ID A0A286XVQ6_CAVPO Unreviewed; 1033 AA.
AC A0A286XVQ6;
DT 22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 1.
DT 27-MAR-2024, entry version 30.
DE SubName: Full=Glutamate receptor interacting protein 1 {ECO:0000313|Ensembl:ENSCPOP00000029412.1};
GN Name=GRIP1 {ECO:0000313|Ensembl:ENSCPOP00000029412.1};
OS Cavia porcellus (Guinea pig).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Hystricomorpha; Caviidae;
OC Cavia.
OX NCBI_TaxID=10141 {ECO:0000313|Ensembl:ENSCPOP00000029412.1, ECO:0000313|Proteomes:UP000005447};
RN [1] {ECO:0000313|Proteomes:UP000005447}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=2N {ECO:0000313|Proteomes:UP000005447};
RX PubMed=21993624; DOI=10.1038/nature10530;
RA Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J., Washietl S.,
RA Kheradpour P., Ernst J., Jordan G., Mauceli E., Ward L.D., Lowe C.B.,
RA Holloway A.K., Clamp M., Gnerre S., Alfoldi J., Beal K., Chang J.,
RA Clawson H., Cuff J., Di Palma F., Fitzgerald S., Flicek P., Guttman M.,
RA Hubisz M.J., Jaffe D.B., Jungreis I., Kent W.J., Kostka D., Lara M.,
RA Martins A.L., Massingham T., Moltke I., Raney B.J., Rasmussen M.D.,
RA Robinson J., Stark A., Vilella A.J., Wen J., Xie X., Zody M.C., Baldwin J.,
RA Bloom T., Chin C.W., Heiman D., Nicol R., Nusbaum C., Young S.,
RA Wilkinson J., Worley K.C., Kovar C.L., Muzny D.M., Gibbs R.A., Cree A.,
RA Dihn H.H., Fowler G., Jhangiani S., Joshi V., Lee S., Lewis L.R.,
RA Nazareth L.V., Okwuonu G., Santibanez J., Warren W.C., Mardis E.R.,
RA Weinstock G.M., Wilson R.K., Delehaunty K., Dooling D., Fronik C.,
RA Fulton L., Fulton B., Graves T., Minx P., Sodergren E., Birney E.,
RA Margulies E.H., Herrero J., Green E.D., Haussler D., Siepel A., Goldman N.,
RA Pollard K.S., Pedersen J.S., Lander E.S., Kellis M.;
RT "A high-resolution map of human evolutionary constraint using 29 mammals.";
RL Nature 478:476-482(2011).
RN [2] {ECO:0000313|Ensembl:ENSCPOP00000029412.1}
RP IDENTIFICATION.
RC STRAIN=2N {ECO:0000313|Ensembl:ENSCPOP00000029412.1};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR EMBL; AAKN02014555; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAKN02014556; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; A0A286XVQ6; -.
DR Ensembl; ENSCPOT00000044193.1; ENSCPOP00000029412.1; ENSCPOG00000013682.4.
DR VEuPathDB; HostDB:ENSCPOG00000013682; -.
DR GeneTree; ENSGT00940000158692; -.
DR Proteomes; UP000005447; Unassembled WGS sequence.
DR Bgee; ENSCPOG00000013682; Expressed in testis and 11 other cell types or tissues.
DR CDD; cd00992; PDZ_signaling; 7.
DR Gene3D; 2.30.42.10; -; 7.
DR InterPro; IPR043545; GRIP1/2.
DR InterPro; IPR001478; PDZ.
DR InterPro; IPR041489; PDZ_6.
DR InterPro; IPR036034; PDZ_sf.
DR PANTHER; PTHR46227:SF3; GLUTAMATE RECEPTOR-INTERACTING PROTEIN 1; 1.
DR PANTHER; PTHR46227; GLUTAMATE RECEPTOR-INTERACTING PROTEIN GRIP; 1.
DR Pfam; PF00595; PDZ; 6.
DR Pfam; PF17820; PDZ_6; 1.
DR SMART; SM00228; PDZ; 7.
DR SUPFAM; SSF50156; PDZ domain-like; 7.
DR PROSITE; PS50106; PDZ; 7.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000005447}.
FT DOMAIN 26..109
FT /note="PDZ"
FT /evidence="ECO:0000259|PROSITE:PS50106"
FT DOMAIN 123..211
FT /note="PDZ"
FT /evidence="ECO:0000259|PROSITE:PS50106"
FT DOMAIN 225..309
FT /note="PDZ"
FT /evidence="ECO:0000259|PROSITE:PS50106"
FT DOMAIN 393..468
FT /note="PDZ"
FT /evidence="ECO:0000259|PROSITE:PS50106"
FT DOMAIN 494..579
FT /note="PDZ"
FT /evidence="ECO:0000259|PROSITE:PS50106"
FT DOMAIN 594..676
FT /note="PDZ"
FT /evidence="ECO:0000259|PROSITE:PS50106"
FT DOMAIN 910..992
FT /note="PDZ"
FT /evidence="ECO:0000259|PROSITE:PS50106"
FT REGION 675..727
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 757..809
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 841..887
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 769..809
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 841..884
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1033 AA; 111823 MW; EC2A83C9405D3660 CRC64;
MIAVSFKCRC QILRRLTKEE FKGSTIVELM KKEGTTLGLT VSGGIDKDGK PRVSNLRQGG
IAARSDQLDV GDYIKAVNGI NLAKFRHDEI ISLLKNVGER VVLEVEYELP PISVQGSSVI
FRTVEVTLHK EGNTFGFVIR GGAHDDRNKS RPVVITCVRP GGPADREGTI KPGDRLLSVD
GIRLLGTTHA EAMSILKQCG QEATLLIEYD VSVMDTVATA SGPLLVEVAK TPGASLGVVL
TTSMCCNKQV IVIDKIKSAS IADRCGALHV GDHILSIDGT SMEYCTLAEA TQFLANTTDQ
VKLEILPHHQ TRLALKGPDH AALVSSSFSP TSMSAYSLSS LNMGTLPRSL YSTSPRGTMM
RRRLKKKDFK SSLSLASSTV GLAGQVVHTE TTEVVLTADP ITGFGIQLQG SVFATETLSS
PPLISYIEAD SPAERCGVLQ IGDRVMAING IPTEDSTFEE ANQLLRNSSI TSKVTLEIEF
DVAESVIPSS GTFHVKLPKK HNVELGITIS SPSSRKPGDP LVISDIKKGS VAHRTGTLEL
GDKLLAIDNI RLDNCSMEDA VQILQQCEDL VKLKIRKDED NSDEQESSGA IIYTVELKRY
GGPLGITISG TEEPFDPIII SSLTKGGLAE RTGAIHIGDR ILAINSSSLK GKPLSEAIHL
LQMAGETVTL KIKKQTEAQS ASSPKKFPVP SHLSDLGDAE EDSSPAQKPG KLSDMYPSTV
PSVDSAVDSW DGSGIDASYG NQGTSFQAPG YNFNTYDWRS PKQRGSLSPV PKPRSQTYPD
VGLSNEDWDR STASGFAGTS DSAEAEQEEN FWSQALEDLE TCGQSGILRE LEATIMSGST
MSLNHEAPTP RNQLGRQASF QERSSSRPHY SQTTRSNTLP SDVGRKSVTL RKMKQEIKEI
MSPTPVELHK VTLYKDSDME DFGFSVADGL LEKGVYVKNI RPAGPGDLGG LKPYDRLLQV
NHVRTRDFDC CLVVPLIAES GNKLDLVISR NPLASQKSVE QTLPRDWSEQ NSAFFQQPSH
SGNLETREPN NTL
//
