ID A0A286XT81_CAVPO Unreviewed; 3976 AA.
AC A0A286XT81;
DT 22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 1.
DT 27-MAR-2024, entry version 31.
DE SubName: Full=Dynein axonemal heavy chain 7 {ECO:0000313|Ensembl:ENSCPOP00000028570.1};
GN Name=DNAH7 {ECO:0000313|Ensembl:ENSCPOP00000028570.1};
OS Cavia porcellus (Guinea pig).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Hystricomorpha; Caviidae;
OC Cavia.
OX NCBI_TaxID=10141 {ECO:0000313|Ensembl:ENSCPOP00000028570.1, ECO:0000313|Proteomes:UP000005447};
RN [1] {ECO:0000313|Proteomes:UP000005447}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=2N {ECO:0000313|Proteomes:UP000005447};
RX PubMed=21993624; DOI=10.1038/nature10530;
RA Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J., Washietl S.,
RA Kheradpour P., Ernst J., Jordan G., Mauceli E., Ward L.D., Lowe C.B.,
RA Holloway A.K., Clamp M., Gnerre S., Alfoldi J., Beal K., Chang J.,
RA Clawson H., Cuff J., Di Palma F., Fitzgerald S., Flicek P., Guttman M.,
RA Hubisz M.J., Jaffe D.B., Jungreis I., Kent W.J., Kostka D., Lara M.,
RA Martins A.L., Massingham T., Moltke I., Raney B.J., Rasmussen M.D.,
RA Robinson J., Stark A., Vilella A.J., Wen J., Xie X., Zody M.C., Baldwin J.,
RA Bloom T., Chin C.W., Heiman D., Nicol R., Nusbaum C., Young S.,
RA Wilkinson J., Worley K.C., Kovar C.L., Muzny D.M., Gibbs R.A., Cree A.,
RA Dihn H.H., Fowler G., Jhangiani S., Joshi V., Lee S., Lewis L.R.,
RA Nazareth L.V., Okwuonu G., Santibanez J., Warren W.C., Mardis E.R.,
RA Weinstock G.M., Wilson R.K., Delehaunty K., Dooling D., Fronik C.,
RA Fulton L., Fulton B., Graves T., Minx P., Sodergren E., Birney E.,
RA Margulies E.H., Herrero J., Green E.D., Haussler D., Siepel A., Goldman N.,
RA Pollard K.S., Pedersen J.S., Lander E.S., Kellis M.;
RT "A high-resolution map of human evolutionary constraint using 29 mammals.";
RL Nature 478:476-482(2011).
RN [2] {ECO:0000313|Ensembl:ENSCPOP00000028570.1}
RP IDENTIFICATION.
RC STRAIN=2N {ECO:0000313|Ensembl:ENSCPOP00000028570.1};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell projection, cilium, flagellum
CC {ECO:0000256|ARBA:ARBA00004230}. Cytoplasm, cytoskeleton, cilium
CC axoneme {ECO:0000256|ARBA:ARBA00004430}.
CC -!- SIMILARITY: Belongs to the dynein heavy chain family.
CC {ECO:0000256|ARBA:ARBA00008887}.
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DR EMBL; AAKN02051336; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR Ensembl; ENSCPOT00000036740.1; ENSCPOP00000028570.1; ENSCPOG00000001018.4.
DR VEuPathDB; HostDB:ENSCPOG00000001018; -.
DR GeneTree; ENSGT00940000155282; -.
DR Proteomes; UP000005447; Unassembled WGS sequence.
DR Bgee; ENSCPOG00000001018; Expressed in testis and 3 other cell types or tissues.
DR GO; GO:0005930; C:axoneme; IEA:UniProt.
DR GO; GO:0030286; C:dynein complex; IEA:UniProtKB-KW.
DR GO; GO:0005874; C:microtubule; IEA:UniProtKB-KW.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR GO; GO:0045505; F:dynein intermediate chain binding; IEA:InterPro.
DR GO; GO:0051959; F:dynein light intermediate chain binding; IEA:InterPro.
DR GO; GO:0008569; F:minus-end-directed microtubule motor activity; IEA:InterPro.
DR GO; GO:0007018; P:microtubule-based movement; IEA:InterPro.
DR Gene3D; 1.10.287.2620; -; 1.
DR Gene3D; 1.10.472.130; -; 1.
DR Gene3D; 1.10.8.1220; -; 1.
DR Gene3D; 1.10.8.710; -; 1.
DR Gene3D; 1.20.1270.280; -; 1.
DR Gene3D; 1.20.58.1120; -; 1.
DR Gene3D; 1.20.920.20; -; 1.
DR Gene3D; 1.20.920.30; -; 1.
DR Gene3D; 3.10.490.20; -; 1.
DR Gene3D; 6.10.140.1060; -; 1.
DR Gene3D; 1.20.140.100; Dynein heavy chain, N-terminal domain 2; 1.
DR Gene3D; 3.20.180.20; Dynein heavy chain, N-terminal domain 2; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 5.
DR Gene3D; 1.10.8.720; Region D6 of dynein motor; 1.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR035699; AAA_6.
DR InterPro; IPR035706; AAA_9.
DR InterPro; IPR041658; AAA_lid_11.
DR InterPro; IPR042219; AAA_lid_11_sf.
DR InterPro; IPR026983; DHC_fam.
DR InterPro; IPR041589; DNAH3_AAA_lid_1.
DR InterPro; IPR042222; Dynein_2_N.
DR InterPro; IPR043157; Dynein_AAA1S.
DR InterPro; IPR041466; Dynein_AAA5_ext.
DR InterPro; IPR041228; Dynein_C.
DR InterPro; IPR043160; Dynein_C_barrel.
DR InterPro; IPR024743; Dynein_HC_stalk.
DR InterPro; IPR024317; Dynein_heavy_chain_D4_dom.
DR InterPro; IPR004273; Dynein_heavy_D6_P-loop.
DR InterPro; IPR013602; Dynein_heavy_linker.
DR InterPro; IPR042228; Dynein_linker_3.
DR InterPro; IPR018247; EF_Hand_1_Ca_BS.
DR InterPro; IPR002048; EF_hand_dom.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR46961:SF18; DYNEIN AXONEMAL HEAVY CHAIN 1; 1.
DR PANTHER; PTHR46961; DYNEIN HEAVY CHAIN 1, AXONEMAL-LIKE PROTEIN; 1.
DR Pfam; PF12774; AAA_6; 1.
DR Pfam; PF12775; AAA_7; 1.
DR Pfam; PF12780; AAA_8; 1.
DR Pfam; PF12781; AAA_9; 1.
DR Pfam; PF17857; AAA_lid_1; 1.
DR Pfam; PF18198; AAA_lid_11; 1.
DR Pfam; PF08393; DHC_N2; 1.
DR Pfam; PF17852; Dynein_AAA_lid; 1.
DR Pfam; PF18199; Dynein_C; 1.
DR Pfam; PF03028; Dynein_heavy; 1.
DR Pfam; PF12777; MT; 1.
DR SMART; SM00382; AAA; 2.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 4.
DR PROSITE; PS00018; EF_HAND_1; 1.
DR PROSITE; PS50222; EF_HAND_2; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Cell projection {ECO:0000256|ARBA:ARBA00023273};
KW Cilium {ECO:0000256|ARBA:ARBA00023069};
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Cytoskeleton {ECO:0000256|ARBA:ARBA00023212};
KW Dynein {ECO:0000256|ARBA:ARBA00023017};
KW Microtubule {ECO:0000256|ARBA:ARBA00022701};
KW Motor protein {ECO:0000256|ARBA:ARBA00023175};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000005447}.
FT DOMAIN 2192..2227
FT /note="EF-hand"
FT /evidence="ECO:0000259|PROSITE:PS50222"
FT COILED 667..694
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 2783..2831
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 3976 AA; 455516 MW; 6E887D23FE2FE2EA CRC64;
MVSTKPQWQQ AAPSFHLNIK QENEIPEPFT VKNEQSYAEY IEHLGKKDRV FHQVEDARPS
TCRSKAKSPH RERENFRSAL VNVILQQEVG LESAIPEEIK ISKMTTSAIE KDILKHYYYI
HHGIDTDHVA PMEDSWLEHV LDLVPQHLKV LTDSIAVLSD EMREDYLLSV KKSIVDFVLK
DPREKDDDKR PSELPPHRAE MEVLPKPWRK SFFTACSYIR DHLNAMNPTM LAVLDLWHSS
YKKLRLVDTE EFHNRQDALE LSIFQNIVMR HIETAKDILL KTWFPEVQNI YYQGNKKKQL
PTSDNSAKLE SFFNCAATLM TLQLQDLALV SMQDFTDLIA QPADSIRAFE HPGFIMRLIL
DNDTIKFEPE FEEYIDILQN VYDVMIKVVN FVPRVETKLY SKWESKSKPT TLKPIILDEI
VGAHKNKIKE VVQRESVAPS EHLRLYDKYD FLISKKAEKD TDLFLEENHH YERIIEEIRK
YQKLVEEIQY TSRKSVRLGM FEAHCEELIR ALAKRAEAIC GRLIVKMYKD HQDLSVRLCE
EFEKIAEKAL STPPNTAELM AMKAYIQKVE ATDMVELGQK LVDSKNCLAF LIECTNFSPA
DIRLNNSVFQ WYGRMGEIFE EHRKIIKEKT EQYQDGLKLR CERFVEELES YAKQAEEFYS
FGDLQDMQRY LKKAQALNTK LDAAADKILQ FNAEEEAFGW LPSIYPQRKK IQDGLNPYLR
LYETSVEFSN KYKAWTEGPY NKVNPDQVEG DVGNYWRGLY KLEKALQDSP NALAMAKKVR
SKVEDFKQYI PLMQVVCNPG LRPRHWEAMS AIVGYPLQPA EDSTVFSFID LNLEPYLDRF
EAISESASKE YSLEKAMEKM IAEWDAMEFV ILPYRESGTY ILSAVDEIQM LLDDHIVKTQ
TMRGSPFIKP YEKQIREWEG RLLLLQEILD EWLKVQATWL YLEPIFSSPD IMSQMPEEGR
RFTTVDKTWR DLMKNVQQNK HVLTVVTIDK MLEKMKKNNE LLELILKGLN EYLEKKRLFF
PRFFFLSNDE LLEILSETKD PTRVQPHLKK CFEGIAKVEF TETLDITHMK SSEGEVVELM
ETISTAKARG QVEKWLVELE RIMINSIHKV IGSAIQAYIN NERINWVREW PGQAVLCVSQ
TFWTKEVQTA IAVGLEALEQ YLEKCNKQID DIVTLVRGKL SKQNRVTLGA LVVLDVHARD
VLATLVQKRV SHDSDFEWLS QLRYYWQENH LETKMINAGL RYGYEYLGNS PRLVITPLTD
RCYRTLFGAL HLHLGGAPEG PAGTGKTETT KDLAKAVAKQ CVVFNCSDGL DYLALGKFFK
GLLSCGAWAC FDEFNRIDLE VLSVVAQQIL TIQRGINAGA DILVFEGTEL KLDPTCAVFI
TMNPGYAGRS ELPDNLKALF RTVAMMVPDY AMIAEIVLYS CGFVTARPLS VKIVATYRLC
SEQLSSQHHY DYGMRAVKSV LTAAGNLKLK YPNENEEILL LRSIIDVNLP KFLAHDLPLF
KGITSDLFPG VKLPKPDYND LLAAIKDNCV SMNLQMTKFF SEKILQIYEM MIVRHGFMIV
GEPFGGKTSA YRVLAGALND ICEKGLMEEN KVQITVLNPK SVTMGQLYGQ FDLVSHEWSD
GILAVSFRAF ASSSTPDRKW LIFDGPVDAV WIENMNTVLD DNKKLCLMSG EIIQMSPQMN
LIFEPMDLEV ASPATVSRCG MIYMEPHMLG WRPLMLSWLN LLPPSISAIQ KEFITGLFDR
MVPVSVEFIR RHTKELSPTT DTNLVRSLMN LIDCFMDIFV DEAKVKERND REVYSLLEGI
FIFSTIWSIG ASCTDEDRMK FNKILRELME GPISDLTRNR FKLQSGTEQV SSKALTVPFP
EKGTIYDYQF ITEGVGRWEP WIKKLEDAPP IPKDVLFNEI IVPTLDTVRY SVLMNLLTTH
QKPSIFVGPT GTGKSSYITN FLLNQLHKEV YKPLIINFSA QTTAAQTQNI IMSKLDKRRK
GVFGPPLGKI MVVFVDDVNM PAREVYGAQP PIELLRQWLD HWNWYDLKDC SVIKLVDIQI
MCAMGPPGGG RNPVTPRYMR HFNIITINEF SDKSMFAIFS RILNWHLQIC YKFPDEFLDL
TTQIVNGTMT LYKDAMKNLL PTPAKSHYLF NLRDFSRVIQ GVCLSRPETA ETKDVMKRLW
VHEVLRVYYD RLLDNSDRNW LVSYIQEILK SRMYEDFHEL FKHLDFDGDG VVQEDDLRSL
MFCDFHDPKR EDTNYREVAN VDALRLTVEA HLEEYNNMSK KPMNLVLFRF AIEHISRISR
ILKQPRSHAL LVGVGGSGRQ SVTRLAAHMC DYAVFHVEIS KGYGNNEWRE DLKAILRKCA
EGDMQGVFLF TDTQIKQETF LEDVNNLLNA GEVPNLFALD EKQEICEKMR QLDRQRDKTK
QTDGSPVALF NMFIDRCRNQ LHVVLAMSPI GDAFRNRLRK FPALVNCCTI DWFQSWPEDA
LHAVASRFLE DIEMSVEIRN GCIDMCKSFH TSTINLSTSF YTELQRYNYV TPTSYLELIS
TFKLLLEKKR SEVMKMKRRY EVGLDKLDSA SSQVATMQTE LEALQPQLRV ASKEVDEMMV
IIEKESIEVA KTEKVVKADE IVANDQAMAA KAIKDECDAD LAGALPILES ALTALDTLTA
QDITVVKSMK SPPAGVKLVM EAICILKGIK ADKIPDPTGS GKKIEDFWGP AKRLLGDIRF
LQSLHEYDKD NIPAAYMNII RKSYIPNPDF IPEKIRNAST AAEGLCKWVI AMDSYDKVAK
IVAPKKIKLA SAEAELKVAM DGLQKKQAAL QAVQDKLARL QDTLELNKQK KADLENQVDL
CSKKLERAEQ LIGGLGGEKT RWSHSALELG QLYINLTGDI LISSGVVAYL GAFTSNYRQN
QTKEWTNLCK ERDIPCSDEY SLMSTLGEAV TIRAWNIAGL PSDSFSIDNG IIIVNARRWP
LMIDPQGQAN KWVKNMEKTN SLQLIKLSDP DYVRTLENCI QFGTPVLLEN VGEELDPILE
PLLLKQTFKQ GGSLCIRLGD TIIEYAPDFR FYITTKLRNP HYLPETSVKV TLLNFMITPE
GMQDQLLGIV VARERPDLEE EKQALILQGA ENKRQLKEIE DKILEVLSSS EGNILEDETA
IKILSSSKAL ANEISQKQEV AEETEKKIDS TRMGYRPIAV HSSILFFSIA DLANIEPMYQ
YSLIWFINLF ILSIENSEKS EHLPVRLHIL RDHFTYSLYV NVCRSLFEKD KLLFSFCLTV
NLLIHDRMIN KAEWRFLLTG GIGLDNPYAN PCTWLPQKSW DEICRLDDLP VFRGIRKEFM
ILKDGWKKVY DSLEPHHEVF PEEWEKKANE FQRMLIIRCL RPDKIIPMLQ EYITNKLGRA
FIEPPPFDLS KAFADSHCCA PLIFVLSPGA DPMAALLKFA DDQGYGGAKL SSLSLGQGQG
PIAMKMLEKA IKEGTWVVLQ NCHLATSWMP TLEKVCEELS PESTHPDFRI WLTSYPSPNF
PVSVLQNGVK MTNEAPKGLR ANIIRSYLMD PISDPEFFGS CKKPEEFKKL LYGLCFFHAL
VQERRKFGPL GWNIPYEFNE TDLRISVQQL HMFLNQYEEL PFDALRYMTG ECNYGGRVTD
DWDRRTLRTI LNKFFCLELV ADSDYQFDSS GIYFVPPVGD HKSYIDYTKN LPLTPAPEVF
GMNANADITK DQAETQLLFD NILLTQSRSA GAGAKSSEEV VNEVAGDILG KLPSNFDVEA
AMRRYPTTYN QSMNTVLVQE MGRFNKLLVT IRESCINIQK AIKGLVVMST DLEEVVSSIL
NVKIPGMWMG KSYPSLKPLG SYVNDFLSRL KFLQQWYESG PPPVFWLSGF FFTQAFLTGA
QQNYARKHTI PIDLLGFDYE VLEDKEYKQG PEDGVYIHGL FLDGASWNRK IKKLAESYPK
ILYDTVPVMW LKPCKRVDIL ERPSYLAPLY KTSERRGTLS TTGHSTNFVI AMTLPSDHPK
EHWIGRGVAL LCQLND
//
