ID A0A286XRS7_CAVPO Unreviewed; 1618 AA.
AC A0A286XRS7;
DT 22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 1.
DT 27-MAR-2024, entry version 22.
DE SubName: Full=NHS like 1 {ECO:0000313|Ensembl:ENSCPOP00000028183.1};
GN Name=NHSL1 {ECO:0000313|Ensembl:ENSCPOP00000028183.1};
OS Cavia porcellus (Guinea pig).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Hystricomorpha; Caviidae;
OC Cavia.
OX NCBI_TaxID=10141 {ECO:0000313|Ensembl:ENSCPOP00000028183.1, ECO:0000313|Proteomes:UP000005447};
RN [1] {ECO:0000313|Proteomes:UP000005447}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=2N {ECO:0000313|Proteomes:UP000005447};
RX PubMed=21993624; DOI=10.1038/nature10530;
RA Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J., Washietl S.,
RA Kheradpour P., Ernst J., Jordan G., Mauceli E., Ward L.D., Lowe C.B.,
RA Holloway A.K., Clamp M., Gnerre S., Alfoldi J., Beal K., Chang J.,
RA Clawson H., Cuff J., Di Palma F., Fitzgerald S., Flicek P., Guttman M.,
RA Hubisz M.J., Jaffe D.B., Jungreis I., Kent W.J., Kostka D., Lara M.,
RA Martins A.L., Massingham T., Moltke I., Raney B.J., Rasmussen M.D.,
RA Robinson J., Stark A., Vilella A.J., Wen J., Xie X., Zody M.C., Baldwin J.,
RA Bloom T., Chin C.W., Heiman D., Nicol R., Nusbaum C., Young S.,
RA Wilkinson J., Worley K.C., Kovar C.L., Muzny D.M., Gibbs R.A., Cree A.,
RA Dihn H.H., Fowler G., Jhangiani S., Joshi V., Lee S., Lewis L.R.,
RA Nazareth L.V., Okwuonu G., Santibanez J., Warren W.C., Mardis E.R.,
RA Weinstock G.M., Wilson R.K., Delehaunty K., Dooling D., Fronik C.,
RA Fulton L., Fulton B., Graves T., Minx P., Sodergren E., Birney E.,
RA Margulies E.H., Herrero J., Green E.D., Haussler D., Siepel A., Goldman N.,
RA Pollard K.S., Pedersen J.S., Lander E.S., Kellis M.;
RT "A high-resolution map of human evolutionary constraint using 29 mammals.";
RL Nature 478:476-482(2011).
RN [2] {ECO:0000313|Ensembl:ENSCPOP00000028183.1}
RP IDENTIFICATION.
RC STRAIN=2N {ECO:0000313|Ensembl:ENSCPOP00000028183.1};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR EMBL; AAKN02045841; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_013003467.1; XM_013148013.1.
DR STRING; 10141.ENSCPOP00000028183; -.
DR Ensembl; ENSCPOT00000044289.1; ENSCPOP00000028183.1; ENSCPOG00000006535.4.
DR GeneID; 100714650; -.
DR CTD; 57224; -.
DR VEuPathDB; HostDB:ENSCPOG00000006535; -.
DR GeneTree; ENSGT00950000182963; -.
DR InParanoid; A0A286XRS7; -.
DR OMA; RNPREEW; -.
DR OrthoDB; 5355272at2759; -.
DR Proteomes; UP000005447; Unassembled WGS sequence.
DR Bgee; ENSCPOG00000006535; Expressed in zone of skin and 12 other cell types or tissues.
DR InterPro; IPR024845; NHS-like.
DR PANTHER; PTHR23039; NANCE-HORAN SYNDROME PROTEIN; 1.
DR PANTHER; PTHR23039:SF3; NHS-LIKE PROTEIN 1; 1.
DR Pfam; PF15273; NHS; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000005447}.
FT REGION 150..194
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 253..295
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 381..418
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 568..624
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 690..720
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 738..784
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 820..1618
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 157..176
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 264..286
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 397..411
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 571..603
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 610..624
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 866..891
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 917..942
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 952..1005
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1017..1054
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1139..1172
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1215..1230
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1354..1404
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1416..1444
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1464..1478
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1482..1496
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1518..1548
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1555..1569
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1618 AA; 171939 MW; 3691819A61A85C95 CRC64;
MKKEGSSGSF RLKANSGSLS RAVSWINFSS LSRQTKRLFR SDGELSVCGQ QVDAEEENWI
YRTQPRKAVS NLDEESRWTV HYTAPWHQQE NVFLPSTRPA CVEDLHRQAK LNLKSVLRDC
ETLRWDGYRS PQYYSQGPCL AAQPSPLCDE YQDEDADTDQ KCSVSSSEDE KLPGVRRPKT
PNSGDFSDLN TQTNWTKSLP LPTPEEKMRQ QAQTVQADVV PINITGENFD RQASLRRSLI
YTDTLVRRPK KVKRRKTITG VPDSIQKELA SGTGQDEASG HSGYSPDHYS TRGRLDSYHC
AGQRSETRDS SCQTEDVRVV PPSVRRIRAH KGLGIATQMS PFSGSSGNMS VLSDPAGVVF
PSRLHSDAGF HSLPRSGARA SAHSLGTLDP TEDVDGSFSY QRGNSQGDNN FGPVGGALRS
GTFFRPKSQE LRHFESENVT SPACMVSPHA TYSTSLIPNA TLSSSSDVII LHTAPSAGQL
DGRMTSSSSC LRIKPKDHLL SRHSVRADHH PCHHWSDGHS SIYSQPFNSH SHSVTTLLPT
CDSEVSPHGS QAMHYNCRNT LSFAVHPQDV DGKSESSSSG SRGQGSMEPW DYRASSSGRT
SPLKSHLAVP GYSTPTSNQS SCSLDQASIK EDAGSLYSED HTVCYKSVHN DSGCGFGNPR
HSVVNVFEGR AHKSPGDQSG YHGKSLARNI SLKKAKKPPL PPSRTDSLRR IPKNSGQSNG
QVLNESLIAT LQQSLQLSLP GKGGSSASQS PCSDFEEPWL SRSRSQSTVS AGSSMTSATT
PNVYSLCGVT PSQSDTSSIR SEYTDPWGYY IDYTGVQEEP GNPAGHCSAS GGAPTGNGPV
RHLQEASRAT IPQVPSGCAK PKVTSPEKSQ RVTSPSSGYS SQSNTPTALT PVPVFLKSVS
PANGKGKAKP KVPERKSSLI SSVSMSSSST SLSSNTSTEG GGTVRKLDAA PALPPLAPPL
PPVPASGPAD KSPLLPPPPP VADGPGGSPL PPSPVFPPPP PEVLTLSCSQ PDGCLPPTPT
ALSPFIPEPP ASLPAPPPFP SSLEPPPAPP LDPKFMKDMR PSFRNSGPVE SSREALRPPL
NKEESARPTM PLITTEALQM VQLRPVRRGS GADVAPSPEP AAQEQRTPTV PQYHLKPSAL
LKSRNSINEM ESESQPASAT SSLPTPAKSP SQGDRDSAAE HGGPASRSPG APCPAPGTGE
AEPGPGLRST PLPDSSPSRK PPPISKKPKL FLVVPPPQRD FTAENVSEAL GDVPSPTRAE
EGSAHSKEAQ ESSAAGAGSH ATGPGSSGLE GGAAGFESLS RVETNAPMVQ PDASPAPTQE
EPPGDSVGSA ETCPSQQDGE AGVQEAHAAE PSSEACDFFH KDDSEEVTTP TRPRTTEDLF
AAIHRSKRKV LGRRDSEDDH SRNHSPSPPV TPTGTAPSLA SPKQVGSIQR SVRRSSTSSD
NFKALLLKKG SRADTSARMS AAEMLRHTDP RFQRSRSEPA PDAPESPSSC SPSKSRRAQE
EWARSEGPMP RSLSFSGPRY CRSRTPPSAA SSRYSVRNRI QSSPMTVISE GEGEAVEATD
PRARRAKSGA SDQDSQGSQG GEVPDASLGP RTPGPADEGG DPSEPPEGVG QEQSQGPS
//
