ID A0A286XU40_CAVPO Unreviewed; 865 AA.
AC A0A286XU40;
DT 22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 1.
DT 27-MAR-2024, entry version 23.
DE SubName: Full=DENN domain containing 2A {ECO:0000313|Ensembl:ENSCPOP00000029055.1};
GN Name=DENND2A {ECO:0000313|Ensembl:ENSCPOP00000029055.1};
OS Cavia porcellus (Guinea pig).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Hystricomorpha; Caviidae;
OC Cavia.
OX NCBI_TaxID=10141 {ECO:0000313|Ensembl:ENSCPOP00000029055.1, ECO:0000313|Proteomes:UP000005447};
RN [1] {ECO:0000313|Proteomes:UP000005447}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=2N {ECO:0000313|Proteomes:UP000005447};
RX PubMed=21993624; DOI=10.1038/nature10530;
RA Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J., Washietl S.,
RA Kheradpour P., Ernst J., Jordan G., Mauceli E., Ward L.D., Lowe C.B.,
RA Holloway A.K., Clamp M., Gnerre S., Alfoldi J., Beal K., Chang J.,
RA Clawson H., Cuff J., Di Palma F., Fitzgerald S., Flicek P., Guttman M.,
RA Hubisz M.J., Jaffe D.B., Jungreis I., Kent W.J., Kostka D., Lara M.,
RA Martins A.L., Massingham T., Moltke I., Raney B.J., Rasmussen M.D.,
RA Robinson J., Stark A., Vilella A.J., Wen J., Xie X., Zody M.C., Baldwin J.,
RA Bloom T., Chin C.W., Heiman D., Nicol R., Nusbaum C., Young S.,
RA Wilkinson J., Worley K.C., Kovar C.L., Muzny D.M., Gibbs R.A., Cree A.,
RA Dihn H.H., Fowler G., Jhangiani S., Joshi V., Lee S., Lewis L.R.,
RA Nazareth L.V., Okwuonu G., Santibanez J., Warren W.C., Mardis E.R.,
RA Weinstock G.M., Wilson R.K., Delehaunty K., Dooling D., Fronik C.,
RA Fulton L., Fulton B., Graves T., Minx P., Sodergren E., Birney E.,
RA Margulies E.H., Herrero J., Green E.D., Haussler D., Siepel A., Goldman N.,
RA Pollard K.S., Pedersen J.S., Lander E.S., Kellis M.;
RT "A high-resolution map of human evolutionary constraint using 29 mammals.";
RL Nature 478:476-482(2011).
RN [2] {ECO:0000313|Ensembl:ENSCPOP00000029055.1}
RP IDENTIFICATION.
RC STRAIN=2N {ECO:0000313|Ensembl:ENSCPOP00000029055.1};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR EMBL; AAKN02015476; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; A0A286XU40; -.
DR STRING; 10141.ENSCPOP00000029055; -.
DR Ensembl; ENSCPOT00000031769.1; ENSCPOP00000029055.1; ENSCPOG00000030550.1.
DR VEuPathDB; HostDB:ENSCPOG00000030550; -.
DR GeneTree; ENSGT00950000182931; -.
DR InParanoid; A0A286XU40; -.
DR OMA; CPAYVPL; -.
DR Proteomes; UP000005447; Unassembled WGS sequence.
DR Bgee; ENSCPOG00000030550; Expressed in cerebellum and 13 other cell types or tissues.
DR GO; GO:0015629; C:actin cytoskeleton; IEA:Ensembl.
DR GO; GO:0005829; C:cytosol; IEA:GOC.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
DR GO; GO:0042147; P:retrograde transport, endosome to Golgi; IEA:Ensembl.
DR Gene3D; 3.30.450.200; -; 1.
DR Gene3D; 3.40.50.11500; -; 1.
DR InterPro; IPR001194; cDENN_dom.
DR InterPro; IPR005112; dDENN_dom.
DR InterPro; IPR043153; DENN_C.
DR InterPro; IPR037516; Tripartite_DENN.
DR InterPro; IPR005113; uDENN_dom.
DR PANTHER; PTHR15288; DENN DOMAIN-CONTAINING PROTEIN 2; 1.
DR PANTHER; PTHR15288:SF3; DENN DOMAIN-CONTAINING PROTEIN 2A; 1.
DR Pfam; PF03455; dDENN; 1.
DR Pfam; PF02141; DENN; 1.
DR Pfam; PF03456; uDENN; 1.
DR SMART; SM00801; dDENN; 1.
DR SMART; SM00799; DENN; 1.
DR SMART; SM00800; uDENN; 1.
DR PROSITE; PS50211; DENN; 1.
PE 4: Predicted;
KW Guanine-nucleotide releasing factor {ECO:0000256|ARBA:ARBA00022658};
KW Reference proteome {ECO:0000313|Proteomes:UP000005447}.
FT DOMAIN 425..827
FT /note="UDENN"
FT /evidence="ECO:0000259|PROSITE:PS50211"
FT REGION 1..209
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 262..285
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 305..334
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 357..392
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 38..66
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 155..176
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 184..200
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 376..392
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 865 AA; 97087 MW; F0919472BFCE1F30 CRC64;
VLEAALDMRG SGRATAGLAA REAGRKPWGA RPEPPSIKDK IWQWEGKKSE EPRAPPAEEA
EAPEQRGRSA GRAGVRGPGL TWPGPDPRTV LTQVQRLERA LQDGSAGLDP QPPGTCYSAP
ALPGKAPRSP PPKPRRTFEH AGDTAGSPGL RKQRGRHPPL PPLPPLPLPA SPPPAALCRR
RGPARPRPST DHRKSYEFED LLQPSSESSR VDWYAQTRLG HTRTLSEENV YEDILDPPLK
ENPYEDIELH GRCLGRKCVL TSPASPTSSI PDTPTKQSLS KPAFFGQNSE KKNFRLLDMR
KLSRDGAVSP PKTSPPSTPS SPDDTTFNLG DLQNGRRKRK IPKLVLRINA IYEARRGKKR
VKRLSQSTES GSGKVTDENS ESDSDTEEKL KAHSQRLVNV QSRLRQAPRY PARELLECQE
RQLFEFFVVV SLHRKQAGAA YVPELTQQFP LKLERTFKFT REAEDQLKAI PQFCFPDAKD
WTPVQQFTSE TFSFVLTGED GSRRFGYCRR LLPGGKGKRL PEVYCIVSRL GCFSLFSKIL
DEVEKRRGIS PALVQPLMRS VMEAPFPALG KTIVVKNFLP GSGTEVIELC RPLDSRLEHV
DFESLFSSLS VRHLVCVFAS LLLERRVIFI ADKLSTLSKC CHAMVALIYP FRWQHTYIPV
LPPAMIDIVC SPTPFLVGLL ASSLPLLHEL PLEEVLVVDL INNRFLRQME DEDSILPRKL
QVALEHILEQ RNELACDQDG GSPDCEHGPR CSPLSEVVSE AFVRFFVEVV GHYPLFLTPG
ERALQREAFR KAVSSKSLRR FLEVFMETQT FRGFMQEREL CRQDTKGLFE VRAQEYLETL
PSGDHSGVNR FLKGLGNKMK FLHKK
//
