ID A0A286XUN7_CAVPO Unreviewed; 1020 AA.
AC A0A286XUN7;
DT 22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 1.
DT 27-MAR-2024, entry version 30.
DE SubName: Full=Collagen type VI alpha 2 chain {ECO:0000313|Ensembl:ENSCPOP00000029194.1};
GN Name=COL6A2 {ECO:0000313|Ensembl:ENSCPOP00000029194.1};
OS Cavia porcellus (Guinea pig).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Hystricomorpha; Caviidae;
OC Cavia.
OX NCBI_TaxID=10141 {ECO:0000313|Ensembl:ENSCPOP00000029194.1, ECO:0000313|Proteomes:UP000005447};
RN [1] {ECO:0000313|Proteomes:UP000005447}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=2N {ECO:0000313|Proteomes:UP000005447};
RX PubMed=21993624; DOI=10.1038/nature10530;
RA Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J., Washietl S.,
RA Kheradpour P., Ernst J., Jordan G., Mauceli E., Ward L.D., Lowe C.B.,
RA Holloway A.K., Clamp M., Gnerre S., Alfoldi J., Beal K., Chang J.,
RA Clawson H., Cuff J., Di Palma F., Fitzgerald S., Flicek P., Guttman M.,
RA Hubisz M.J., Jaffe D.B., Jungreis I., Kent W.J., Kostka D., Lara M.,
RA Martins A.L., Massingham T., Moltke I., Raney B.J., Rasmussen M.D.,
RA Robinson J., Stark A., Vilella A.J., Wen J., Xie X., Zody M.C., Baldwin J.,
RA Bloom T., Chin C.W., Heiman D., Nicol R., Nusbaum C., Young S.,
RA Wilkinson J., Worley K.C., Kovar C.L., Muzny D.M., Gibbs R.A., Cree A.,
RA Dihn H.H., Fowler G., Jhangiani S., Joshi V., Lee S., Lewis L.R.,
RA Nazareth L.V., Okwuonu G., Santibanez J., Warren W.C., Mardis E.R.,
RA Weinstock G.M., Wilson R.K., Delehaunty K., Dooling D., Fronik C.,
RA Fulton L., Fulton B., Graves T., Minx P., Sodergren E., Birney E.,
RA Margulies E.H., Herrero J., Green E.D., Haussler D., Siepel A., Goldman N.,
RA Pollard K.S., Pedersen J.S., Lander E.S., Kellis M.;
RT "A high-resolution map of human evolutionary constraint using 29 mammals.";
RL Nature 478:476-482(2011).
RN [2] {ECO:0000313|Ensembl:ENSCPOP00000029194.1}
RP IDENTIFICATION.
RC STRAIN=2N {ECO:0000313|Ensembl:ENSCPOP00000029194.1};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR EMBL; AAKN02051914; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_003463209.2; XM_003463161.3.
DR AlphaFoldDB; A0A286XUN7; -.
DR STRING; 10141.ENSCPOP00000029194; -.
DR Ensembl; ENSCPOT00000044591.1; ENSCPOP00000029194.1; ENSCPOG00000021819.2.
DR GeneID; 100732068; -.
DR KEGG; cpoc:100732068; -.
DR CTD; 1292; -.
DR VEuPathDB; HostDB:ENSCPOG00000021819; -.
DR eggNOG; KOG3544; Eukaryota.
DR GeneTree; ENSGT00940000155682; -.
DR InParanoid; A0A286XUN7; -.
DR OMA; ELYRDDY; -.
DR OrthoDB; 2906665at2759; -.
DR Proteomes; UP000005447; Unassembled WGS sequence.
DR Bgee; ENSCPOG00000021819; Expressed in uterine cervix and 12 other cell types or tissues.
DR GO; GO:0031012; C:extracellular matrix; IEA:Ensembl.
DR GO; GO:0005576; C:extracellular region; IEA:Ensembl.
DR GO; GO:0032991; C:protein-containing complex; IEA:Ensembl.
DR GO; GO:0042383; C:sarcolemma; IEA:Ensembl.
DR GO; GO:0005518; F:collagen binding; IEA:Ensembl.
DR GO; GO:0051402; P:neuron apoptotic process; IEA:Ensembl.
DR GO; GO:0043491; P:phosphatidylinositol 3-kinase/protein kinase B signal transduction; IEA:Ensembl.
DR GO; GO:0009411; P:response to UV; IEA:Ensembl.
DR CDD; cd01480; vWA_collagen_alpha_1-VI-type; 1.
DR CDD; cd00198; vWFA; 1.
DR Gene3D; 1.20.5.320; 6-Phosphogluconate Dehydrogenase, domain 3; 1.
DR Gene3D; 3.40.50.410; von Willebrand factor, type A domain; 3.
DR InterPro; IPR008160; Collagen.
DR InterPro; IPR002035; VWF_A.
DR InterPro; IPR036465; vWFA_dom_sf.
DR PANTHER; PTHR24020; COLLAGEN ALPHA; 1.
DR PANTHER; PTHR24020:SF70; PH DOMAIN-CONTAINING PROTEIN; 1.
DR Pfam; PF01391; Collagen; 5.
DR Pfam; PF00092; VWA; 3.
DR PRINTS; PR00453; VWFADOMAIN.
DR SMART; SM00327; VWA; 3.
DR SUPFAM; SSF53300; vWA-like; 3.
DR PROSITE; PS50234; VWFA; 3.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000005447};
KW Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..20
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 21..1020
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5011780367"
FT DOMAIN 48..235
FT /note="VWFA"
FT /evidence="ECO:0000259|PROSITE:PS50234"
FT DOMAIN 616..806
FT /note="VWFA"
FT /evidence="ECO:0000259|PROSITE:PS50234"
FT DOMAIN 834..1015
FT /note="VWFA"
FT /evidence="ECO:0000259|PROSITE:PS50234"
FT REGION 258..589
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 560..585
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1020 AA; 108641 MW; F5E2C45B1A6EF3FE CRC64;
MLRGPLSALL LGGLLGALHA QQQEVVLPDT VTSERTNSCP EKTDCPVNVY FVLDTSESVA
MQSPTDSLLY HMQQFVPQLI SQLQNEFYLD QVVLSWRYGG LHFSDQVEVF SPPGSDRASF
TKSLQGITSF RRGTFTDCAL ANMTQEIRRS GVRGVNFAVV ITDGHVTGSP CGGIKLQAER
ARDEGIRLFA VSPNQNLNEQ GLRDIASTPH ELYRSNYATM RPDSTEIDQN TINRIIKVMK
HEAYGECYKV SCLEIPGPAG PKGYRGQKGA KGNMGEPGEP GQKGRQGDPG IEGPIGFPGP
KGVPGFKGEK GEFGADGRKG APGLAGKNGT DGQKGKLGRI GPPGCKGDPG DRGPDGYPGD
AGSPGEQGDQ GAKGDAGRPG RRGPPGDPGD KGSKGYQGNN GAPGSPGVKG AKGGPGPRGP
KGEPGRRGDP GTKGSPGNDG PKGEKGDPGP EGPRGLAGEV GSKGAKGDRG LPGPRGPQGA
LGEPGKQGSR GDPGDAGPRG ESGQPGPKGD PGRPGFSYPG PRGTPGNKGE PGPPGPEGSR
GDFGMKGRPG RKGAKGEPAD PGPPGEPGPR GPRGEPGPEG EPGPPGDPGL TECDVMTYVR
ETCGCCDCEK RCGALDVVFV IDSSESIGYT NFTLEKNFVI NVVNRLGAIA KDPKSETGTR
VGVVQYSHEG TFEAIQLDDE RINSLSSFKE AVKNLEWIAG GTWTPSALKF AYNQLIKESR
RQKTRVFAVV ITDGRHDPRD DDLNLRALCD RDVTVTAIGI GDMFHERHES ENLYSIACDK
PQQVRNMTLF SDLVAEKFID DMEEVLCPDP QIVCPELPCQ TELYVAQCTQ RPVDIVFLLD
GSERLGEQNF HKARRFVEEV ARRLTLARRD DDPLNARVAL LQFGGLQEQQ LAFPLTTNLT
VIQEALEDAR YLNSFSHVGA GVVHAINHVV RGARAGARRH AELSFVFLTD GVTGNESLEE
AVHSMRKQNV VPTVVAVGSD VDMDVLTKIS LGDRAAIFRE KDFDSLTQPS FFDRFIRWIC
//
