ID A0A286XSD0_CAVPO Unreviewed; 1064 AA.
AC A0A286XSD0;
DT 22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 1.
DT 27-MAR-2024, entry version 23.
DE SubName: Full=Ras association (RalGDS/AF-6) and pleckstrin homology domains 1 {ECO:0000313|Ensembl:ENSCPOP00000028424.1};
GN Name=RAPH1 {ECO:0000313|Ensembl:ENSCPOP00000028424.1};
OS Cavia porcellus (Guinea pig).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Hystricomorpha; Caviidae;
OC Cavia.
OX NCBI_TaxID=10141 {ECO:0000313|Ensembl:ENSCPOP00000028424.1, ECO:0000313|Proteomes:UP000005447};
RN [1] {ECO:0000313|Proteomes:UP000005447}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=2N {ECO:0000313|Proteomes:UP000005447};
RX PubMed=21993624; DOI=10.1038/nature10530;
RA Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J., Washietl S.,
RA Kheradpour P., Ernst J., Jordan G., Mauceli E., Ward L.D., Lowe C.B.,
RA Holloway A.K., Clamp M., Gnerre S., Alfoldi J., Beal K., Chang J.,
RA Clawson H., Cuff J., Di Palma F., Fitzgerald S., Flicek P., Guttman M.,
RA Hubisz M.J., Jaffe D.B., Jungreis I., Kent W.J., Kostka D., Lara M.,
RA Martins A.L., Massingham T., Moltke I., Raney B.J., Rasmussen M.D.,
RA Robinson J., Stark A., Vilella A.J., Wen J., Xie X., Zody M.C., Baldwin J.,
RA Bloom T., Chin C.W., Heiman D., Nicol R., Nusbaum C., Young S.,
RA Wilkinson J., Worley K.C., Kovar C.L., Muzny D.M., Gibbs R.A., Cree A.,
RA Dihn H.H., Fowler G., Jhangiani S., Joshi V., Lee S., Lewis L.R.,
RA Nazareth L.V., Okwuonu G., Santibanez J., Warren W.C., Mardis E.R.,
RA Weinstock G.M., Wilson R.K., Delehaunty K., Dooling D., Fronik C.,
RA Fulton L., Fulton B., Graves T., Minx P., Sodergren E., Birney E.,
RA Margulies E.H., Herrero J., Green E.D., Haussler D., Siepel A., Goldman N.,
RA Pollard K.S., Pedersen J.S., Lander E.S., Kellis M.;
RT "A high-resolution map of human evolutionary constraint using 29 mammals.";
RL Nature 478:476-482(2011).
RN [2] {ECO:0000313|Ensembl:ENSCPOP00000028424.1}
RP IDENTIFICATION.
RC STRAIN=2N {ECO:0000313|Ensembl:ENSCPOP00000028424.1};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR EMBL; AAKN02019466; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAKN02019467; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; A0A286XSD0; -.
DR STRING; 10141.ENSCPOP00000028424; -.
DR Ensembl; ENSCPOT00000037227.1; ENSCPOP00000028424.1; ENSCPOG00000020239.2.
DR VEuPathDB; HostDB:ENSCPOG00000020239; -.
DR GeneTree; ENSGT00940000156552; -.
DR InParanoid; A0A286XSD0; -.
DR OMA; FPIPAQF; -.
DR Proteomes; UP000005447; Unassembled WGS sequence.
DR Bgee; ENSCPOG00000020239; Expressed in liver and 12 other cell types or tissues.
DR GO; GO:0031252; C:cell leading edge; IEA:Ensembl.
DR GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR GO; GO:0016604; C:nuclear body; IEA:Ensembl.
DR GO; GO:0005886; C:plasma membrane; IEA:Ensembl.
DR GO; GO:0048675; P:axon extension; IEA:Ensembl.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR CDD; cd01259; PH_APBB1IP; 1.
DR CDD; cd16136; RA_MRL_Lpd; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR InterPro; IPR039664; GRB/APBB1IP.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR039665; PH_APBB1IP.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR000159; RA_dom.
DR InterPro; IPR029071; Ubiquitin-like_domsf.
DR PANTHER; PTHR11243; GROWTH FACTOR RECEPTOR-BOUND PROTEIN; 1.
DR PANTHER; PTHR11243:SF15; RAS-ASSOCIATED AND PLECKSTRIN HOMOLOGY DOMAINS-CONTAINING PROTEIN 1; 1.
DR Pfam; PF00169; PH; 1.
DR Pfam; PF00788; RA; 1.
DR PRINTS; PR01217; PRICHEXTENSN.
DR SMART; SM00233; PH; 1.
DR SMART; SM00314; RA; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR SUPFAM; SSF54236; Ubiquitin-like; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
DR PROSITE; PS50200; RA; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000005447}.
FT DOMAIN 269..355
FT /note="Ras-associating"
FT /evidence="ECO:0000259|PROSITE:PS50200"
FT DOMAIN 396..505
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT REGION 1..25
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 104..148
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 169..222
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 537..572
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 610..914
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 926..975
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 990..1064
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 7..21
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 104..118
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 131..148
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 169..221
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 537..560
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 622..651
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 696..716
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 731..761
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 819..836
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 879..901
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 990..1006
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1064 AA; 115001 MW; CC191CBD17525EA2 CRC64;
MEQLSDEEID HGAEEDSDKE DQDLDKMFGA WLGELDKLTQ SLDSDKSVEP VKRSPLRQET
NMANFSYRFS IYNLNEALSQ GETVDLDALM ADLCSIEQEL SSIGSGSSKR QITEPKATQK
LAASRHPSKH GTLKGLSSSS NRIAKPSHAN YSLDDITAQL EQASLSMDEA AQQSVLEDTK
PVVTNQHRRT ASAGTVSDAE VRSMSNSSRS SVTSAASSMD SLDIDKVTRP QELDLTPQGQ
PIAEEEQAAK LKAEKIRVAL EKIKEAQVKK LVIRVHMSDD SSKTMMVDER QTVRQVLANL
MDKSHCGYGL DWSLVETISE LQMERIFEDH ENLVENLLNW TRDSQNKLIF MERIEKYALF
KNPQNYLLGK KETAEMADRN KEVLLEECFC GSSVTVPEIE GVLWLKDDGK KSWKKRYFLL
RASGIYYVPK GKAKVSRDLV CFLQLDHVNV YYGQDYRNKY KAPTDYCLVL KHPQIQKKSQ
YIKYLCCDDM RTLHQWVNGI RIAKYGKQLY ANYQEAMKRT ESAYDWTSLS SSSIKSGSSS
SSIPESQSNH SNQSDSGVSD TPPAGAGHVR SQSAVSSIFS EAWKRGTQLE ESSKARTESL
CRPYASLVTP LSPQMRPSAP CVASQPSPPL PPPPPPPPPP PPPPPPLPSQ ATPSSGAAAA
PTFVKYSTIA RLQHAAQHSD SLFKPPPPGA PHSPAASQAS KPQLLVPPTA LNPGLSNSPP
AVKAKPKWQP GAAPVPSPDF PPPPPENSLV FPPPPPVAPA SDKGGSPGKK PGKLASPGGK
KPPPAPQRNS SIRVGGVGSE QPEPARPSVD SLVSRFAPPA DEAPPPPPPP APPKPGKLQL
SAVGVGVAFP SAPGAEAPAR AAVPGGRGKD SGLEFPSPPS DSDFPPPPPE TELPLPPVEI
PPVFSGSGTA SPKVAVVNPQ PQLWCKTSVK KAPPPTRPKR NDSTRLTQVE PPEPPTLAAV
VPQVPTSPKS SLSVQPGFLA DLNRTLQRKS ITRHGSLTST RVSRAEPTAT MDDMALPPPP
PELLADPQKA VYGGSHISGY ATLRRGPPPA PPKRDQSTKL SRDW
//
