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Database: UniProt
Entry: A0A286XTT8_CAVPO
LinkDB: A0A286XTT8_CAVPO
Original site: A0A286XTT8_CAVPO 
ID   A0A286XTT8_CAVPO        Unreviewed;       568 AA.
AC   A0A286XTT8;
DT   22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT   22-NOV-2017, sequence version 1.
DT   10-APR-2019, entry version 13.
DE   RecName: Full=Zinc finger protein {ECO:0000256|PIRNR:PIRNR037162};
DE            EC=2.1.1.- {ECO:0000256|PIRNR:PIRNR037162};
GN   Name=PRDM5 {ECO:0000313|Ensembl:ENSCPOP00000028893};
OS   Cavia porcellus (Guinea pig).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia;
OC   Hystricomorpha; Caviidae; Cavia.
OX   NCBI_TaxID=10141 {ECO:0000313|Ensembl:ENSCPOP00000028893, ECO:0000313|Proteomes:UP000005447};
RN   [1] {ECO:0000313|Ensembl:ENSCPOP00000028893, ECO:0000313|Proteomes:UP000005447}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=2N {ECO:0000313|Ensembl:ENSCPOP00000028893,
RC   ECO:0000313|Proteomes:UP000005447};
RX   PubMed=21993624; DOI=10.1038/nature10530;
RA   Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J.,
RA   Washietl S., Kheradpour P., Ernst J., Jordan G., Mauceli E.,
RA   Ward L.D., Lowe C.B., Holloway A.K., Clamp M., Gnerre S., Alfoldi J.,
RA   Beal K., Chang J., Clawson H., Cuff J., Di Palma F., Fitzgerald S.,
RA   Flicek P., Guttman M., Hubisz M.J., Jaffe D.B., Jungreis I.,
RA   Kent W.J., Kostka D., Lara M., Martins A.L., Massingham T., Moltke I.,
RA   Raney B.J., Rasmussen M.D., Robinson J., Stark A., Vilella A.J.,
RA   Wen J., Xie X., Zody M.C., Baldwin J., Bloom T., Chin C.W., Heiman D.,
RA   Nicol R., Nusbaum C., Young S., Wilkinson J., Worley K.C., Kovar C.L.,
RA   Muzny D.M., Gibbs R.A., Cree A., Dihn H.H., Fowler G., Jhangiani S.,
RA   Joshi V., Lee S., Lewis L.R., Nazareth L.V., Okwuonu G.,
RA   Santibanez J., Warren W.C., Mardis E.R., Weinstock G.M., Wilson R.K.,
RA   Delehaunty K., Dooling D., Fronik C., Fulton L., Fulton B., Graves T.,
RA   Minx P., Sodergren E., Birney E., Margulies E.H., Herrero J.,
RA   Green E.D., Haussler D., Siepel A., Goldman N., Pollard K.S.,
RA   Pedersen J.S., Lander E.S., Kellis M.;
RT   "A high-resolution map of human evolutionary constraint using 29
RT   mammals.";
RL   Nature 478:476-482(2011).
RN   [2] {ECO:0000313|Ensembl:ENSCPOP00000028893}
RP   IDENTIFICATION.
RC   STRAIN=2N {ECO:0000313|Ensembl:ENSCPOP00000028893};
RG   Ensembl;
RL   Submitted (OCT-2017) to UniProtKB.
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DR   EMBL; AAKN02011293; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AAKN02011294; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AAKN02011295; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AAKN02011296; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AAKN02011297; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AAKN02011298; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   STRING; 10141.ENSCPOP00000011596; -.
DR   Ensembl; ENSCPOT00000033675; ENSCPOP00000028893; ENSCPOG00000012883.
DR   GeneTree; ENSGT00940000158340; -.
DR   Proteomes; UP000005447; Unassembled WGS sequence.
DR   GO; GO:0016604; C:nuclear body; IEA:Ensembl.
DR   GO; GO:0005730; C:nucleolus; IEA:Ensembl.
DR   GO; GO:0001227; F:DNA-binding transcription repressor activity, RNA polymerase II-specific; IEA:Ensembl.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0070491; F:repressing transcription factor binding; IEA:Ensembl.
DR   GO; GO:0000978; F:RNA polymerase II proximal promoter sequence-specific DNA binding; IEA:Ensembl.
DR   GO; GO:1990830; P:cellular response to leukemia inhibitory factor; IEA:Ensembl.
DR   GO; GO:0016575; P:histone deacetylation; IEA:Ensembl.
DR   GO; GO:0051567; P:histone H3-K9 methylation; IEA:Ensembl.
DR   GO; GO:0000278; P:mitotic cell cycle; IEA:Ensembl.
DR   InterPro; IPR001214; SET_dom.
DR   InterPro; IPR036236; Znf_C2H2_sf.
DR   InterPro; IPR013087; Znf_C2H2_type.
DR   InterPro; IPR017125; Znf_PRDM5-like.
DR   Pfam; PF00096; zf-C2H2; 10.
DR   PIRSF; PIRSF037162; PRDM; 3.
DR   SMART; SM00355; ZnF_C2H2; 15.
DR   SUPFAM; SSF57667; SSF57667; 8.
DR   PROSITE; PS50280; SET; 1.
DR   PROSITE; PS00028; ZINC_FINGER_C2H2_1; 15.
DR   PROSITE; PS50157; ZINC_FINGER_C2H2_2; 15.
PE   4: Predicted;
KW   Complete proteome {ECO:0000313|Proteomes:UP000005447};
KW   Metal-binding {ECO:0000256|PIRNR:PIRNR037162};
KW   Nucleus {ECO:0000256|PIRNR:PIRNR037162};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005447};
KW   Zinc {ECO:0000256|PIRNR:PIRNR037162};
KW   Zinc-finger {ECO:0000256|PROSITE-ProRule:PRU00042}.
FT   DOMAIN        1     93       SET. {ECO:0000259|PROSITE:PS50280}.
FT   DOMAIN      136    164       C2H2-type. {ECO:0000259|PROSITE:PS50157}.
FT   DOMAIN      168    190       C2H2-type. {ECO:0000259|PROSITE:PS50157}.
FT   DOMAIN      200    230       C2H2-type. {ECO:0000259|PROSITE:PS50157}.
FT   DOMAIN      233    255       C2H2-type. {ECO:0000259|PROSITE:PS50157}.
FT   DOMAIN      258    285       C2H2-type. {ECO:0000259|PROSITE:PS50157}.
FT   DOMAIN      286    313       C2H2-type. {ECO:0000259|PROSITE:PS50157}.
FT   DOMAIN      314    341       C2H2-type. {ECO:0000259|PROSITE:PS50157}.
FT   DOMAIN      342    369       C2H2-type. {ECO:0000259|PROSITE:PS50157}.
FT   DOMAIN      370    398       C2H2-type. {ECO:0000259|PROSITE:PS50157}.
FT   DOMAIN      399    426       C2H2-type. {ECO:0000259|PROSITE:PS50157}.
FT   DOMAIN      427    454       C2H2-type. {ECO:0000259|PROSITE:PS50157}.
FT   DOMAIN      455    482       C2H2-type. {ECO:0000259|PROSITE:PS50157}.
FT   DOMAIN      483    510       C2H2-type. {ECO:0000259|PROSITE:PS50157}.
FT   DOMAIN      511    538       C2H2-type. {ECO:0000259|PROSITE:PS50157}.
FT   DOMAIN      540    563       C2H2-type. {ECO:0000259|PROSITE:PS50157}.
SQ   SEQUENCE   568 AA;  66074 MW;  4EA207D259EAEB0B CRC64;
     GEKFGPFAGE KRMPEDLDEN MDYRLMWEVR GSKGEVLYIL DATNPRHSNW LRFVHEAPSQ
     EQKNLAAIQE GENIFYLAVE DIETDTELLI GYLDSDMEAD EEEQQIMTVI KEGEVENSKG
     QSATGRKDPL CCEEDYACPQ CESSFPSEEI LAEHLQTLHQ KPTEEKEFKC KNCGKKFPVK
     QALQRHFEQH QETCRGDARF VCKADSCGKR LKSKDALKRH QENVHTGDTK KKLICSVCNK
     KCSSPSSLQQ HRKIHEIFDC QECMKKFISA NQLKRHMITH SEKRPYKCEI CNKSFKRLDQ
     VGAHKVIHSE DKPYKCKLCG KGFAHRNVYK NHKKTHSEER PFQCGECKAL FRTPFSLQRH
     LLIHNSERTF KCHHCDATFK RKDTLNVHVQ VVHERHKKYR CELCNKAFVT PSVLRSHKKT
     HTGEKEKVCP YCGQKFASSG TLRVHIRSHT GERPYQCPYC EKGFSKNDGL KMHIRTHTRE
     KPYKCSECSK AFSQKRGLDE HKRTHTGEKP FQCDVCDLAF SLKKMLIRHK MTHNPNRPLA
     ECQFCHKKFT RNDYLKVHMD NIHGVADS
//
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