ID A0A286XVZ6_CAVPO Unreviewed; 725 AA.
AC A0A286XVZ6;
DT 22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 1.
DT 24-JAN-2024, entry version 32.
DE SubName: Full=Solute carrier family 26 member 6 {ECO:0000313|Ensembl:ENSCPOP00000029502.1};
GN Name=SLC26A6 {ECO:0000313|Ensembl:ENSCPOP00000029502.1};
OS Cavia porcellus (Guinea pig).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Hystricomorpha; Caviidae;
OC Cavia.
OX NCBI_TaxID=10141 {ECO:0000313|Ensembl:ENSCPOP00000029502.1, ECO:0000313|Proteomes:UP000005447};
RN [1] {ECO:0000313|Proteomes:UP000005447}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=2N {ECO:0000313|Proteomes:UP000005447};
RX PubMed=21993624; DOI=10.1038/nature10530;
RA Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J., Washietl S.,
RA Kheradpour P., Ernst J., Jordan G., Mauceli E., Ward L.D., Lowe C.B.,
RA Holloway A.K., Clamp M., Gnerre S., Alfoldi J., Beal K., Chang J.,
RA Clawson H., Cuff J., Di Palma F., Fitzgerald S., Flicek P., Guttman M.,
RA Hubisz M.J., Jaffe D.B., Jungreis I., Kent W.J., Kostka D., Lara M.,
RA Martins A.L., Massingham T., Moltke I., Raney B.J., Rasmussen M.D.,
RA Robinson J., Stark A., Vilella A.J., Wen J., Xie X., Zody M.C., Baldwin J.,
RA Bloom T., Chin C.W., Heiman D., Nicol R., Nusbaum C., Young S.,
RA Wilkinson J., Worley K.C., Kovar C.L., Muzny D.M., Gibbs R.A., Cree A.,
RA Dihn H.H., Fowler G., Jhangiani S., Joshi V., Lee S., Lewis L.R.,
RA Nazareth L.V., Okwuonu G., Santibanez J., Warren W.C., Mardis E.R.,
RA Weinstock G.M., Wilson R.K., Delehaunty K., Dooling D., Fronik C.,
RA Fulton L., Fulton B., Graves T., Minx P., Sodergren E., Birney E.,
RA Margulies E.H., Herrero J., Green E.D., Haussler D., Siepel A., Goldman N.,
RA Pollard K.S., Pedersen J.S., Lander E.S., Kellis M.;
RT "A high-resolution map of human evolutionary constraint using 29 mammals.";
RL Nature 478:476-482(2011).
RN [2] {ECO:0000313|Ensembl:ENSCPOP00000029502.1}
RP IDENTIFICATION.
RC STRAIN=2N {ECO:0000313|Ensembl:ENSCPOP00000029502.1};
RG Ensembl;
RL Submitted (JUL-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141,
CC ECO:0000256|RuleBase:RU362052}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141, ECO:0000256|RuleBase:RU362052}.
CC -!- SIMILARITY: Belongs to the SLC26A/SulP transporter (TC 2.A.53) family.
CC {ECO:0000256|RuleBase:RU362052}.
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DR EMBL; AAKN02012885; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_005006601.1; XM_005006544.2.
DR RefSeq; XP_013015010.1; XM_013159556.1.
DR AlphaFoldDB; A0A286XVZ6; -.
DR STRING; 10141.ENSCPOP00000029502; -.
DR Ensembl; ENSCPOT00000034568.1; ENSCPOP00000029502.1; ENSCPOG00000033409.1.
DR GeneID; 100689283; -.
DR CTD; 65010; -.
DR VEuPathDB; HostDB:ENSCPOG00000033409; -.
DR GeneTree; ENSGT01070000253775; -.
DR InParanoid; A0A286XVZ6; -.
DR OMA; FMTICNE; -.
DR OrthoDB; 1067648at2759; -.
DR Proteomes; UP000005447; Unassembled WGS sequence.
DR Bgee; ENSCPOG00000033409; Expressed in adult mammalian kidney and 13 other cell types or tissues.
DR GO; GO:0016324; C:apical plasma membrane; IEA:Ensembl.
DR GO; GO:0016323; C:basolateral plasma membrane; IEA:Ensembl.
DR GO; GO:0031526; C:brush border membrane; IEA:Ensembl.
DR GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR GO; GO:0097225; C:sperm midpiece; IEA:Ensembl.
DR GO; GO:0012506; C:vesicle membrane; IEA:Ensembl.
DR GO; GO:0140900; F:chloride:bicarbonate antiporter activity; IEA:Ensembl.
DR GO; GO:0015499; F:formate transmembrane transporter activity; IEA:Ensembl.
DR GO; GO:0019531; F:oxalate transmembrane transporter activity; IEA:Ensembl.
DR GO; GO:0030165; F:PDZ domain binding; IEA:Ensembl.
DR GO; GO:0008271; F:secondary active sulfate transmembrane transporter activity; IEA:InterPro.
DR GO; GO:0071320; P:cellular response to cAMP; IEA:Ensembl.
DR GO; GO:0071332; P:cellular response to fructose stimulus; IEA:Ensembl.
DR GO; GO:0071346; P:cellular response to type II interferon; IEA:Ensembl.
DR GO; GO:0042045; P:epithelial fluid transport; IEA:Ensembl.
DR GO; GO:0051649; P:establishment of localization in cell; IEA:Ensembl.
DR GO; GO:0050892; P:intestinal absorption; IEA:Ensembl.
DR GO; GO:0051454; P:intracellular pH elevation; IEA:Ensembl.
DR GO; GO:0015797; P:mannitol transmembrane transport; IEA:Ensembl.
DR GO; GO:0046724; P:oxalic acid secretion; IEA:Ensembl.
DR GO; GO:2001150; P:positive regulation of dipeptide transmembrane transport; IEA:Ensembl.
DR GO; GO:0048240; P:sperm capacitation; IEA:Ensembl.
DR GO; GO:0030321; P:transepithelial chloride transport; IEA:Ensembl.
DR CDD; cd07042; STAS_SulP_like_sulfate_transporter; 1.
DR Gene3D; 3.30.750.24; STAS domain; 1.
DR InterPro; IPR018045; S04_transporter_CS.
DR InterPro; IPR011547; SLC26A/SulP_dom.
DR InterPro; IPR001902; SLC26A/SulP_fam.
DR InterPro; IPR002645; STAS_dom.
DR InterPro; IPR036513; STAS_dom_sf.
DR NCBIfam; TIGR00815; sulP; 1.
DR PANTHER; PTHR11814:SF113; SOLUTE CARRIER FAMILY 26 MEMBER 6; 1.
DR PANTHER; PTHR11814; SULFATE TRANSPORTER; 1.
DR Pfam; PF01740; STAS; 1.
DR Pfam; PF00916; Sulfate_transp; 1.
DR SUPFAM; SSF52091; SpoIIaa-like; 1.
DR PROSITE; PS01130; SLC26A; 1.
DR PROSITE; PS50801; STAS; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU362052};
KW Reference proteome {ECO:0000313|Proteomes:UP000005447};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU362052};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU362052}; Transport {ECO:0000256|RuleBase:RU362052}.
FT TRANSMEM 83..110
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362052"
FT TRANSMEM 116..137
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362052"
FT TRANSMEM 158..182
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362052"
FT TRANSMEM 235..255
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362052"
FT TRANSMEM 267..284
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362052"
FT TRANSMEM 320..340
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362052"
FT TRANSMEM 352..371
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362052"
FT TRANSMEM 383..403
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362052"
FT TRANSMEM 447..478
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362052"
FT DOMAIN 502..708
FT /note="STAS"
FT /evidence="ECO:0000259|PROSITE:PS50801"
FT REGION 560..598
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 567..581
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 725 AA; 79198 MW; F273E956D7DC131C CRC64;
MELHVKRPLL NQEQLEQLGH WGPAPRTYQW RTWFQCSRSR AHGLLLKYLP VLSWLPHYRV
REWLLGDLLS GLSVAIMQLP QGLAYALLAG LPPVFGLYSS FYPVFIYFLF GTSRHISVGT
FAIMSVMVGS VTESMVVDET VQQNTNSTEE ARVPLASTLS VLVGLFQVAL GLVQFGFVVN
YLSEPLVRGY TTAASVQVFV SQLKYVFGIQ VSSRSGPLSL IQTFIEICQK LPNTVIGTMV
TALVAGVALV MVKILNEKLH RRLPLPIPGE LLTLIVATGI SYGANLDSRF NVDVVGSIPA
GLIAPVAPKP ELFAKLVGNA FAIAMVGFAI AISLGKIFAL RHGYRVDSNQ ELVALGLSNF
IGGFFQCFPV SCSMSRSLVQ ETTGGNTQVA GAVSSLFILL IILKLGELFQ KLPKAVLAAI
IIVNLKGMLK QFSDIRSLWK TNRVDLLIWL VTFVATILLD LDLGLVVAVV FSLLLVVVRT
QLPRYSVLGQ VPDTDIYRDV AEYSEAKEVP GVKVFRSSAT LYFANAELYS DALKQRCGVD
VDHLLAQKKK RLRKQALKLK RQQKDKQAAP PNGTSVSVSV DPSLGDVKGS GTVDSRAKVN
PENELEDVAV SGQEDAKAPD ASVLKALGLP RPDFHTLILD LGALSFVDTV CIKSLKNIFR
DFREIEVEVY IAACHSPVIT QLETGHFFDA SITKQHLFVS VHDAVTFALQ HSRPGPSSPV
SATKL
//