ID A0A286XVX2_CAVPO Unreviewed; 2729 AA.
AC A0A286XVX2;
DT 22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 1.
DT 27-MAR-2024, entry version 29.
DE SubName: Full=Neurofibromin 1 {ECO:0000313|Ensembl:ENSCPOP00000029620.1};
GN Name=NF1 {ECO:0000313|Ensembl:ENSCPOP00000029620.1};
OS Cavia porcellus (Guinea pig).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Hystricomorpha; Caviidae;
OC Cavia.
OX NCBI_TaxID=10141 {ECO:0000313|Ensembl:ENSCPOP00000029620.1, ECO:0000313|Proteomes:UP000005447};
RN [1] {ECO:0000313|Proteomes:UP000005447}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=2N {ECO:0000313|Proteomes:UP000005447};
RX PubMed=21993624; DOI=10.1038/nature10530;
RA Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J., Washietl S.,
RA Kheradpour P., Ernst J., Jordan G., Mauceli E., Ward L.D., Lowe C.B.,
RA Holloway A.K., Clamp M., Gnerre S., Alfoldi J., Beal K., Chang J.,
RA Clawson H., Cuff J., Di Palma F., Fitzgerald S., Flicek P., Guttman M.,
RA Hubisz M.J., Jaffe D.B., Jungreis I., Kent W.J., Kostka D., Lara M.,
RA Martins A.L., Massingham T., Moltke I., Raney B.J., Rasmussen M.D.,
RA Robinson J., Stark A., Vilella A.J., Wen J., Xie X., Zody M.C., Baldwin J.,
RA Bloom T., Chin C.W., Heiman D., Nicol R., Nusbaum C., Young S.,
RA Wilkinson J., Worley K.C., Kovar C.L., Muzny D.M., Gibbs R.A., Cree A.,
RA Dihn H.H., Fowler G., Jhangiani S., Joshi V., Lee S., Lewis L.R.,
RA Nazareth L.V., Okwuonu G., Santibanez J., Warren W.C., Mardis E.R.,
RA Weinstock G.M., Wilson R.K., Delehaunty K., Dooling D., Fronik C.,
RA Fulton L., Fulton B., Graves T., Minx P., Sodergren E., Birney E.,
RA Margulies E.H., Herrero J., Green E.D., Haussler D., Siepel A., Goldman N.,
RA Pollard K.S., Pedersen J.S., Lander E.S., Kellis M.;
RT "A high-resolution map of human evolutionary constraint using 29 mammals.";
RL Nature 478:476-482(2011).
RN [2] {ECO:0000313|Ensembl:ENSCPOP00000029620.1}
RP IDENTIFICATION.
RC STRAIN=2N {ECO:0000313|Ensembl:ENSCPOP00000029620.1};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR EMBL; AAKN02033368; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAKN02033369; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAKN02033370; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAKN02033371; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAKN02033372; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAKN02033373; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR Ensembl; ENSCPOT00000044827.1; ENSCPOP00000029620.1; ENSCPOG00000006112.4.
DR VEuPathDB; HostDB:ENSCPOG00000006112; -.
DR GeneTree; ENSGT00550000074797; -.
DR Proteomes; UP000005447; Unassembled WGS sequence.
DR Bgee; ENSCPOG00000006112; Expressed in heart left ventricle and 12 other cell types or tissues.
DR GO; GO:0005096; F:GTPase activator activity; IEA:UniProtKB-KW.
DR CDD; cd13313; PH_NF1; 1.
DR CDD; cd05130; RasGAP_Neurofibromin; 1.
DR CDD; cd00170; SEC14; 1.
DR Gene3D; 3.40.525.10; CRAL-TRIO lipid binding domain; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR001251; CRAL-TRIO_dom.
DR InterPro; IPR036865; CRAL-TRIO_dom_sf.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR039360; Ras_GTPase.
DR InterPro; IPR023152; RasGAP_CS.
DR InterPro; IPR001936; RasGAP_dom.
DR InterPro; IPR008936; Rho_GTPase_activation_prot.
DR PANTHER; PTHR10194:SF142; NEUROFIBROMIN; 1.
DR PANTHER; PTHR10194; RAS GTPASE-ACTIVATING PROTEINS; 1.
DR Pfam; PF13716; CRAL_TRIO_2; 1.
DR Pfam; PF00616; RasGAP; 1.
DR SMART; SM00323; RasGAP; 1.
DR SMART; SM00516; SEC14; 1.
DR SUPFAM; SSF48371; ARM repeat; 2.
DR SUPFAM; SSF48350; GTPase activation domain, GAP; 1.
DR PROSITE; PS50191; CRAL_TRIO; 1.
DR PROSITE; PS00509; RAS_GTPASE_ACTIV_1; 1.
DR PROSITE; PS50018; RAS_GTPASE_ACTIV_2; 1.
PE 4: Predicted;
KW GTPase activation {ECO:0000256|ARBA:ARBA00022468};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000005447}.
FT DOMAIN 1187..1382
FT /note="Ras-GAP"
FT /evidence="ECO:0000259|PROSITE:PS50018"
FT DOMAIN 1511..1669
FT /note="CRAL-TRIO"
FT /evidence="ECO:0000259|PROSITE:PS50191"
FT REGION 2677..2729
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2692..2721
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2729 AA; 307229 MW; 873E05B4943B0D69 CRC64;
PIKTGQQNTH NKVSTEHNKE CLINISKYKF SLVISGLTTI LKNVNNMRIF GEAAEKNLYL
SQLIILDTLE KCLAGQPKDT MRLDETMLVK QLLPEICHFL HTCREGNQHA AELRNSASGV
LFSLSCNNFN AVFSRISTRL QELTVCSEDS VDVHDIELLQ YINVDCAKLK RLLKEIAFKF
KALKKVAQLA VINSLEKAFW NWVENYPDEF TKLYQIPQTD MAGKKKFLPY DPELFFFSIH
IFCLFWKLFL DSLRKALAGH GGSRQLTESA AIACVKLCKA STYINWEDNS VIFLLVQSMV
VDLKNLLFNP TKPFSRGSQP ADVDLMIDCL VSCFRISPQN NQHFKICLAQ NSPSTFHYVL
VNSLHRIITN SALDWWPKID AVYCHSVELR NMFGETLHKA VQGCGAHPAI RMAPSLTFKE
KVTSLKFKEK PTDLETRSYK YLLLSMVKLI HADPKLLLCN PRKQGPETQG STAELITGLV
QLVPQSHMPE IAQEAMEALL VLHQLDSIDL WNPDAPVETF WEISSQMLFY ICKKLTSHQM
LSSTEILKWL REILICRNKF LLKNKQADRS SCHFLFLYGV GCDVSASGSA TQMSMDHEEL
LRACTPGASL RKGKGNSSMD SAAGYSGTPP ICRQAQTKLE VALYMFLWSP DTEAVLVAMS
CFRHLCEEAD IRCGVDEVSV HNFLPNYSTF MEFASVSNMM STGRAALQKR VMALLRRIEH
PTAGNTEAWE DTHAKWEQAT KLILNYPKAK MEDGQAAESL HKTIVKRRMS HVSGGGSIDL
SDTDSLQEWI NMTGFLCALG GVCLQQRSNS GLATYSPPMG AVSERKGSMI SVMSSEGNVD
TPVSKFMDRL LSLMVCNHEK VGLQIRSNVK DLVGLELSPA LYPMLFNKLK NTISKFFDSQ
GQVLLTDTNT QFVEQTIAIM KNLLDNHTEG SSEHLGQASI ETMMLNLVRY VRVLGNMVHA
IQIKTKLCQL VEVMMARRDD LSFCQEMKFR NKMVEYLTDW VMGTSNQAAD DDVKCLTRDL
DQASMEAVVS LLAGLPLQPE EGDGVELMEA KSQLFLKYFT LFMNLLNDCS EVEDENAQTG
GRKRGMSRRL ASLRHCTVLA MSNLLNANVD SGLMHSIGLG YHKDLQTRAT FMEVLTKILQ
QGTEFDTLAE TVLADRFERL VELVTMMGDQ GELPIAMALA NVVPCSQWDE LARVLVTLFD
SRHLLYQLLW NMFSKEVELA DSMQTLFRGN SLASKIMTFC FKVYGATYLQ KLLDPLLRIV
ITSSEWQHVS FEVDPTRLEP SESLEENQRN LLQMTEKFFH AIVSSSLEFP PQLRSVCHCL
YQVVSQRFPQ NSIGAVGSAM FLRFINPAIV SPYEAGILDK KPPPRIERGL KLMSKILQSI
ANHVLFTKEE HMRPFNDFVK SNFDAARRFF LDIASDCPTS DAVNHSLSFI SDGNVLALHR
LLWNNQEKIG QYLSSNRDHK AVGRRPFDKM ATLLAYLGPP EHKPVADTHW SSLNLTSSKF
EEFMTRHQVH EKEEFKALKT LNIFYQAGTS KAGNPIFYYV ARRFKTGQIN GDLLIYHVLL
TLKPYYAKPY EIVVDLTHTG PSNRFKTDFL SKWFVVFPGF AYDNVSAVYI YNCNSWVREY
TKYHERLLTG LKGSKRLIFI DCPGKLAEHI EHDQQKLPAA TLALEEDLKV FHNALKLAHK
DTKVSIKVGS TAVQVTSAER TKVLGQSVFL NDIYYASEIE EICLVDENQF TLTIANQGTP
LTFMHQECEA IVQSIIHIRT RWELSQPDSI PQHTKIRPKD VPGTLLNIAL LNLGSSDPSL
RSAAYNLLCA LTCTFNLKIE GQLLETSGLC IPANNTLFIV SISKTLAANE PHLTLEFLEE
CISGFSKSSI ELKHLCLEYM TPWLSNLVRF CKHNDDAKRQ RVTAILDKLI TMTINEKQMY
PSIQAKIWGS LGQITDLLDV VLDSFIKTSA TGGLGSIKAE VMADTAVALA SGNVKLVSSK
VIGRMCKIID KTCLSPTPTL EQHLMWDDIA ILARYMLMLS FNNSLDVAAH LPYLFHVVTF
LVATGPLSLR ASTHGLVINI IHSLCTCSQL HFSEETKQVL RLSLTEFSLP KFYLLFGISK
VKSAAVIAFR SSYRDRSFSP GSYERETFAL TSLETVTEAL LEIMEACMRD IPTCKWLDQW
TELAQRFAFQ YNPSLQPRAL VVFGCISKRV SHGQIKQIIR ILSKALESCL KGPDTYNSQV
LIEATVIALT KLQPLLNKDS PLHRALFWVA MAVLQLDEIN LYSAGTALLE QNLHTLDSLR
IFNDKSPEEV FMAIRNPLEW HCKQMDHFVG LNFNSNFNFA LVGHLLKGYR HPSPAIVART
VRILHTLLTL VNKHRNCDKF EVNTQSVAYL AALLTVSEEV RSRCSLKHRK SLLLTDISME
NVPMDIYPIH HGDPSYRTLK ENQPWSSPKG SEGYLAATYP TMGQTSPRAR KSMSLDMGQP
SQANTKKLLG TRKSFDHLIS DTKAPKRQEM ESGITTPPKM RRVAETDYEM ETQRVSSSQQ
HPHLRKVSVS ESNVLLDEEV LTDPKIQALL LTVLMNTLLT LCQDPNLLNP IHGIVQSVVY
HEESPPQYQT SYLQSFGFNG LWRFAGPFSK QTQIPDYAEL IVKFLDALID TYLPGIDEET
SEESLLTPTS PYPPALQSQL SITANLNLSN SMTSLATSQH SPGIDKENVE LSPTTGHCNS
GRTRHGSASQ VQKQRSAGSF KRNSIKKIM
//
