ID A0A286XVQ8_CAVPO Unreviewed; 1265 AA.
AC A0A286XVQ8;
DT 22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 1.
DT 27-MAR-2024, entry version 30.
DE RecName: Full=Cohesin subunit SA {ECO:0000256|RuleBase:RU369063};
DE AltName: Full=SCC3 homolog {ECO:0000256|RuleBase:RU369063};
DE AltName: Full=Stromal antigen {ECO:0000256|RuleBase:RU369063};
GN Name=STAG1 {ECO:0000313|Ensembl:ENSCPOP00000029623.1};
OS Cavia porcellus (Guinea pig).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Hystricomorpha; Caviidae;
OC Cavia.
OX NCBI_TaxID=10141 {ECO:0000313|Ensembl:ENSCPOP00000029623.1, ECO:0000313|Proteomes:UP000005447};
RN [1] {ECO:0000313|Proteomes:UP000005447}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=2N {ECO:0000313|Proteomes:UP000005447};
RX PubMed=21993624; DOI=10.1038/nature10530;
RA Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J., Washietl S.,
RA Kheradpour P., Ernst J., Jordan G., Mauceli E., Ward L.D., Lowe C.B.,
RA Holloway A.K., Clamp M., Gnerre S., Alfoldi J., Beal K., Chang J.,
RA Clawson H., Cuff J., Di Palma F., Fitzgerald S., Flicek P., Guttman M.,
RA Hubisz M.J., Jaffe D.B., Jungreis I., Kent W.J., Kostka D., Lara M.,
RA Martins A.L., Massingham T., Moltke I., Raney B.J., Rasmussen M.D.,
RA Robinson J., Stark A., Vilella A.J., Wen J., Xie X., Zody M.C., Baldwin J.,
RA Bloom T., Chin C.W., Heiman D., Nicol R., Nusbaum C., Young S.,
RA Wilkinson J., Worley K.C., Kovar C.L., Muzny D.M., Gibbs R.A., Cree A.,
RA Dihn H.H., Fowler G., Jhangiani S., Joshi V., Lee S., Lewis L.R.,
RA Nazareth L.V., Okwuonu G., Santibanez J., Warren W.C., Mardis E.R.,
RA Weinstock G.M., Wilson R.K., Delehaunty K., Dooling D., Fronik C.,
RA Fulton L., Fulton B., Graves T., Minx P., Sodergren E., Birney E.,
RA Margulies E.H., Herrero J., Green E.D., Haussler D., Siepel A., Goldman N.,
RA Pollard K.S., Pedersen J.S., Lander E.S., Kellis M.;
RT "A high-resolution map of human evolutionary constraint using 29 mammals.";
RL Nature 478:476-482(2011).
RN [2] {ECO:0000313|Ensembl:ENSCPOP00000029623.1}
RP IDENTIFICATION.
RC STRAIN=2N {ECO:0000313|Ensembl:ENSCPOP00000029623.1};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: Component of cohesin complex, a complex required for the
CC cohesion of sister chromatids after DNA replication. The cohesin
CC complex apparently forms a large proteinaceous ring within which sister
CC chromatids can be trapped. At anaphase, the complex is cleaved and
CC dissociates from chromatin, allowing sister chromatids to segregate.
CC {ECO:0000256|RuleBase:RU369063}.
CC -!- SUBUNIT: Part of the cohesin complex which is composed of a heterodimer
CC between a SMC1 protein (SMC1A or SMC1B) and SMC3, which are attached
CC via their hinge domain, and RAD21 which link them at their heads, and
CC one STAG protein. {ECO:0000256|RuleBase:RU369063}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|RuleBase:RU369063}.
CC Chromosome {ECO:0000256|RuleBase:RU369063}. Chromosome, centromere
CC {ECO:0000256|RuleBase:RU369063}.
CC -!- SIMILARITY: Belongs to the SCC3 family. {ECO:0000256|ARBA:ARBA00005486,
CC ECO:0000256|RuleBase:RU369063}.
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DR EMBL; AAKN02013085; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAKN02013086; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAKN02013087; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAKN02013088; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAKN02013089; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAKN02013090; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAKN02013091; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAKN02013092; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAKN02013093; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAKN02013094; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; A0A286XVQ8; -.
DR STRING; 10141.ENSCPOP00000029623; -.
DR Ensembl; ENSCPOT00000036924.1; ENSCPOP00000029623.1; ENSCPOG00000013210.4.
DR VEuPathDB; HostDB:ENSCPOG00000013210; -.
DR GeneTree; ENSGT00950000182972; -.
DR InParanoid; A0A286XVQ8; -.
DR OMA; THTINFI; -.
DR Proteomes; UP000005447; Unassembled WGS sequence.
DR Bgee; ENSCPOG00000013210; Expressed in heart left ventricle and 12 other cell types or tissues.
DR GO; GO:0000785; C:chromatin; IEA:UniProtKB-UniRule.
DR GO; GO:0000775; C:chromosome, centromeric region; IEA:UniProtKB-SubCell.
DR GO; GO:0008278; C:cohesin complex; IEA:UniProtKB-UniRule.
DR GO; GO:0097431; C:mitotic spindle pole; IEA:Ensembl.
DR GO; GO:0016604; C:nuclear body; IEA:Ensembl.
DR GO; GO:0016363; C:nuclear matrix; IEA:Ensembl.
DR GO; GO:0003682; F:chromatin binding; IEA:Ensembl.
DR GO; GO:0051301; P:cell division; IEA:UniProtKB-UniRule.
DR GO; GO:0051179; P:localization; IEA:Ensembl.
DR GO; GO:0090307; P:mitotic spindle assembly; IEA:Ensembl.
DR GO; GO:0007062; P:sister chromatid cohesion; IEA:UniProtKB-UniRule.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR039662; Cohesin_Scc3/SA.
DR InterPro; IPR020839; SCD.
DR InterPro; IPR013721; STAG.
DR PANTHER; PTHR11199:SF6; COHESIN SUBUNIT SA-1; 1.
DR PANTHER; PTHR11199; STROMAL ANTIGEN; 1.
DR Pfam; PF21581; SCD; 1.
DR Pfam; PF08514; STAG; 1.
DR SUPFAM; SSF48371; ARM repeat; 1.
DR PROSITE; PS51425; SCD; 1.
PE 3: Inferred from homology;
KW Cell cycle {ECO:0000256|RuleBase:RU369063};
KW Cell division {ECO:0000256|RuleBase:RU369063};
KW Chromosome {ECO:0000256|RuleBase:RU369063};
KW Chromosome partition {ECO:0000256|RuleBase:RU369063};
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Nucleus {ECO:0000256|RuleBase:RU369063};
KW Reference proteome {ECO:0000313|Proteomes:UP000005447}.
FT DOMAIN 294..379
FT /note="SCD"
FT /evidence="ECO:0000259|PROSITE:PS51425"
FT REGION 1..82
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1054..1094
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1126..1146
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 258..288
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 1..18
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 19..33
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 47..62
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1055..1075
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1265 AA; 145427 MW; B3AEB9CF6FB47EEB CRC64;
KTHQLPLMDS TNETTAHSDA GSELEETEVK GKRKRGRPGR PPSTNKKPRK SPGEKTRIEA
GVRGTGRGRA NGHPQQNGEG EPVTLFEVVK LGKSAMQSVV DDWIESYKQD RDIALLDLIN
FFIQCSGCRG TVRIEMFRNM QNAEIIRKMT EEFDEDSGDY PLTMPGPQWK KFRSNFCEFI
GVLIRQCQYS IIYDEYMMDT VISLLTGLSD SQVRAFRHTS TLAAMKLMTA LVNVALNLSI
HQDNTQRQYE AERNKMIGKR ANERLELLLQ KRKELQENQD EIENMMNSIF KGIFVHRYRD
AIAEIRAICI EEIGVWMKMY SDAFLNDSYL KYVGWTLHDR QGEVRLKCLK ALQSLYTNRE
LFPKLELFTN RFKDRIVSMT LDKEYDVAVE AIRLVTLILH GSEEALSNED CENVYHLVYS
AHRPVAVAAG EFLHKKLFSR HDPQAEEALA KRRGRNSPNG NLIRMLVLFF LESELHEHAA
YLVDSLWESS QELLKDWECM TELLLEEPVQ GEEAMSDRQE SALIELMVCT IRQAAEAHPP
VGRGTGKRVL TAKERKTQID DRNKLTEHFI ITLPMLLSKY SADAEKVANL LQIPQYFDLE
IYSTGRMEKH LDALLKQIKF VVEKHVESDV LEACSKTYSI LCSEEYTIQN RVDIARSQLI
DEFVDRFSHS VEDLLQEGEE ADDDDIYNVL STLKRLTSFH NAHDLTKWDL FGNCYRLLKT
GIEHGAMPEQ IVVQALQCSH YSILWQLVKI TDGSPSKEDL LVLRKTVKSF LAVCQQCLSN
VNTPVKEQAF MLLCDLLMIF SHQLMTGGRE GLQPLVFNPD TGLQSELLSF VMDHVFIDQD
EENQSMEGDE EDEANKIEAL HKRRNLLAAF SKLIIYDIVD MHAAADIFKH YMKYYNDYGD
IIKETLSKTR QIDKIQCAKT LILSLQQLFN ELVQEQGPNL DRTSAHVSAL RNWHALCPYI
GLDQIKTARS AILFYFRDGI EFAFKYQNQK GQEYPPPNLA FLEVLSEFSS KLLRQDKKTV
HSYLEKFLTE QMMERREDVW LPLISYRNSL VTGGEDDRMS VNSGSSSSKT SSVRNKKGRP
PLHKKRVEDE SLDNTWLNRT DTMIQTPGPL PAPQLTSTVL RENSRPLGEQ MQEPESEHGS
EPDFLHNPQM QISWLGQPKL EDLNRKDRTG MNYMKVRTGV RHAVRGLMEE DAEPIFEDVM
MSSRSQLEDM NEEFEDTMVI DLPPSRNRRE RAELRPDFFD SAAIIEDDSV NIELLLVFLE
LTGFG
//
