ID A0A286XX08_CAVPO Unreviewed; 628 AA.
AC A0A286XX08;
DT 22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 1.
DT 27-MAR-2024, entry version 30.
DE SubName: Full=Transmembrane and coiled-coil domains 4 {ECO:0000313|Ensembl:ENSCPOP00000029862.1};
GN Name=TMCO4 {ECO:0000313|Ensembl:ENSCPOP00000029862.1};
OS Cavia porcellus (Guinea pig).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Hystricomorpha; Caviidae;
OC Cavia.
OX NCBI_TaxID=10141 {ECO:0000313|Ensembl:ENSCPOP00000029862.1, ECO:0000313|Proteomes:UP000005447};
RN [1] {ECO:0000313|Proteomes:UP000005447}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=2N {ECO:0000313|Proteomes:UP000005447};
RX PubMed=21993624; DOI=10.1038/nature10530;
RA Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J., Washietl S.,
RA Kheradpour P., Ernst J., Jordan G., Mauceli E., Ward L.D., Lowe C.B.,
RA Holloway A.K., Clamp M., Gnerre S., Alfoldi J., Beal K., Chang J.,
RA Clawson H., Cuff J., Di Palma F., Fitzgerald S., Flicek P., Guttman M.,
RA Hubisz M.J., Jaffe D.B., Jungreis I., Kent W.J., Kostka D., Lara M.,
RA Martins A.L., Massingham T., Moltke I., Raney B.J., Rasmussen M.D.,
RA Robinson J., Stark A., Vilella A.J., Wen J., Xie X., Zody M.C., Baldwin J.,
RA Bloom T., Chin C.W., Heiman D., Nicol R., Nusbaum C., Young S.,
RA Wilkinson J., Worley K.C., Kovar C.L., Muzny D.M., Gibbs R.A., Cree A.,
RA Dihn H.H., Fowler G., Jhangiani S., Joshi V., Lee S., Lewis L.R.,
RA Nazareth L.V., Okwuonu G., Santibanez J., Warren W.C., Mardis E.R.,
RA Weinstock G.M., Wilson R.K., Delehaunty K., Dooling D., Fronik C.,
RA Fulton L., Fulton B., Graves T., Minx P., Sodergren E., Birney E.,
RA Margulies E.H., Herrero J., Green E.D., Haussler D., Siepel A., Goldman N.,
RA Pollard K.S., Pedersen J.S., Lander E.S., Kellis M.;
RT "A high-resolution map of human evolutionary constraint using 29 mammals.";
RL Nature 478:476-482(2011).
RN [2] {ECO:0000313|Ensembl:ENSCPOP00000029862.1}
RP IDENTIFICATION.
RC STRAIN=2N {ECO:0000313|Ensembl:ENSCPOP00000029862.1};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the TMCO4 family.
CC {ECO:0000256|ARBA:ARBA00009824}.
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DR EMBL; AAKN02028755; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_003471411.1; XM_003471363.3.
DR AlphaFoldDB; A0A286XX08; -.
DR STRING; 10141.ENSCPOP00000029862; -.
DR Ensembl; ENSCPOT00000040244.1; ENSCPOP00000029862.1; ENSCPOG00000031285.1.
DR GeneID; 100722998; -.
DR KEGG; cpoc:100722998; -.
DR CTD; 255104; -.
DR VEuPathDB; HostDB:ENSCPOG00000031285; -.
DR eggNOG; KOG2385; Eukaryota.
DR GeneTree; ENSGT00390000001400; -.
DR InParanoid; A0A286XX08; -.
DR OMA; DWLLRFI; -.
DR OrthoDB; 8526at2759; -.
DR Proteomes; UP000005447; Unassembled WGS sequence.
DR Bgee; ENSCPOG00000031285; Expressed in adult mammalian kidney and 12 other cell types or tissues.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR InterPro; IPR029058; AB_hydrolase.
DR InterPro; IPR007941; DUF726.
DR PANTHER; PTHR17920:SF3; TRANSMEMBRANE AND COILED-COIL DOMAIN-CONTAINING PROTEIN 4; 1.
DR PANTHER; PTHR17920; TRANSMEMBRANE AND COILED-COIL DOMAIN-CONTAINING PROTEIN 4 TMCO4; 1.
DR Pfam; PF05277; DUF726; 1.
DR SUPFAM; SSF53474; alpha/beta-Hydrolases; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000005447};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 184..210
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 216..243
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT REGION 1..24
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 530..628
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..15
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 530..559
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 613..628
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 628 AA; 67271 MW; BA1B7E04B22948F6 CRC64;
MATWDRPSQK QPQGTEPAAE REPVGRELAE ANRFAYAALC GISLSQLFPE PEQSSFCTEF
MAGLVKWLEL SEAVLPTMTA FASGLGGEGT DMFAEILLKD PILKGDPSLI TQDLLSFSLK
EGRYDARARV LVCHITSLLQ VPLEELDVLE ETFLESLKET REEESETAEA SRKKKENRRK
WKRYLLIGLA TVGGGTVIGV TGGLAAPLVA AGAATVIGSA GAAALGSAAG IAVMTSLFGA
AGAGLTGYKM KKRVGAIEEF TFLPLTEGRQ LHITIAITGW LASGRYRTFS APWTALAHSR
EQYCLAWEAK YLMELGNALE TILSGLANMV AQEALKYTVL SGIVAALTWP ASLLSVANVI
DNPWGVCLHR SAEVGKHLAH ILLSRQQGQR PVTLVGFSLG ARVIYFCLQE MAQEKGCQGI
IEDVVLLGAP VEGDPKHWEP FRKVVSGRIV NGYSRGDWLL SFVYRTSSVQ LRVAGLQPVL
LQDRRMENVD LSLVVGGHLD YAKKMDIILK AVGIRTKPGW GEKGLLLAPS NQSQEEPHQA
TAASSAGQIP HQDGQTQEPA PGDTPKVAEP PDPSHTQVLA ELDQSEGASL PAIQGPDESA
HVCSHGMGPN PLGCPNCSQS QGPCPGLD
//
