERVSERH GWAVQCLEPL QMMALHIPEE NRCVDILELC EQEDLMRFHY HTLRLYSAVC
     ALGNSRVAYA LCSHVDLSQL FYAIDNKYLP GLLRSGFFDL LISIHLANAK ERKLMMKNEY
     IIPINSTTRN IRLYPDESKR HGLPGVGLRT CLKPGFRFST PCFVVTSEEH QKQSPEIPLE
     ILKTKALSML TEAVHCSGAH IRDPVGGSIE FQFVPVLKLI GTLLVIGVFD DDDVRQILLL
     IDPSVFGEHG GETEEGAEKE EVTQVEEKAV EAGEKASKEA PVKGLLQTRL PESVKLQMCE
     LLSYLCDCEL QHRVEAIVAF GDIYVSKLQA NQKFRYNELM QALNMSAALT ARKTREFRSP
     PQEQINMLLN FQLGENCPCP EEIREELYDF HEDLLLHCGV PLEEEKEEEE DTSWTGKLCA
     LVHKIKAPSK PEKEQPAEEE ERCPATLKEL VSQTMIHWAQ EDQIQDAELV RMMFNLLRRQ
     YDSIGELLQA LRKTYTISQA SVSDTINLLA ALGQIRSLLS VRMGKEEELL MINGLGDIMN
     NKVFYQHPNL MRVLGMHETV MEVMVNVLGT EKSQIAFPKM VASCCRFLCY FCRISRQNQK
     AMFEHLSYLL ENSSVGLASP SMRGSTPLDV AASSVMDNNE LALGLEEPDL EKVVTYLAGC
     GLQSCPMLLA KGYPDVGWNP IEGERYLSFL RFAVFVNSES VEENASVVVK LLIRRPECFG
     PALRGEGGNG LLAAMQGAIK ISENPALDLP SQGYKRAVTE DREEEEEIVY MGNAIMSFYS
     ALIDLLGRCA PEMHLIQTGK GEAIRIRSIL RSLVPTEDLV GIISIPLKLP CLNKDGSVSE
     PNMAANFCPD HKAPMVLFLD RVYGIKDQTF LLHLLEVGFL PDLRASASLD TVSLSTTEAA
     LALNRYICSA VLPLLTRCAP LFAGTEHCTS LIDSTLQTIY RLSKGRSLTK AQRDTIEECL
     LAICNHLRPS MLQQLLRRLV FDVPLLNEYC KMPLKLLTNH YEQCWKYYCL PSGWGSYGLA
     VEEELHLTEK LFWGIFDSLS HKRYDPDLFR MALPCLSAIA GALPPDYLDT RITGTLEKQV
     SVDADGNFDP KPINTMNFSL PEKLEYIVTK YAEHSHDKWA CDKSQNGWKY GISLDENVKT
     HPLIRPFKTL TEKEKEIYRW PARESLKTML AVGWTVERTK EGEALVQQRE NEKLRSVSQT
     SQGNSYSPAP LDLSNVVLSR ELQGMVEVVA ENYHNIWAKK KKLELESKGG GSHPLLVPYD
     TLTAKEKFRD REKAQDLFKF LQVNGIIVSR GMKGMELDAS SMEKRFAYKF LKKILKYVDS
     AQEFIAHLEA IVSSGKTEKS PHDQEIKFFA KVLLPLVDQY FTNHRLYFLS SPLKPLSSSG
     YASHKEKEMV ASLFCKLAAL VRHRISLFGS DSATMVSCLH ILAQTLDTRT VMKSGSELVK
     AGLRGFFENA AEDLEKTSEN LKLGKFTHSR TQIRGVSQNI NYTTVALLPI LTSIFEHVAQ
     HQFGVDLLLG DVQISCYHIL CSLYSLGTGK NIYVERQRPA LGECLASLAA AIPVAFLEPT
     LNRYNPLSVF NTKTSRERSI LGMPDTVEEM SGESGARTQR CPRHRGDLPM PLNYLSYWWE
     RGPENLPPST GPCCTQVTSE HLSLILGNIL KIINNNLGID EASWMKRIAV FAQPIISKAR
     PDLLRSHFIP TLEKLKKKAV KTVQEEEQLK ADGKGDTQEA ELLILDEFAV LCRDLYAFYP
     MLIRYVDNNR SNWLKSPDDD SDQLFRMVAE VFILWCKSHN FKREEQNFVI QNEINNLAFL
     TGDSKSKMSK VSPYKSSGGQ DQERKKTKRR GDLYSIQTSL IVAALKKMLP IGLNMCTPGD
     QELISLAKSR YSCRDTDEEV KEHLRNNLHL QEKSDDPAVK WQLNLYKDVL RNEEPATPER
     TVERVQRISA AVFHLEQVEQ PLRSKKAVWH KLLSKQRKRA VVACFRMAPL YNLPRHRSIN
     LFLHGYQRFW IETEAYSFEE KLVQDLAKSP KVEEEEEEEM EKQPDPLHQI ILHFSRNALT
     ERSKLEDDPL YTSYSSMMAK SCQSAEDEEE EDKEKTFEEK EMEKQKTLYQ QARLHERGAA
     EMVLQMISAS KGEMSPMVVE TLKLGIAILN GGNTGVQQKM LDYLKEKKDA GFFQSLSGLM
     QSCSVLDLNA FERQNKAEGL GMVTEEGTLC YVFQGEKVLQ NDEFTRDLFR FLQLLCEGHN
     SDFQNFLRTQ MGNTTTVNII ISTVDYLLRL QESISDFYWY YSGKDIIDES GQHNFSKALA
     VTKQIFNSLT EYIQGPCIGN QQSLAHSRLW DAVVGFLHVF ANMQMKLSQD SSQIELLKEL
     LDLLQDMVVM LLSLLEGNVV NGTIGKQMVD TLVESSTNVE MILKFFDMFL KLKDLTSSDT
     FKEYDPDGKG IISKKEFQKA MEGQKQYTQS EIDFLLSCAE ADENDMFNYI DFVNRFHEPA
     KDIGFNVAVL LTNLSEHMPN DSRLKCLLDP AESVLNYFEP YLGRIEIMGG AKKIERVYFE
     ISESSRTQWE KPQVKESKRQ FIFDVVNEGG EQEKMELFVN FCEDTIFEMQ LASQISESDS
     ADRPEEEEEE NDSPCVLEVE GEKEEDKPLE PASAFALACV SAKRNVSSLL RKATLRNLRR
     QCRNVKKMSA RELVKVFFSF YWMVFVGLFQ MCFTILGGIF QVLWSTVFGG GLVEGAKNIR
     VTKILGDMPD PTQFGIHDDA MEAERVDVGE PDLTAELVHC VRDEKGDPDI MSDLFGLHPK
     KEGGSKHGPE VGLGDLSEII SKDEPPTLES TVQKKRKAQA AEMKVAHEVG GKAESEKADM
     EDGEKGDRAK EEEQAEYLWA EVTKRKKRRR GQKVEKPEAF MANFFKGLEI YQTKLLHYLA
     RNFYNLRFLA LFVAFAINFI LLFYKVTEEP LEEETEDAAN LWNSFNDEEE EEAMVFFVLQ
     ESTGYMAPTL RALAVVHTII SFVCVIGYYC LKVPLVVFKR EKEIARKLEF DGLYITEQPS
     EDDIKGQWDR LVINTPSFPN NYWDKFVKRK VINKYGDLYG AERIAELLGL DKNALDFSPV
     EEIKAEAASL VSWLSSIDMK YHIWKLGVVF TDNSFLYLAW YTTMSILGHY NNFFFAAHLL
     DIAMGFKTLR TILSSVTHNG KQLVLTVGLL AVVVYLYTVV AFNFFRKFYN KSEDDDEPDM
     KCDDMMTCYL FHMYVGVRAG GGIGDEIEDP AGDPYEMYRI VFDITFFFFV IVILLAIIQG
     LIIDAFGELR DQQEQVREDM ETKCFICGIG NDYFDTTPHG FETHTLQEHN LANYLFFLMY
     LINKDETEHT GQESYVWKMY QERCWDFFPA GDCFRKQYED QLG
//
DBGET integrated database retrieval system