ID A0A286XT88_CAVPO Unreviewed; 1322 AA.
AC A0A286XT88;
DT 22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 1.
DT 27-MAR-2024, entry version 26.
DE SubName: Full=Mitogen-activated protein kinase 8 interacting protein 3 {ECO:0000313|Ensembl:ENSCPOP00000028698.1};
GN Name=MAPK8IP3 {ECO:0000313|Ensembl:ENSCPOP00000028698.1};
OS Cavia porcellus (Guinea pig).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Hystricomorpha; Caviidae;
OC Cavia.
OX NCBI_TaxID=10141 {ECO:0000313|Ensembl:ENSCPOP00000028698.1, ECO:0000313|Proteomes:UP000005447};
RN [1] {ECO:0000313|Proteomes:UP000005447}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=2N {ECO:0000313|Proteomes:UP000005447};
RX PubMed=21993624; DOI=10.1038/nature10530;
RA Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J., Washietl S.,
RA Kheradpour P., Ernst J., Jordan G., Mauceli E., Ward L.D., Lowe C.B.,
RA Holloway A.K., Clamp M., Gnerre S., Alfoldi J., Beal K., Chang J.,
RA Clawson H., Cuff J., Di Palma F., Fitzgerald S., Flicek P., Guttman M.,
RA Hubisz M.J., Jaffe D.B., Jungreis I., Kent W.J., Kostka D., Lara M.,
RA Martins A.L., Massingham T., Moltke I., Raney B.J., Rasmussen M.D.,
RA Robinson J., Stark A., Vilella A.J., Wen J., Xie X., Zody M.C., Baldwin J.,
RA Bloom T., Chin C.W., Heiman D., Nicol R., Nusbaum C., Young S.,
RA Wilkinson J., Worley K.C., Kovar C.L., Muzny D.M., Gibbs R.A., Cree A.,
RA Dihn H.H., Fowler G., Jhangiani S., Joshi V., Lee S., Lewis L.R.,
RA Nazareth L.V., Okwuonu G., Santibanez J., Warren W.C., Mardis E.R.,
RA Weinstock G.M., Wilson R.K., Delehaunty K., Dooling D., Fronik C.,
RA Fulton L., Fulton B., Graves T., Minx P., Sodergren E., Birney E.,
RA Margulies E.H., Herrero J., Green E.D., Haussler D., Siepel A., Goldman N.,
RA Pollard K.S., Pedersen J.S., Lander E.S., Kellis M.;
RT "A high-resolution map of human evolutionary constraint using 29 mammals.";
RL Nature 478:476-482(2011).
RN [2] {ECO:0000313|Ensembl:ENSCPOP00000028698.1}
RP IDENTIFICATION.
RC STRAIN=2N {ECO:0000313|Ensembl:ENSCPOP00000028698.1};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the JIP scaffold family.
CC {ECO:0000256|ARBA:ARBA00009866}.
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DR EMBL; AAKN02007398; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_003478501.1; XM_003478453.3.
DR Ensembl; ENSCPOT00000040968.1; ENSCPOP00000028698.1; ENSCPOG00000005354.4.
DR GeneID; 100725966; -.
DR KEGG; cpoc:100725966; -.
DR CTD; 23162; -.
DR VEuPathDB; HostDB:ENSCPOG00000005354; -.
DR GeneTree; ENSGT00940000153496; -.
DR OrthoDB; 3685563at2759; -.
DR Proteomes; UP000005447; Unassembled WGS sequence.
DR Bgee; ENSCPOG00000005354; Expressed in frontal cortex and 13 other cell types or tissues.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0005078; F:MAP-kinase scaffold activity; IEA:InterPro.
DR Gene3D; 1.20.58.1770; -; 1.
DR Gene3D; 1.20.5.1000; arf6 gtpase in complex with a specific effector, jip4; 1.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 1.
DR InterPro; IPR039911; JIP3/JIP4.
DR InterPro; IPR032486; JIP_LZII.
DR InterPro; IPR019143; JNK/Rab-associated_protein-1_N.
DR InterPro; IPR034743; RH1.
DR InterPro; IPR034744; RH2.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR PANTHER; PTHR13886:SF3; C-JUN-AMINO-TERMINAL KINASE-INTERACTING PROTEIN 3; 1.
DR PANTHER; PTHR13886; JNK/SAPK-ASSOCIATED PROTEIN; 1.
DR Pfam; PF16471; JIP_LZII; 1.
DR Pfam; PF09744; Jnk-SapK_ap_N; 1.
DR Pfam; PF19056; WD40_2; 1.
DR SUPFAM; SSF50978; WD40 repeat-like; 1.
DR PROSITE; PS51776; RH1; 1.
DR PROSITE; PS51777; RH2; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Reference proteome {ECO:0000313|Proteomes:UP000005447}.
FT DOMAIN 12..100
FT /note="RH1"
FT /evidence="ECO:0000259|PROSITE:PS51776"
FT DOMAIN 506..580
FT /note="RH2"
FT /evidence="ECO:0000259|PROSITE:PS51777"
FT REGION 183..211
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 245..318
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 705..754
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 866..955
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 66..167
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 443..534
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 245..301
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 304..318
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 722..752
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 870..889
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1322 AA; 146026 MW; 38A189D6877618E2 CRC64;
MMEIQMDENG GVVVYQDDYC SGSVMSERVS GLAGSIYREF ERLIHCYDEE VVKELMPLVV
NVLENLDSVL SENQEHEVEL ELLREDNEQL LTQYEREKAL RKQAEEKFIE FEDALEQEKK
ELQIQVEHYE FQTRQLELKA KNYADQISRL EERESEMKKE YNALHQRHTE MIQTYVEHIE
RSKMQQVGGT SQTESSLPGR SRKERPTSLN VFPLADGMVR AQMGGKLMPA GDHWHLNDLG
QLQSSSSYQC PHDEMSESGQ SSAAATPSTT GTKSNTPTSS VPSAAVTPLN ESLQPLGDYG
SGTKNSKRAR EKRNSRNMEV QVTQEVRNVS IGMGSSDEWS DVQDIIDSTP ELDMCPETRL
DRTGNSPTQG IVNKAFGINT DSLYHELSTA GSEVIGDVDE GADLLGEFSG MGKEVGNLLL
ENSQLLETKN ALNVVKNDLI AKVDQLSGEQ EVLKGELEAA KQAKVKLENR IKELEEELKR
VKSEAVVARR EPREEVEDDK IPMAQRRRFT RVEMARVLME RNQYKERLME LQEAVRWTEM
IRASREHPSV QEKKKSTIWQ FFSRLFSSSS SPPPAKRSYP SVNIHYKSPT AASFSQRRSH
ALCQISAGSR PLEFFPDDDC TSSARREQKR EQYRQVREHV RNDDGRLQAC GWSLPAKYKQ
LSPNGGQEDT RMKNVPVPVY CRPLVEKDPT MKLWCAAGVN LSGWKPSEED SGNGIKPIPG
RDPLTCDREV EDEPKSNHTS PERKKAKELP ETDATSSRVW ILTSTLTTSK VVIIDANQPG
TVVDQFTVCN AHVLCISSIP AASDSDYPPG EMFLDSDMNP EDSSTDGVLA GITLVGCATR
CNVPRSNCSS RGDTPVLDKG QGEMAAAANG KVNPSQSTEE ATEATEVPDS GSSEPVAAAV
RPGPLTEHVF TDPAPAPPSS TQPGSENGPE VGGNSVQPQP EPAGDPSAPS SSAAPTMWLG
AQNGWLYVHS AVNNWKKCLH SIKLKDSVLS LVHVKGRVLV ALADGTLAIF HRGEDGQWDL
SNYHLMDLGH PHHSIRCMAV VYDRVWCGYK NKVHVIQPKT MQIEKSFDAH PRRESQVRQL
AWIGDGVWVS IRLDSTLRLY HAHTHQHLQD VDIEPYVSKM LGTGKLGFSF VRITALLIAG
NRLWVGTGNG VVISIPLTET VVLHRGQLLG LRANKTSPTS GEGTRPGGVI HVYGDDSSDK
SASSFIPYCS MAQAQLCFHG HRDAVKFFVS VPGNVLATLN GSVLDSPSEG PGPAAPAVDT
EGQKLKNALV LSGGEGYIDF RIGDGEDDET EEGTGDISQV KPVLSKAERS HIIVWQVSYT
PE
//
