ID A0A286XSP8_CAVPO Unreviewed; 291 AA.
AC A0A286XSP8;
DT 22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 1.
DT 27-MAR-2024, entry version 28.
DE RecName: Full=Gamma-sarcoglycan {ECO:0000256|ARBA:ARBA00020453};
GN Name=SGCG {ECO:0000313|Ensembl:ENSCPOP00000028390.1};
OS Cavia porcellus (Guinea pig).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Hystricomorpha; Caviidae;
OC Cavia.
OX NCBI_TaxID=10141 {ECO:0000313|Ensembl:ENSCPOP00000028390.1, ECO:0000313|Proteomes:UP000005447};
RN [1] {ECO:0000313|Proteomes:UP000005447}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=2N {ECO:0000313|Proteomes:UP000005447};
RX PubMed=21993624; DOI=10.1038/nature10530;
RA Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J., Washietl S.,
RA Kheradpour P., Ernst J., Jordan G., Mauceli E., Ward L.D., Lowe C.B.,
RA Holloway A.K., Clamp M., Gnerre S., Alfoldi J., Beal K., Chang J.,
RA Clawson H., Cuff J., Di Palma F., Fitzgerald S., Flicek P., Guttman M.,
RA Hubisz M.J., Jaffe D.B., Jungreis I., Kent W.J., Kostka D., Lara M.,
RA Martins A.L., Massingham T., Moltke I., Raney B.J., Rasmussen M.D.,
RA Robinson J., Stark A., Vilella A.J., Wen J., Xie X., Zody M.C., Baldwin J.,
RA Bloom T., Chin C.W., Heiman D., Nicol R., Nusbaum C., Young S.,
RA Wilkinson J., Worley K.C., Kovar C.L., Muzny D.M., Gibbs R.A., Cree A.,
RA Dihn H.H., Fowler G., Jhangiani S., Joshi V., Lee S., Lewis L.R.,
RA Nazareth L.V., Okwuonu G., Santibanez J., Warren W.C., Mardis E.R.,
RA Weinstock G.M., Wilson R.K., Delehaunty K., Dooling D., Fronik C.,
RA Fulton L., Fulton B., Graves T., Minx P., Sodergren E., Birney E.,
RA Margulies E.H., Herrero J., Green E.D., Haussler D., Siepel A., Goldman N.,
RA Pollard K.S., Pedersen J.S., Lander E.S., Kellis M.;
RT "A high-resolution map of human evolutionary constraint using 29 mammals.";
RL Nature 478:476-482(2011).
RN [2] {ECO:0000313|Ensembl:ENSCPOP00000028390.1}
RP IDENTIFICATION.
RC STRAIN=2N {ECO:0000313|Ensembl:ENSCPOP00000028390.1};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: Component of the sarcoglycan complex, a subcomplex of the
CC dystrophin-glycoprotein complex which forms a link between the F-actin
CC cytoskeleton and the extracellular matrix.
CC {ECO:0000256|ARBA:ARBA00002860}.
CC -!- SUBCELLULAR LOCATION: Cell membrane, sarcolemma
CC {ECO:0000256|ARBA:ARBA00004274}; Single-pass type II membrane protein
CC {ECO:0000256|ARBA:ARBA00004274}.
CC -!- SIMILARITY: Belongs to the sarcoglycan beta/delta/gamma/zeta family.
CC {ECO:0000256|ARBA:ARBA00007574}.
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DR EMBL; AAKN02010376; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAKN02010377; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAKN02010378; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAKN02010379; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAKN02010380; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_012996414.1; XM_013140960.1.
DR RefSeq; XP_012996415.1; XM_013140961.1.
DR AlphaFoldDB; A0A286XSP8; -.
DR Ensembl; ENSCPOT00000033540.1; ENSCPOP00000028390.1; ENSCPOG00000012598.4.
DR GeneID; 100716857; -.
DR CTD; 6445; -.
DR VEuPathDB; HostDB:ENSCPOG00000012598; -.
DR eggNOG; KOG3950; Eukaryota.
DR GeneTree; ENSGT00940000159187; -.
DR OMA; CACFNGK; -.
DR OrthoDB; 2913504at2759; -.
DR Proteomes; UP000005447; Unassembled WGS sequence.
DR Bgee; ENSCPOG00000012598; Expressed in heart and 8 other cell types or tissues.
DR GO; GO:0016012; C:sarcoglycan complex; IEA:InterPro.
DR GO; GO:0042383; C:sarcolemma; IEA:UniProtKB-SubCell.
DR InterPro; IPR006875; Sarcoglycan.
DR InterPro; IPR039972; Sarcoglycan_gamma/delta/zeta.
DR PANTHER; PTHR12939:SF4; GAMMA-SARCOGLYCAN; 1.
DR PANTHER; PTHR12939; SARCOGLYCAN; 1.
DR Pfam; PF04790; Sarcoglycan_1; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000005447};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 35..58
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
SQ SEQUENCE 291 AA; 32449 MW; 42F6A3067948451A CRC64;
MVQEQYMATT EGTQVERPES QDVYKIGIYG WRKRCLYLFV LLLLIILVVN LALTIWILKV
MWFFPTGMGH LLVTKDGLRL EGESEFLFPL YAKVIHSRLD SSLLLQSTQN VTVSARNSEG
EVTGRLKVGP KMVEVQSQQF RINSKDGKPL FTVDEKEVVV GTDRLRVTGP EGALFEHSVE
TPLVRADPFE DLRLESPTRS LSMDAPRGIH INARAGQIEA LSQMDIIFQS SDGMLTLDAE
TIRLPKVVEG TQGRSRSPQG LYEICVCADG KLYLSAAGEG TTCQEHSEVC L
//
