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Database: UniProt
Entry: A0A286XVZ6_CAVPO
LinkDB: A0A286XVZ6_CAVPO
Original site: A0A286XVZ6_CAVPO 
ID   A0A286XVZ6_CAVPO        Unreviewed;       725 AA.
AC   A0A286XVZ6;
DT   22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT   22-NOV-2017, sequence version 1.
DT   24-JAN-2024, entry version 32.
DE   SubName: Full=Solute carrier family 26 member 6 {ECO:0000313|Ensembl:ENSCPOP00000029502.1};
GN   Name=SLC26A6 {ECO:0000313|Ensembl:ENSCPOP00000029502.1};
OS   Cavia porcellus (Guinea pig).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Hystricomorpha; Caviidae;
OC   Cavia.
OX   NCBI_TaxID=10141 {ECO:0000313|Ensembl:ENSCPOP00000029502.1, ECO:0000313|Proteomes:UP000005447};
RN   [1] {ECO:0000313|Proteomes:UP000005447}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=2N {ECO:0000313|Proteomes:UP000005447};
RX   PubMed=21993624; DOI=10.1038/nature10530;
RA   Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J., Washietl S.,
RA   Kheradpour P., Ernst J., Jordan G., Mauceli E., Ward L.D., Lowe C.B.,
RA   Holloway A.K., Clamp M., Gnerre S., Alfoldi J., Beal K., Chang J.,
RA   Clawson H., Cuff J., Di Palma F., Fitzgerald S., Flicek P., Guttman M.,
RA   Hubisz M.J., Jaffe D.B., Jungreis I., Kent W.J., Kostka D., Lara M.,
RA   Martins A.L., Massingham T., Moltke I., Raney B.J., Rasmussen M.D.,
RA   Robinson J., Stark A., Vilella A.J., Wen J., Xie X., Zody M.C., Baldwin J.,
RA   Bloom T., Chin C.W., Heiman D., Nicol R., Nusbaum C., Young S.,
RA   Wilkinson J., Worley K.C., Kovar C.L., Muzny D.M., Gibbs R.A., Cree A.,
RA   Dihn H.H., Fowler G., Jhangiani S., Joshi V., Lee S., Lewis L.R.,
RA   Nazareth L.V., Okwuonu G., Santibanez J., Warren W.C., Mardis E.R.,
RA   Weinstock G.M., Wilson R.K., Delehaunty K., Dooling D., Fronik C.,
RA   Fulton L., Fulton B., Graves T., Minx P., Sodergren E., Birney E.,
RA   Margulies E.H., Herrero J., Green E.D., Haussler D., Siepel A., Goldman N.,
RA   Pollard K.S., Pedersen J.S., Lander E.S., Kellis M.;
RT   "A high-resolution map of human evolutionary constraint using 29 mammals.";
RL   Nature 478:476-482(2011).
RN   [2] {ECO:0000313|Ensembl:ENSCPOP00000029502.1}
RP   IDENTIFICATION.
RC   STRAIN=2N {ECO:0000313|Ensembl:ENSCPOP00000029502.1};
RG   Ensembl;
RL   Submitted (JUL-2023) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141,
CC       ECO:0000256|RuleBase:RU362052}; Multi-pass membrane protein
CC       {ECO:0000256|ARBA:ARBA00004141, ECO:0000256|RuleBase:RU362052}.
CC   -!- SIMILARITY: Belongs to the SLC26A/SulP transporter (TC 2.A.53) family.
CC       {ECO:0000256|RuleBase:RU362052}.
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DR   EMBL; AAKN02012885; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   RefSeq; XP_005006601.1; XM_005006544.2.
DR   RefSeq; XP_013015010.1; XM_013159556.1.
DR   AlphaFoldDB; A0A286XVZ6; -.
DR   STRING; 10141.ENSCPOP00000029502; -.
DR   Ensembl; ENSCPOT00000034568.1; ENSCPOP00000029502.1; ENSCPOG00000033409.1.
DR   GeneID; 100689283; -.
DR   CTD; 65010; -.
DR   VEuPathDB; HostDB:ENSCPOG00000033409; -.
DR   GeneTree; ENSGT01070000253775; -.
DR   InParanoid; A0A286XVZ6; -.
DR   OMA; FMTICNE; -.
DR   OrthoDB; 1067648at2759; -.
DR   Proteomes; UP000005447; Unassembled WGS sequence.
DR   Bgee; ENSCPOG00000033409; Expressed in adult mammalian kidney and 13 other cell types or tissues.
DR   GO; GO:0016324; C:apical plasma membrane; IEA:Ensembl.
DR   GO; GO:0016323; C:basolateral plasma membrane; IEA:Ensembl.
DR   GO; GO:0031526; C:brush border membrane; IEA:Ensembl.
DR   GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR   GO; GO:0097225; C:sperm midpiece; IEA:Ensembl.
DR   GO; GO:0012506; C:vesicle membrane; IEA:Ensembl.
DR   GO; GO:0140900; F:chloride:bicarbonate antiporter activity; IEA:Ensembl.
DR   GO; GO:0015499; F:formate transmembrane transporter activity; IEA:Ensembl.
DR   GO; GO:0019531; F:oxalate transmembrane transporter activity; IEA:Ensembl.
DR   GO; GO:0030165; F:PDZ domain binding; IEA:Ensembl.
DR   GO; GO:0008271; F:secondary active sulfate transmembrane transporter activity; IEA:InterPro.
DR   GO; GO:0071320; P:cellular response to cAMP; IEA:Ensembl.
DR   GO; GO:0071332; P:cellular response to fructose stimulus; IEA:Ensembl.
DR   GO; GO:0071346; P:cellular response to type II interferon; IEA:Ensembl.
DR   GO; GO:0042045; P:epithelial fluid transport; IEA:Ensembl.
DR   GO; GO:0051649; P:establishment of localization in cell; IEA:Ensembl.
DR   GO; GO:0050892; P:intestinal absorption; IEA:Ensembl.
DR   GO; GO:0051454; P:intracellular pH elevation; IEA:Ensembl.
DR   GO; GO:0015797; P:mannitol transmembrane transport; IEA:Ensembl.
DR   GO; GO:0046724; P:oxalic acid secretion; IEA:Ensembl.
DR   GO; GO:2001150; P:positive regulation of dipeptide transmembrane transport; IEA:Ensembl.
DR   GO; GO:0048240; P:sperm capacitation; IEA:Ensembl.
DR   GO; GO:0030321; P:transepithelial chloride transport; IEA:Ensembl.
DR   CDD; cd07042; STAS_SulP_like_sulfate_transporter; 1.
DR   Gene3D; 3.30.750.24; STAS domain; 1.
DR   InterPro; IPR018045; S04_transporter_CS.
DR   InterPro; IPR011547; SLC26A/SulP_dom.
DR   InterPro; IPR001902; SLC26A/SulP_fam.
DR   InterPro; IPR002645; STAS_dom.
DR   InterPro; IPR036513; STAS_dom_sf.
DR   NCBIfam; TIGR00815; sulP; 1.
DR   PANTHER; PTHR11814:SF113; SOLUTE CARRIER FAMILY 26 MEMBER 6; 1.
DR   PANTHER; PTHR11814; SULFATE TRANSPORTER; 1.
DR   Pfam; PF01740; STAS; 1.
DR   Pfam; PF00916; Sulfate_transp; 1.
DR   SUPFAM; SSF52091; SpoIIaa-like; 1.
DR   PROSITE; PS01130; SLC26A; 1.
DR   PROSITE; PS50801; STAS; 1.
PE   3: Inferred from homology;
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU362052};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005447};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW   ECO:0000256|RuleBase:RU362052};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|RuleBase:RU362052}; Transport {ECO:0000256|RuleBase:RU362052}.
FT   TRANSMEM        83..110
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU362052"
FT   TRANSMEM        116..137
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU362052"
FT   TRANSMEM        158..182
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU362052"
FT   TRANSMEM        235..255
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU362052"
FT   TRANSMEM        267..284
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU362052"
FT   TRANSMEM        320..340
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU362052"
FT   TRANSMEM        352..371
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU362052"
FT   TRANSMEM        383..403
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU362052"
FT   TRANSMEM        447..478
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU362052"
FT   DOMAIN          502..708
FT                   /note="STAS"
FT                   /evidence="ECO:0000259|PROSITE:PS50801"
FT   REGION          560..598
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        567..581
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   725 AA;  79198 MW;  F273E956D7DC131C CRC64;
     MELHVKRPLL NQEQLEQLGH WGPAPRTYQW RTWFQCSRSR AHGLLLKYLP VLSWLPHYRV
     REWLLGDLLS GLSVAIMQLP QGLAYALLAG LPPVFGLYSS FYPVFIYFLF GTSRHISVGT
     FAIMSVMVGS VTESMVVDET VQQNTNSTEE ARVPLASTLS VLVGLFQVAL GLVQFGFVVN
     YLSEPLVRGY TTAASVQVFV SQLKYVFGIQ VSSRSGPLSL IQTFIEICQK LPNTVIGTMV
     TALVAGVALV MVKILNEKLH RRLPLPIPGE LLTLIVATGI SYGANLDSRF NVDVVGSIPA
     GLIAPVAPKP ELFAKLVGNA FAIAMVGFAI AISLGKIFAL RHGYRVDSNQ ELVALGLSNF
     IGGFFQCFPV SCSMSRSLVQ ETTGGNTQVA GAVSSLFILL IILKLGELFQ KLPKAVLAAI
     IIVNLKGMLK QFSDIRSLWK TNRVDLLIWL VTFVATILLD LDLGLVVAVV FSLLLVVVRT
     QLPRYSVLGQ VPDTDIYRDV AEYSEAKEVP GVKVFRSSAT LYFANAELYS DALKQRCGVD
     VDHLLAQKKK RLRKQALKLK RQQKDKQAAP PNGTSVSVSV DPSLGDVKGS GTVDSRAKVN
     PENELEDVAV SGQEDAKAPD ASVLKALGLP RPDFHTLILD LGALSFVDTV CIKSLKNIFR
     DFREIEVEVY IAACHSPVIT QLETGHFFDA SITKQHLFVS VHDAVTFALQ HSRPGPSSPV
     SATKL
//
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