ID A0A286XTX6_CAVPO Unreviewed; 1078 AA.
AC A0A286XTX6;
DT 22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 1.
DT 27-MAR-2024, entry version 26.
DE SubName: Full=Roundabout guidance receptor 4 {ECO:0000313|Ensembl:ENSCPOP00000028933.1};
GN Name=ROBO4 {ECO:0000313|Ensembl:ENSCPOP00000028933.1};
OS Cavia porcellus (Guinea pig).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Hystricomorpha; Caviidae;
OC Cavia.
OX NCBI_TaxID=10141 {ECO:0000313|Ensembl:ENSCPOP00000028933.1, ECO:0000313|Proteomes:UP000005447};
RN [1] {ECO:0000313|Proteomes:UP000005447}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=2N {ECO:0000313|Proteomes:UP000005447};
RX PubMed=21993624; DOI=10.1038/nature10530;
RA Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J., Washietl S.,
RA Kheradpour P., Ernst J., Jordan G., Mauceli E., Ward L.D., Lowe C.B.,
RA Holloway A.K., Clamp M., Gnerre S., Alfoldi J., Beal K., Chang J.,
RA Clawson H., Cuff J., Di Palma F., Fitzgerald S., Flicek P., Guttman M.,
RA Hubisz M.J., Jaffe D.B., Jungreis I., Kent W.J., Kostka D., Lara M.,
RA Martins A.L., Massingham T., Moltke I., Raney B.J., Rasmussen M.D.,
RA Robinson J., Stark A., Vilella A.J., Wen J., Xie X., Zody M.C., Baldwin J.,
RA Bloom T., Chin C.W., Heiman D., Nicol R., Nusbaum C., Young S.,
RA Wilkinson J., Worley K.C., Kovar C.L., Muzny D.M., Gibbs R.A., Cree A.,
RA Dihn H.H., Fowler G., Jhangiani S., Joshi V., Lee S., Lewis L.R.,
RA Nazareth L.V., Okwuonu G., Santibanez J., Warren W.C., Mardis E.R.,
RA Weinstock G.M., Wilson R.K., Delehaunty K., Dooling D., Fronik C.,
RA Fulton L., Fulton B., Graves T., Minx P., Sodergren E., Birney E.,
RA Margulies E.H., Herrero J., Green E.D., Haussler D., Siepel A., Goldman N.,
RA Pollard K.S., Pedersen J.S., Lander E.S., Kellis M.;
RT "A high-resolution map of human evolutionary constraint using 29 mammals.";
RL Nature 478:476-482(2011).
RN [2] {ECO:0000313|Ensembl:ENSCPOP00000028933.1}
RP IDENTIFICATION.
RC STRAIN=2N {ECO:0000313|Ensembl:ENSCPOP00000028933.1};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR EMBL; AAKN02024660; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAKN02024661; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; A0A286XTX6; -.
DR STRING; 10141.ENSCPOP00000028933; -.
DR Ensembl; ENSCPOT00000033832.1; ENSCPOP00000028933.1; ENSCPOG00000000082.4.
DR VEuPathDB; HostDB:ENSCPOG00000000082; -.
DR eggNOG; KOG4222; Eukaryota.
DR GeneTree; ENSGT00940000161382; -.
DR InParanoid; A0A286XTX6; -.
DR OMA; WEPPPHE; -.
DR Proteomes; UP000005447; Unassembled WGS sequence.
DR Bgee; ENSCPOG00000000082; Expressed in thyroid gland and 12 other cell types or tissues.
DR GO; GO:0001525; P:angiogenesis; IEA:Ensembl.
DR GO; GO:0061028; P:establishment of endothelial barrier; IEA:Ensembl.
DR Gene3D; 2.60.40.10; Immunoglobulins; 4.
DR InterPro; IPR003961; FN3_dom.
DR InterPro; IPR036116; FN3_sf.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR013098; Ig_I-set.
DR InterPro; IPR003599; Ig_sub.
DR InterPro; IPR003598; Ig_sub2.
DR PANTHER; PTHR44170; PROTEIN SIDEKICK; 1.
DR PANTHER; PTHR44170:SF49; PROTEIN SIDEKICK; 1.
DR Pfam; PF00041; fn3; 1.
DR Pfam; PF07679; I-set; 1.
DR Pfam; PF13927; Ig_3; 1.
DR SMART; SM00060; FN3; 2.
DR SMART; SM00409; IG; 2.
DR SMART; SM00408; IGc2; 2.
DR SUPFAM; SSF49265; Fibronectin type III; 1.
DR SUPFAM; SSF48726; Immunoglobulin; 2.
DR PROSITE; PS50853; FN3; 1.
DR PROSITE; PS50835; IG_LIKE; 2.
PE 4: Predicted;
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Immunoglobulin domain {ECO:0000256|ARBA:ARBA00023319};
KW Reference proteome {ECO:0000313|Proteomes:UP000005447};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}; Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..27
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 28..1078
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5012109109"
FT DOMAIN 32..130
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 136..223
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 346..441
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT REGION 590..631
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 709..784
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 797..817
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 847..881
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 612..629
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 723..745
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 759..781
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 859..881
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1078 AA; 115332 MW; F81AFE82E5E06CE8 CRC64;
MGSGGVGLLG GRGPLLLLLL CAGGGKTQES PPQILVHPQD QLLQDSGSAK MSCRASGQPP
PTIRWLLNGQ PLNIDVDLYH LFSDGTLLLL RPPAQGRAHD DQALAMILGI YTCEASNQLG
TAVSRGARLS VAVLREDFQI QPQDTVAMVG EQLVLECGPP WGYPEPTVSW WKDGKPLALQ
PGRHTVSRGS LLVSRAEKSD TGIYMCAATN NAGQRESRAA RVSIQESQDH SEPVELLAVR
IQLENVTLLN PDPKKGSKPG PAVWLSWKVS GPAAPAQSYT ALFRARTAQG GQRAPWAEAL
LDGWQSAELG GLRWGQAYEF KVRPSSGRAR GPDSNVLLLS LPEQVPSAPP QEVTLKHNNS
SILVSWVPPP AENHNGVIRG YQVWSLGNTS LPPINCTVVG AQTQLEMDAQ MSGSYCVQVA
AFTGAGAGAP SSPVCLLLEK PMEQSAQEPS EQGPWALEWL RATVRRPEVI ASGGVLLWLL
LLGIAVCIYR RHQARVHMGP GLYRYTSEDA ILKHRMDHSD SPWLADTWRS TSGSRDLSSS
SSLNSRLGVD PRDPLDCRRS LISWDPRSPG VPLLPDTSTF YGSLIAELPS SPPSRLSPQT
PAARRRPPQL IRTSSPWPSS DSLCNHRGPD SPCSLSLAPA EAWKTKKKQE LHQANSSPLL
RGSHSLELWA WELGHRSSKN LSQSPAVPGA LVAWRALGPQ LLRSSNELAT RPLPPAPLSP
GGAPTQNPQT QHTVEPQASA PLSVLSPSRP PSPQPSSLSG PSPASSRLSS SSLSSLGEDQ
DSVLTPEEVA LCLELSEGEE TPRNSTSPMP RAPSPPTTYG YISIPTASEL ADVGGAGGRV
ASERGGLLCP PRPCPTPTPS EGSLANGWGS ASEDNGPSAR ASLVSSSDGS FFADAHFARA
LGMAVDSFGF GLEPREADCV FTDASSPPSP RDDISLTPTF PLSLWEWRPD WLEDIEINHT
QQLGKGLPPW TPDSGISSQR SRLSCHVPKA GGKCGGLAMV ASFPRGLWGG AKCKPGSSRR
HRVKGGDSTL PHSYYRLLLT RVPGIGHQGH PSRLLTRLAC ARASRRVLPP RLLQKKER
//
